메뉴 건너뛰기




Volumn 22, Issue 4, 1997, Pages 397-410

New acetylcholinesterase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

7 METHOXYTACRINE; 9 AMINO 8 FLUORO 1,2,3,4 TETRAHYDRO 2,4 METHANOACRIDINE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMIRIDINE; CHOLINE ACETYLTRANSFERASE; CHOLINESTERASE INHIBITOR; CP 118954; DONEPEZIL; GALANTAMINE; HEPTYLSTIGMINE TARTRATE; HUPERZINE A; PHENSERINE; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG; ZANEPEZIL; ZIFROSILONE;

EID: 0030860195     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (61)

References (69)
  • 1
    • 0028922963 scopus 로고
    • Alzheimer's disease: Arthritis of the brain?
    • McGeer, P.L., McGeer, E.G. Alzheimer's disease: Arthritis of the brain? Drug News Perspect 1995, 8(2): 80-3.
    • (1995) Drug News Perspect , vol.8 , Issue.2 , pp. 80-83
    • McGeer, P.L.1    McGeer, E.G.2
  • 2
    • 0002361315 scopus 로고
    • Cholinomimetic replacement of cholinergic function in Alzheimer disease
    • E.M. Meyer, J.W. Simpkins, J. Yamamoto, F.T. Crews (Eds.). Plenum Press: New York
    • Giacobini, E. Cholinomimetic replacement of cholinergic function in Alzheimer disease. In: Treatment of Dementias: A New Generation of Progress. Advances in Behavioral Biology, Vol. 40. E.M. Meyer, J.W. Simpkins, J. Yamamoto, F.T. Crews (Eds.). Plenum Press: New York 1992, 19-34.
    • (1992) Treatment of Dementias: A New Generation of Progress. Advances in Behavioral Biology , vol.40 , pp. 19-34
    • Giacobini, E.1
  • 4
    • 0025778840 scopus 로고
    • Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein
    • Sussmann, J.L., Harel, M., Frolow, F. et al. Atomic structure of acetylcholinesterase from Torpedo californica: A prototypic acetylcholine-binding protein. Science 1991, 253: 872-4.
    • (1991) Science , vol.253 , pp. 872-874
    • Sussmann, J.L.1    Harel, M.2    Frolow, F.3
  • 5
    • 0020198689 scopus 로고
    • Current problems in mechanistic studies of serine and cysteine proteinases
    • Plgar, L., Hulasz, P. Current problems in mechanistic studies of serine and cysteine proteinases. Biochem J 1982, 207: 1-10.
    • (1982) Biochem J , vol.207 , pp. 1-10
    • Plgar, L.1    Hulasz, P.2
  • 6
    • 0025132889 scopus 로고
    • Anionic subsites of the acetylcholinesterase from Torpedo californica: Affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridium
    • Weise, C., Kreienkamp, H.J., Raba, R., Pedak, A., Aaviksaar, A., Hucho, F. Anionic subsites of the acetylcholinesterase from Torpedo californica: Affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridium. EMBO J 1990, 9: 3885-8.
    • (1990) EMBO J , vol.9 , pp. 3885-3888
    • Weise, C.1    Kreienkamp, H.J.2    Raba, R.3    Pedak, A.4    Aaviksaar, A.5    Hucho, F.6
  • 8
    • 0002651869 scopus 로고
    • Alignment of amino acid sequences of acetylcholinesterases and butyrylcholinesterases
    • J. Massoulié, F. Bacou, E. Barnard, A. Chatonnet, B. P. Doctor, D. M. Quinn (Eds.). Americam Chemical Society
    • Gentry, M.K., Doctor, B.P. Alignment of amino acid sequences of acetylcholinesterases and butyrylcholinesterases. In: Cholinesterases: Structure, Function, Mechanism, Genetics and Cell Biology. J. Massoulié, F. Bacou, E. Barnard, A. Chatonnet, B. P. Doctor, D. M. Quinn (Eds.). Americam Chemical Society 1991, 394-8.
    • (1991) Cholinesterases: Structure, Function, Mechanism, Genetics and Cell Biology , pp. 394-398
    • Gentry, M.K.1    Doctor, B.P.2
  • 9
    • 0026454813 scopus 로고
    • Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis
    • Harel, M., Susmann, J.L., Krejci, E. et al. Conversion of acetylcholinesterase to butyrylcholinesterase: Modeling and mutagenesis. Proc Natl Acad Sci USA 1992, 89: 10827-31.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10827-10831
    • Harel, M.1    Susmann, J.L.2    Krejci, E.3
  • 10
    • 0026031111 scopus 로고
    • Role of the peripheral anionic site on acetylcholinesterase: Inhibition by substrates and coumarin derivatives
    • Radic, Z., Reiner, E., Taylor, P. Role of the peripheral anionic site on acetylcholinesterase: Inhibition by substrates and coumarin derivatives. Mol Pharmacol 1991, 39: 98-104.
    • (1991) Mol Pharmacol , vol.39 , pp. 98-104
    • Radic, Z.1    Reiner, E.2    Taylor, P.3
  • 11
    • 0026794041 scopus 로고
    • Changes in acetylcholinesterase and butyrylcholinesterase in Alzeimer's disease resemble embryonic development - A study of molecular forms
    • Arendt, T., Bruckner, M.K., Lange, M., Bigi, V. Changes in acetylcholinesterase and butyrylcholinesterase in Alzeimer's disease resemble embryonic development - A study of molecular forms. Neurochem Int 1992, 21: 381-396.
    • (1992) Neurochem Int , vol.21 , pp. 381-396
    • Arendt, T.1    Bruckner, M.K.2    Lange, M.3    Bigi, V.4
  • 12
    • 0023628370 scopus 로고
    • Tacrine
    • Tacrine. Drugs Fut 1987, 12: 1032-5.
    • (1987) Drugs Fut , vol.12 , pp. 1032-1035
  • 13
    • 0028234186 scopus 로고
    • NIK-247
    • NIK-247. Drugs Fut 1994, 19: 343-6.
    • (1994) Drugs Fut , vol.19 , pp. 343-346
  • 14
    • 0026071072 scopus 로고
    • SM-10888
    • SM-10888. Drugs Fut 1991, 16: 33-6.
    • (1991) Drugs Fut , vol.16 , pp. 33-36
  • 15
    • 0025363727 scopus 로고
    • 7-Methoxytacrine
    • 7-Methoxytacrine. Drugs Fut 1990, 15: 126-9.
    • (1990) Drugs Fut , vol.15 , pp. 126-129
  • 16
    • 0345033773 scopus 로고
    • 3-D Structure of acetylcholinesterase and complexes of it with anticholinesterase agents
    • A. Pullman et al. (Eds.). Kluwer Academic Press: Netherlands
    • Sussman, J.L., Harel, L., Silman, I. 3-D Structure of acetylcholinesterase and complexes of it with anticholinesterase agents. In: Membrane Proteins: Structures, Interactions and Models. A. Pullman et al. (Eds.). Kluwer Academic Press: Netherlands 1992, 161-75.
    • (1992) Membrane Proteins: Structures, Interactions and Models , pp. 161-175
    • Sussman, J.L.1    Harel, L.2    Silman, I.3
  • 17
    • 0006729578 scopus 로고
    • Structure-function relationships in the binding of reversible inhibitors in the active-site gorge of acetylcholinesterase
    • E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston
    • Silman, I., Harel, M., Eichler, J., Sussman, J.L., Anselmet, A., Massouliè, J. Structure-function relationships in the binding of reversible inhibitors in the active-site gorge of acetylcholinesterase. In: Alzheimer Disease: Therapeutic Strategies. E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston 1994, 88-92.
    • (1994) Alzheimer Disease: Therapeutic Strategies , pp. 88-92
    • Silman, I.1    Harel, M.2    Eichler, J.3    Sussman, J.L.4    Anselmet, A.5    Massouliè, J.6
  • 19
    • 0023732194 scopus 로고
    • New analogs of physostigmine: Alternative drugs for Alzheimers disease?
    • Marta, M., Castellano, C., Oliverio, A. et al. New analogs of physostigmine: Alternative drugs for Alzheimers disease? Life Sci 1988, 43: 1921-8.
    • (1988) Life Sci , vol.43 , pp. 1921-1928
    • Marta, M.1    Castellano, C.2    Oliverio, A.3
  • 20
    • 0028894072 scopus 로고
    • Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease
    • Craig, N.H., Pei, X.F., Soncrant T.T., Ingram D.K., Brossi A. Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease. Med Res Rev 1995, 15: 3-31.
    • (1995) Med Res Rev , vol.15 , pp. 3-31
    • Craig, N.H.1    Pei, X.F.2    Soncrant, T.T.3    Ingram, D.K.4    Brossi, A.5
  • 21
    • 0027989343 scopus 로고
    • SDZ-ENA-713
    • SDZ-ENA-713. Drugs Fut 1994, 19: 656.
    • (1994) Drugs Fut , vol.19 , pp. 656
  • 22
    • 0001945744 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: An overview of their mechanisms of action
    • E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston
    • Enz, A., Florsheim, P. Cholinesterase inhibitors: An overview of their mechanisms of action. In: Alzheimer Disease: From Molecular Biology to Therapy. E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston 1996, 211-5.
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 211-215
    • Enz, A.1    Florsheim, P.2
  • 23
    • 0028935521 scopus 로고
    • TAK-147
    • TAK-147. Drugs Fut 1995, 20: 248.
    • (1995) Drugs Fut , vol.20 , pp. 248
  • 24
    • 0029099970 scopus 로고
    • 5,7-Dihydro-3-[2-[(1 - Phenylmethyl) - 4 - piperidinyl] - ethyl] - 6H - pyrrolo -[3,2-f]-1,2-benzisoxazol-6-one: A potent and centrally selective inhibitor of acetylcholinesterase with improved margin of safety
    • Villabos, A., Butler, T.N., Chapin, D.S. et al. 5,7-Dihydro-3-[2-[(1 - phenylmethyl) - 4 - piperidinyl] - ethyl] - 6H - pyrrolo -[3,2-f]-1,2-benzisoxazol-6-one: A potent and centrally selective inhibitor of acetylcholinesterase with improved margin of safety. J Med Chem 1995, 38: 2802-8.
    • (1995) J Med Chem , vol.38 , pp. 2802-2808
    • Villabos, A.1    Butler, T.N.2    Chapin, D.S.3
  • 25
    • 0028710014 scopus 로고
    • Prediction of the binding site of 1-benzyl-4-[(5,6-di-methoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYDOC program
    • Panq, Y-P., Kozikowski, A. Prediction of the binding site of 1-benzyl-4-[(5,6-di-methoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYDOC program. J Comput Aided Mol Des 1994, 8: 683-93.
    • (1994) J Comput Aided Mol des , vol.8 , pp. 683-693
    • Panq, Y.-P.1    Kozikowski, A.2
  • 26
    • 0022419375 scopus 로고
    • Aromatic-aromatic interaction: A mechanism of protein structure stabilization
    • Burly, S.K., Petsko, G.A. Aromatic-aromatic interaction: A mechanism of protein structure stabilization. Science 1985, 229: 23-8.
    • (1985) Science , vol.229 , pp. 23-28
    • Burly, S.K.1    Petsko, G.A.2
  • 27
    • 0001227655 scopus 로고
    • The nature of π-π interactions
    • Hunter, C.A., Sanders, K.M. The nature of π-π interactions. J Am Chem Soc 1990, 112: 5525-34.
    • (1990) J Am Chem Soc , vol.112 , pp. 5525-5534
    • Hunter, C.A.1    Sanders, K.M.2
  • 29
    • 0026551055 scopus 로고
    • QSAR analyses of the substituted indanone and benzyl-piperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase
    • published erratum, J Med Chem 1992, 35: 4767
    • Cardozo, M.G., Iimura, Y., Sugimoto, H., Yamanishi, Y., Hopfinger, A.J. QSAR analyses of the substituted indanone and benzyl-piperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. J Med Chem 1992, 35: 584-9 (published erratum, J Med Chem 1992, 35: 4767).
    • (1992) J Med Chem , vol.35 , pp. 584-589
    • Cardozo, M.G.1    Iimura, Y.2    Sugimoto, H.3    Yamanishi, Y.4    Hopfinger, A.J.5
  • 30
    • 0026539070 scopus 로고
    • Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase
    • published erratum, J Med Chem 1992, 35: 4768
    • Cardozo, M.G., Kawai, T., Iimura, Y., Sugimoto, H., Yamanishi, Y., Hopfinger, A. J. Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. J Med Chem 1992, 35: 590-601 (published erratum, J Med Chem 1992, 35: 4768).
    • (1992) J Med Chem , vol.35 , pp. 590-601
    • Cardozo, M.G.1    Kawai, T.2    Iimura, Y.3    Sugimoto, H.4    Yamanishi, Y.5    Hopfinger, A.J.6
  • 31
    • 0029920219 scopus 로고    scopus 로고
    • Galanthamine derivatives for the treatment of Alzheimer's disease
    • Bores, G.M., Kosley, R.W. Galanthamine derivatives for the treatment of Alzheimer's disease. Drugs Fut 1996, 21: 621-35.
    • (1996) Drugs Fut , vol.21 , pp. 621-635
    • Bores, G.M.1    Kosley, R.W.2
  • 32
    • 1842381307 scopus 로고
    • Huperzine A
    • Huperzine A. Drugs Fut 1987, 12: 531-2.
    • (1987) Drugs Fut , vol.12 , pp. 531-532
  • 33
    • 1842279334 scopus 로고
    • Zifrosilone
    • Zifrosilone. Drugs Fut 1994, 19: 854.
    • (1994) Drugs Fut , vol.19 , pp. 854
  • 34
    • 0028693767 scopus 로고
    • Prediction of the binding site of huperzine A in acetylcholinesterase by docking studies
    • Pang, Y-P., Kozikowski, A. Prediction of the binding site of huperzine A in acetylcholinesterase by docking studies. J Comput Aided Mol Des 1994, 8: 669-81.
    • (1994) J Comput Aided Mol des , vol.8 , pp. 669-681
    • Pang, Y.-P.1    Kozikowski, A.2
  • 35
    • 0018163960 scopus 로고
    • Metrifonate: Summary of toxicological and pharmacological information available
    • Holmsted, B., Nordgren, I., Sandoz, M., Sundwall, A. Metrifonate: Summary of toxicological and pharmacological information available. Arch Toxicol 1978, 41: 3-29.
    • (1978) Arch Toxicol , vol.41 , pp. 3-29
    • Holmsted, B.1    Nordgren, I.2    Sandoz, M.3    Sundwall, A.4
  • 36
    • 0018731624 scopus 로고
    • Mode of action of anticholinesterases
    • Main, A.R. Mode of action of anticholinesterases. Pharmacol Ther 1979, 6: 579-628.
    • (1979) Pharmacol Ther , vol.6 , pp. 579-628
    • Main, A.R.1
  • 38
    • 0016654358 scopus 로고
    • A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations
    • Johnson, C.D., Russell, R.L. A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal Biochem 1975, 64: 229-38.
    • (1975) Anal Biochem , vol.64 , pp. 229-238
    • Johnson, C.D.1    Russell, R.L.2
  • 39
    • 0027239591 scopus 로고
    • Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex
    • Messamore, E., Warpman, U., Ogane, N., Giacobini, E. Cholinesterase inhibitor effects on extracellular acetylcholine in rat cortex. Neuropharmacology 1993, 32: 754-60.
    • (1993) Neuropharmacology , vol.32 , pp. 754-760
    • Messamore, E.1    Warpman, U.2    Ogane, N.3    Giacobini, E.4
  • 40
    • 0028341720 scopus 로고
    • Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo
    • Cuadra, G., Summers, K., Giacobini, E. Cholinesterase inhibitor effects on neurotransmitters in rat cortex in vivo. J Pharmacol Exp Ther 1994, 270: 277-84.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 277-284
    • Cuadra, G.1    Summers, K.2    Giacobini, E.3
  • 41
    • 0028918426 scopus 로고
    • Cholinesterase inhibitors increase secretion of APPs in rat brain cortex
    • Mori, F., Lai, C.C., Fusi, F. Giacobini, E. Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. NeuroReport 1995, 6: 633-6.
    • (1995) NeuroReport , vol.6 , pp. 633-636
    • Mori, F.1    Lai, C.C.2    Fusi, F.3    Giacobini, E.4
  • 42
    • 0027453490 scopus 로고
    • Activation of protein kinase C inhibits cellular production of the amyloid β-protein
    • Hung, A.Y., Haas, C., Nitsch, R.M. et al. Activation of protein kinase C inhibits cellular production of the amyloid β-protein. J Biol Chem 1993, 268: 22959-62.
    • (1993) J Biol Chem , vol.268 , pp. 22959-22962
    • Hung, A.Y.1    Haas, C.2    Nitsch, R.M.3
  • 43
    • 0028207004 scopus 로고
    • Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
    • Buxbaum, J.D., Ruefli, A.A., Parker, C.A., Cypress, A.M., Greengard, P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc Natl Acad Sci USA 1994, 91: 4489-93.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4489-4493
    • Buxbaum, J.D.1    Ruefli, A.A.2    Parker, C.A.3    Cypress, A.M.4    Greengard, P.5
  • 44
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle, J.T., Price, D.L., De Lang, M.R. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 1983, 219: 1184-90.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    De Lang, M.R.3
  • 45
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R.T., Dean, R.L., Beer, B. Lippa, A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217: 408-17.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 46
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosem, W.G., Mohs, R.C., Davis, K.I. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984, 141: 1356-64.
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosem, W.G.1    Mohs, R.C.2    Davis, K.I.3
  • 48
    • 0024246154 scopus 로고
    • Alzheimer's disease assessment scale (ADAS)
    • Mohs, R.C., Cohen, I. Alzheimer's disease assessment scale (ADAS). Psychopharmacol Bull 1988, 24: 672-8.
    • (1988) Psychopharmacol Bull , vol.24 , pp. 672-678
    • Mohs, R.C.1    Cohen, I.2
  • 49
    • 0016823810 scopus 로고
    • Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician
    • Eolstein, M.F., Falstein, S.E., McHugh, P.R. Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12: 189-98.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Eolstein, M.F.1    Falstein, S.E.2    McHugh, P.R.3
  • 50
    • 0027090348 scopus 로고
    • Misclassification of dementia by the Mini-Mental State Examination: Are education and social class the only factors?
    • Jagger, C., Clarke, M., Anderson, J., Battcock, T. Misclassification of dementia by the Mini-Mental State Examination: Are education and social class the only factors? Age Ageing 1992, 21: 404-11.
    • (1992) Age Ageing , vol.21 , pp. 404-411
    • Jagger, C.1    Clarke, M.2    Anderson, J.3    Battcock, T.4
  • 51
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
    • Knapp, M.J., Knopman, D.S., Solomon, P.R. et al. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA 1994, 271: 985-91.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3
  • 52
    • 0019967975 scopus 로고
    • The Global Deterioration Scale for assessment of primary degenerative dementia
    • Raisberg, B., Ferris, S.H., De Leon, M.J., Crook, T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982, 139: 1136-9.
    • (1982) Am J Psychiatry , vol.139 , pp. 1136-1139
    • Raisberg, B.1    Ferris, S.H.2    De Leon, M.J.3    Crook, T.4
  • 53
    • 0025908283 scopus 로고
    • Scales for the assessment of Alzheimer's disease
    • Kluger, A., Ferris, S.H. Scales for the assessment of Alzheimer's disease. Psychiatr Clin North Am 1991, 14: 309-26.
    • (1991) Psychiatr Clin North Am , vol.14 , pp. 309-326
    • Kluger, A.1    Ferris, S.H.2
  • 54
    • 0022899577 scopus 로고
    • Oral tetrahydroaminoacridine in long-term treatment of senile dementia. Alzheimer type
    • Summers, N.K., Majovski, L.V., Marsh, G.M., Tachiki, K., Kling, A. Oral tetrahydroaminoacridine in long-term treatment of senile dementia. Alzheimer type. New Engl J Med 1986, 315: 1241-5.
    • (1986) New Engl J Med , vol.315 , pp. 1241-1245
    • Summers, N.K.1    Majovski, L.V.2    Marsh, G.M.3    Tachiki, K.4    Kling, A.5
  • 55
    • 0026756286 scopus 로고
    • A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group
    • Davis, K.L., Thal, L.J., Gamzu, E.R. et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. New Engl J Med 1992, 237: 1253-9.
    • (1992) New Engl J Med , vol.237 , pp. 1253-1259
    • Davis, K.L.1    Thal, L.J.2    Gamzu, E.R.3
  • 56
    • 0026792979 scopus 로고
    • A controlled trial of tacrine for Alzheimer's disease. The Tacrine Study Group
    • Farlow, M., Gracon, S.I., Hershey, L.A., Lewis, K.W., Sadowsky, C.H., Dolan-Ureno, J. A controlled trial of tacrine for Alzheimer's disease. The Tacrine Study Group. JAMA 1992, 327: 2523-9.
    • (1992) JAMA , vol.327 , pp. 2523-2529
    • Farlow, M.1    Gracon, S.I.2    Hershey, L.A.3    Lewis, K.W.4    Sadowsky, C.H.5    Dolan-Ureno, J.6
  • 57
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease
    • Watkins, P.B., Zimmerman, H.J., Knapp, M.J., Gracon, S.I., Lewis, K.W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994, 17: 992-8.
    • (1994) JAMA , vol.17 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3    Gracon, S.I.4    Lewis, K.W.5
  • 58
    • 1842360136 scopus 로고
    • Pharmacodynamic strategy to optimize the clinical response to eptastigmine (MF-201)
    • (May 11-15, Springfield) Abst 31
    • Imbimbo, P.B., Lucchelli, P.E. Pharmacodynamic strategy to optimize the clinical response to eptastigmine (MF-201). 3rd Int Springfield Symp Adv Alzheimer Ther (May 11-15, Springfield) 1994, Abst 31.
    • (1994) 3rd Int Springfield Symp Adv Alzheimer Ther
    • Imbimbo, P.B.1    Lucchelli, P.E.2
  • 59
    • 84938457805 scopus 로고
    • Eptastigmine (MF-201). A double-blind placebo-controlled clinical trial in Alzheimer's disease patients
    • (May 11-15, Springfield) Abst 32
    • Canal, N., Franceschi, M. Eptastigmine (MF-201). A double-blind placebo-controlled clinical trial in Alzheimer's disease patients. 3rd Int Springfield Symp Adv Alzheimer Ther (May 11-15, Springfield) 1994, Abst 32.
    • (1994) 3rd Int Springfield Symp Adv Alzheimer Ther
    • Canal, N.1    Franceschi, M.2
  • 60
    • 1842320526 scopus 로고
    • Chronic low dose eptastigmine in Alzheimer patients: Relationship between acetylcholinesterase inhibition and cognitive effects
    • Abst 410
    • Imbimbo, P.B., Lucchelli, P.E. Chronic low dose eptastigmine in Alzheimer patients: Relationship between acetylcholinesterase inhibition and cognitive effects. Neurobiol Aging 1994, 15(Suppl. 1): Abst 410.
    • (1994) Neurobiol Aging , vol.15 , Issue.1 SUPPL.
    • Imbimbo, P.B.1    Lucchelli, P.E.2
  • 61
    • 1842391998 scopus 로고    scopus 로고
    • Eptastigmine: The cholinergic approach to the treatment of Alzheimer's disease
    • November 1, Rome
    • Imbimbo, B.P., Lucchelli, P.E. Eptastigmine: The cholinergic approach to the treatment of Alzheimer's disease. 2nd Cong Eur Fed Neurol Soc (November 1, Rome) 1996.
    • (1996) 2nd Cong Eur Fed Neurol Soc
    • Imbimbo, B.P.1    Lucchelli, P.E.2
  • 62
    • 10244259208 scopus 로고    scopus 로고
    • The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicenter randomized, double-blind, placebo-controlled trial
    • Rogers, S.L., Friedhoff, L.T. et al. The efficacy and safety of donepezil in patients with Alzheimer's disease: Results of a US multicenter randomized, double-blind, placebo-controlled trial. Dementia 1996, 7: 293-303.
    • (1996) Dementia , vol.7 , pp. 293-303
    • Rogers, S.L.1    Friedhoff, L.T.2
  • 63
    • 1842380319 scopus 로고    scopus 로고
    • Sandoz's Exelon shows positive results in phase III
    • August 9
    • Sandoz's Exelon shows positive results in phase III. Prous Science Daily Essentials. August 9, 1996 (http://www.prous.com/ home_daily).
    • (1996) Prous Science Daily Essentials
  • 64
    • 1842343573 scopus 로고    scopus 로고
    • Clinical confirmation of pre-clinical attributes: The ADENA program
    • (July 24-29, Osaka) Abst 349
    • Anand, R., Enz, A. Clinical confirmation of pre-clinical attributes: The ADENA program. 5th Int Conf Alzheimer's Dis Relat Disord (July 24-29, Osaka) 1996, Abst 349.
    • (1996) 5th Int Conf Alzheimer's Dis Relat Disord
    • Anand, R.1    Enz, A.2
  • 65
    • 0002095425 scopus 로고    scopus 로고
    • Anoverview of the development of SDZ-ENA-713, a brain selective cholinesterase inhibitor
    • E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston
    • Anand, R., Hartman, R.D., Hayes, P.E., Gharabawi, M. Anoverview of the development of SDZ-ENA-713, a brain selective cholinesterase inhibitor. In: Alzheimer Disease: From Molecular Biology to Therapy. E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston 1996, 239-43.
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 239-243
    • Anand, R.1    Hartman, R.D.2    Hayes, P.E.3    Gharabawi, M.4
  • 66
    • 0029766994 scopus 로고    scopus 로고
    • Efficacy and safety results of the early phase studies with Exelon (ENA-713) in Alzheimer's disease: An overview
    • Arnad, R., Gharabaw, G. Efficacy and safety results of the early phase studies with Exelon (ENA-713) in Alzheimer's disease: An overview. J Drug Dev Clin Pract 1996, 8: 109-16.
    • (1996) J Drug Dev Clin Pract , vol.8 , pp. 109-116
    • Arnad, R.1    Gharabaw, G.2
  • 67
    • 0029778789 scopus 로고    scopus 로고
    • Clinical developpement of Exelon (ENA-713): The ADENA programme
    • Arnad. R., Gharabawi, G. Clinical developpement of Exelon (ENA-713): The ADENA programme. J Drug Dev Clin Pract 1996, 8: 117-22.
    • (1996) J Drug Dev Clin Pract , vol.8 , pp. 117-122
    • Arnad, R.1    Gharabawi, G.2
  • 68
    • 0344867755 scopus 로고
    • Butyrylcholinesterases in Alzheimer's disease
    • E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston
    • Mesulam, M.M. Butyrylcholinesterases in Alzheimer's disease. In: Alzheimer Disease: Therapeutic Strategies. E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston 1994, 79-83.
    • (1994) Alzheimer Disease: Therapeutic Strategies , pp. 79-83
    • Mesulam, M.M.1
  • 69
    • 0002994207 scopus 로고
    • Second and third generation cholinesterase inhibitors: From preclinical studies to clinical studies to clinical efficacy
    • E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston
    • Giacobini E., Cuadra G. Second and third generation cholinesterase inhibitors: From preclinical studies to clinical studies to clinical efficacy. In: Alzheimer Disease: Therapeutic Strategies. E. Giacobini, R. Becker (Eds.). Birkhäuser: Boston 1994, 155-71.
    • (1994) Alzheimer Disease: Therapeutic Strategies , pp. 155-171
    • Giacobini, E.1    Cuadra, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.