Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1

Clinical Cancer Research

Volumn 6, Issue 10, 2000, Pages 4136-4141

  Soh, Jae Won ^a   Mao, Yuehua ^a   Kim, Min Gab ^a   Pamukcu, Rifat ^b   Li, Han ^b   Piazza, Gary A ^b   Thompson, W Joseph ^b   Weinstein, I Bernard ^a  

^a Columbia University ^*  (United States)

^b Cell Pathways Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP PHOSPHODIESTERASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE; STRESS ACTIVATED PROTEIN KINASE; SULINDAC;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS;

APOPTOSIS; COLONIC NEOPLASMS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GENES, DOMINANT; HUMANS; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SULINDAC; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0033755261     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Sulfone metabolite of sulindac inhibits mammary carcinogenesis
2. Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction
3. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels
4. Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines
5. Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis
6. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
7. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
8. Exisulind (Prevatac) induced apoptosis in cultured colonic tumor cells involves inhibition of cyclic GMP (cG) phosphodiesterase (PDE)
9. Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15
10. Requirement for cGMP in nerve cell death caused by glutathione depletion
11. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates
12. Stress signals for apoptosis: Ceramide and c-Jun kinase
13. Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme
14. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
15. Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway
16. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
17. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)
18. The molecular biology of cyclic nucleotide phosphodiesterases
19. Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation
20. Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents
21. Distinct and specific functions of cGMP-dependent protein kinases
22. Signalling by cGMP-dependent protein kinases
23. (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor
24. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
25. The TAO of MEKK
26. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
27. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
28. The role of proteases during apoptosis
29. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
30. Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1
31. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
32. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis
33. Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter
34. Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element