Minocycline protects photoreceptors from light and oxidative stress in primary bovine retinal cell culture

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 1, 2007, Pages 412-421

  Leung, David W ^a   Lindlief, Lance A ^a   Laabich, Aicha ^a   Vissvesvaran, Ganesh P ^a   Kamat, Mahesh ^a   Lieu, Kuo L ^a   Fawzi, Ahmad ^a   Kubota, Ryo ^a  

^a Acucela Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORTETRACYCLINE; DEMECLOCYCLINE; DOXYCYCLINE; MECLOCYCLINE; METACYCLINE; MINOCYCLINE; OXYTETRACYCLINE; TETRACYCLINE; ANTIINFECTIVE AGENT; CASPASE; FLUORESCENT DYE; ORGANIC COMPOUND; REACTIVE OXYGEN METABOLITE; SYTOX GREEN; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; COW; DEVICE; DRUG MECHANISM; DRUG STRUCTURE; IMMUNOCYTOCHEMISTRY; LIGHT; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PHOTOTOXICITY; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; RETINA CELL; ANIMAL; APOPTOSIS; CATTLE; CHEMICALLY INDUCED DISORDER; CULTURE TECHNIQUE; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GLIA; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RETINA DISEASE;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; CASPASES; CATTLE; CELL CULTURE TECHNIQUES; CYTOPROTECTION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUORESCENT DYES; LIGHT; MINOCYCLINE; NEUROGLIA; ORGANIC CHEMICALS; OXIDATIVE STRESS; PHOTORECEPTORS, VERTEBRATE; RADIATION INJURIES, EXPERIMENTAL; REACTIVE OXYGEN SPECIES; RETINAL BIPOLAR CELLS; RETINAL DISEASES; TERT-BUTYLHYDROPEROXIDE;

EID: 33846915795     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-0522     Document Type: Article

References (47)

1. Stirling DP, Koochesfahani KM, Steeves JD, Tetzlaff W. Minocycline as a neuroprotective agent. Neuroscientist. 2005;11:308-322.
2. Algvere PV, Marshall J, Seregard S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand. 2006;84:4-15.
3. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
4. Kutty RK, Kutty G, Wiggert B, Chader GJ, Darrow RM, Organisciak DT. Induction of heme oxygenase 1 in the retina by intense visible light: Suppression by the antioxidant dimethylthiourea. Proc Natl Acad Sci USA. 1995;92:1177-1181.
5. Organisciak DT, Darrow RM, Barsalou L, et al. Light history and age-related changes in retinal light damage. Invest Ophthalmol Vis Sci. 1998;39:1107-1116.
6. Reme CE. The dark side of light: rhodopsin and the silent death of vision: The Proctor Lecture. Invest Ophthalmol Vis Sci. 2005;46:2671-2682.
7. Rozanowska M, Sarna T. Light-induced damage to the retina: role of rhodopsin chromophore revisited. Photochem Photobiol. 2005;81:1305-1330.
8. Wenzel A, Grimm C, Samardzija M, Reme CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005;24:275-306.
9. Hafezi F, Marti A, Munz K, Reme CE. Light-induced apoptosis: differential timing in the retina and pigment epithelium. Exp Eye Res. 1997;64:963-970.
10. Zhang C, Lei B, Lam TT, Yang F, Sinha D, Tso MO. Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2004;45:2753-2759.
11. Chang CJ, Cherng CH, Liou WS, Liao CL. Minocycline partially inhibits caspase-3 activation and photoreceptor degeneration after photic injury. Ophthalmic Res. 2005;37:202-213.
12. Hughes EH, Schlichtenbrede FC, Murphy CC, et al. Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp Eye Res. 2004;78:1077-1084.
13. Roque RS, Rosales AA, Jingjing L, Agarwal N, Al-Ubaidi MR. Retina-derived microglial cells induce photoreceptor cell death in vitro. Brain Res. 1999;836:110-119.
14. Srinivasan B, Roque CH, Hempstead BL, Al-Ubaidi MR, Roque RS. Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. J Biol Chem. 2004;279:41839-41845.
15. Wirostko E, Wirostko WJ, Wirostko BM. Age-related macular degeneration is an inflammatory disease possibly treatable with minocycline. Acta Ophthalmol Scand. 2004;82:243-244.
16. Diguet E, Gross CE, Tison F, Bezard E. Rise and fall of minocycline in neuroprotection: need to promote publication of negative results. Exp Neurol. 2004;189:1-4.
17. Fernandez-Gomez FJ, Gomez-Lazaro M, Pastor D, et al. Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death. Neurobiol Dis. 2005;20:384-391.
18. Sriram K, Miller DB, O'Callaghan JP. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. J Neurochem. 2006;96:706-718.
19. Stefanova N, Mitschnigg M, Ghorayeb I, et al. Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration. J Neurosci Res. 2004;78:87-91.
20. Bantubungi K, Jacquard C, Greco A, et al. Minocycline in phenotypic models of Huntington's disease. Neurobiol Dis. 2005;18:206-217.
21. Laabich A, Vissvesvaran GP, Lieu KL, et al. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol Vis Sci. 2006;47:3156-3163.
22. Gao X, Dinkova-Kostova AT, Talalay P. Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane. Proc Natl Acad Sci USA. 2001;98:15221-15226.
23. Haverkamp S, Haeseleer F, Hendrickson A. A comparison of immunocytochemical markers to identify bipolar cell types in human and monkey retina. Vis Neurosci. 2003;20:589-600.
24. Zhang JH, Chung TD, Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen. 1999;4:67-73.
25. Baptiste DC, Hartwick AT, Jollimore CA, Baldridge WH, Seigel GM, Kelly ME. An investigation of the neuroprotective effects of tetracycline derivatives in experimental models of retinal cell death. Mol Pharmacol. 2004;66:1113-1122.
26. Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005;280:33811-33818.
27. Nunez G, Benedict MA, Hu Y, Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene. 1998;17:3237-3245.
28. Bedner E, Smolewski P, Amstad P, Darzynkiewicz Z. Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (flica): correlation with DNA fragmentation. Exp Cell Res. 2000;259:308-313.
29. Kraus RL, Pasieczny R, Lariosa-Willingham K, Turner MS, Jiang A, Trauger JW. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem. 2005;94:819-827.
30. Morimoto N, Shimazawa M, Yamashima T, Nagai H, Hara H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res. 2005;1044:8-15.
31. Yang JH, Basinger SF, Gross RL, Wu SM. Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport. Invest Ophthalmol Vis Sci. 2003;44:1312-1319.
32. Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and n-acetylcysteine. Proc Natl Acad Sci USA. 1991;88:986-990.
33. Margrain TH, Boulton M, Marshall J, Sliney DH. Do blue light filters confer protection against age-related macular degeneration. Prog Retin Eye Res. 2004;23:523-531.
34. Gaudin C, Forster V, Sahel J, Dreyfus H, Hicks D. Survival and regeneration of adult human and other mammalian photoreceptors in culture. Invest Ophthalmol Vis Sci. 1996;37:2258-2268.
35. Picaud S, Pattnaik B, Hicks D, et al. Gabaa and gabac receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model. J Physiol. 1998;513:33-42.
36. Martin JP Jr, Colina K, Logsdon N. Role of oxygen radicals in the phototoxicity of tetracyclines toward Escherichia coli b. J Bacteriol. 1987;169:2516-2522.
37. Wainwright NJ, Collins P, Ferguson J. Photosensitivity associated with antibacterial agents. Drug Saf. 1993;9:437-440.
38. Layton AM, Cunliffe WJ. Phototoxic eruptions due to doxycycline: a dose-related phenomenon. Clin Exp Dermatol. 1993;18:425-427.
39. Scarabelli TM, Stephanou A, Pasini E, et al. Minocycline inhibits caspase activation and reactivation, increases the ratio of xiap to smac/diablo, and reduces the mitochondrial leakage of cytochrome c and smac/diablo. J Am Coll Cardiol. 2004;43:865-874.
40. Wang J, Wei Q, Wang C-Y, Hill WD, Hess DC, Dong Z. Minocycline up-regulates bcl-2 and protects against cell death in mitochondria. J Biol Chem. 2004;279:19948-19954.
41. Wang X, Zhu S, Drozda M, et al. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci USA. 2003;100:10483-10487.
42. Lasarow RM, Isseroff RR, Gomez EC. Quantitative in vitro assessment of phototoxicity by a fibroblast-neutral red assay. J Invest Dermatol. 1992;98:725-729.
43. Hasan T, Khan AU. Phototoxicity of the tetracyclines: photosensitized emission of singlet delta dioxygen. Proc Natl Acad Sci USA. 1986;83:4604-4606.
44. Martinez LJ, Sik RH, Chignell CF. Fluoroquinolone antimicrobials: singlet oxygen, superoxide and phototoxicity. Photochem Photobiol. 1998;67:399-403.
45. Martinez L, Chignell CF. Photocleavage of DNA by the fluoroquinolone antibacterials. J Photochem Photobiol B. 1998;45:51-59.
46. Lertvorachon J, Kim JP, Soldatov DV, et al. 1,12-substituted tetracyclines as antioxidant agents. Bioorg Med Chem. 2005;13:4627-4637.
47. Nelson ML, Ismail MY, McIntyre L, et al. Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via pd-catalyzed reactions. J Org Chem. 2003;68:5838-5851.