Regulation of hepatic metabolism by enteral delivery of nutrients

Nutrition Research Reviews

Volumn 19, Issue 2, 2006, Pages 161-173

  Dardevet, D ^a,b   Moore, M C ^c   Remond, D ^a,b   Everett Grueter, C A ^c   Cherrington, A D ^c  

^a Human Nutrition Research Centre of Clermont Ferrand   (France)

^b CEMAGREF   (France)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amino acids; Glucose; Hepatic metabolism; Lipids; Nutrient homeostasis

Indexed keywords

AMINO ACID; GLUCOSE; INSULIN; NICOTINIC ACID;

ENTERIC FEEDING; FOOD INTAKE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIVER METABOLISM; MACRONUTRIENT; NONHUMAN; PROTEIN SYNTHESIS; REVIEW;

EID: 33846828392     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422407315175     Document Type: Review

References (134)

1. Abumrad NN, Cherrington AD, Williams PE, Lacy WW & Rabin D (1982) Absorption and disposition of a glucose load in the conscious dog. American Journal of Physiology 242, E398-E406.
2. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE & Cherrington AD (1987) Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. Journal of Clinical Investigation 79, 557-565.
3. Adkins-Marshall B, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB Jr & Cherrington AD (1992) Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. American Journal of Physiology 262, E679-E686.
4. Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B & Cherrington AD (1990) Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes 39, 87-95.
5. Agius L (1994) Control of glucokinase translocation in rat hepatocytes by sorbitol and the cytosolic redox state. Biochemical Journal 298, 237-243.
6. Agius L & Peak M (1993) Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochemical Journal 296, 785-796.
7. Ahlman B, Charlton M, Fu A, Berg C, O'Brien P & Nair KS (2001) Insulin's effect on synthesis rates of liver proteins. A swine model comparing various precursors of protein synthesis. Diabetes 50, 947-954.
8. Andersen DK, Ruiz CL & Burant CF (1994) Insulin regulation of hepatic glucose transporter protein is impaired in chronic pancreatitis. Annals of Surgery 219, 679-686; discussion 686-677.
9. Arnal MA, Mosoni L, Boirie Y, et al. (2000). Protein feeding pattern does not affect protein retention in young women. Journal of Nutrition 130, 1700-1704.
10. Balage M, Sinaud S, Prod'homme M, Dardevet D, Vary TC, Kimball SR, Jefferson LS & Grizard J (2001) Amino acids and insulin are both required to regulate assembly of the eIF4E.eIF4G complex in rat skeletal muscle. American Journal of Physiology 281, E565-E574.
11. Ballmer PE, McNurlan MA, Essen P, Anderson SE & Garlick PJ (1995) Albumin synthesis rates measured with [2H5ring]-phenylalanine are not responsive to short-term intravenous nutrients in healthy humans. Journal of Nutrition 125, 512-519.
12. Barle H, Nyberg B, Essen P, Andersson K, McNurlan MA, Wernerman J & Garlick PJ (1997) The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humans. Hepatology 25, 154-158.
13. Barrett EJ, Bevilacqua S, DeFronzo RA & Ferrannini E (1994) Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods. Metabolism 43, 285-292.
14. Barrett EJ, Ferrannini E, Gusberg R, Bevilacqua S & DeFronzo RA (1985) Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog. Metabolism 34, 410-420.
15. Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF & Rizza RA (2000) Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 49, 272-283.
16. Benn JJ, Bozzard SJ, Kelley D, Mitrakou A, Aoki T, Sorensen J, Gerich J & Sonksen PH (1989) Persistent abnormalities of the metabolism of an oral glucose load in insulin-treated type I diabetics. Metabolism 38, 1047-1055.
17. Bergman RN, Beir JR & Hourigan PM (1982) Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes 31, 27-35.
18. Berthold HK, Jahoor F, Klein PD & Reeds PJ (1995) Estimates of the effect of feeding on whole-body protein degradation in women vary with the amino acid used as tracer. Journal of Nutrition 125, 2516-2527.
19. Bertolo RF, Chen CZ, Law G, Pencharz PB & Ball RO (1998) Threonine requirement of neonatal piglets receiving total parenteral nutrition is considerably lower than that of piglets receiving an identical diet intragastrically. Journal of Nutrition 128, 1752-1759.
20. Biolo G, Tessari P, Inchiostro S, Bruttomesso D, Fongher C, Sabadin L, Fratton MG, Valerio A & Tiengo A (1992) Leucine and phenylalanine kinetics during mixed meal ingestion: a multiple tracer approach. American Journal of Physiology 262, E455-E463.
21. Boden G, Cheung P, Stein TP, Kresge K & Mozzoli M (2002) FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. American Journal of Physiology 283, E12-E19.
22. Boirie Y, Gachon P, Corny S, Fauquant J, Maubois JL & Beaufrere B (1996). Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. American Journal of Physiology 271, E1083-E1091.
23. Boirie Y, Gachon P & Beaufrere B (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. American Journal of Clinical Nutrition 65, 489-495.
24. Bollen M, Keppens S & Stalmans W (1998) Specific features of glycogen metabolism in the liver. Biochemical Journal 336, 19-31.
25. Bolster DR, Jefferson LS & Kimball SR (2004) Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proceedings of the Nutrition Society 63, 351-356.
26. Burrin DG & Davis TA (2004) Proteins and amino acids in enteral nutrition. Current Opinion in Clinical Nutrition and Metabolic Care 7, 79-87.
27. Cardin S, Pagliassotti MJ, Moore MC, Edgerton DS, Lautz M, Farmer B, Neal DW & Cherrington AD (2004) Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in the conscious dog. American Journal of Physiology 287, R742-R748.
28. Cayol M, Boirie Y, Prugnaud J, Gachon P, Beaufrere B & Obled C (1996) Precursor pool for hepatic protein synthesis in humans: effects of tracer route infusion and dietary proteins. American Journal of Physiology 270, E980-E987.
29. Cayol M, Boirie Y, Rambourdin F, Prugnaud J, Gachon P, Beaufrere B & Obled C (1997) Influence of protein intake on whole body and splanchnic leucine kinetics in humans. American Journal of Physiology 272, E584-E591.
30. Chap Z, Ishida T, Chou J, Lewis R, Hartley C, Entman M & Field JB (1985) Effects of atropine and gastric inhibitory polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. Journal of Clinical Investigation 76, 1174-1181.
31. Chen SS, Torres-Sanchez CJ, Hosein N, Zhang Y, Lacy DB, Chang C & McGuinness OP (2005) Route-dependent effect of nutritional support on liver glucose uptake. American Journal of Physiology 289, R1319-R1327.
32. Cherrington AD (1999) Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 48, 1198-1214.
33. Cherrington AD, Liljenquist JE, Shulman GI, Williams PE & Lacy WW (1979) Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency. American Journal of Physiology 236, E263-E271.
34. Cherrington AD, Williams PE, Abou-Mourad N, Lacy WW, Steiner KE & Liljenquist JE (1982) Insulin as a mediator of hepatic glucose uptake in the conscious dog. American Journal of Physiology 242, E97-E101.
35. Chu CA, Fujimoto Y, Igawa K, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD & Shiota M (2004) Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. American Journal of Physiology 286, G627-G634.
36. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. Journal of Clinical Investigation 94, 2369-2376.
37. Dardevet D, Sornet C, Balage M & Grizard J (2000) Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age. Journal of Nutrition 130, 2630-2635.
38. Dardevet D, Sornet C, Bayle G, Prugnaud J, Pouyet C & Grizard J (2002) Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal. Journal of Nutrition 132, 95-100.
39. Davis TA, Fiorotto ML, Burrin DG, Reeds PJ, Nguyen HV, Beckett PR, Vann RC & O'Connor PM (2002) Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs. American Journal of Physiology 282, E880-E890.
40. De Feo P, Horber FF & Raymond MW (1992) Meal stimulation of albumin synthesis: a significant contributor to whole body protein synthesis in humans. American Journal of Physiology 263, E794-E799.
41. De Feo P & Lucidi P (2002) Liver protein synthesis in physiology and in disease states. Current Opinion in Clinical Nutrition and Metabolic Care 5, 47-50.
42. DeFronzo RA, Ferrannini E, Hendler R, Felig P & Wahren J (1983) Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32, 35-45.
43. DeFronzo RA, Ferrannini E, Hendler R, Wahren J & Felig P (1978) Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proceedings of the National Academy of Sciences USA 75, 5173-5177.
44. Detheux M & van Schaftingen E (1994) Heterologous expression of an active rat regulatory protein of glucokinase. FEBS Letters 355, 27-29.
45. DiCostanzo CA, Dardevet D, Neal DW, Lautz M, Allen E, Snead W & Cherrington AD (2006) Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. American Journal of Physiology 290, E9-E16.
46. Dunning BE, Moore MC, Ikeda T, Neal DW, Scott MF & Cherrington AD (2002) Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs. Metabolism 51, 1324-1330.
47. Elango R, Pencharz PB & Ball RO (2002) The branched-chain amino acid requirement of parenterally fed neonatal piglets is less than the enteral requirement. Journal of Nutrition 132, 3123-3129.
48. Everett CA, Rivera N, Rodewald T, Neal D, Donahue EP, Williams PE & Cherrington AD (2005) Chronic postprandial intraportal infusion of FFA results in hepatic and adipose tissue insulin resistance. Diabetes 54, A329.
49. Felig P, Wahren J & Hendler R (1975) Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes 24, 468-475.
50. Felig P, Wahren J & Hendler R (1978) Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes 27, 121-126.
51. Ferrannini E, Bjorkman O, Reichard GA Jr, Pilo A, Olsson M, Wahren J & DeFronzo RA (1985) The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes 34, 580-588.
52. Ferrannini E, DeFronzo RA, Gusberg R, Tepler J, Jacob R, Aaron M, Smith D & Barrett EJ (1988) Splanchnic amino acid and glucose metabolism during amino acid infusion in dogs. Diabetes 37, 237-245.
53. Fery F, Deviere J & Balasse EO (2001) Metabolic handling of intraduodenal vs. intravenous glucose in humans. American Journal of Physiology 281, E261-E268.
54. Fery F, Tappy L, Deviere J & Balasse EO (2004) Comparison of intraduodenal and intravenous glucose metabolism under clamp conditions in humans. American Journal of Physiology 286, E176-E183.
55. Firth RG, Bell PM, Marsh HM, Hansen I & Rizza RA (1986) Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. Journal of Clinical Investigation 77, 1525-1532.
56. Frizzell RT, Hendrick GK, Biggers DW, Lacy DB, Donahue DP, Green DR, Carr RK, Williams PE, Stevenson RW & Cherrington AD (1988) Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes 37, 749-759.
57. Galassetti P, Chu CA, Neal DW, Reed GW, Wasserman DH & Cherrington AD (1999) A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. American Journal of Physiology 277, E126-E134.
58. Galassetti P, Shiota M, Zinker BA, Wasserman DH & Cherrington AD (1998) A negative arterial-portal venous glucose gradient decreases skeletal muscle glucose uptake. American Journal of Physiology 275, E101-E111.
59. Garlick PJ, Fern M & Preedy VR (1983) The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats. Biochemical Journal 210, 669-676.
60. Holste LC, Connolly CC, Moore MC, Neal DW & Cherrington AD (1997) Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. American Journal of Physiology 273, E488-E496.
61. Homko CJ, Cheung P & Boden G (2003) Effects of free fatty acids on glucose uptake and utilization in healthy women. Diabetes 52, 487-491.
62. 14C]phenylalanine. American Journal of Clinical Nutrition 67, 67-73.
63. Hsieh PS, Moore MC, Neal DW & Cherrington AD (1998) Hepatic glucose uptake rapidly decreases after removal of the portal signal in conscious dogs. American Journal of Physiology 275, E987-E992.
64. Hsieh PS, Moore MC, Neal DW, Emshwiller M & Cherrington AD (1999) Rapid reversal of the effects of the portal signal under hyperinsulinaemic conditions in the conscious dog. American Journal of Physiology 276, E930-E937.
65. Hunter KA, Ballmer PE, Anderson SE, Broom J, Garlick PJ & McNurlan MA (1995) Acute stimulation of albumin synthesis rate with oral meal feeding in healthy subjects measured with [ring-2H5]phenylalanine. Clinical Science (London) 88, 235-242.
66. Ishida T, Chap Z, Chou J, Lewis R, Hartley C, Entman M & Field JB (1983) Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs. Journal of Clinical Investigation 72, 590-601.
67. Kawamori R, Morishima T, Ikeda M, Kubota M, Kishimoto M, Shiba Y, Matsuhisa M, Kodama M, Watarai T, et al. (1994) Effect of strict metabolic control on glucose handling by the liver and peripheral tissues in non-insulin-dependent diabetes mellitus. Diabetes Research and Clinical Practice 23, 155-161.
68. Kelley D, Mokan M & Veneman T (1994) Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus. Metabolism 43, 1549-1557.
69. Lautt WW (1983) Afferent and efferent neural roles in liver function. Progress in Neurobiology 21, 323-348.
70. Lautt WW (2004) A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis. Journal of Pharmacological Science 95, 9-17.
71. Liu Z, Gardner LB & Barrett EJ (1993) An endogenous glycogen-associated compound modulates glucose-6-phosphatase activity in rat liver microsomes. Biochemical and Biophysical Research Communications 195, 173-178.
72. Ludvik B, Nolan JJ, Roberts A, Baloga J, Joyce M, Bell JM & Olefsky JM (1997) Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus. Journal of Clinical Investigation 100, 2354-2361.
73. McGuinness OP, Friedman A & Cherrington AD (1990) Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog. Metabolism 39, 127-132.
74. Mari A, Wahren J, DeFronzo RA & Ferrannini E (1994) Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. Metabolism 43, 1419-1425.
75. Matthews DE, Marano MA & Campbell RG (1993) Splanchnic bed utilization of leucine and phenylalanine in humans. American Journal of Physiology 264, E109-E118.
76. Meek SE, Nair KS & Jensen MD (1999) Insulin regulation of regional free fatty acid metabolism. Diabetes 48, 10-14.
77. Minokoshi Y, Okano Y & Shimazu T (1994) Regulatory mechanism of the ventromedial hypothalamus in enhancing glucose uptake in skeletal muscles. Brain Research 649, 343-347.
78. Moore MC, Cherrington AD, Cline G, Pagliassotti MJ, Jones EM, Neal DW, Badet C & Shulman GI (1991) Sources of carbon for hepatic glycogen synthesis in the conscious dog. Journal of Clinical Investigation 88, 578-587.
79. Moore MC, Flakoll PJ, Hsieh PS, Pagliassotti MJ, Neal DW, Monohan MT, Venable C & Cherrington AD (1998) Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog. American Journal of Physiology 274, E893-E902.
80. Moore MC, Hsieh PS, Flakoll PJ, Neal DW & Cherrington AD (1999a) Differential effect of amino acid infusion route on net hepatic glucose uptake in the dog. American Journal of Physiology 276, E295-E302.
81. Moore MC, Hsieh PS, Flakoll PJ, Neal DW & Cherrington AD (1999a) Net hepatic gluconeogenic amino acid uptake in response to peripheral versus portal amino acid infusion in conscious dogs. Journal of Nutrition 129, 2218-2224.
82. Moore MC, Pagliassotti MJ, Swift LL, Asher J, Murrell J, Neal D & Cherrington AD (1994) Disposition of a mixed meal by the conscious dog. American Journal of Physiology 266, E666-E675.
83. Moore MC, Satake S, Lautz M, Soleimanpour SA, Neal DW, Smith M & Cherrington AD (2004) Nonesterified fatty acids and hepatic glucose metabolism in the conscious dog. Diabetes 53, 32-40.
84. Mosoni L, Patureau Mirand P, Houlier ML & Arnal M (1993) Age-related changes in protein synthesis measured in vivo in rat liver and gastrocnemius muscle. Mechanisms of Ageing and Development 68, 209-220.
85. Mosoni L, Valluy MC, Serrurier B, Prugnaud J, Obled C, Guezennec CY & Mirand PP (1995) Altered response of protein synthesis to nutritional state and endurance training in old rats. American Journal of Physiology 268, E328-E335.
86. Myers SR, Biggers DW, Neal DW & Cherrington AD (1991a) Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. Journal of Clinical Investigation 88, 158-167.
87. Myers SR, Diamond MP, Adkins-Marshall BA, Williams PE, Stinsen R & Cherrington AD (1991b) Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metabolism 40, 66-71.
88. Myers SR, McGuinness OP, Neal DW & Cherrington AD (1991c) Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. Journal of Clinical Investigation 87, 930-939.
89. Nauck MA, Hornberger E, Siegel EG, Allen RC, Eaton RP, Ebert R & Creutzfeldt W (1986) Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. Journal of Clinical Endocrinology and Metabolism 63, 492-498.
90. Niijima A (1982) Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig. Journal of Physiology 332, 315-323.
91. Niijima A (1983) Glucose-sensitive afferent nerve fibers in the liver and their role in food intake and blood glucose regulation. Journal of the Autonomic Nervous System 9, 207-220.
92. Niijima A (1984) Reflex control of the autonomic nervous system activity from the glucose sensors in the liver in normal and midpontine-transected animals. Journal of the Autonomic Nervous System 10, 279-285.
93. Niijima A (1985) Blood glucose levels modulate efferent activity in the vagal supply to the rat liver. Journal of Physiology 364, 105-112.
94. Niijima A & Meguid MM (1994) Parenteral nutrients in rat suppresses hepatic vagal afferent signals from portal vein to hypothalamus. Surgery 116, 294-301.
95. Niijima A & Meguid MM (1995) An electrophysiological study on amino acid sensors in the hepato-portal system in the rat. Obesity Research 3, Suppl. 5, 741S-745S.
96. Nygren J & Nair KS (2003) Differential regulation of protein dynamics in splanchnic and skeletal muscle beds by insulin and amino acids in healthy human subjects. Diabetes 52, 1377-1385.
97. O'Connor PM, Bush JA, Suryawan A, Nguyen HV & Davis TA (2003a) Insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonatal pigs. American Journal of Physiology 284, E110-E119.
98. O'Connor PM, Kimball SR, Suryawan A, Bush JA, Nguyen HV, Jefferson LS & Davis TA (2003b) Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs. American Journal of Physiology 285, E40-E53.
99. Pacy PJ, Price GM, Halliday D, Quevedo MR & Millward DJ (1994). Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clin Sci (Lond), 86, 103-116.
100. Pagliassotti MJ, Holste LC, Moore MC, Neal DW & Cherrington AD (1996) Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. Journal of Clinical Investigation 97, 81-91.
101. Pehling G, Tessari P, Gerich JE, Raymond MW, Service FJ & Rizza RA (1984) Abnormal meal carbohydrate disposition in insulin-dependent diabetes. Relative contributions of endogenous glucose production and initial splanchnic uptake and effect of intensive insulin therapy. Journal of Clinical Investigation 74, 985-991.
102. Perrin C, Knauf C & Burcelin R (2004) Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis. Endocrinology 145, 4025-4033.
103. Prod'homme M, Balage M, Debras E, Farges MC, Kimball S, Jefferson L & Grizard J (2004) Differential effects of insulin and dietary amino acids on muscle protein synthesis in adult and old rats. Journal of Physiology 563, 235-248.
104. Puschel GP (2004) Control of hepatocyte metabolism by sympathetic and parasympathetic hepatic nerves. The Anatomical Record 280A, 854-867.
105. Radziuk J (1989) Hepatic glycogen in humans. I. Direct formation after oral and intravenous glucose or after a 24-h fast. American Journal of Physiology 257, E145-E157.
106. Reaven GM (2005) Compensatory hyperinsulinemia and the development of an atherogenic lipoprotein profile: the price paid to maintain glucose homeostasis in insulin-resistant individuals. Endocrinology and Metabolism Clinics of North America 34, 49-62.
107. Reaven GM, Hollenbeck C, Jeng CY, Wu MS & Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37, 1020-1024.
108. Rennie MJ, Edwards RH, Halliday D, Matthews DE, Wolman SL & Millward DJ (1982). Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clin Sci (Lond), 63, 519-523.
109. Russek M (1963) Participation of hepatic glucoreceptors in the control of intake of food. Nature 197, 79-80.
110. Russek M (1981) Current status of the hepatostatic theory of food intake control. Appetite 2, 137-143.
111. Scheen AJ & Luyckx FH (2002) Obesity and liver disease. Best Practice and Research. Clinical Endocrinology and Metabolism 16, 703-716.
112. Schmitt M (1973) Influences of hepatic portal receptors on hypothalamic feeding and satiety centers. American Journal of Physiology 225, 1089-1095.
113. Shimazu T (1967) Glycogen synthetase activity in liver: regulation by the autonomic nerves. Science 156, 1256-1257.
114. Shimazu T (1971) Regulation of glycogen metabolism in liver by the autonomic nervous system. V. Activation of glycogen synthetase by vagal stimulation. Biochimica et Biophysica Acta 252, 28-38.
115. Shimazu T (1987) Neuronal regulation of hepatic glucose metabolism in mammals. Diabetes/Metabolism Reviews 3, 185-206.
116. Shimazu T & Fujimoto T (1971) Regulation of glycogen metabolism in liver by the autonomic nervous system. IV. Neural control of glycogen biosynthesis. Biochimica et Biophysica Acta 252, 18-27.
117. Shiota M, Galassetti P, Monohan M, Neal DW & Cherrington AD (1998) Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Diabetes 47, 867-873.
118. Shiota M, Jackson P, Galassetti P, Scott M, Neal DW & Cherrington AD (2000) Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. American Journal of Physiology 278, E544-E552.
119. Shoveller AK, Brunton JA, Pencharz PB & Ball RO (2003) The methionine requirement is lower in neonatal piglets fed parenterally than in those fed enterally. Journal of Nutrition 133, 1390-1397.
120. Shulman GI, Liljenquist JE, Williams PE & Lacy WW (1978) Glucose disposal during insulinopenia in somatostatin-treated dogs. The roles of glucose and glucagon. Journal of Clinical Investigation 62, 487-491.
121. Shulman GI, Rossetti L, Rothman DL, Blair JB & Smith D (1987) Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. Journal of Clinical Investigation 80, 387-393.
122. Sindelar DK, Chu CA, Rohlie M, Neal DW, Swift LL & Cherrington AD (1997) The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes 46, 187-196.
123. Stoll B, Burrin DG, Henry J, Yu H, Jahoor F & Reeds PJ (1998) Dietary amino acids are the preferential source of hepatic protein synthesis in piglets. Journal of Nutrition 128, 1517-1524.
124. Stumpel F & Jungermann K (1997) Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver. FEBS Letters 406, 119-122.
125. Svanberg E, Jefferson LS, Lundholm K & Kimball SR (1997) Postprandial stimulation of muscle protein synthesis is independent of changes in insulin. American Journal of Physiology 272, E841-E847.
126. Thorne A, Lonnqvist F, Apelman J, Hellers G & Arner P (2002) A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding. International Journal of Obesity and Related Metabolic Disorders 26, 193-199.
127. van Schaftingen E (1994) Short-term regulation of glucokinase. Diabetologia 37, Suppl. 2, S43-S47.
128. Vella A, Shah P, Basu R, Basu A, Camilleri M, Schwenk WF & Rizza RA (2002) Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans. American Journal of Physiology 283, E259-E266.
129. Volpi E, Lucidi P, Cruciani G, Monacchia F, Reboldi G, Brunetti P, Belli GB & De Feo P (1996) Contribution of amino acids and insulin to protein anabolism during meal absorption. Diabetes 45, 1245-1252.
130. Volpi E, Mittendorfer B, Wolf SE & Wolfe RR (1999) Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. American Journal of Physiology 277, E513-E520.
131. Watanabe Y, Takahashi A & Shimazu T (1990) Neural control of biosynthesis and secretion of serum transferrin in perfused rat liver. Biochemical Journal 267, 545-548.
132. Weinstein SP, O'Boyle E, Fisher M & Haber RS (1994) Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone: evidence for hormonal regulation of the hepatic glucose transport system. Endocrinology 135, 649-654.
133. Woerle HJ, Szoke E, Meyer C, Dostou JM, Wittlin SD, Gosmanov NR, Welle SL & Gerich JE (2006) Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes. American Journal of Physiology 290, E67-E77.
134. Yoshizawa F, Kimball SR & Jefferson LS (1997) Modulation of translation initiation in rat skeletal muscle and liver in response to food intake. Biochemical and Biophysical Research Communications 240, 825-831.