Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-β2 in human retinal pigment epithelial cells

Experimental Eye Research

Volumn 84, Issue 3, 2007, Pages 464-472

  Itoh, Yuji ^a   Kimoto, Kenichi ^a   Imaizumi, Masamoto ^a   Nakatsuka, Kazuo ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

collagen; retinal pigment epithelium; RhoA Rho kinase; TGF 2; vitreoretinopathy

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; MESSENGER RNA; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA2; VISUAL PIGMENT;

ARTICLE; CELL CULTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME REPRESSION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA;

AMIDES; BENZAMIDES; CELL LINE; COLLAGEN TYPE I; DEPRESSION, CHEMICAL; DIOXOLES; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PIGMENT EPITHELIUM OF EYE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SIMVASTATIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA2;

EID: 33846811615     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.10.017     Document Type: Article

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