메뉴 건너뛰기




Volumn 24, Issue 4, 1999, Pages 417-424

Cholinergic therapies in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 3 (2 PYRROLIDINYLMETHOXY)PYRIDINE; 2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE; 3 (2 DIETHYLAMINO 2 METHYLPROPYLAMINO) 6 PHENYL 5 PROPYLPYRIDAZINE; 3 [3 (3 METHOXYPHENYL) 2 PROPYNYLOXYIMINO] 1 AZABICYCLO[2.2.1]HEPTANE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; BESIPIRDINE; CEVIMELINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; HUPERZINE A; LINOPIRDINE; METRIFONATE; MILAMELINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC AGENT; OTENZEPAD; PD 142505; PHENSERINE; PHYSOSTIGMINE; RIVASTIGMINE; RO 46 5934; TACRINE; TALSACLIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELNACRINE; XANOMELINE;

EID: 0033036158     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.04.668318     Document Type: Review
Times cited : (79)

References (81)
  • 1
    • 0024317904 scopus 로고
    • Prevalence of Alzheimer's disease in a community population of older persons
    • Evans, D.A., Funkenstein, H., Albert, M.S. et al. Prevalence of Alzheimer's disease in a community population of older persons. JAMA 1989, 262: 2551-6.
    • (1989) JAMA , vol.262 , pp. 2551-2556
    • Evans, D.A.1    Funkenstein, H.2    Albert, M.S.3
  • 2
    • 0029838038 scopus 로고    scopus 로고
    • Neuropsychiatric aspects of Alzheimer's disease: The cholinergic hypothesis revisited
    • Cummings, J.L., Kaufer, D. Neuropsychiatric aspects of Alzheimer's disease: The cholinergic hypothesis revisited. Neurology 1996, 47: 876-83.
    • (1996) Neurology , vol.47 , pp. 876-883
    • Cummings, J.L.1    Kaufer, D.2
  • 3
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R.T., Dean, R.L. III, Beer, B., Lippa, A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217: 408-17.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean R.L. III2    Beer, B.3    Lippa, A.S.4
  • 4
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle, J.T., Price, D.L., DeLong, M.R. Alzheimer's disease: A disorder of cortical cholinergic innervation. Science 1983, 219: 1184-90.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    DeLong, M.R.3
  • 5
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse, P.J., Price, D.L., Strubble, R.G., Clark, A.W., DeLong, M.R. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 1982, 215: 1237-9.
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Strubble, R.G.3    Clark, A.W.4    DeLong, M.R.5
  • 6
    • 0022869345 scopus 로고
    • 2 muscarine receptors in the rat brain
    • 2 muscarine receptors in the rat brain. Neuroscience 1986, 19: 551-64.
    • (1986) Neuroscience , vol.19 , pp. 551-564
    • Mash, D.C.1    Potter, L.T.2
  • 7
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies, P., Maloney, A.J.F. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976, 2: 1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 8
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse, P.J., Price, D.L., Clark, A.W., Coyle, J.T., DeLong, M.R. Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981, 10: 122-6.
    • (1981) Ann Neurol , vol.10 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3    Coyle, J.T.4    DeLong, M.R.5
  • 9
    • 0017652462 scopus 로고
    • Memory and cognitive function in man: Does the cholinergic system have a specific role?
    • Drachman, D.A. Memory and cognitive function in man: Does the cholinergic system have a specific role? Neurology 1977, 27: 783-90.
    • (1977) Neurology , vol.27 , pp. 783-790
    • Drachman, D.A.1
  • 10
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • Perry, E.K., Tomlinson, B.E., Blessed, G., Bergman, K., Gibson, P.H., Perry, R.H. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 1978, 2: 1457-9.
    • (1978) Br Med J , vol.2 , pp. 1457-1459
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3    Bergman, K.4    Gibson, P.H.5    Perry, R.H.6
  • 11
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry, R.D., Masliah, E., Salmon, D.P. et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991, 30: 572-80.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3
  • 12
    • 0030757246 scopus 로고    scopus 로고
    • Cognition-enhancing drugs in dementia: A guide to the near future
    • Van Reckum, R., Black, S.E., Conn, D., Clarke, D. Cognition-enhancing drugs in dementia: A guide to the near future. Can J Psychiatry 1997, 42(Suppl. 1): S35-50.
    • (1997) Can J Psychiatry , vol.42 , Issue.1 SUPPL.
    • Van Reckum, R.1    Black, S.E.2    Conn, D.3    Clarke, D.4
  • 13
    • 0030446532 scopus 로고    scopus 로고
    • Cholinomimetic treatment of Alzheimer's disease
    • Thai, L.J. Cholinomimetic treatment of Alzheimer's disease. Prog Brain Res 1996, 109: 299-309.
    • (1996) Prog Brain Res , vol.109 , pp. 299-309
    • Thai, L.J.1
  • 15
    • 0029561898 scopus 로고
    • Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine
    • Asthana, S., Raffaele, K.C., Berardi, A. et al. Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine. Alzheimer Dis Assoc Disord 1995, 9: 223-32.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , pp. 223-232
    • Asthana, S.1    Raffaele, K.C.2    Berardi, A.3
  • 16
    • 10544220019 scopus 로고    scopus 로고
    • A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease
    • Thal, L.J., Schwartz, G., Sano, M. et al. A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease. Neurology 1996, 47: 1389-95.
    • (1996) Neurology , vol.47 , pp. 1389-1395
    • Thal, L.J.1    Schwartz, G.2    Sano, M.3
  • 17
    • 0025729062 scopus 로고
    • Tacrine in Alzheimer's Disease
    • Eagger, S.A., Levy, R., Sahakian, B.J. Tacrine in Alzheimer's Disease. Lancet 1991, 337: 990-2.
    • (1991) Lancet , vol.337 , pp. 990-992
    • Eagger, S.A.1    Levy, R.2    Sahakian, B.J.3
  • 18
    • 0026792979 scopus 로고
    • A controlled trial of tacrine in Alzheimer's disease
    • Farlow, M., Gracon, S.I., Hershey, L.A. et al. A controlled trial of tacrine in Alzheimer's disease. JAMA 1992, 268: 2523-9.
    • (1992) JAMA , vol.268 , pp. 2523-2529
    • Farlow, M.1    Gracon, S.I.2    Hershey, L.A.3
  • 19
    • 33746140058 scopus 로고
    • Clinical pharmacology of aminoacridines in Alzheimer's disease
    • Schneider, L.S. Clinical pharmacology of aminoacridines in Alzheimer's disease. Neurology 1993, 43(Suppl. 4): S64-79.
    • (1993) Neurology , vol.43 , Issue.4 SUPPL.
    • Schneider, L.S.1
  • 21
    • 0029914548 scopus 로고    scopus 로고
    • Effect of tacrine on behavioral symptoms in Alzheimer's disease: An open-label study
    • Kaufer, D.I., Cummings, J.L., Christine, D. Effect of tacrine on behavioral symptoms in Alzheimer's disease: An open-label study. J Geriatr Psychiatry Neural 1996, 9: 1-6.
    • (1996) J Geriatr Psychiatry Neural , vol.9 , pp. 1-6
    • Kaufer, D.I.1    Cummings, J.L.2    Christine, D.3
  • 22
    • 0030035653 scopus 로고    scopus 로고
    • Long-term tacrine (Cognex) treatment: Effects on nursing home placement and mortality
    • Knopman, D., Schneider, L., Davis, K. et al. Long-term tacrine (Cognex) treatment: Effects on nursing home placement and mortality. Neurology 1996, 47: 166-77.
    • (1996) Neurology , vol.47 , pp. 166-177
    • Knopman, D.1    Schneider, L.2    Davis, K.3
  • 23
    • 0030750439 scopus 로고    scopus 로고
    • Donepezil (Aricept) therapy for Alzheimer's disease
    • Geldmacher, D.S. Donepezil (Aricept) therapy for Alzheimer's disease. Compr Ther 1997, 23: 492-3.
    • (1997) Compr Ther , vol.23 , pp. 492-493
    • Geldmacher, D.S.1
  • 24
    • 0001854077 scopus 로고    scopus 로고
    • E2020 produces both clinical global and cognitive test improvement in patients with mild to moderately severe Alzheimer's disease: Results of a 30-week phase III trial
    • Rogers, S.L., Doody, R., Mohs, R., Friedhoff, L.T. E2020 produces both clinical global and cognitive test improvement in patients with mild to moderately severe Alzheimer's disease: Results of a 30-week phase III trial. Neurology 1996, 46(Suppl.): A217.
    • (1996) Neurology , vol.46 , Issue.SUPPL.
    • Rogers, S.L.1    Doody, R.2    Mohs, R.3    Friedhoff, L.T.4
  • 25
    • 0029924782 scopus 로고    scopus 로고
    • Double-blind placebo-controlled study of velnacrine in Alzheimer's disease
    • Zemlan, F.P., Keys, M., Richter, R.W., Strub, R.L. Double-blind placebo-controlled study of velnacrine in Alzheimer's disease. Life Sci 1996, 58: 1823-32.
    • (1996) Life Sci , vol.58 , pp. 1823-1832
    • Zemlan, F.P.1    Keys, M.2    Richter, R.W.3    Strub, R.L.4
  • 26
    • 10544234610 scopus 로고    scopus 로고
    • Velnacrine for the treatment of Alzheimer's disease: A double-blind, placebo-controlled trial
    • Zemlan, F.P. et al. Velnacrine for the treatment of Alzheimer's disease: A double-blind, placebo-controlled trial. J Neural Transm 1996, 103: 1105-16.
    • (1996) J Neural Transm , vol.103 , pp. 1105-1116
    • Zemlan, F.P.1
  • 27
    • 0029143531 scopus 로고
    • Effectiveness and safety of velnacrine for the treatment of Alzheimer's disease
    • Antuono, P.G. et al. Effectiveness and safety of velnacrine for the treatment of Alzheimer's disease. Arch Intern Med 1995, 155: 1766-72.
    • (1995) Arch Intern Med , vol.155 , pp. 1766-1772
    • Antuono, P.G.1
  • 28
    • 0029915565 scopus 로고    scopus 로고
    • Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos
    • Hinz, V.C., Grewig, S., Schmidt, B.H. Metrifonate induces cholinesterase inhibition exclusively via slow release of dichlorvos. Neurochem Res 1996, 21: 331-7.
    • (1996) Neurochem Res , vol.21 , pp. 331-337
    • Hinz, V.C.1    Grewig, S.2    Schmidt, B.H.3
  • 30
    • 0029917179 scopus 로고    scopus 로고
    • Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease
    • Sramek, J.J., Anand, R., Wardle, T.S., Irwin, P., Hartman, R.D., Cutler, N.R. Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease. Life Sci 1996, 58: 1201-7.
    • (1996) Life Sci , vol.58 , pp. 1201-1207
    • Sramek, J.J.1    Anand, R.2    Wardle, T.S.3    Irwin, P.4    Hartman, R.D.5    Cutler, N.R.6
  • 31
    • 0029081083 scopus 로고
    • Second generation cholinesterase inhibitor: Effect of (L)-huperzine a on cortical biogenic amines
    • Zhu, X.D., Giacobini, E. Second generation cholinesterase inhibitor: Effect of (L)-huperzine A on cortical biogenic amines. J Neurosci Res 1995, 41: 828-35.
    • (1995) J Neurosci Res , vol.41 , pp. 828-835
    • Zhu, X.D.1    Giacobini, E.2
  • 32
    • 0030893633 scopus 로고    scopus 로고
    • Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate
    • Ved, H.S., Koenig, M.L., Dave, J.R., Doctor, B.P. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. NeuroReport 1997, 8: 963-8.
    • (1997) NeuroReport , vol.8 , pp. 963-968
    • Ved, H.S.1    Koenig, M.L.2    Dave, J.R.3    Doctor, B.P.4
  • 33
    • 0030896029 scopus 로고    scopus 로고
    • Huperzine A, a novel promising acetylcholinesterase inhibitor
    • Cheng, D.H., Ren, H., Tang, X.C. Huperzine A, a novel promising acetylcholinesterase inhibitor. NeuroReport 1996, 8: 97-101.
    • (1996) NeuroReport , vol.8 , pp. 97-101
    • Cheng, D.H.1    Ren, H.2    Tang, X.C.3
  • 34
    • 12644273785 scopus 로고    scopus 로고
    • Pharmacological evaluation of novel Alzheimer's disease therapeutics: Acetylcholinesterase inhibitors related to galanthamine
    • Bores, G.M., Huger, F.P., Petko, W. et al. Pharmacological evaluation of novel Alzheimer's disease therapeutics: Acetylcholinesterase inhibitors related to galanthamine. J Pharmacol Exp Ther 1996, 277: 728-38.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 728-738
    • Bores, G.M.1    Huger, F.P.2    Petko, W.3
  • 35
    • 0028819939 scopus 로고
    • The pharmacology of galanthamine and its analogues
    • Harvey, A.L. The pharmacology of galanthamine and its analogues. Pharmacol Ther 1995, 68: 113-28.
    • (1995) Pharmacol Ther , vol.68 , pp. 113-128
    • Harvey, A.L.1
  • 36
    • 0027367122 scopus 로고
    • Phenserine: A physostigmine derivative that is a long acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze
    • Iijima, S., Grieg, N.H., Garofalo, P. et al. Phenserine: A physostigmine derivative that is a long acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. Psychopharmacology 1993, 112: 415-20.
    • (1993) Psychopharmacology , vol.112 , pp. 415-420
    • Iijima, S.1    Grieg, N.H.2    Garofalo, P.3
  • 37
    • 0029148786 scopus 로고
    • Clinical heterogeneity: Responders to cholinergic therapy
    • Eagger, S.A., Harvey, R.J. Clinical heterogeneity: Responders to cholinergic therapy. Alzheimer Dis Assoc Disord 1995, 9(Suppl. 2): 37-42.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.2 SUPPL. , pp. 37-42
    • Eagger, S.A.1    Harvey, R.J.2
  • 38
    • 0029087595 scopus 로고
    • Predicting response to cholinesterase inhibitors in Alzheimer's disease
    • Schneider, L.S., Farlow, M.R. Predicting response to cholinesterase inhibitors in Alzheimer's disease. CNS Drugs 1995, 42: 114-24.
    • (1995) CNS Drugs , vol.42 , pp. 114-124
    • Schneider, L.S.1    Farlow, M.R.2
  • 39
    • 0007691164 scopus 로고
    • Apolipoprotein epsilon4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease
    • Poirier, J., Delisle, M-C., Quirion, R. et al. Apolipoprotein epsilon4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer's disease. Proc Natl Acad Sci USA 1995, 92: 12260-4.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12260-12264
    • Poirier, J.1    Delisle, M.-C.2    Quirion, R.3
  • 40
    • 0024417125 scopus 로고
    • Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease
    • Geula, C., Mesulam, M. Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain Res 1989, 498: 185-9.
    • (1989) Brain Res , vol.498 , pp. 185-189
    • Geula, C.1    Mesulam, M.2
  • 41
    • 0029164755 scopus 로고
    • Cholinesterases and the pathology of Alzheimer disease
    • Geula, C., Mesulam, M.M. Cholinesterases and the pathology of Alzheimer disease. Alzheimer Dis Assoc Disord 1995, 9(Suppl. 2): 23-8.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.2 SUPPL. , pp. 23-28
    • Geula, C.1    Mesulam, M.M.2
  • 42
    • 0023589282 scopus 로고
    • Anatomy of cholinesterase inhibition in Alzheimer's disease: Effect of physostigmine and tetrahydroaminoacridine on plaques and tangles
    • Mesulam, M.M., Geula, C., Moran, A. Anatomy of cholinesterase inhibition in Alzheimer's disease: Effect of physostigmine and tetrahydroaminoacridine on plaques and tangles. Ann Neurol 1987, 22: 683-91.
    • (1987) Ann Neurol , vol.22 , pp. 683-691
    • Mesulam, M.M.1    Geula, C.2    Moran, A.3
  • 43
    • 0027429837 scopus 로고
    • Brain selective inhibition of acetylcholinesterase: A novel approach to therapy for Alzheimer's disease
    • Enz, A., Amstutz, R., Boddeke, H., Gmelin, G., Malanowski, J. Brain selective inhibition of acetylcholinesterase: A novel approach to therapy for Alzheimer's disease. Prog Brain Res 1993, 98: 431-8.
    • (1993) Prog Brain Res , vol.98 , pp. 431-438
    • Enz, A.1    Amstutz, R.2    Boddeke, H.3    Gmelin, G.4    Malanowski, J.5
  • 44
    • 0024437944 scopus 로고
    • Muscarinic receptor subtypes: Physiology and clinical implications
    • Goyal, R.K. Muscarinic receptor subtypes: Physiology and clinical implications. New Eng J Med 1989, 321: 1022-9.
    • (1989) New Eng J Med , vol.321 , pp. 1022-1029
    • Goyal, R.K.1
  • 45
    • 0025943814 scopus 로고
    • Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
    • Levey, A.I., Kitt, C.A., Simonds, W.F., Price, D.L., Brann, M.R. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 1991, 11: 3218-26.
    • (1991) J Neurosci , vol.11 , pp. 3218-3226
    • Levey, A.I.1    Kitt, C.A.2    Simonds, W.F.3    Price, D.L.4    Brann, M.R.5
  • 46
    • 0031051353 scopus 로고    scopus 로고
    • Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain
    • Jope, R.S., Song, L., Powers, R.E. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiol Aging 1997, 18: 111-20.
    • (1997) Neurobiol Aging , vol.18 , pp. 111-120
    • Jope, R.S.1    Song, L.2    Powers, R.E.3
  • 47
    • 0027758398 scopus 로고
    • Biochemical pathology and treatment strategies in Alzheimer's disease: Emphasis on the cholinergic system
    • Winblad, B., Messamore, E., O'Neill, C., Cowburn, R. Biochemical pathology and treatment strategies in Alzheimer's disease: Emphasis on the cholinergic system. Acta Neurol Scand 1993, (Suppl. 149): 4-6.
    • (1993) Acta Neurol Scand , Issue.149 SUPPL. , pp. 4-6
    • Winblad, B.1    Messamore, E.2    O'Neill, C.3    Cowburn, R.4
  • 50
    • 0030902127 scopus 로고    scopus 로고
    • Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
    • Bodick, N.C., Offen, W.W., Levey, A.I. et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 1997, 54: 465-73.
    • (1997) Arch Neurol , vol.54 , pp. 465-473
    • Bodick, N.C.1    Offen, W.W.2    Levey, A.I.3
  • 51
    • 0030686570 scopus 로고    scopus 로고
    • The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease
    • Bodick, N.C., Offen, W.W., Shannon, H.E. et al. The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease. Alzheimer Dis Assoc Disord 1997, 11(Suppl. 4): S16-22.
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.4 SUPPL.
    • Bodick, N.C.1    Offen, W.W.2    Shannon, H.E.3
  • 53
    • 0030958347 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients
    • Cummings, J.L. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 1997, 48(Suppl. 6): S10-6.
    • (1997) Neurology , vol.48 , Issue.6 SUPPL.
    • Cummings, J.L.1
  • 56
    • 0026476297 scopus 로고
    • Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
    • Nitsch, R.M., Slack, B.E., Wurtman, R.J., Growdon, J.H. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 1992, 258: 304-7.
    • (1992) Science , vol.258 , pp. 304-307
    • Nitsch, R.M.1    Slack, B.E.2    Wurtman, R.J.3    Growdon, J.H.4
  • 57
    • 0000134682 scopus 로고    scopus 로고
    • Cholinesterase inhibitors do more than inhibit cholinesterase
    • Becker, R., Giacobini, E. (Eds.). Birkhauser: Boston
    • Giacobini, E. Cholinesterase inhibitors do more than inhibit cholinesterase. In: Alzheimer Disease: From Molecular Biology to Therapy. Becker, R., Giacobini, E. (Eds.). Birkhauser: Boston 1997, 187-204.
    • (1997) Alzheimer Disease: from Molecular Biology to Therapy , pp. 187-204
    • Giacobini, E.1
  • 60
    • 0007797343 scopus 로고    scopus 로고
    • 1-agonist xanomeline and four other clinical candidates for Alzheimer's disease
    • 1-agonist xanomeline and four other clinical candidates for Alzheimer's disease. Soc Neurosci 1997, 23: 1751.
    • (1997) Soc Neurosci , vol.23 , pp. 1751
    • DeLapp, N.1    Butler, T.2    Tnomsen, C.3
  • 61
    • 0030956507 scopus 로고    scopus 로고
    • A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease
    • Rockwood, K., Beattie, L., Eastwood, M.R. et al. A randomized, controlled trial of linopirdine in the treatment of Alzheimer's disease. Can J Neurol Sci 1997, 24: 140-5.
    • (1997) Can J Neurol Sci , vol.24 , pp. 140-145
    • Rockwood, K.1    Beattie, L.2    Eastwood, M.R.3
  • 62
    • 0030744573 scopus 로고    scopus 로고
    • The acetylcholine releaser linopirdine increases parietal regional cerebral blood flow in Alzheimer's disease
    • Van Dyck, C.H., Lin, C.H., Robinson, R. et al. The acetylcholine releaser linopirdine increases parietal regional cerebral blood flow in Alzheimer's disease. Psychopharmacology 1997, 132: 217-26.
    • (1997) Psychopharmacology , vol.132 , pp. 217-226
    • Van Dyck, C.H.1    Lin, C.H.2    Robinson, R.3
  • 63
    • 0030446775 scopus 로고    scopus 로고
    • The systems-level organization of cholinergic innervation in the cerebral cortex and its alterations in Alzheimer's disease
    • Mesulam, M.M. The systems-level organization of cholinergic innervation in the cerebral cortex and its alterations in Alzheimer's disease. Prog Brain Res 1996, 109: 285-97.
    • (1996) Prog Brain Res , vol.109 , pp. 285-297
    • Mesulam, M.M.1
  • 64
    • 0030946884 scopus 로고    scopus 로고
    • α-Adrenergic activity and cardiovascular effects of besipirdine HCL (HP 749) and metabolite P 7480 in vitro and in the conscious rat and dog
    • Hubbard, J.W., Nordstrom, S.T., Smith, C.P. et al. α-Adrenergic activity and cardiovascular effects of besipirdine HCL (HP 749) and metabolite P 7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther 1997, 281: 337-46.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 337-346
    • Hubbard, J.W.1    Nordstrom, S.T.2    Smith, C.P.3
  • 65
    • 9344219884 scopus 로고    scopus 로고
    • A treatment and withdrawal trial of besipirdine in Alzheimer disease
    • Huff, F.J., Antuono, P.G., Delagandara, J.E. et al. A treatment and withdrawal trial of besipirdine in Alzheimer disease. Alzheimer Dis Assoc Disord 1996, 10: 93-102.
    • (1996) Alzheimer Dis Assoc Disord , vol.10 , pp. 93-102
    • Huff, F.J.1    Antuono, P.G.2    Delagandara, J.E.3
  • 66
    • 0027725881 scopus 로고
    • Mechanism of action of cholinesterase inhibitors in Alzheimer's disease
    • Hakansson, L. Mechanism of action of cholinesterase inhibitors in Alzheimer's disease. Acta Neurol Scand 1993, (Suppl. 149): 7-9.
    • (1993) Acta Neurol Scand , Issue.149 SUPPL. , pp. 7-9
    • Hakansson, L.1
  • 67
    • 0029970479 scopus 로고    scopus 로고
    • 2-Adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat
    • 2-Adrenoceptor antagonists potentiate acetylcholinesterase inhibitor effects on passive avoidance learning in the rat. Psychopharmacology 1996, 124: 347-54.
    • (1996) Psychopharmacology , vol.124 , pp. 347-354
    • Camacho, F.1    Smith, C.P.2    Vargas, H.M.3    Winslow, J.T.4
  • 69
    • 0030464044 scopus 로고    scopus 로고
    • New trends in cholinergic therapy for Alzheimer disease: Nicotinic agonists or cholinesterase inhibitors?
    • Giacobini, E. New trends in cholinergic therapy for Alzheimer disease: Nicotinic agonists or cholinesterase inhibitors? Prog Brain Res 1996, 109: 311-23.
    • (1996) Prog Brain Res , vol.109 , pp. 311-323
    • Giacobini, E.1
  • 70
    • 0029091371 scopus 로고
    • Distribution of nicotinic subtypes in human brain
    • Court, J., Clementi, F. Distribution of nicotinic subtypes in human brain. Alzheimer Dis Assoc Disord 1995, 9(Suppl. 2): 6-14.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.2 SUPPL. , pp. 6-14
    • Court, J.1    Clementi, F.2
  • 72
    • 0023225478 scopus 로고
    • Nicotinic receptor abnormalities in Alzheimer's disease and Parkinson's disease
    • Perry, E.K., Perry, R.H., Smith, C.J. et al. Nicotinic receptor abnormalities in Alzheimer's disease and Parkinson's disease. J Neurol Neurosurg Psychiatry 1987, 50: 806-9.
    • (1987) J Neurol Neurosurg Psychiatry , vol.50 , pp. 806-809
    • Perry, E.K.1    Perry, R.H.2    Smith, C.J.3
  • 73
    • 0027741511 scopus 로고
    • Cholinergic therapy in dementia
    • Whitehouse, P.J. Cholinergic therapy in dementia. Acta Neurol Scand 1993, (Suppl. 149): 42-5.
    • (1993) Acta Neurol Scand , Issue.149 SUPPL. , pp. 42-45
    • Whitehouse, P.J.1
  • 74
    • 0029092685 scopus 로고
    • Alzheimerdisease, attention, and the cholinergic system
    • Lawrence, A.D., Sahakian, B.J. Alzheimerdisease, attention, and the cholinergic system. Alzheimer Dis Assoc Disord 1995, 9(Suppl. 2): 43-9.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.2 SUPPL. , pp. 43-49
    • Lawrence, A.D.1    Sahakian, B.J.2
  • 75
    • 0030756236 scopus 로고    scopus 로고
    • Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
    • Kihara, T., Shimohama, S., Sawada, H. et al. Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Ann Neurol 1997, 42: 159-63.
    • (1997) Ann Neurol , vol.42 , pp. 159-163
    • Kihara, T.1    Shimohama, S.2    Sawada, H.3
  • 76
    • 0025845571 scopus 로고
    • Relation between nicotine intake and Alzheimer's disease
    • Van Duijn, C.M., Hofman, A. Relation between nicotine intake and Alzheimer's disease. Br Med J 1991, 302: 1491-4.
    • (1991) Br Med J , vol.302 , pp. 1491-1494
    • Van Duijn, C.M.1    Hofman, A.2
  • 77
    • 0025740733 scopus 로고
    • Alcohol and tobacco consumption as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies
    • Graves, A.B., Van Duijn, C.M., Chandra, V. et al. Alcohol and tobacco consumption as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies. Int J Epidemiol 1991, 20(Suppl. 2): S48-57.
    • (1991) Int J Epidemiol , vol.20 , Issue.2 SUPPL.
    • Graves, A.B.1    Van Duijn, C.M.2    Chandra, V.3
  • 78
    • 0029086251 scopus 로고
    • Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties
    • Arneric, S.P., Sullivan, J.P., Decker, M.W. et al. Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties. Alzheimer Dis Assoc Disord 1995, 9(Suppl. 2): 50-61.
    • (1995) Alzheimer Dis Assoc Disord , vol.9 , Issue.2 SUPPL. , pp. 50-61
    • Arneric, S.P.1    Sullivan, J.P.2    Decker, M.W.3
  • 79
    • 15444351510 scopus 로고    scopus 로고
    • ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties
    • Sullivan, J.P., Donnelly-Roberts, D., Briggs, C.A. et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther 1997, 283: 235-46.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 235-246
    • Sullivan, J.P.1    Donnelly-Roberts, D.2    Briggs, C.A.3
  • 80
    • 14444276048 scopus 로고    scopus 로고
    • ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitve performance in rats and monkeys
    • Decker, M.W., Bannon, A.W., Curson, P. et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitve performance in rats and monkeys. J Pharmacol Exp Ther 1997, 283: 247-58.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 247-258
    • Decker, M.W.1    Bannon, A.W.2    Curson, P.3
  • 81
    • 0002613011 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: Potential treatment of Alzheimer's disease with novel cholinergic channel activators
    • Brioni, J.D., Decker, M.W. (Eds.). Wiley-Liss, Inc.: New York
    • Decker, M.W., Brioni, J.D. Neuronal nicotinic receptors: Potential treatment of Alzheimer's disease with novel cholinergic channel activators. In: Pharmacological Treatment of Alzheimer's Disease. Brioni, J.D., Decker, M.W. (Eds.). Wiley-Liss, Inc.: New York 1997, 433-59.
    • (1997) Pharmacological Treatment of Alzheimer's Disease , pp. 433-459
    • Decker, M.W.1    Brioni, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.