Inflammation, damage repair and liver fibrosis - Role of cytokines and different cell types

Zeitschrift fur Gastroenterologie

Volumn 45, Issue 1, 2007, Pages 77-86

  Saile, B ^a   Ramadori, G ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Cirrhosis; Cytokines; Fibrosis; HSC; Liver; Myofibroblasts

Indexed keywords

CYTOKINE;

APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; INFLAMMATION; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER REGENERATION; MORBIDITY; MORTALITY; MYOFIBROBLAST; NONHUMAN; REVIEW; SCAR FORMATION; TISSUE INJURY; TISSUE REPAIR; WOUND HEALING;

ANIMALS; CELL COMMUNICATION; CYTOKINES; HEPATITIS; HEPATOCYTES; HUMANS; IMMUNOLOGIC FACTORS; LIVER CIRRHOSIS; LIVER REGENERATION; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES;

EID: 33846849290     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-927395     Document Type: Review

References (107)

1. Batusic DS, Armbrust T, Saile B et al. Induction of Mx-2 in rat liver by toxic injury. J Hepatol 2004; 40: 446-453
2. Knittel T, Mehde M, Kobold D et al. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol 1999; 30: 48-60
3. Neubauer K, Ritzel A, Saile B et al. Decrease of platelet-endothelial cell adhesion molecule 1-gene-expression in inflammatory cells and in endothelial cells in the rat liver following CC14-administration and in vitro after treatment with TNFalpha. Immunol Lett 2000; 74: 153-164
4. Sewnath ME, Van Der PT, Van Noorden CJ et al. Endogenous interferon gamma protects against cholestatic liver injury in mice. Hepatology 2002; 36: 1466-1477
5. Arii S, Imamura M. Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J Hepatobiliary Pancreat Surg 2000; 7: 40-48
6. Bhunchet E, Wake K. Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 1992; 16: 1452-1473
7. Salmi M, Adams D, Jalkanen S. Cell adhesion and migration. IV. Lymphocyte trafficking in the intestine and liver. Am J Physiol 1998; 274: G1-G6
8. Baldus SE, Zirbes TK, Weidner IC et al. Comparative quantitative analysis of macrophage populations defined by CD68 and carbohydrate antigens in normal and pathologically altered human liver tissue. Anal Cell Pathol 1998; 16: 141-150
9. Sun Z, Wada T, Maemura K et al. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl 2003; 9: 489-497
10. Canbay A, Higuchi H, Bronk SF et al. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 2002; 123: 1323-1330
11. Wisse E, Luo D, Vermijlen D et al. On the function of pit cells, the liver-specific natural killer cells. Semin Liver Dis 1997; 17: 265-286
12. Bioulac-Sage P, Kuiper J, Van Berkel TJ et al. Lymphocyte and macrophage populations in the liver. Hepatogastroenterology 1996; 43: 4-14
13. Vanderkerken K, Bouwens L, Van Rooijen N et al. The role of Kupffer cells in the differentiation process of hepatic natural killer cells. Hepatology 1995; 22: 283-290
14. Li X, Klintman D, Liu Q et al. Critical role of CXC chemokines in endotoxemic liver injury in mice. J Leukoc Biol 2004; 75: 443-452
15. Schumann J, Wolf D, Pahl A et al. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol 2000; 157: 1671-1683
16. Bertolino P, McCaughan GW, Bowen DG. Role of primary intrahepatic T-cell activation in the "liver tolerance effect". Immunol Cell Biol 2002; 80: 84-92
17. Muhlen KA, Schumann J, Wittke F et al. NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice. J Immunol 2004; 172: 3034-3041
18. Crispe IN, Dao T, Klugewitz K et al. The liver as a site of T-cell apoptosis: graveyard, or killing field? Immunol Rev 2000; 174: 47-62
19. Safadi R, Ohta M, Alvarez CE et al. Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 2004; 127: 870-882
20. Smith CI, Cooksley WG, Powell LW. Cell-mediated immunity to liver antigen in toxic liver injury. II. Role in pathogenesis of liver damage. Clin Exp Immunol 1980; 39: 618-625
21. Warnatz H, Scheiffarth F, Schmeissner R. Studies on the cytotoxic effect of in vivo and in vitro immunized lymphocytes on liver target cells. Clin Exp Immunol 1975; 21: 250-258
22. Finotto S, Siebler J, Hausding M et al. Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut 2004; 53: 392-400
23. Ramadori G, Moebius U, Dienes HP et al. Lymphocytes from hepatic inflammatory infiltrate kill rat hepatocytes in primary culture. Comparison with peripheral blood lymphocytes. Virchows Arch B Cell Pathol Incl Mol Pathol 1990; 59: 263-270
24. Novobrantseva TI, Majeau GR, Amatucci A et al. Attenuated liver fibrosis in the absence of B cells. J Clin Invest 2005; 115: 3072-3082
25. Xue H, McCauley RL, Zhang W. Elevated interleukin-6 expression in keloid fibroblasts. J Surg Res 2000; 89: 74-77
26. Choi I, Kang HS, Yang Y et al. IL-6 induces hepatic inflammation and collagen synthesis in vivo. Clin Exp Immunol 1994; 95: 530-535
27. Natsume M, Tsuji H, Harada A et al. Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice. J Leukoc Biol 1999; 66: 601-608
28. Bansal MB, Kovalovich K, Gupta R et al. Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol 2005; 42: 548-556
29. Bot A. Immunoglobulin deficient mice generated by gene targeting as models for studying the immune response. Int Rev Immunol 1996; 13: 327-340
30. Zhou X, Tan FK, Milewicz DM et al. Autoantibodies to fibrillin-1 activate normal human fibroblasts in culture through the TGF-beta pathway to recapitulate the "scleroderma phenotype". J Immunol 2005; 175: 4555-4560
31. Neubauer K, Knittel T, Armbrust T et al. Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury. Gastroenterology 1995; 108: 1124-1135
32. Romero-Gomez M, Montes-Cano MA, Otero-Fernandez MA et al. SLC11A1 promoter gene polymorphisms and fibrosis progression in chronic hepatitis C. Gut 2004; 53: 446-450
33. Bataller R, North KE, Brenner DA. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 2003; 37: 493-503
34. Ramadori G, Saile B. Portal tract fibrogenesis in the liver. Lab Invest 2004; 84: 153-159
35. Reeves HL, Friedman SL. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front Biosci 2002; 7: d808-d826
36. Marra F, Romanelli RG, Giannini C et al. Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells. Hepatology 1999; 29: 140-148
37. Kinnman N, Hultcrantz R, Barbu V et al. PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury. Laboratory Investigation 2000; 80: 697-707
38. Knittel T, Kobold D, Saile B et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999; 117: 1205-1221
39. Lorena D, Darby IA, Reinhardt DP et al. Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: Modulation by mechanical stress and role in cell adhesion. Lab Invest 2004; 84: 203-212
40. Dubuisson L, Lepreux S, Bioulac-Sage P et al. Expression and cellular localization of fibrillin-1 in normal and pathological human liver. J Hepatol 2001; 34: 514-522
41. Friedman SL. Stellate cells: A moving target in hepatic fibrogenesis. Hepatology 2004; 40: 1041-1043
42. Magness ST, Bataller R, Yang L et al. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 2004; 40: 1151-1159
43. Knittel T, Kobold D, Piscaglia F et al. Localization of liver myofibroblasts and hepatic stellate cells in normal and diseased rat livers: distinct roles of (myo-)fibroblast subpopulations in hepatic tissue repair. Histochem Cell Biol 1999; 112: 387-401
44. Dudas J, Saile B, El Armouche H et al. Endoreplication and polyploidy in primary culture of rat hepatic stellate cells. Cell Tissue Res 2003; 313: 301-311
45. Saile B, Knittel T, Matthes N et al. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 1997; 151: 1265-1272
46. Saile B, Matthes N, Knittel T et al. Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells. Hepatology 1999; 30: 196-202
47. Saile B, Matthes N, Neubauer K et al. Rat liver myofibroblasts and hepatic stellate cells differ in CD95-mediated apoptosis and response to TNF-alpha. Am J Physiol Gastrointest Liver Physiol 2002; 283: G435-G444
48. Saile B, DiRocco P, Dudas J et al. IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF). Lab Invest 2004; 84: 1037-1049
49. Kinnman N, Goria O, Wendum D et al. Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury. Lab Invest 2001; 81: 1709-1716
50. Kinnman N, Francoz C, Barbu V et al. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab Invest 2003; 83: 163-173
51. Tuchweber B, Desmouliere A, Bochaton-Piallat ML et al. Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat. Lab Invest 1996; 74: 265-278
52. Kinnman N, Housset C. Peribiliary myofibroblasts in biliary type liver fibrosis. Front Biosci 2002; 7: d496-d503
53. Desmouliere A, Darby I, Costa AM et al. Extracellular matrix deposition, lysyl oxidase expression, and myofibroblastic differentiation during the initial stages of cholestatic fibrosis in the rat. Lab Invest 1997; 76: 765-778
54. Slott PA, Liu MH, Tavoloni N. Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat. Gastroenterology 1990; 99: 466-477
55. Sedlaczek N, Jia JD, Bauer M et al. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 2001; 158: 1239-1244
56. Bhunchet E, Wake K. Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 1992; 16: 1452-1473
57. Andrade ZA, Guerret S, Fernandes AL. Myofibroblasts in schistosomal portal fibrosis of man. Mem Inst Oswaldo Cruz 1999; 94: 87-93
58. Desmouliere A, Guyot C, Gabbiani G. The stroma reaction myofibroblast: a key player in the control of tumor cell behavior. Int J Dev Biol 2004; 48: 509-517
59. Jahoda CA, Reynolds AJ. Hair follicle dermal sheath cells: unsung participants in wound healing. The Lancet 2001; 358: 1445-1448
60. Forbes SJ, Russo FP, Rey V et al. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004; 126: 955-963
61. Abe R, Donnelly SC, Peng T et al. Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites. J Immunol 2001; 166: 7556-7562
62. Russo FP, Alison MR, Bigger BW et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006; 130: 1807-1821
63. Quan TE, Cowper S, Wu SP et al. Circulating fibrocytes: collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol 2004; 36: 598-606
64. Kisseleva T, Uchinami H, Feirt N et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006; 45: 429-438
65. Czaja MJ, Flanders KC, Biempica L et al. Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury. Growth Factors 1989; 1: 219-226
66. Nakatsukasa H, Nagy P, Evarts RP et al. Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 1990; 85: 1833-1843
67. Bissell DM, Wang SS, Jarnagin WR et al. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995; 96: 447-455
68. Davis BH. Transforming growth factor beta responsiveness is modulated by the extracellular collagen matrix during hepatic Ito cell culture. J Cell Physiol 1988; 136: 547-553
69. Czaja MJ, Weiner FR, Flanders KC et al. In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. J Cell Biol 1989; 108: 2477-2482
70. Pinzani M, Gesualdo L, Sabbah GM et al. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989; 84: 1786-1793
71. Gressner AM. Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules. Z Gastroenterol 1992; 30 (Suppl 1): 5-16
72. Dooley S, Hamzavi J, Breitkopf K et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 2003; 125: 178-191
73. Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver 1998; 18: 2-13
74. Schonherr E, Hausser HJ. Extracellular matrix and cytokines: a functional unit. Dev Immunol 2000; 7: 89-101
75. Schuppan D, Ruehl M, Somasundaram R et al. Matrix as a modulator of hepatic fibrogenesis. Semin Liver Dis 2001; 21: 351-372
76. Friedman SL. The virtuosity of hepatic stellate cells. Gastroenterology 1999; 117: 1244-1246
77. Gaca MD, Zhou X, Issa R et al. Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. Matrix Biol 2003; 22: 229-239
78. Sohara N, Znoyko I, Levy MT et al. Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. J Hepatol 2002; 37: 214-221
79. Ramadori G, Saile B. Mesenchymal cells in the liver - one cell type or two? Liver 2002; 22: 283-294
80. Kim WH, Matsumoto K, Bessho K et al. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 2005; 166: 1017-1028
81. Sancho-Bru P, Bataller R, Gasull X et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005; 43: 272-282
82. Inside Lab Invest. Lab Invest 2004; 84: 149-150
83. Cassiman D, Libbrecht L, Desmet V et al. Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 2002; 36: 200-209
84. Cassiman D, Roskams T. Beauty is in the eye of the beholder: emerging concepts and pitfalls in hepatic stellate cell research. J Hepatol 2002; 37: 527-535
85. Geerts A. On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal? J Hepatol 2004; 40: 331-334
86. Cassiman D, Barlow A, Vander BS et al. Hepatic stellate cells do not derive from the neural crest. J Hepatol 2006; 44: 1098-1104
87. Cassiman D, Roskams T, van PJ et al. Alpha B-crystallin expression in human and rat hepatic stellate cells. J Hepatol 2001; 35: 200-207
88. Dudas J, Mansuroglu T, Saile B et al. Comparison of Thy-1 expression in human liver cirrhosis and different models of rat liver injury. Z Gastroenterol 2006; 54: 86
89. Uchio K, Tuchweber B, Manabe N et al. Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts. Lab Invest 2002; 82: 619-628
90. Lepreux S, Bioulac-Sage P, Gabbiani G et al. Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations. J Hepatol 2004; 40: 774-780
91. Dranoff JA, Kruglov EA, Robson SC et al. The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver. Hepatology 2002; 36: 1135-1144
92. Wanless IR, Crawford JM. Cirrhosis; Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders, 2004: 863-884
93. Gall EA, Dobrogorski O. Hepatic alterations in obstructive jaundice. Am J Clin Pathol 1964; 41: 126-139
94. Iredale JP, Benyon RC, Pickering J et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998; 102: 538-549
95. Murphy FR, Issa R, Zhou X et al. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition. Implications for reversibility of liver fibrosis. J Biol Chem 2002; 277: 11 069-11 076
96. Issa R, Zhou X, Constandinou CM et al. Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking. Gastroenterology 2004; 126: 1795-1808
97. Birns M, Masek B, Uerbach O. The effects of experimental acute biliary obstruction and release on the rat liver. A histochemical study. Am J Pathol 1962; 40: 95-111
98. Hammel P, Couvelard A, O'Toole D et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med 2001; 344: 418-423
99. Costa AM, Tuchweber B, Lamireau T et al. Role of apoptosis in the remodeling of cholestatic liver injury following release of the mechanical stress. Virchows Arch 2003; 442: 372-380
100. Desmet VJ, Roskams T. Cirrhosis reversal: a duel between dogma and myth. J Hepatol 2004; 40: 860-867
101. Pol S, Carnot F, Nalpas et al. Reversibility of hepatitis C virus-related cirrhosis. Hum Pathol 2004; 35: 107-112
102. Wanless IR, Nakashima E, Sherman M. Regression of human cirrhosis: Morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol & Lab Medicine 2000; 124: 1599-1607
103. Parsons CJ, Bradford BU, Pan CQ et al. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 2004; 40: 1106-1115
104. Lotersztajn S, Julien B, Teixeira-Clerc F et al. Hepatic fibrosis: Molecular mechanisms and drug targets. Ann Rev Pharmacol & Toxicol 2005; 45: 605-628
105. Beljaars L, Meijer DK, Poelstra K. Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. Front Biosci 2002; 7: e214-e222
106. Garcia-Banuelos J, Siller-Lopez F, Miranda A et al. Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence of cirrhosis reversion. Gene Ther 2002; 9: 127-134
107. Sakaida I, Terai S, Yamamoto N et al. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 2004; 40: 1304-1311