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Volumn 25, Issue 6, 2006, Pages 502-508

Low Folate and the Risk of Cognitive and Functional Deficits in the Very Old: The Monzino 80-plus Study

Author keywords

Cognitive deficits; Dementia; Elderly; Folate; Functional disability; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID;

EID: 33846612334     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2006.10719565     Document Type: Article
Times cited : (22)

References (60)
  • 2
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the us population. Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA: Alzheimer disease in the US population. Prevalence estimates using the 2000 census. Arch Neurol 60: 1119-1122, 2003.
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 3
    • 0035812860 scopus 로고    scopus 로고
    • Frontiers of aging
    • Martin GM: Frontiers of aging. Science 294: 13, 2001.
    • (2001) Science , vol.294 , pp. 13
    • Martin, G.M.1
  • 4
    • 4544274539 scopus 로고    scopus 로고
    • The age gap between patients in clinical studies and in the general population: A pitfall for dementia research
    • Schoenmaker N, Van Gool WA: The age gap between patients in clinical studies and in the general population: a pitfall for dementia research. Lancet Neurol 3: 627-630, 2004.
    • (2004) Lancet Neurol , vol.3 , pp. 627-630
    • Schoenmaker, N.1    Van Gool, W.A.2
  • 5
    • 0033983288 scopus 로고    scopus 로고
    • B vitamins, homocysteine, and neurocognitive function in the elderly
    • Selhub J, Bagley LC, Miller J, Rosenberg IH: B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 71(Suppl): 614S-620S, 2000.
    • (2000) Am J Clin Nutr , vol.71 , pp. 614S-620S
    • Selhub, J.1    Bagley, L.C.2    Miller, J.3    Rosenberg, I.H.4
  • 6
    • 0013788226 scopus 로고
    • Psychiatric syndromes due to avitaminosis b12 with normal blood and bone marrow
    • Strachan RW, Henderson JG: Psychiatric syndromes due to avitaminosis B12 with normal blood and bone marrow. Q J Med 34: 303-317, 1965.
    • (1965) Q J Med , vol.34 , pp. 303-317
    • Strachan, R.W.1    Henderson, J.G.2
  • 7
    • 0014078738 scopus 로고
    • Dementia and folate deficiency
    • Strachan RW, Henderson JG: Dementia and folate deficiency. Q J Med 36: 189-204, 1967.
    • (1967) Q J Med , vol.36 , pp. 189-204
    • Strachan, R.W.1    Henderson, J.G.2
  • 8
    • 0020582844 scopus 로고
    • Association between nutritional status and cognitive functioning in a healthy elderly population
    • Goodwin JS, Goodwin JM, Garry PJ: Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 249: 2917-2921, 1983.
    • (1983) JAMA , vol.249 , pp. 2917-2921
    • Goodwin, J.S.1    Goodwin, J.M.2    Garry, P.J.3
  • 11
    • 3042784367 scopus 로고    scopus 로고
    • Homocysteine, folate, and vitamin b-12 in mild cognitive impairment, alzheimer's disease and vascular dementia
    • Quadri P, Fragiacomo C, Pezzati R, Zanda E, Forloni G, Tettamanti M, Lucca U: Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer's disease and vascular dementia. Am J Clin Nutr 80: 114-122, 2004.
    • (2004) Am J Clin Nutr , vol.80 , pp. 114-122
    • Quadri, P.1    Fragiacomo, C.2    Pezzati, R.3    Zanda, E.4    Forloni, G.5    Tettamanti, M.6    Lucca, U.7
  • 13
    • 0031671672 scopus 로고    scopus 로고
    • Folate status, vascular disease and cognition in elderly canadians
    • Ebly EM, Schaefer JP, Campbell NRC, Hogan DB: Folate status, vascular disease and cognition in elderly Canadians. Age Ageing 27: 485-491, 1998.
    • (1998) Age Ageing , vol.27 , pp. 485-491
    • Ebly, E.M.1    Schaefer, J.P.2    Campbell, N.3    Hogan, D.B.4
  • 14
    • 0034068273 scopus 로고    scopus 로고
    • Serum folate and severity of atrophy of the neocortex in alzheimer's disease: Findings from the nun study
    • Snowdon DA, Tully CL, Smith CD, Perez Riley K, Markesbery WR: Serum folate and severity of atrophy of the neocortex in Alzheimer's disease: findings from the Nun Study. Am J Clin Nutr 71: 993-998, 2000.
    • (2000) Am J Clin Nutr , vol.71 , pp. 993-998
    • Snowdon, D.A.1    Tully, C.L.2    Smith, C.D.3    Perez Riley, K.4    Markesbery, W.R.5
  • 15
    • 0017566043 scopus 로고    scopus 로고
    • Folate-responsive neurological and mental disorders: Report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies
    • Botez MI, Fontaine F, Botez T, Bachevalier J: Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol 16: 230-246, 1997.
    • (1997) Eur Neurol , vol.16 , pp. 230-246
    • Botez, M.I.1    Fontaine, F.2    Botez, T.3    Bachevalier, J.4
  • 16
    • 0031597388 scopus 로고    scopus 로고
    • Folate, vitamin b12, and serum total homocysteine levels in confirmed alzheimer disease
    • Clarke R, Smith D, Jobst KA, Refsum H, Sutton L, Ueland PM: Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55: 1449-1455, 1998.
    • (1998) Arch Neurol , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, D.2    Jobst, K.A.3    Refsum, H.4    Sutton, L.5    Ueland, P.M.6
  • 17
    • 0024453856 scopus 로고
    • The consortium to establish a registry for alzheimer's disease (Cerad). Part i. Clinical and neuropsychological assessment of alzheimer's disease
    • Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C, and the CERAD investigators: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39: 1159-1165, 1989.
    • (1989) Neurology , vol.39 , pp. 1159-1165
    • Morris, J.C.1    Heyman, A.2    Mohs, R.C.3    Hughes, J.P.4    Van Belle, G.5    Fillenbaum, G.6    Mellits, E.D.7    Clark, C.8
  • 18
    • 0016823810 scopus 로고
    • –mini-mental state—. A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR: –Mini-Mental State—. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198, 1975.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 19
    • 0014579432 scopus 로고
    • Assessment of older people: Self-maintaining and instrumental activities of daily living
    • Lawton MP, Brody EM: Assessment of older people: Self-Maintaining and Instrumental Activities of Daily Living. Gerontologist 9: 179-186, 1969.
    • (1969) Gerontologist , vol.9 , pp. 179-186
    • Lawton, M.P.1    Brody, E.M.2
  • 20
    • 0344263689 scopus 로고    scopus 로고
    • Spontaneous behaviour interview: From test performance to daily life-based alzheimer patient evaluation (abstract). –the challenge of dementias.— edinburgh
    • Lucca U, Tettamanti M, Martelli P, Lucchelli F, Alberoni M, Spagnoli A: Spontaneous Behaviour Interview: from test performance to daily life-based Alzheimer patient evaluation (Abstract). –The Challenge of Dementias.— Edinburgh, UK: The Lancet, p 58, 1996.
    • (1996) UK: The Lancet , pp. 58
    • Lucca, U.1    Tettamanti, M.2    Martelli, P.3    Lucchelli, F.4    Alberoni, M.5    Spagnoli, A.6
  • 21
    • 0027969238 scopus 로고
    • Screening, detection and management of depression in elderly primary care attenders. I: The acceptability and performance of the 15 item geriatric depression scale (gds15) and the development of short versions
    • D'Ath P, Katona P, Mullan E, Evans S, Katona C: Screening, detection and management of depression in elderly primary care attenders. I: the acceptability and performance of the 15 item Geriatric Depression Scale (GDS15) and the development of short versions. Fam Pract 11: 260-266, 1994.
    • (1994) Fam Pract , vol.11 , pp. 260-266
    • D'Ath, P.1    Katona, P.2    Mullan, E.3    Evans, S.4    Katona, C.5
  • 22
    • 84870465485 scopus 로고
    • 4th ed. DSM-IV. Washington, DC: American Psychiatric Association
    • –Diagnostic and Statistical Manual of Mental Disorders,— 4th ed. DSM-IV. Washington, DC: American Psychiatric Association, 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 23
    • 0022621224 scopus 로고
    • Alzheimer's disease: A correlational analysis of the blessed information-memory-concentration test and the mini-mental state exam
    • Thal LJ, Grundman M, Golden R: Alzheimer's disease: A correlational analysis of the Blessed Information-Memory-Concentration Test and the Mini-Mental State Exam. Neurology 36: 262-264, 1986.
    • (1986) Neurology , vol.36 , pp. 262-264
    • Thal, L.J.1    Grundman, M.2    Golden, R.3
  • 24
    • 0032700958 scopus 로고    scopus 로고
    • Correlational analysis of five commonly used measures of mental status/functional abilities in patients with alzheimer disease
    • Solomon PR, Adams FA, Groccia ME, DeVeaux R, Growdon JH, Pendlebury WW: Correlational analysis of five commonly used measures of mental status/functional abilities in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 13: 147-150, 1999.
    • (1999) Alzheimer Dis Assoc Disord , vol.13 , pp. 147-150
    • Solomon, P.R.1    Adams, F.A.2    Groccia, M.E.3    DeVeaux, R.4    Growdon, J.H.5    Pendlebury, W.W.6
  • 25
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G, Tomlinson BE, Roth M: The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Brit J Psychiat 114: 797-811, 1968.
    • (1968) Brit J Psychiat , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 26
    • 13444260835 scopus 로고    scopus 로고
    • Homocysteine versus the vitamins folate, b6, and b12 as predictors of cognitive function and decline in older high-functioning adults: Macarthur studies of successful aging
    • Kado DM, Karlamangla AS, Huang M-H, Troen A, Rowe JW, Selhub J, Seeman TE: Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 118: 161-167, 2005.
    • (2005) Am J Med , vol.118 , pp. 161-167
    • Kado, D.M.1    Karlamangla, A.S.2    Huang, M.-H.3    Troen, A.4    Rowe, J.W.5    Selhub, J.6    Seeman, T.E.7
  • 29
    • 0028170372 scopus 로고
    • Serum vitamin b12 concentrations and incidence of dementia in a healthy elderly population: A report from the bronx longitudinal aging study
    • Crystal HA, Ortof E, Frishman WH, Gruber A, Hershman D, Aronson M: Serum vitamin B12 concentrations and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study. J Am Geriatr Soc 42: 933-936, 1994.
    • (1994) J am Geriatr Soc , vol.42 , pp. 933-936
    • Crystal, H.A.1    Ortof, E.2    Frishman, W.H.3    Gruber, A.4    Hershman, D.5    Aronson, M.6
  • 30
    • 0027982836 scopus 로고
    • Cobalamin concentrations are not reduced in alzheimer's disease: Results from a populationbased study
    • Basun H, Fratiglioni L, Winbland B: Cobalamin concentrations are not reduced in Alzheimer's disease: results from a populationbased study. J Am Geriatr Soc 42: 132-136, 1994.
    • (1994) J am Geriatr Soc , vol.42 , pp. 132-136
    • Basun, H.1    Fratiglioni, L.2    Winbland, B.3
  • 32
    • 0029956585 scopus 로고    scopus 로고
    • Effects of serum vitamin b12 and folate status on episodic memory performance in very old age: A population-based study
    • Wahlin Å, Hill RD, Winbland B, Bäckman L: Effects of serum vitamin B12 and folate status on episodic memory performance in very old age: A population-based study. Psychol Aging 11: 487-496, 1996.
    • (1996) Psychol Aging , vol.11 , pp. 487-496
    • Wahlin, Å.1    Hill, R.D.2    Winbland, B.3    Bäckman, L.4
  • 33
    • 0033621707 scopus 로고    scopus 로고
    • Serum vitamin b12, c and folate concentrations in the new mexico elder survey: Correlations with cognitive and affective functions
    • Lindeman RD, Romero LJ, Koehler KM, Liang HC, LaRue A, Baumgartner RN, Garry PJ: Serum vitamin B12, C and folate concentrations in the New Mexico Elder Survey: correlations with cognitive and affective functions. J Am Coll Nutr 19: 68-76, 2000.
    • (2000) J am Coll Nutr , vol.19 , pp. 68-76
    • Lindeman, R.D.1    Romero, L.J.2    Koehler, K.M.3    Liang, H.C.4    LaRue, A.5    Baumgartner, R.N.6    Garry, P.J.7
  • 34
    • 0025331267 scopus 로고
    • Diagnosis of cobalamin deficiency: I. Usefulness of serum methylmalonic acid and total homocysteine concentrations
    • Allen RH, Stabler SP, Savage DG, Lindenbaum J: Diagnosis of cobalamin deficiency: I. Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 34: 90-98, 1990.
    • (1990) Am J Hematol , vol.34 , pp. 90-98
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 35
    • 0028223165 scopus 로고
    • Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiency
    • Savage DG, Lindenbaum J, Stabler SP, Allen RH: Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiency. Am J Med 96: 239-246, 1994.
    • (1994) Am J Med , vol.96 , pp. 239-246
    • Savage, D.G.1    Lindenbaum, J.2    Stabler, S.P.3    Allen, R.H.4
  • 36
    • 0029666381 scopus 로고    scopus 로고
    • Cobalamin deficiency (Reply to a letter)
    • Green R, Kinsella LJ: Cobalamin deficiency (reply to a letter). Neurology 47: 310-311, 1996.
    • (1996) Neurology , vol.47 , pp. 310-311
    • Green, R.1    Kinsella, L.J.2
  • 37
    • 0030763118 scopus 로고    scopus 로고
    • Diagnosis of cobalamin deficiency: The old and the new
    • Chanarin I, Metz J: Diagnosis of cobalamin deficiency: the old and the new. Br J Haematol 97: 695-700, 1997.
    • (1997) Br J Haematol , vol.97 , pp. 695-700
    • Chanarin, I.1    Metz, J.2
  • 38
    • 0034090534 scopus 로고    scopus 로고
    • Current concepts in cobalamin deficiency
    • Carmel R: Current concepts in cobalamin deficiency. Annu Rev Med 51: 357-375, 2000.
    • (2000) Annu Rev Med , vol.51 , pp. 357-375
    • Carmel, R.1
  • 39
    • 12844254924 scopus 로고    scopus 로고
    • Cobalamin-responsive disorders in the ambulatory care setting: Unreliability of cobalamin, methylmalonic acid, and homocysteine testing
    • Solomon LR: Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Blood 105: 978-985, 2005.
    • (2005) Blood , vol.105 , pp. 978-985
    • Solomon, L.R.1
  • 43
    • 0032740452 scopus 로고    scopus 로고
    • Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic population: Ethnic and sex differences in cobalamin and metabolite abnormalities
    • Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C: Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr 70: 904-910, 1999.
    • (1999) Am J Clin Nutr , vol.70 , pp. 904-910
    • Carmel, R.1    Green, R.2    Jacobsen, D.W.3    Rasmussen, K.4    Florea, M.5    Azen, C.6
  • 44
    • 0036713436 scopus 로고    scopus 로고
    • Elevated serum methylmalonic acid concentrations are common among elderly americans
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J: Elevated serum methylmalonic acid concentrations are common among elderly Americans. J Nutr 132: 2799-2803, 2002.
    • (2002) J Nutr , vol.132 , pp. 2799-2803
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 45
    • 0020606810 scopus 로고
    • Application of a simple immunoadsorption assay for the measurement of saturated and unsaturated transcobalamin ii and r-binders
    • Lindemans J, Schoester M, van Kapel J: Application of a simple immunoadsorption assay for the measurement of saturated and unsaturated transcobalamin II and R-binders. Clin Chim Acta 132: 53-61, 1983.
    • (1983) Clin Chim Acta , vol.132 , pp. 53-61
    • Lindemans, J.1    Schoester, M.2    Van Kapel, J.3
  • 46
    • 14844317329 scopus 로고    scopus 로고
    • Holotranscobalamin-a first choice assays for diagnosing early vitamin b12 deficiency?
    • Hvas A-M, Nexo E: Holotranscobalamin-a first choice assays for diagnosing early vitamin B12 deficiency? J Intern Med 257: 289-298, 2005.
    • (2005) J Intern Med , vol.257 , pp. 289-298
    • Hvas, A.-M.1    Nexo, E.2
  • 48
    • 0344945664 scopus 로고    scopus 로고
    • Holotranscobalamin as an indicator of dietary vitamin b12 deficiency
    • Lloyd-Wright Z, Hvas A-M, Møller J, Sanders TAB, Nexø E: Holotranscobalamin as an indicator of dietary vitamin B12 deficiency. Clin Chem 49: 2076-2078, 2003.
    • (2003) Clin Chem , vol.49 , pp. 2076-2078
    • Lloyd-Wright, Z.1    Hvas, A.-M.2    Møller, J.3    Sanders, T.4    Nexø, E.5
  • 49
    • 0038480240 scopus 로고    scopus 로고
    • Low vitamin b-12 status in confirmed alzheimer's disease as revealed by serum holotranscobalamin
    • Refsum H, Smith AD: Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. J Neurol Neurosurg Psychiatry 74: 959-961, 2003.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 959-961
    • Refsum, H.1    Smith, A.D.2
  • 51
    • 3242744561 scopus 로고    scopus 로고
    • Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms
    • Nilsson K, Isakson A, Gustafson L, Hultberg B: Clinical utility of serum holotranscobalamin as a marker of cobalamin status in elderly patients with neuropsychiatric symptoms. Clin Chem Lab Med 42: 637-643, 2004.
    • (2004) Clin Chem Lab Med , vol.42 , pp. 637-643
    • Nilsson, K.1    Isakson, A.2    Gustafson, L.3    Hultberg, B.4
  • 52
    • 0036182125 scopus 로고    scopus 로고
    • Measuring and interpreting holo-transcobalamin (Holotranscobalamin ii)
    • Carmel R: Measuring and interpreting holo-transcobalamin (holotranscobalamin II). Clin Chem 48: 407-409, 2002.
    • (2002) Clin Chem , vol.48 , pp. 407-409
    • Carmel, R.1
  • 53
    • 0037157563 scopus 로고    scopus 로고
    • Folic acid, ageing, depression, and dementia
    • Reynolds EH: Folic acid, ageing, depression, and dementia. BMJ 324: 1512-1515, 2002.
    • (2002) BMJ , vol.324 , pp. 1512-1515
    • Reynolds, E.H.1
  • 54
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • Mattson MP, Shea TB: Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26: 137-146, 2003.
    • (2003) Trends Neurosci , vol.26 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 56
    • 0025606597 scopus 로고
    • Cerebrospinal fluid s-adenosylmethionine in depression and dementia: Effects of treatment with parenteral and oral s-adenosylmethionine
    • Bottiglieri T, Godfrey P, Flynn T, Carney MWP, Toone BK, Reynolds EH: Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine. J Neurol Neurosurg Psychiatry 53: 1096-1098, 1990.
    • (1990) J Neurol Neurosurg Psychiatry , vol.53 , pp. 1096-1098
    • Bottiglieri, T.1    Godfrey, P.2    Flynn, T.3    Carney, M.4    Toone, B.K.5    Reynolds, E.H.6
  • 57
    • 0029799427 scopus 로고    scopus 로고
    • Brain s-adenosylmethionine levels are severely decreased in alzheimer's disease
    • Morrison LD, Smith DD, Kish SJ: Brain S-adenosylmethionine levels are severely decreased in Alzheimer's disease. J Neurochem 67: 1328-1331, 1996.
    • (1996) J Neurochem , vol.67 , pp. 1328-1331
    • Morrison, L.D.1    Smith, D.D.2    Kish, S.J.3
  • 59
    • 0036523032 scopus 로고    scopus 로고
    • Folic acid deficiency and homocysteine impair dna repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of alzheimer's disease
    • Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP: Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J Neurosci 22: 1752-1762, 2002.
    • (2002) J Neurosci , vol.22 , pp. 1752-1762
    • Kruman, I.I.1    Kumaravel, T.S.2    Lohani, A.3    Pedersen, W.A.4    Cutler, R.G.5    Kruman, Y.6    Haughey, N.7    Lee, J.8    Evans, M.9    Mattson, M.P.10
  • 60
    • 0036140785 scopus 로고    scopus 로고
    • Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering
    • Doshi SN, McDowell IFW, Moat SJ, Payne N, Durrant HJ, Lewis MJ, Goodfellow J: Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 105: 22-26, 2002.
    • (2002) Circulation , vol.105 , pp. 22-26
    • Doshi, S.N.1    McDowell, I.2    Moat, S.J.3    Payne, N.4    Durrant, H.J.5    Lewis, M.J.6    Goodfellow, J.7


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