Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis

Apoptosis

Volumn 12, Issue 2, 2007, Pages 423-431

  Lim, Soo Jeong ^a   Lee, Young Ju ^b   Park, Dae Hun ^b   Lee, Eunmyong ^a   Choi, Moon Kyung ^b   Park, Wanseo ^b   Chun, Kyung Hee ^b   Choi, Han Gon ^c   Cho, Jung Sik ^d  

^a Sejong University   (South Korea)

^b National Cancer Center   (South Korea)

^c Yeungnam University   (South Korea)

^d National Institute of Toxicological Research   (South Korea)

Author keywords

Tocopheryl succinate; Apoptosis; Caspase; Colon cancer; Exisulind; JNK

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CASPASE 3; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CASPASE 9 INHIBITOR; CASPASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; SULINDAC SULFONE;

ADJUVANT THERAPY; APOPTOSIS; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SENSITIZATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL GROWTH PROCESSES; COLONIC NEOPLASMS; DRUG SYNERGISM; ENZYME ACTIVATION; ENZYME INHIBITORS; HCT116 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; SULINDAC; VITAMIN E;

TOSCANA VIRUS;

EID: 33846524824     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0620-9     Document Type: Article

References (31)

1. Goluboff ET (2001) Exisulind, a selective apoptotic antineoplastic drug. Expert Opin Investig Drugs 10:1875-1882
2. Stoner GD, Budd GT, Ganapathi R, et al (1999) Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis. Adv Exp Med Biol 470:45-53
3. Goluboff ET, Shabsigh A, Saidi JA, et al (1999) Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis. Urology 53:440-445
4. Whitehead CM, Earle KA, Fetter J, et al (2003) Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival. Mol Cancer Ther 2:479-488
5. Yoon JT, Palazzo AF, Xiao D, et al (2002) CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells. Mol Cancer Ther 1:393-404
6. Xiao D, Deguchi A, Gundersen GG, Oehlen B, Arnold L, Weinstein IB (2006) The sulindac derivatives OSI-461, OSIP486823, and OSIP487703 arrest colon cancer cells in mitosis by causing microtubule depolymerization. Mol Cancer Ther 5:60-67
7. Soh JW, Mao Y, Kim MG, et al (2000) Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1. Clin Cancer Res 6:4136-4141
8. Rice PL, Goldberg RJ, Ray EC, Driggers LJ, Ahnen DJ (2001) Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites. Cancer Res 61:1541-1547
9. Li H, Liu L, David ML, et al (2002) Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation. Biochem Pharmacol 64:1325-1336
10. Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R, Weinstein IB (2001) Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1. J Biol Chem 276:16406-16410
11. Thompson WJ, Piazza GA, Li H, et al (2000) Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res 60:3338-3342
12. Czibere A, Prall WC, Zerbini LF, et al (2005) The nonsteroidal anti-inflammatory drug Exisulind selectively induces apoptosis via JNK in secondary acute myeloid leukemia after myelodysplastic syndrome. Cell Cycle 4:812-817
13. Weber T, Lu M, Andera L, et al (2002) Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res 8:863-869
14. Kang YH, Lee E, Choi MK, et al (2004) Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. Int J Cancer 112:385-392
15. Zu K, Hawthorn L, Ip C (2005) Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. Mol Cancer Ther 4:43-50
16. Zhao B, Yu W, Qian M, et al (1997) Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells. Mol Carcinog 19:180-190
17. Lim SJ, Simeone AM, Kim CK, Tari AM (2002) Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells. Int J Cancer 101:243-247
18. Lim SJ, Lopez-Berestein G, Hung MC, Lupu R, Tari AM (2000) Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells. Oncogene 19:6271-6276
19. Rice PL, Kelloff J, Sullivan H, et al (2003) Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. Mol Cancer Ther 2:885-892
20. Minami T, Adachi M, Kawamura R, Zhang Y, Shinomura Y, Imai K (2005) Sulindac enhances the proteasome inhibitor bortezomib-mediated oxidative stress and anticancer activity. Clin Cancer Res 11:5248-5256
21. Ohishi T, Kishimoto Y, Miura N, et al (2002) Synergistic effects of (-)-epigallocatechin gallate with sulindac against colon carcinogenesis of rats treated with azoxymethane. Cancer Lett 177:49-56
22. Chan DC, Earle KA, Zhao TL, et al (2002) Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors. Clin Cancer Res 8:904-912
23. Soriano AF, Helfrich B, Chan DC, Heasley LE, Bunn PA Jr, Chou TC (1999) Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. Cancer Res 59:6178-6184
24. Lei K, Davis RJ (2003) JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A 100:2432-2437
25. Ma WY, Huang C, Dong Z (1998) Inhibition of ultraviolet C irradiation-induced AP-1 activity by aspirin is through inhibition of JNKs but not erks or P38 MAP kinase. Int J Oncol 12:565-568
26. Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19:8469-8478
27. Martindale JL, Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1-15
28. Shen HM, Liu ZG (2006) JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40:928-939
29. Rice PL, Peters SL, Beard KS, Ahnen DJ (2006) Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic GMP-dependent protein kinase signaling pathways. Mol Cancer Ther 5:746-754
30. Witta SE, Gustafson DL, Pierson AS, et al (2004) A phase I and pharmacokinetic study of exisulind and docetaxel in patients with advanced solid tumors. Clin Cancer Res 10:7229-7237
31. Jones SF, Kuhn JG, Greco FA, et al (2005) A phase I/II study of exisulind in combination with docetaxel/carboplatin in patients with metastatic non-small-cell lung cancer. Clin Lung Cancer 6:361-366