-
1
-
-
17744376942
-
Induction of cancer cell apoptosis by α-tocopheryl succinate: Molecular pathways and structural requirements
-
Neuzil J, Weber T, Schroder A, Lu M, Ostermann G, Gellert N, Mayne GC, Olejnicka B, Negre-Salvayre A, Sticha M, Coffey RJ, Weber C. Induction of cancer cell apoptosis by α-tocopheryl succinate: molecular pathways and structural requirements. FASEB J 2001;15:403-15.
-
(2001)
FASEB J
, vol.15
, pp. 403-415
-
-
Neuzil, J.1
Weber, T.2
Schroder, A.3
Lu, M.4
Ostermann, G.5
Gellert, N.6
Mayne, G.C.7
Olejnicka, B.8
Negre-Salvayre, A.9
Sticha, M.10
Coffey, R.J.11
Weber, C.12
-
2
-
-
0035418623
-
2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells
-
2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells. Cancer Res 2001;61:6569-76.
-
(2001)
Cancer Res
, vol.61
, pp. 6569-6576
-
-
Yu, W.1
Liao, Q.Y.2
Hantash, F.M.3
Sanders, B.G.4
Kline, K.5
-
3
-
-
0037188486
-
Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells
-
Zhang Y, Ni J, Messing EM, Chang E, Yang CR, Yeh S. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc Natl Acad Sci USA 2002;99:7408-13.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 7408-7413
-
-
Zhang, Y.1
Ni, J.2
Messing, E.M.3
Chang, E.4
Yang, C.R.5
Yeh, S.6
-
4
-
-
0036389582
-
Vitamin E succinate inhibits colon cancer liver metastases
-
Barnett KT, Fokum FD, Malafa MP. Vitamin E succinate inhibits colon cancer liver metastases. J Surg Res 2002;106:292-8.
-
(2002)
J Surg Res
, vol.106
, pp. 292-298
-
-
Barnett, K.T.1
Fokum, F.D.2
Malafa, M.P.3
-
5
-
-
0036301439
-
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo
-
Weber T, Lu M, Andera L, Lahm H, Gellert N, Fariss MW, Korinek V, Sattler W, Ucker DS, Terman A, Schroder A, Erl W, et al. Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res 2002;8:863-9.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 863-869
-
-
Weber, T.1
Lu, M.2
Andera, L.3
Lahm, H.4
Gellert, N.5
Fariss, M.W.6
Korinek, V.7
Sattler, W.8
Ucker, D.S.9
Terman, A.10
Schroder, A.11
Erl, W.12
-
6
-
-
0035137727
-
Selective cancer cell killing by α-tocopheryl succinate
-
Neuzil J, Weber T, Gellert N, Weber C. Selective cancer cell killing by α-tocopheryl succinate. Br J Cancer 2001;84:87-9.
-
(2001)
Br J Cancer
, vol.84
, pp. 87-89
-
-
Neuzil, J.1
Weber, T.2
Gellert, N.3
Weber, C.4
-
7
-
-
0030751535
-
Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells
-
Zhao B, Yu W, Qian M, Simmons-Menchaca M, Brown P, Birrer MJ, Sanders BG, Kline K. Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells. Mol Carcinog 1997;19:180-90.
-
(1997)
Mol Carcinog
, vol.19
, pp. 180-190
-
-
Zhao, B.1
Yu, W.2
Qian, M.3
Simmons-Menchaca, M.4
Brown, P.5
Birrer, M.J.6
Sanders, B.G.7
Kline, K.8
-
8
-
-
0030793191
-
Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: Increased binding of cyclin A negatively regulates E2F transactivation activity
-
Turley JM, Ruscetti FW, Kim SJ, Fu T, Gou FV, Birchenall-Roberts MC. Vitamin E succinate inhibits proliferation of BT-20 human breast cancer cells: increased binding of cyclin A negatively regulates E2F transactivation activity. Cancer Res 1997;57:2668-75.
-
(1997)
Cancer Res
, vol.57
, pp. 2668-2675
-
-
Turley, J.M.1
Ruscetti, F.W.2
Kim, S.J.3
Fu, T.4
Gou, F.V.5
Birchenall-Roberts, M.C.6
-
9
-
-
0036216407
-
Role of extracellular signal-regulated kinase pathway in RRR-α-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells
-
You H, Yu W, Munoz-Medellin D, Brown PH, Sanders BG, Kline K. Role of extracellular signal-regulated kinase pathway in RRR-α-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. Mol Carcinog 2002;33:228-36.
-
(2002)
Mol Carcinog
, vol.33
, pp. 228-236
-
-
You, H.1
Yu, W.2
Munoz-Medellin, D.3
Brown, P.H.4
Sanders, B.G.5
Kline, K.6
-
10
-
-
0033557969
-
r 43,000 Fas in VES-triggered apoptosis
-
r 43,000 Fas in VES-triggered apoptosis. Cancer Res 1999;59:953-61.
-
(1999)
Cancer Res
, vol.59
, pp. 953-961
-
-
Yu, W.1
Israel, K.2
Liao, Q.Y.3
Aldaz, C.M.4
Sanders, B.G.5
Kline, K.6
-
11
-
-
0033052252
-
Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation
-
Neuzil J, Svensson I, Weber T, Weber C, Brunk UT. Alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. FEBS Lett 1999;445:295-300.
-
(1999)
FEBS Lett
, vol.445
, pp. 295-300
-
-
Neuzil, J.1
Svensson, I.2
Weber, T.3
Weber, C.4
Brunk, U.T.5
-
12
-
-
0345103741
-
Mitochondria play a central role in apoptosis induced by α-tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling
-
Weber T, Dalen H, Andera L, Negre-Salvayre A, Auge N, Sticha M, Lloret A, Terman A, Witting PK, Higuchi M, Plasilova M, Zivny J, et al. Mitochondria play a central role in apoptosis induced by α-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 2003;42:4277-91.
-
(2003)
Biochemistry
, vol.42
, pp. 4277-4291
-
-
Weber, T.1
Dalen, H.2
Andera, L.3
Negre-Salvayre, A.4
Auge, N.5
Sticha, M.6
Lloret, A.7
Terman, A.8
Witting, P.K.9
Higuchi, M.10
Plasilova, M.11
Zivny, J.12
-
13
-
-
0036478970
-
Mitochondrial reactive oxygen species in cell death signaling
-
Fleury C, Mignotte B, Vayssiere JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002;84:131-41.
-
(2002)
Biochimie
, vol.84
, pp. 131-141
-
-
Fleury, C.1
Mignotte, B.2
Vayssiere, J.L.3
-
14
-
-
0030953881
-
Effect of α-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells
-
Ottino P, Duncan JR. Effect of α-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells. Free Radic Biol Med 1997;22:1145-51.
-
(1997)
Free Radic Biol Med
, vol.22
, pp. 1145-1151
-
-
Ottino, P.1
Duncan, J.R.2
-
15
-
-
0037027755
-
High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems
-
Kogure K, Hama S, Manabe S, Tokumura A, Fukuzawa K. High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems. Cancer Lett 2002;186:151-6.
-
(2002)
Cancer Lett
, vol.186
, pp. 151-156
-
-
Kogure, K.1
Hama, S.2
Manabe, S.3
Tokumura, A.4
Fukuzawa, K.5
-
16
-
-
0035839019
-
Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection
-
Alleva R, Tomasetti M, Andera L, Gellert N, Borghi B, Weber C, Murphy MP, Neuzil J. Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. FEBS Lett 2001;503:46-50.
-
(2001)
FEBS Lett
, vol.503
, pp. 46-50
-
-
Alleva, R.1
Tomasetti, M.2
Andera, L.3
Gellert, N.4
Borghi, B.5
Weber, C.6
Murphy, M.P.7
Neuzil, J.8
-
17
-
-
0035018235
-
Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells
-
Zang Y, Beard RL, Chandraratna RA, Kang JX. Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. Cell Death Differ 2001;8:477-85.
-
(2001)
Cell Death Differ
, vol.8
, pp. 477-485
-
-
Zang, Y.1
Beard, R.L.2
Chandraratna, R.A.3
Kang, J.X.4
-
18
-
-
0033135367
-
Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice
-
Fujimura M, Morita-Fujimura Y, Kawase M, Copin JC, Calagui B, Epstein CJ, Chan PH. Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome c and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci 1999;19:3414-22.
-
(1999)
J Neurosci
, vol.19
, pp. 3414-3422
-
-
Fujimura, M.1
Morita-Fujimura, Y.2
Kawase, M.3
Copin, J.C.4
Calagui, B.5
Epstein, C.J.6
Chan, P.H.7
-
19
-
-
0034003504
-
Dietary vitamin A modulates the concentrations of RRR-α-tocopherol in plasma lipoproteins from calves fed milk replacer
-
Ametaj BN, Nonnecke BJ, Franklin ST, Horst RL, Bidlack WR, Stuart RL, Beitz DC. Dietary vitamin A modulates the concentrations of RRR-α- tocopherol in plasma lipoproteins from calves fed milk replacer. J Nutr 2000;130:629-36.
-
(2000)
J Nutr
, vol.130
, pp. 629-636
-
-
Ametaj, B.N.1
Nonnecke, B.J.2
Franklin, S.T.3
Horst, R.L.4
Bidlack, W.R.5
Stuart, R.L.6
Beitz, D.C.7
-
20
-
-
0036022545
-
D-α-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells
-
Kumar B, Jha MN, Cole WC, Bedford JS, Prasad KN. D-α-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. J Am Coll Nutr 2002;21:339-43.
-
(2002)
J Am Coll Nutr
, vol.21
, pp. 339-343
-
-
Kumar, B.1
Jha, M.N.2
Cole, W.C.3
Bedford, J.S.4
Prasad, K.N.5
-
21
-
-
0034649505
-
Grb2 down-regulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells
-
Lim SJ, Lopez-Berestein G, Hung MC, Lupu R, Tari AM. Grb2 down-regulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells. Oncogene 2000;19:6271-6.
-
(2000)
Oncogene
, vol.19
, pp. 6271-6276
-
-
Lim, S.J.1
Lopez-Berestein, G.2
Hung, M.C.3
Lupu, R.4
Tari, A.M.5
-
22
-
-
0033804503
-
Mechanism of α-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells
-
Yamamoto S, Tamai H, Ishisaka R, Kanno T, Arita K, Kobuchi H, Utsumi K. Mechanism of α-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells. Free Radic Res 2000;33:407-18.
-
(2000)
Free Radic Res
, vol.33
, pp. 407-418
-
-
Yamamoto, S.1
Tamai, H.2
Ishisaka, R.3
Kanno, T.4
Arita, K.5
Kobuchi, H.6
Utsumi, K.7
-
23
-
-
0036073293
-
α-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion
-
Neuzil J. α-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion. Biochem Biophys Res Commun 2002;293:1309-13.
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 1309-1313
-
-
Neuzil, J.1
-
24
-
-
0042672741
-
Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: Involvement of cytochrome c oxidase inhibition and the production of reactive oxygen species in mitochondria
-
Yuyama K, Yamamoto H, Nishizaki I, Kato T, Sora I, Yamamoto T. Caspase-independent cell death by low concentrations of nitric oxide in PC12 cells: involvement of cytochrome c oxidase inhibition and the production of reactive oxygen species in mitochondria. J Neurosci Res 2003;73:351-63.
-
(2003)
J Neurosci Res
, vol.73
, pp. 351-363
-
-
Yuyama, K.1
Yamamoto, H.2
Nishizaki, I.3
Kato, T.4
Sora, I.5
Yamamoto, T.6
-
25
-
-
0033188158
-
Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I
-
Goossens V, Stange G, Moens K, Pipeleers D, Grooten J. Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I. Antioxid Redox Signal 1999;1:285-95.
-
(1999)
Antioxid Redox Signal
, vol.1
, pp. 285-295
-
-
Goossens, V.1
Stange, G.2
Moens, K.3
Pipeleers, D.4
Grooten, J.5
-
26
-
-
0037370784
-
Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
-
Maianski NA, Roos D, Kuijpers TW. Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils. Blood 2003;101:1987-95.
-
(2003)
Blood
, vol.101
, pp. 1987-1995
-
-
Maianski, N.A.1
Roos, D.2
Kuijpers, T.W.3
-
27
-
-
0038362225
-
Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat
-
Murahashi H, Azuma H, Zamzami N, Furuya KJ, Ikebuchi K, Yamaguchi M, Yamada Y, Sato N, Fujihara M, Kroemer G, Ikeda H. Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat. J Leukoc Biol 2003;73:399-406.
-
(2003)
J Leukoc Biol
, vol.73
, pp. 399-406
-
-
Murahashi, H.1
Azuma, H.2
Zamzami, N.3
Furuya, K.J.4
Ikebuchi, K.5
Yamaguchi, M.6
Yamada, Y.7
Sato, N.8
Fujihara, M.9
Kroemer, G.10
Ikeda, H.11
-
28
-
-
0036163175
-
Vitamin E inhibits melanoma growth in mice
-
Malafa MP, Fokum FD, Mowlavi A, Abusief M, King M. Vitamin E inhibits melanoma growth in mice. Surgery 2002;131:85-91.
-
(2002)
Surgery
, vol.131
, pp. 85-91
-
-
Malafa, M.P.1
Fokum, F.D.2
Mowlavi, A.3
Abusief, M.4
King, M.5
-
29
-
-
0032077879
-
Nuclear factor kappa B dependent induction of γ glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells
-
Iwanaga M, Mori K, Iida T, Urata Y, Matsuo T, Yasunaga A, Shibata S, Kondo T. Nuclear factor kappa B dependent induction of γ glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells. Free Radic Biol Med 1998;24:1256-68.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 1256-1268
-
-
Iwanaga, M.1
Mori, K.2
Iida, T.3
Urata, Y.4
Matsuo, T.5
Yasunaga, A.6
Shibata, S.7
Kondo, T.8
-
30
-
-
0034724383
-
Expression and functional activity of heat shock proteins in human glioblastoma multiforme
-
Hermisson M, Strik H, Rieger J, Dichgans J, Meyermann R, Weller M. Expression and functional activity of heat shock proteins in human glioblastoma multiforme. Neurology 2000;54:1357-65.
-
(2000)
Neurology
, vol.54
, pp. 1357-1365
-
-
Hermisson, M.1
Strik, H.2
Rieger, J.3
Dichgans, J.4
Meyermann, R.5
Weller, M.6
-
31
-
-
0031452308
-
Effect of glutathione-modulating compounds on hydrogen-peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines
-
Iida M, Sunaga S, Hirota N, Kuribayashi N, Sakagami H, Takeda M, Matsumoto K. Effect of glutathione-modulating compounds on hydrogen-peroxide- induced cytotoxicity in human glioblastoma and glioma cell lines. J Cancer Res Clin Oncol 1997;123:619-22.
-
(1997)
J Cancer Res Clin Oncol
, vol.123
, pp. 619-622
-
-
Iida, M.1
Sunaga, S.2
Hirota, N.3
Kuribayashi, N.4
Sakagami, H.5
Takeda, M.6
Matsumoto, K.7
-
32
-
-
0035801839
-
Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by α-tocopheryl hemisuccinate
-
Kogure K, Morita M, Nakashima S, Hama S, Tokumura A, Fukuzawa K. Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by α-tocopheryl hemisuccinate. Biochim Biophys Acta 2001;1528:25-30.
-
(2001)
Biochim Biophys Acta
, vol.1528
, pp. 25-30
-
-
Kogure, K.1
Morita, M.2
Nakashima, S.3
Hama, S.4
Tokumura, A.5
Fukuzawa, K.6
-
33
-
-
0038520017
-
RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria
-
Yu W, Sanders BG, Kline K. RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. Cancer Res 2003;63:2483-91.
-
(2003)
Cancer Res
, vol.63
, pp. 2483-2491
-
-
Yu, W.1
Sanders, B.G.2
Kline, K.3
-
34
-
-
0043234207
-
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
-
Bidere N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C, Senik A. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 2003;278:31401-11.
-
(2003)
J Biol Chem
, vol.278
, pp. 31401-31411
-
-
Bidere, N.1
Lorenzo, H.K.2
Carmona, S.3
Laforge, M.4
Harper, F.5
Dumont, C.6
Senik, A.7
-
35
-
-
0032752882
-
Granzyme B-induced loss of mitochondrial inner membrane potential (ΔΨm) and cytochrome c release are caspase independent
-
Heibein JA, Barry M, Motyka B, Bleackley RC. Granzyme B-induced loss of mitochondrial inner membrane potential (ΔΨm) and cytochrome c release are caspase independent. J Immunol 1999;163:4683-93.
-
(1999)
J Immunol
, vol.163
, pp. 4683-4693
-
-
Heibein, J.A.1
Barry, M.2
Motyka, B.3
Bleackley, R.C.4
-
36
-
-
0037086662
-
α-tocopheryl succinate, an agent with in vivo antitumour activity, induces apoptosis by causing lysosomal instability
-
Neuzil J, Zhao M, Ostermann G, Sticha M, Gellert N, Weber C, Eaton JW, Brunk UT. α-tocopheryl succinate, an agent with in vivo antitumour activity, induces apoptosis by causing lysosomal instability. Biochem J 2002;362:709-15.
-
(2002)
Biochem J
, vol.362
, pp. 709-715
-
-
Neuzil, J.1
Zhao, M.2
Ostermann, G.3
Sticha, M.4
Gellert, N.5
Weber, C.6
Eaton, J.W.7
Brunk, U.T.8
-
37
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
Marzo, I.4
Snow, B.E.5
Brothers, G.M.6
Mangion, J.7
Jacotot, E.8
Costantini, P.9
Loeffler, M.10
Larochette, N.11
Goodlett, D.R.12
-
38
-
-
0037052687
-
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells
-
Ruefli AA, Bernhard D, Tainton KM, Kofler R, Smyth MJ, Johnstone RW. Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells. Int J Cancer 2002;99:292-8.
-
(2002)
Int J Cancer
, vol.99
, pp. 292-298
-
-
Ruefli, A.A.1
Bernhard, D.2
Tainton, K.M.3
Kofler, R.4
Smyth, M.J.5
Johnstone, R.W.6
|