Glycochenodeoxycholate (GCDC) Inhibits Cytokine Induced iNOS Expression in Rat Hepatocytes

Journal of Surgical Research

Volumn 138, Issue 1, 2007, Pages 15-21

  Bucher, Brian T ^a   Feng, Xuesheng ^a   Jeyabalan, Geetha ^a   Zhang, Baochun ^a   Shao, Lifang ^a   Guo, Zhong ^a   Geller, David A ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

apoptosis; bile acid; cholestatic liver injury; nitric oxide

Indexed keywords

CASPASE 3; CYTOKINE; DNA; GLYCOCHENODEOXYCHOLIC ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATITIS; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CHOLESTASIS, EXTRAHEPATIC; CYTOKINES; DETERGENTS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; LIGATION; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 33846864450     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.05.015     Document Type: Article

References (45)

1. Schlottman K., Wachs F.P., Krieg R.C., Kullmann F., Scholmerich J., and Rogler G. Characterization of bile salt-induced apoptosis in colon cancer cell lines. Cancer Res 60 (2000) 4270
2. Roberts L.R., Kurosawa H., Bronk S.F., et al. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes. Gastroenterology 113 (1997) 1714
3. Webster C.R., and Anwer M.S. Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology 27 (1998) 1324
4. Jones B.A., Rao Y.P., Stravitz R.T., and Gores G.J. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. Am J Physiol 272 (1997) G1109
5. Sodeman T., Bronk S.F., Roberts P.J., Miyoshi H., and Gores G.J. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am J Physiol Gastrointest Liver Physiol 278 (2000) G992
6. Baker P.R., Wilton J.C., Jones C.E., Stenzel D.J., Watson N., and Smith G.J. Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. Br J Cancer 65 (1992) 566
7. Yerushalmi B., Dahl R., Devereaux M.W., Gumpricht E., and Sokol R.J. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 33 (2001) 616
8. Takikawa Y., Miyoshi H., Rust C., et al. The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes. Gastroenterology 120 (2001) 1810
9. Gurantz D., and Hofmann A.F. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol 247 (1984) G736
10. Qiao L., Studer E., Leach K., et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Mol Biol Cell 12 (2001) 2629
11. Scaffidi C., Fulda S., Srinivasan A., et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17 (1998) 1675
12. Li J., Bombeck C.A., Yang S., Kim Y.M., and Billiar T.R. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J Biol Chem 274 (1999) 17325
13. Zamora R., Alarcon L., Vodovotz Y., et al. Nitric oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes. J Biol Chem 276 (2001) 46887
14. Arnett H.A., Hellendall R.P., Matsushima G.K., et al. The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol 168 (2002) 427
15. Gardner C.R., Heck D.E., et al. Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat. Hepatology 27 (1998) 748
16. Li J., and Billiar T.R. The role of nitric oxide in apoptosis. Semin Perinatol 24 (2000) 46
17. Farzaneh-Far R., and Moore K. Nitric oxide and the liver. Liver 21 (2001) 161
18. Beltran B., Mathur A., Duchen M.R., Erusalimsky J.D., and Moncada S. The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proc Natl Acad Sci USA 97 (2000) 14602
19. Salvucci O., Carsana M., Bersani I., Tragni G., and Anichini A. Antiapoptotic role of endogenous nitric oxide in human melanoma cells. Cancer Res 61 (2001) 318
20. Li J., and Billiar T.R. The anti-apoptotic actions of nitric oxide in hepatocytes. Cell Death Differ 6 (1999) 952
21. Kim Y.M., Kim T.H., Chung H.T., Talanian R.V., Yin X.M., and Billiar T.R. Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 32 (2000) 770
22. Kim Y.M., Talanian R.V., and Billiar T.R. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 272 (1997) 31138
23. Lee Y.J., Lee K.H., Kim H.R., et al. Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells. Oncogene 20 (2001) 1476
24. Beltran B., Quintero M., Garcia-Zaragoza E., O'Connor E., Esplugues J.V., and Moncada S. Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signaling. Proc Natl Acad Sci USA 99 (2002) 8892
25. Payne C.M., Crowley C., Washo-Stultz D., et al. The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis. Cell Death Differ 5 (1998) 623
26. Pope M., Marsden P.A., Cole E., et al. Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide. J Virol 72 (1998) 7084
27. Washo-Stultz D., Hoglen N., Bernstein H., Bernstein C., and Payne C.M. Role of nitric oxide and peroxynitrite in bile salt-induced apoptosis: Relevance to colon carcinogenesis. Nutr Cancer 35 (1999) 180
28. Suzuki H., Menegazzi M., Carcereri D.P., Mariotto S., and Armato U. Nitric oxide in the liver: Physiopathological roles. Adv Neuroimmunol 5 (1995) 379
29. Secchiero P., Gonelli A., Celeghini C., et al. Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies. Blood 98 (2001) 2220
30. Feng X., Guo Z., Nourbakhsh M., et al. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene. Proc Natl Acad Sci USA 99 (2002) 14212
31. Tzeng E., Billiar T.R., Williams D.L., Li J., Lizonova A., Kovesdi I., and Kim Y.M. Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis. Surgery 124 (1998) 278
32. Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269 (1994) 4705
33. Taylor B.S., de Vera M.E., Ganster R.W., et al. Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem 273 (1998) 15148
34. Ganster R.W., Taylor B.S., Shao L., and Geller D.A. Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci USA 98 (2001) 8638
35. Invernizzi P., Salzman A.L., Szabo C., Ueta I., O'Connor M., and Setchell K.D. Ursodeoxycholate inhibits induction of NOS in human intestinal epithelial cells and in vivo. Am J Physiol 273 (1997) G131
36. Ma J., Nakajima T., Iida H., et al. Inhibitory effects of ursodeoxygholic acid on the induction of nitric oxide synthase in vascular smooth muscle cells. Eur J Pharmacol 464 (2003) 79
37. Miyoshi H., Rust C., Guicciardi M.E., and Gores G.J. NF-kappaB is activated in cholestasis and functions to reduce liver injury. Am J Pathol 158 (2001) 967
38. Schoemaker M.H., Gommans W.M., de la Rosa L.C., et al. Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol 39 (2003) 153
39. Higuchi H., Miyashi H., Bronk S.F., Zhang H., Dean N., and Gores G.J. Bid antisense bile acid-induced apoptosis and cholestatic liver injury. J Pharmacol Exp Ther 299 (2001) 866
40. Gumpricht E., Dahl R., Yerushalmi B., Devereaux M.W., and Sokol R.J. Nitric oxide ameliorates hydrophobic bile acid-induced apoptosis in isolated rat hepatocytes by non-mitochondrial pathways. J Biol Chem 277 (2002) 25823
41. Baron V., Hernandez J., Noyola M., Escalante B., and Muriel P. Nitric oxide and inducible nitric oxide synthase expression are downregulated in acute cholestasis in the rat accompanied by liver ischemia. Comp Biochem Physiol C Toxicol Pharmacol 127 (2000) 243
42. Ozturk H., Yagmur Y., Buyukbayram H., Dokucu A.I., and Gurel A. Effects of the nitric oxide donor molsidomine on the early stages of liver damage in rats with bile duct ligation: A biochemical and immunohistochemical approach. Eur Surg Res 34 (2002) 285
43. Taylor B.S., and Geller D.A. Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene. Shock 13 (2000) 413
44. Kim P.K., Zamora R., Petrosko P., and Billiar T.R. The regulatory role of nitric oxide in apoptosis. Int Immunopharmacol 1 (2001) 1421
45. Kim Y.M., de Vera M.E., Watkins S.C., and Billiar T.R. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J Biol Chem 272 (1997) 1402