Sulindac metabolites induce caspase- and proteasome-dependent degradation of β-catenin protein in human colon cancer cells

Molecular Cancer Therapeutics

Volumn 2, Issue 9, 2003, Pages 885-892

  Rice, Pamela L ^a,b   Kelloff, Jennifer ^c   Sullivan, Holly ^b   Driggers, Linda J ^c   Beard, K Scott ^c   Kuwada, Scott ^d   Piazza, Gary ^e   Ahnen, Dennis J ^a,b,c  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF UTAH   (United States)

^e CTRC Institute for Drug Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; BETA CATENIN; CASP3 PROTEIN, HUMAN; CASPASE; CASPASE 3; CTNNB1 PROTEIN, HUMAN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; CYTOSKELETON PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; LEUPEPTIN; MULTIENZYME COMPLEX; PROTEASOME; SULINDAC; SULINDAC SULFIDE; SULINDAC SULFONE; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL NUCLEUS; COLON POLYPOSIS; COLON TUMOR; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ADENOMATOUS POLYPOSIS COLI; ANTINEOPLASTIC AGENTS; APOPTOSIS; BETA CATENIN; CASPASE 3; CASPASES; CELL NUCLEUS; COLONIC NEOPLASMS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYTOSKELETAL PROTEINS; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; LEUPEPTINS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; SULINDAC; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0642287832     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

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