Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice

Brain Research

Volumn 1135, Issue 1, 2007, Pages 12-21

  Payette, Daniel J ^a   Xie, Jun ^a   Guo, Qing ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Cerebral cortex; Choline; Hemicholinium 3; High affinity choline transporter 1; Presenilin 1

Indexed keywords

CARRIER PROTEIN; CHOLINE ACETYLTRANSFERASE; CHOLINE TRANSPORTER 1; HEMICHOLINIUM 3; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOTINYLATION; BRAIN CORTEX; CHOLINERGIC ACTIVITY; CHOLINERGIC NERVE CELL; GENE MUTATION; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANIMALS; CEREBRAL CORTEX; CHOLINE; CHOLINE O-ACETYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMICHOLINIUM 3; MEMBRANE TRANSPORT PROTEINS; METHIONINE; MICE; MICE, TRANSGENIC; MUTATION; NEURONS; NEUROTRANSMITTER UPTAKE INHIBITORS; PRESENILIN-1; PROTEIN BINDING; TIME FACTORS; VALINE;

MUS;

EID: 33846616940     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.12.005     Document Type: Article

References (56)

1. Annaert W.G., Levesque L., Craessaerts K., Dierinck I., Snellings G., Westaway D., George-Hyslop P.S., Cordell B., Fraser P., and De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. J. Cell Biol. 147 (1999) 277-294
2. Auld D.S., Kornecook T.J., Bastianetto S., and Quirion R. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog. Neurobiol. 68 (2002) 209-245
3. Bales K.R., Tzavara E.T., Wu S., Wade M.R., Bymaster F.P., Paul S.M., and Nomikos G.G. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-Abeta antibody. J. Clin. Invest. 116 (2006) 825-832
4. Benagiano V., Virgintino D., Flace P., Girolamo F., Errede M., Roncali L., and Ambrosi G. Choline acetyltransferase-containing neurons in the human parietal neocortex. Eur. J. Histochem. 47 (2003) 253-256
5. Bennett D.A., Schneider J.A., Bienias J.L., Evans D.A., and Wilson R.S. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 64 (2005) 834-841
6. Bonthius D.J., Solodkin A., and Van Hoesen G.W. Pathology of the insular cortex in Alzheimer disease depends on cortical architecture. J. Neuropathol. Exp. Neurol. 64 (2005) 910-922
7. Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., Copeland N.G., Price D.L., and Sisodia S.S. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19 (1997) 939-945
8. Breer H., and Knipper M. Regulation of high affinity choline uptake. J. Neurobiol. 21 (1990) 269-275
9. 1 as a negative regulator of beta-amyloid formation. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 1941-1946
10. Capell A., Steiner H., Romig H., Keck S., Baader M., Grim M.G., Baumeister R., and Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nat. Cell Biol. 2 (2000) 205-211
11. Chui D.H., Tanahashi H., Ozawa K., Ikeda S., Checler F., Ueda O., Suzuki H., Araki W., Inoue H., Shirotani K., Takahashi K., Gallyas F., and Tabira T. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat. Med. 5 (1999) 560-564
12. Coyle J.T., Price D.L., and DeLong M.R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219 (1983) 1184-1190
13. De Sarno P., Lesort M., Bijur G.N., Johnson G.V., and Jope R.S. Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1. Brain Res. 903 (2001) 226-230
14. Delatour B., Blanchard V., Pradier L., and Duyckaerts C. Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model. Neurobiol. Dis. 16 (2004) 41-47
15. Dickinson-Anson H., Winkler J., Fisher L.J., Song H.J., Poo M., and Gage F.H. Acetylcholine-secreting cells improve age-induced memory deficits. Mol. Ther. 8 (2003) 51-61
16. Duff K., Eckman C., Zehr C., Yu X., Prada C.M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M.N., Holcomb L., Refolo L., Zenk B., Hardy J., and Younkin S. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383 (1996) 710-713
17. Eckenstein F., and Baughman R.W. Two types of cholinergic innervation in cortex, one co-localized with vasoactive intestinal polypeptide. Nature 309 (1984) 153-155
18. Fine A., Dunnett S.B., Bjorklund A., and Iversen S.D. Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 5227-5230
19. Fischer W., Wictorin K., Bjorklund A., Williams L.R., Varon S., and Gage F.H. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329 (1987) 65-68
20. Geula C., and Mesulam M.M. Cholinesterases and the pathology of Alzheimer disease. Alzheimer Dis. Assoc. Disord. 9 Suppl. 2 (1995) 23-28
21. Gibbs R.B., and Aggarwal P. Estrogen and basal forebrain cholinergic neurons: implications for brain aging and Alzheimer's disease-related cognitive decline. Horm. Behav. 34 (1998) 98-111
22. Gottfries C.G., Adolfsson R., Aquilonius S.M., Carlsson A., Eckernas S.A., Nordberg A., Oreland L., Svennerholm L., Wiberg A., and Winblad B. Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT). Neurobiol. Aging 4 (1983) 261-271
23. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport 8 (1996) 379-383
24. Guo Q., Sopher B.L., Furukawa K., Pham D.G., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17 (1997) 4212-4222
25. Guo Q., Fu W., Xie J., Luo H., Sells S.F., Geddes J.W., Bondada V., Rangnekar V.M., and Mattson M.P. Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat. Med. 4 (1998) 957-962
26. Guo Q., Fu W., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., and Mattson M.P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nat. Med. 5 (1999) 101-106
27. Guo Q., Sebastian L., Sopher B.L., Miller M.W., Glazner G.W., Ware C.B., Martin G.M., and Mattson M.P. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 4125-4130
28. Guo Q., Sebastian L., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., and Mattson M.P. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J. Neurochem. 72 (1999) 1019-1029
29. Hartmann J., Erb C., Ebert U., Baumann K.H., Popp A., Konig G., and Klein J. Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice. Neuroscience 125 (2004) 1009-1017
30. Hernandez D., Sugaya K., Qu T., McGowan E., Duff K., and McKinney M. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. NeuroReport 12 (2001) 1377-1384
31. Houser C.R., Crawford G.D., Salvaterra P.M., and Vaughn J.E. Immunocytochemical localization of choline acetyltransferase in rat cerebral cortex: a study of cholinergic neurons and synapses. J. Comp. Neurol. 234 (1985) 17-34
32. Johnston M.V., McKinney M., and Coyle J.T. Neocortical cholinergic innervation: a description of extrinsic and intrinsic components in the rat. Exp. Brain Res. 43 (1981) 159-172
33. Kristt D.A. Acetylcholinesterase-containing neurons of layer VIb in immature neocortex: possible component of an early formed intrinsic cortical circuit. Anat. Embryol. (Berl) 157 (1979) 217-226
34. Mattson M.P., Guo Q., Furukawa K., and Pedersen W.A. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70 (1998) 1-14
35. Minger S.L., Honer W.G., Esiri M.M., McDonald B., Keene J., Nicoll J.A., Carter J., Hope T., and Francis P.T. Synaptic pathology in prefrontal cortex is present only with severe dementia in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60 (2001) 929-936
36. Okuda T., and Haga T. Functional characterization of the human high-affinity choline transporter. FEBS Lett. 484 (2000) 92-97
37. Okuda T., Haga T., Kanai Y., Endou H., Ishihara T., and Katsura I. Identification and characterization of the high-affinity choline transporter. Nat. Neurosci. 3 (2000) 120-125
38. Okuda T., Okamura M., Kaitsuka C., Haga T., and Gurwitz D. Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. J. Biol. Chem. 277 (2002) 45315-45322
39. Pascual J., Fontan A., Zarranz J.J., Berciano J., Florez J., and Pazos A. High-affinity choline uptake carrier in Alzheimer's disease: implications for the cholinergic hypothesis of dementia. Brain Res. 552 (1991) 170-174
40. Pedersen W.A., Guo Q., Hartman B.K., and Mattson M.P. Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. J. Biol. Chem. 272 (1997) 22397-22400
41. Price D.L., Kitt C.A., Struble R.G., Whitehouse P.J., Cork L.C., and Walker L.C. Neurobiological studies of transmitter systems in aging and in Alzheimer-type dementia. Ann. N. Y. Acad. Sci. 457 (1985) 35-51
42. Price D.L., Koliatsos V.E., and Clatterbuck R.C. Cholinergic systems: human diseases, animal models, and prospects for therapy. Prog. Brain Res. 98 (1993) 51-60
43. Ribeiro F.M., Alves-Silva J., Volknandt W., Martins-Silva C., Mahmud H., Wilhelm A., Gomez M.V., Rylett R.J., Ferguson S.S., Prado V.F., and Prado M.A. The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles. J. Neurochem. 87 (2003) 136-146
44. Ribeiro F.M., Black S.A., Cregan S.P., Prado V.F., Prado M.A., Rylett R.J., and Ferguson S.S. Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. J. Neurochem. 94 (2005) 86-96
45. Rosenberg C.K., Pericak-Vance M.A., Saunders A.M., Gilbert J.R., Gaskell P.C., and Hulette C.M. Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation. Acta Neuropathol. (Berl.) 100 (2000) 145-152
46. Samuel W., Terry R.D., DeTeresa R., Butters N., and Masliah E. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch. Neurol. 51 (1994) 772-778
47. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., and Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2 (1996) 864-870
48. Vaucher E., Fluit P., Chishti M.A., Westaway D., Mount H.T., and Kar S. Object recognition memory and cholinergic parameters in mice expressing human presenilin 1 transgenes. Exp. Neurol. 175 (2002) 398-406
49. Warburton E.C., Koder T., Cho K., Massey P.V., Duguid G., Barker G.R., Aggleton J.P., Bashir Z.I., and Brown M.W. Cholinergic neurotransmission is essential for perirhinal cortical plasticity and recognition memory. Neuron 38 (2003) 987-996
50. Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., and Delon M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215 (1982) 1237-1239
51. Winkler J., Suhr S.T., Gage F.H., Thal L.J., and Fisher L.J. Essential role of neocortical acetylcholine in spatial memory. Nature 375 (1995) 484-487
52. Wong T.P., Debeir T., Duff K., and Cuello A.C. Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J. Neurosci. 19 (1999) 2706-2716
53. Xie J., and Guo Q. Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. J. Biol. Chem. 279 (2004) 28266-28275
54. Xie J., Chang X., Zhang X., and Guo Q. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice. Brain Res. 915 (2001) 1-10
55. Xie J., Awad K.S., and Guo Q. RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice. J. Neurochem. 92 (2005) 59-71
56. Zapata A., Capdevila J.L., and Trullas R. Role of high-affinity choline uptake on extracellular choline and acetylcholine evoked by NMDA. Synapse. 35 (2000) 272-280