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Volumn 47, Issue 7, 2006, Pages 3156-3163

Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture

Author keywords

[No Author keywords available]

Indexed keywords

CROCIN; CAROTENOID; PLANT EXTRACT;

EID: 33746733130     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-1621     Document Type: Article
Times cited : (61)

References (50)
  • 1
    • 0033795036 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of age-related macular degeneration
    • Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
    • (2000) Surv Ophthalmol , vol.45 , pp. 115-134
    • Beatty, S.1    Koh, H.2    Phil, M.3    Henson, D.4    Boulton, M.5
  • 4
    • 33144459399 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of age-related macular degeneration
    • Donoso LA, Kim D, Frost A, Callahan A, Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2006;51:137-152.
    • (2006) Surv Ophthalmol , vol.51 , pp. 137-152
    • Donoso, L.A.1    Kim, D.2    Frost, A.3    Callahan, A.4    Hageman, G.5
  • 5
    • 0032992736 scopus 로고    scopus 로고
    • Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration
    • Frank RN, Amin RH, Puklin JE. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. Am J Ophthalmol. 1999;127:694-709.
    • (1999) Am J Ophthalmol , vol.127 , pp. 694-709
    • Frank, R.N.1    Amin, R.H.2    Puklin, J.E.3
  • 6
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385-389.
    • (2005) Science , vol.308 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 7
    • 0027410970 scopus 로고    scopus 로고
    • Retinal age pigments generated by self-assembling lysosomotropic detergents
    • Eldred GE, Lasky MR. Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature. 361:724-726.
    • Nature , vol.361 , pp. 724-726
    • Eldred, G.E.1    Lasky, M.R.2
  • 9
    • 0034105724 scopus 로고    scopus 로고
    • Protection of RPE65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration
    • Grimm C, Wenzel A, Hafezi F, Yu S, Redmond TM, Reme CE. Protection of RPE65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration. Nat Genet. 2000;25:63-66.
    • (2000) Nat Genet , vol.25 , pp. 63-66
    • Grimm, C.1    Wenzel, A.2    Hafezi, F.3    Yu, S.4    Redmond, T.M.5    Reme, C.E.6
  • 11
    • 0035144009 scopus 로고    scopus 로고
    • Protective effect of halothane anesthesia on retinal light damage: Inhibition of metabolic rhodopsin regeneration
    • Keller C, Grimm C, Wenzel A, Hafezi F, Reme CE. Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration. Invest Ophthalmol Vis Sci. 2001;42:476-480.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 476-480
    • Keller, C.1    Grimm, C.2    Wenzel, A.3    Hafezi, F.4    Reme, C.E.5
  • 12
    • 0033760069 scopus 로고    scopus 로고
    • Blue light's effects on rhodopsin: Photoreversal of bleaching in living rat eyes
    • Grimm C, Reme CE, Rol PO, Williams TP. Blue light's effects on rhodopsin: photoreversal of bleaching in living rat eyes. Invest Ophthalmol Vis Sci. 2000;41:3984-3990.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3984-3990
    • Grimm, C.1    Reme, C.E.2    Rol, P.O.3    Williams, T.P.4
  • 13
    • 0346271764 scopus 로고    scopus 로고
    • Light-induced photoreceptor damage triggers DNA repair: Differential fate of rods and cones
    • Cortina MS, Gordon WC, Lukiw WJ, Bazan NG. Light-induced photoreceptor damage triggers DNA repair: differential fate of rods and cones. Adv Exp Med Biol. 2003;533:229-240.
    • (2003) Adv Exp Med Biol , vol.533 , pp. 229-240
    • Cortina, M.S.1    Gordon, W.C.2    Lukiw, W.J.3    Bazan, N.G.4
  • 14
    • 0023224438 scopus 로고
    • Pathophysiology of age-related macular degeneration
    • Young RW. Pathophysiology of age-related macular degeneration. Surv Ophthalmol. 1987;31:291-306.
    • (1987) Surv Ophthalmol , vol.31 , pp. 291-306
    • Young, R.W.1
  • 16
    • 0031732461 scopus 로고    scopus 로고
    • The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the retina
    • Sugawara T, Sieving PA, Luvone PM, Bush RA. The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the retina. Invest Ophthalmol Vis Sci. 1998;39:2458-2465.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 2458-2465
    • Sugawara, T.1    Sieving, P.A.2    Luvone, P.M.3    Bush, R.A.4
  • 17
    • 0033173601 scopus 로고    scopus 로고
    • Light-induced damage in the retina: Differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation
    • Organisciak DT, Darrow RA, Barsalou L, Barrow RM, Lininger LA. Light-induced damage in the retina: differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation. Photochem Photobiol. 1999;70:261-268.
    • (1999) Photochem Photobiol , vol.70 , pp. 261-268
    • Organisciak, D.T.1    Darrow, R.A.2    Barsalou, L.3    Barrow, R.M.4    Lininger, L.A.5
  • 18
    • 0042866149 scopus 로고    scopus 로고
    • Biologic mechanisms of the protective role of lutein and Zeaxanthin in the eye
    • Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and Zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201.
    • (2003) Annu Rev Nutr , vol.23 , pp. 171-201
    • Krinsky, N.I.1    Landrum, J.T.2    Bone, R.A.3
  • 19
    • 16244378900 scopus 로고    scopus 로고
    • Sulforaphane induces thioredoxin through the anti-oxidant-responsive element and attenuates retinal light damage in mice
    • Tanito M, Masutani H, Kim YC, Nishikawa M, Ohira A, Yodoi J. Sulforaphane induces thioredoxin through the anti-oxidant-responsive element and attenuates retinal light damage in mice. Invest Ophthalmol Vis Sci. 2005;46:979-987.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 979-987
    • Tanito, M.1    Masutani, H.2    Kim, Y.C.3    Nishikawa, M.4    Ohira, A.5    Yodoi, J.6
  • 20
    • 0025774015 scopus 로고
    • Inhibitory effects of nigella sativa and saffron on chemical carcinogenesis in mice
    • Salomi MJ, Nair SC, Pannikar KR. Inhibitory effects of nigella sativa and saffron on chemical carcinogenesis in mice. Nutr Cancer. 1991;16:67-72.
    • (1991) Nutr Cancer , vol.16 , pp. 67-72
    • Salomi, M.J.1    Nair, S.C.2    Pannikar, K.R.3
  • 21
    • 0016852683 scopus 로고
    • The use of crocetin in experimental atherosclerosis
    • Gainer JL, Jones JR. The use of crocetin in experimental atherosclerosis. Experientia. 1975;31:548-549.
    • (1975) Experientia , vol.31 , pp. 548-549
    • Gainer, J.L.1    Jones, J.R.2
  • 22
    • 0025780593 scopus 로고
    • Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats
    • Wang CJ, Shiow SJ, Lin JK. Effects of crocetin on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Carcinogenesis. 1991;12:459-462.
    • (1991) Carcinogenesis , vol.12 , pp. 459-462
    • Wang, C.J.1    Shiow, S.J.2    Lin, J.K.3
  • 23
    • 0141746538 scopus 로고    scopus 로고
    • Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
    • Hosseinzadeh H, Younesi H. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002;2:7.
    • (2002) BMC Pharmacol , vol.2 , pp. 7
    • Hosseinzadeh, H.1    Younesi, H.2
  • 24
    • 0028090631 scopus 로고
    • Ethanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo
    • Sugiura M, Shoyama Y, Saito H, Abe K. Ethanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. J Pharmacol Exp Ther. 1994;271:703-707.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 703-707
    • Sugiura, M.1    Shoyama, Y.2    Saito, H.3    Abe, K.4
  • 25
    • 0033399114 scopus 로고    scopus 로고
    • Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo
    • Abe K, Sugiura M, Yamaguchi S, Shoyama Y, Saito H. Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res. 1999;851:287-289.
    • (1999) Brain Res , vol.851 , pp. 287-289
    • Abe, K.1    Sugiura, M.2    Yamaguchi, S.3    Shoyama, Y.4    Saito, H.5
  • 26
    • 0032536730 scopus 로고    scopus 로고
    • Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons
    • Abe K, Sugiura M, Shoyama Y, Saito H. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res. 1998;787:132-138.
    • (1998) Brain Res , vol.787 , pp. 132-138
    • Abe, K.1    Sugiura, M.2    Shoyama, Y.3    Saito, H.4
  • 27
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 28
    • 0037336143 scopus 로고    scopus 로고
    • Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport
    • Yang JH, Basinger SF, Gross RL, Wu SM. Blue light-induced generation of reactive oxygen species in photoreceptor ellipsoids requires mitochondrial electron transport. Invest Ophthalmol Vis Sci. 2003;44:1312-1319.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 1312-1319
    • Yang, J.H.1    Basinger, S.F.2    Gross, R.L.3    Wu, S.M.4
  • 29
    • 11144273817 scopus 로고    scopus 로고
    • Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection of retinal degeneration
    • Wenzel A, Grimm C, Samardzija M, Reme CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection of retinal degeneration. Prog Retin Eye Res. 2005;275-306.
    • (2005) Prog Retin Eye Res , pp. 275-306
    • Wenzel, A.1    Grimm, C.2    Samardzija, M.3    Reme, C.E.4
  • 30
    • 0141764823 scopus 로고    scopus 로고
    • Basic fibroblast and epidermal growth factors stimulate survival in adult porcine photoreceptor cell cultures
    • Traverso V, Kinkl N, Grimm L, Sahel J, Hicks D. Basic fibroblast and epidermal growth factors stimulate survival in adult porcine photoreceptor cell cultures. Invest Ophthalmol Vis Sci. 2003;44:4550-4558.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 4550-4558
    • Traverso, V.1    Kinkl, N.2    Grimm, L.3    Sahel, J.4    Hicks, D.5
  • 31
    • 0027276606 scopus 로고
    • Monoclonal antibody substrates facilitate long-term regenerative growth of adult primate retinal neurons
    • O'Malley MB, MacLeish PR. Monoclonal antibody substrates facilitate long-term regenerative growth of adult primate retinal neurons. J Neurosci Methods. 1993;47:61-71.
    • (1993) J Neurosci Methods , vol.47 , pp. 61-71
    • O'Malley, M.B.1    MacLeish, P.R.2
  • 32
    • 0025828833 scopus 로고
    • Organization and development of the primate photoreceptor mosaic
    • Osbourne N, Chader J, eds, Oxford, UK: Pergamon Press;
    • Curcio CA, Hendrickson AE. Organization and development of the primate photoreceptor mosaic. In: Osbourne N, Chader J, eds. Progress in Retinal Research. Oxford, UK: Pergamon Press; 1991: 89-120.
    • (1991) Progress in Retinal Research , pp. 89-120
    • Curcio, C.A.1    Hendrickson, A.E.2
  • 33
    • 0036310829 scopus 로고    scopus 로고
    • Distribution and density of medium-and short-wavelength selective cones in the domestic pig retina
    • Hendrickson A, Hicks D. Distribution and density of medium-and short-wavelength selective cones in the domestic pig retina. Exp Eye Res. 2002;74:435-444.
    • (2002) Exp Eye Res , vol.74 , pp. 435-444
    • Hendrickson, A.1    Hicks, D.2
  • 34
    • 4043130958 scopus 로고    scopus 로고
    • Do blue light filters confer protection against age-related macular degeneration?
    • Margrain TH, Boulton M, Marshall J, Sliney DH. Do blue light filters confer protection against age-related macular degeneration? Prog Retin Eye Res. 2004;23:523-531.
    • (2004) Prog Retin Eye Res , vol.23 , pp. 523-531
    • Margrain, T.H.1    Boulton, M.2    Marshall, J.3    Sliney, D.H.4
  • 35
    • 11144273817 scopus 로고    scopus 로고
    • Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration
    • Wenzel A, Grimm C, Samardzija M, Reme CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005;24:275-306.
    • (2005) Prog Retin Eye Res , vol.24 , pp. 275-306
    • Wenzel, A.1    Grimm, C.2    Samardzija, M.3    Reme, C.E.4
  • 36
    • 0032493433 scopus 로고    scopus 로고
    • Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse
    • Mohand-Said S, Deudon-Combe A, Hicks D, et al. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse. Proc Natl Acad Sci USA. 1998;95:8357-8362.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8357-8362
    • Mohand-Said, S.1    Deudon-Combe, A.2    Hicks, D.3
  • 37
    • 0037308591 scopus 로고    scopus 로고
    • Partial characterization of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration
    • Fintz AC, Audo I, Hicks D, et al. Partial characterization of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2003;44:818-825.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 818-825
    • Fintz, A.C.1    Audo, I.2    Hicks, D.3
  • 38
    • 0033524924 scopus 로고    scopus 로고
    • Photo-oxidative stress down-modulates the activity of nuclear factor-kB via involvement of caspase-1, leading to apoptosis of photoreceptor cells
    • Krishnamoorthy RR, Crawford MJ, Chaturvedi MM, et al. Photo-oxidative stress down-modulates the activity of nuclear factor-kB via involvement of caspase-1, leading to apoptosis of photoreceptor cells. J Biol Chem. 1999;274:3734-3743.
    • (1999) J Biol Chem , vol.274 , pp. 3734-3743
    • Krishnamoorthy, R.R.1    Crawford, M.J.2    Chaturvedi, M.M.3
  • 39
    • 0029798041 scopus 로고    scopus 로고
    • Survival and regeneration of adult human and other mammalian photoreceptors in culture
    • Gaudin C, Forster V, Sahel J, Dreyfus H, Hicks D. Survival and regeneration of adult human and other mammalian photoreceptors in culture. Invest Ophthalmol Vis Sci. 1996;37:2258-2268.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , pp. 2258-2268
    • Gaudin, C.1    Forster, V.2    Sahel, J.3    Dreyfus, H.4    Hicks, D.5
  • 40
    • 0032533746 scopus 로고    scopus 로고
    • GABAA and GABAC receptors in adult porcine cones: Evidence from a photoreceptor-glia coculture model
    • Picaud S, Pattnaik B, Hicks D, et al. GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia coculture model. J Physiol. 1998;513:33-42.
    • (1998) J Physiol , vol.513 , pp. 33-42
    • Picaud, S.1    Pattnaik, B.2    Hicks, D.3
  • 41
    • 2942527125 scopus 로고    scopus 로고
    • A comparison of immunocytochemical markers to identify bipolar cell types in human and primate retina
    • Haverkamp S, Haeseleer F, Hendrickson A. A comparison of immunocytochemical markers to identify bipolar cell types in human and primate retina. Vis Neurosci. 2003;20:589-600.
    • (2003) Vis Neurosci , vol.20 , pp. 589-600
    • Haverkamp, S.1    Haeseleer, F.2    Hendrickson, A.3
  • 42
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Graslkraupp B, Ruttkaynedecky B, Koudelka H, Bukowska K, Bursch W, Schultehermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 1995;21:1465-1468.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Graslkraupp, B.1    Ruttkaynedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schultehermann, R.6
  • 43
    • 0027184894 scopus 로고
    • Biological effects of saffron
    • Abdullaev FI. Biological effects of saffron. Biofactors. 1993;4:83-86.
    • (1993) Biofactors , vol.4 , pp. 83-86
    • Abdullaev, F.I.1
  • 44
    • 0005377589 scopus 로고    scopus 로고
    • Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen
    • Pham TO, Cormier F, Farnworth E, Tong VH, Van Calstern MR. Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. J Agricul Food Chem. 2000;48:1455-1461.
    • (2000) J Agricul Food Chem , vol.48 , pp. 1455-1461
    • Pham, T.O.1    Cormier, F.2    Farnworth, E.3    Tong, V.H.4    Van Calstern, M.R.5
  • 45
    • 2442604428 scopus 로고    scopus 로고
    • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
    • Ochiai T, Ohno S, Soeda S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol. Neurosci Lett. 2004;362:61-64.
    • (2004) Neurosci Lett , vol.362 , pp. 61-64
    • Ochiai, T.1    Ohno, S.2    Soeda, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 46
    • 0038125510 scopus 로고    scopus 로고
    • Protective effects of saffron (Crocus sativus L) on genotoxins-induced oxidative stress in swiss albino mice
    • Premkumar K, Suresh K, Santhiya ST, Ramesh A. Protective effects of saffron (Crocus sativus L) on genotoxins-induced oxidative stress in swiss albino mice. Phytother Res. 2003;17:614-617.
    • (2003) Phytother Res , vol.17 , pp. 614-617
    • Premkumar, K.1    Suresh, K.2    Santhiya, S.T.3    Ramesh, A.4
  • 47
    • 0345304238 scopus 로고    scopus 로고
    • Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increase glutathione synthesis
    • Ochiai T, Soeda S, Ohno S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increase glutathione synthesis. Neurochem Int. 2004;44:321-330.
    • (2004) Neurochem Int , vol.44 , pp. 321-330
    • Ochiai, T.1    Soeda, S.2    Ohno, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 48
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science. 1998;281:1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 49
    • 0035798068 scopus 로고    scopus 로고
    • Crocin suppresses tumor necrosis factor-α -induced cell death of neuronally differentiated PC-12 cells
    • Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H. Crocin suppresses tumor necrosis factor-α -induced cell death of neuronally differentiated PC-12 cells. Life Sci. 2001;69:2887-2898.
    • (2001) Life Sci , vol.69 , pp. 2887-2898
    • Soeda, S.1    Ochiai, T.2    Paopong, L.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 50
    • 0032911271 scopus 로고    scopus 로고
    • Effects of crocin analogs on ocular blood flow and retinal function
    • Xuan B, Zhou YH, Li N, Min ZD, Chiou GCY. Effects of crocin analogs on ocular blood flow and retinal function. J Ocular Phamacol. 1999;15:143-152.
    • (1999) J Ocular Phamacol , vol.15 , pp. 143-152
    • Xuan, B.1    Zhou, Y.H.2    Li, N.3    Min, Z.D.4    Chiou, G.C.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.