Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 4 56-4, 2004, Pages

  Cardin, Sylvain ^a,b   Pagliassotti, Michael J ^a,c   Moore, Mary Courtney ^a   Edgerton, Dale S ^a   Lautz, Margaret ^a   Farmer, Ben ^a   Neal, Doss W ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Wellstat Therapeutics Corporation   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Efferent neural transmission; Vagus nerve

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; NORADRENALIN; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONSCIOUSNESS; CONTROLLED STUDY; DOG; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; HEART RATE; INSULIN BLOOD LEVEL; LIVER BLOOD FLOW; MALE; NEUROTRANSMISSION; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; SYMPATHETIC TONE; VAGUS NERVE; VAGUS NERVE STIMULATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BLOOD GLUCOSE; COLD; DOGS; FEMALE; GLUCAGON; GLUCOSE; HEART RATE; HEMODYNAMIC PROCESSES; HYDROCORTISONE; INFUSIONS, INTRAVENOUS; INSULIN; LACTIC ACID; LIVER; LIVER CIRCULATION; LIVER GLYCOGEN; MALE; NOREPINEPHRINE; P-AMINOHIPPURIC ACID; PORTAL VEIN; VAGUS NERVE;

EID: 4644224581     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00041.2004     Document Type: Article

References (47)

1. Adkins BA, Myers SR, Hendrick GK, Stevenson RW, Williams PE, and Cherrington AD. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79: 557-565, 1987.
2. Adkins-Marshall BA, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB Jr, and Cherrington AD. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol Endocrinol Metab 262: E679-E686, 1992.
3. Akiyoshi H, Gonda T, and Terada T. A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers. Liver 18: 352-359, 1998.
4. Apatu RS and Barnes RJ. Release of glucose from the liver of fetal and postnatal sheep by portal vein infusion of catecholamines or glucagon. J Physiol 436: 449-468, 1991.
5. Bollen M, Keppens S, and Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 336: 19-31, 1998.
6. Chap Z, Ishida T, Chou J, Lewis R, Hartley C, Entman M, and Field JB. Effects of atropine and gastric inhibitoiy polypeptide on hepatic glucose uptake and insulin extraction in conscious dogs. J Clin Invest 76: 1174-1181, 1985.
7. Chu CA, Sindelar DK, Neal DW, Alien EJ, Donahue EP, and Cherrington AD. Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis. Am J Physiol Endocrinol Metab 274: E162-E171, 1998.
8. Chung SA, Valdez DT, and Diamant NE. Adrenergic blockage does not restore the canine gastric migrating motor complex during vagal blockade. Gastroenterology 103: 1491-1497, 1992.
9. Coker RH, Krishna MG, Lacy DB, Alien EJ, and Wasserman DH. Sympathetic drive to liver and nonhepatic splanchnic tissue during heavy exercise. J Appl Physiol 82: 1244-1249, 1997.
10. Coker RH, Krishna MG, Zinker BA, Allen EJ, Lacy DB, and Wasserman DH. Sympathetic drive to liver and nonhepatic splanchnic tissue during prolonged exercise is increased in diabetes. Metabolism 46: 1327-1332, 1997.
11. Dobbins RL, Davis SN, Neal DW, Cobelli C, Jaspan J, and Cherrington AD. Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism 44: 452-459, 1995.
12. Dunning BE, Moore MC, Ikeda T, Neal DW, Scott MF, and Cherrington AD. Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs. Metabolism 51: 1324-1330, 2002.
13. Franz DN and Iggo A. Conduction failure in myelinated and non-myelinated axons at low temperatures. J Physiol 199: 319-345, 1968.
14. Hartmann H, Beckh K, and Jungermann K. Direct control of glycogen metabolism in the perfused rat liver by the sympathetic innervation. Eur J Biochem 123: 521-526, 1982.
15. Hendrick GK, Frizzell RT, Williams PE, and Cherrington AD. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am J Physiol Endocrinol Metab 258: E841-E849, 1990.
16. Holste LC, Connolly CC, Moore MC, Neal DW, and Cherrington AD. Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery. Am J Physiol Endocrinol Metab 273: E488-E496, 1997.
17. Hsieh PS, Moore MC, Neal DW, Emshwiller M, and Cherrington AD. Rapid reversal of the effects of the portal signal under hyperinsulinemic conditions in the conscious dog. Am J Physiol Endocrinol Metab 276: E930-E937, 1999.
18. Hsieh PS, Moore MC, Neal DW, Venson P, and Cherrington AD. Hepatic glucose uptake rapidly decreases after elimination of the portal signal in conscious dogs. Am J Physiol Endocrinol Metab 275: E987-E992, 1998.
19. Ikeda T, Scott M, Emshwiller MG, Monohan MT, Alien E, Sindelar DK, and Dunning B. Hyperglycemia reduces sympathetic nervous signaling to the liver and gut in the dog (Abstract). Diabetes 46: 232A, 1997.
20. Jackson PA, Pagliassotti MJ, Shiota M, Neal DW, Cardin S, and Cherrington AD. Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am J Physiol Endocrinol Metab 273: E1178-E1188, 1997.
21. Leon DF, Shaver JA, and Leonard JJ. Reflex heart rate control in man. Am Heart J 80: 729-739, 1970.
22. Mari A. Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am J Physiol Endocrinol Metab 263: E400-E415, 1992.
23. Myers SR, Biggers DW, Neal DW, and Cherrington AD. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J Clin Invest 88: 158-167, 1991.
24. Myers SR, McGuinness OP, Neal DW, and Cherrington AD. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J Clin Invest 87: 930-939, 1991.
25. Nagase H, Inoue S, Tanaka K, Takamura Y, and Niijima A. Hepatic glucose-sensitive unit regulation of glucose-induced insulin secretion in rats. Physiol Behav 53: 139-143, 1993.
26. Narvanen S. Role of 5-hydroxytryptamine (serotonin) in oral glucose intolerance. Scand J Clin Lab Invest Suppl 167: 1-53, 1983.
27. Niijima A. Afferent impulse discharges from glucoreceptors in the liver of the guinea pig. Ann NY Acad Sci 157: 690-700, 1969.
28. Niijima A. Visceral afferents and metabolic function. Diabetologia Suppl 20: 325-330, 1981.
29. Niijima A. Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig. J Physiol 332: 315-323, 1982.
30. Niijima A. Electrophysiological study on nervous pathway from splanchnic nerve to vagus nerve in rat. Am J Physiol Regul Integr Comp Physiol 244: R888-R890, 1983.
31. Niijima A. Glucose-sensitive afferent nerve fibers in the liver and their role in food intake and blood glucose regulation. J Auton Nerv Syst 9: 207-220, 1983.
32. Niijima A. Reflex control of the autonomic nervous system activity from the glucose sensors in the liver in normal and midpontine-transected animals. J Auton Nerv Syst 10: 279-285, 1984.
33. Niijima A. Blood glucose levels modulate efferent activity in the vagal supply to the rat liver. J Physiol 364: 105-112, 1985.
34. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, and Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the dog. J Clin Invest 97: 81-91, 1996.
35. Pagliassotti MJ, Myers SR, Moore MC, Neal DW, and Cherrington AD. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes 40: 1659-1668, 1991.
36. Rothman DL, Magnusson I, Katz LD, Shulman RG, and Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 254: 573-576, 1991.
37. Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, and Cherrington AD. Direct and indirect effects of insulin on glucose uptake and storage by the liver. Diabetes 51: 1663-1671, 2002.
38. Scher AM and Young AC. Reflex control of heart rate in the unanesthetized dog. Am J Physiol 218: 780-789, 1970.
39. Shimazu T. Glycogen synthetase activity in liver: regulation by the autonomic nerves. Science 156: 1256-1257, 1967.
40. Shimazu T. Neuronal regulation of hepatic glucose metabolism in mammals. Diabetes Metab Rev 3: 185-206, 1987.
41. Shimizu N, Oomura Y, Novin D, Grijalva CV, and Cooper PH. Functional correlations between lateral hypothalamic glucose-sensitive neurons and hepatic portal glucose-sensitive units in rat. Brain Res 265: 49-54, 1983.
42. Shiota M, Jackson P, Galassetti P, Scott M, Neal DW, and Cherrington AD. Combined intraportal infusion of acetylcholine and adrenergic blockers augments net hepatic glucose uptake. Am J Physiol Endocrinol Metab 278: E544-E552, 2000.
43. Stumpel F and Jungermann K. Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver. FEES Lett 406: 119-122, 1997.
44. Stumpel F, Kucera T, Bazotte R, and Puschel GP. Loss of regulation by sympathetic hepatic nerves of liver metabolism and haemodynamics in chronically streptozotocin-diabetic rats. Diabetologia 39: 161-165, 1996.
45. Xue C, Aspelund G, Sritharan KC, Wang JP, Slezak LA, and Andersen DK. Isolated hepatic cholinergic denervation impairs glucose and glycogen metabolism. J Surg Res 90: 19-25, 2000.
46. Yamatani K, Ohnuma H, Niijima A, Igarashi M, Sugiyama K, Daimon M, Manaka H, Tominaga M, and Sasaki H. Impaired vagus nerve-mediated control of insulin secretion in Wistar fatty rats. Metabolism 47: 1167-1173, 1998.
47. Yamazaki M and Sakaguchi T. Pancreatic vagal functional distribution in the secretion of insulin evoked by portal infusion of D-glucose. Brain Res 484: 357-360, 1989.