Humoral immune responses to the human immunodeficiency virus type-1 (HIV-1) in the genital tract compared to other mucosal sites (DOI:10.1016/j.jri.2006.05.006)

Journal of Reproductive Immunology

Volumn 73, Issue 1, 2007, Pages 86-97

  Mestecky, Jiri ^a,b  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

AIDS; Antibodies; Human immunodeficiency virus type 1 (HIV 1); IgA; Mucosal immunity

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PEPTIDE DERIVATIVE; RECOMBINANT VACCINE; RGP 120 VACCINE; RGP 41 VACCINE; UNCLASSIFIED DRUG;

DRUG EFFICACY; ERRATUM; FEMALE GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; MALE GENITAL SYSTEM; MUCOSA; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANTIBODY FORMATION; GENITALIA; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, MUCOSAL; MUCOUS MEMBRANE; VACCINATION;

EID: 33846503192     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2007.01.006     Document Type: Erratum

References (122)

1. Alexander N.J. Sexual transmission of human immunodeficiency virus: virus entry into the male and female genital tract. World Health Organization, Global Programme on Acquired Immune Deficiency Syndrome. Fertil. Steril. 54 (1990) 1-18
2. Amadori A., and Chieco-Bianchi L. B-cell activation and HIV-1 infection: deeds and misdeeds. Immunol. Today 11 (1990) 374-379
3. Anderson D.J., and Pudney J. Human male genital tract immunity and experimental models. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 1647-1657
4. Archibald D., et al. Detection of HIV-specific antibodies in saliva and cervical secretions. Vaccine Res. 1 (1992) 215-219
5. Artenstein A.W., et al. Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: a comparison by site and correlation with clinical information. J. Infect. Dis. 175 (1997) 265-271
6. Baba T.W., et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat. Med. 6 (2000) 200-206
7. Battle-Miller K., et al. Antibody-dependent cell-mediated cytotoxicity in cervical lavage fluids of human immunodeficiency virus type 1-infected women. J. Infect. Dis. 185 (2002) 439-447
8. Belec L., et al. Cervicovaginal overproduction of specific IgG to human immunodeficiency virus (HIV) contrasts with normal or impaired IgA local response in HIV infection. J. Infect. Dis. 172 (1995) 691-697
9. Belec L., et al. Decreased cervicovaginal production of both IgA1 and IgA2 subclasses in women with AIDS. Clin. Exp. Immunol. 101 (1995) 100-106
10. Belec L., et al. Antibodies to human immunodeficiency virus in vaginal secretions of heterosexual women. J. Infect. Dis. 160 (1989) 385-391
11. Bergquist C., et al. Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina. Infect. Immun. 65 (1997) 2676-2684
12. Bevan M.J. Helping the CD8(+) T-cell response. Nat. Rev. Immunol. 4 (2004) 595-602
13. Beyrer C., et al., Chiang Mai HEPS Working Group. Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type 1 highly exposed, persistently seronegative female sex workers in northern Thailand. J. Infect. Dis. 179 (1999) 59-67
14. Blattner, W.A., et al., 2003. Safety and immunogenicity of a Salmonella-vectored HIV vaccine: AVEG 028. AIDS Vaccine 2003. Abstr. 58LB, 62.
15. Bomsel M. Transcytosis of infectious human immunodeficiency virus across a tight human epithelial cell line barrier. Nat. Med. 3 (1997) 42-47
16. Bouvet J.P., et al. Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination. Infect. Immun. 62 (1994) 3957-3961
17. Boyaka P.N., et al. Mucosal vaccines: an overview. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 855-873
18. Brenchley J.M., et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200 (2004) 749-759
19. Broliden K., et al. Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers. Immunol. Lett. 79 (2001) 29-36
20. Buchacz K., et al. HIV-specific IgG in cervicovaginal secretions of exposed HIV-uninfected female sexual partners of HIV-infected men. AIDS Res. Hum. Retroviruses 17 (2001) 1689-1693
21. Burns J.W., et al. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 272 (1996) 104-107
22. Burton D.R., et al. HIV vaccine design and the neutralizing antibody problem. Nat. Immunol. 5 (2004) 233-236
23. Clayton F., et al. Selective depletion of rectal lamina propria rather than lymphoid aggregate CD4 lymphocytes in HIV infection. Clin. Exp. Immunol. 107 (1997) 288-292
24. Crowley-Nowick P.A., et al. Normal uterine cervix: characterization of isolated lymphocyte phenotypes and immunoglobulin secretion. Am. J. Reprod. Immunol. 34 (1995) 241-247
25. Crowley-Nowick P.A., et al. Rectal immunization for induction of specific antibody in the genital tract of women. J. Clin. Immunol. 17 (1997) 370-379
26. Crowley-Nowick P.A., et al. Menstrual cycle: effects on vaccine-induced antibodies in genital tract secretions. In: Husband A.J., et al. (Ed). Advances in Mucosal Immunology vol. 1 (1997), University of Sydney, Sydney, Australia 393-401
27. Cummins Jr. J.E., and Dezzutti C.S. Sexual HIV-1 transmission and mucosal defense mechanisms. AIDS Rev. 2 (2000) 144-154
28. Derdeyn C.A., et al. Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. Science 303 (2004) 2019-2022
29. Devito C., et al. Mucosal and plasma IgA from HIV-1-exposed uninfected individuals inhibit HIV-1 transcytosis across human epithelial cells. J. Immunol. 165 (2000) 5170-5176
30. Devito C., et al. Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate. AIDS 14 (2000) 1917-1920
31. Devito C., et al. Cross-clade HIV-1-specific neutralizing IgA in mucosal and systemic compartments of HIV-1-exposed, persistently seronegative subjects. J. Acquir. Immune Defic. Syndr. 30 (2002) 413-420
32. Dorrell L., et al. Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia. AIDS 14 (2000) 1117-1122
33. Eriksson K., et al. Intestinal antibody responses to oral vaccination in HIV-infected individuals. AIDS 7 (1993) 1087-1091
34. Eriksson K., et al. Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals. AIDS 9 (1995) 695-700
35. Eriksson K., et al. Induction and expression of intestinal humoral immunity in HIV-infected individuals: prospects for vaccination against secondary enteric infections. Pathobiology 66 (1998) 176-182
36. Fiore J.R., et al. Limited secretory-IgA response in cervicovaginal secretions from HIV-1 infected, but not high risk seronegative women: lack of correlation to genital viral shedding. New Microbiol. 23 (2000) 85-92
37. Goodrich M.E., and McGee D.W. Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells. Immunol. Lett. 67 (1999) 11-14
38. Goodrich M.E., and McGee D.W. Preferential enhancement of B cell IgA secretion by intestinal epithelial cell-derived cytokines and interleukin-2. Immunol. Invest. 28 (1999) 67-75
39. Guadalupe M., et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J. Virol. 77 (2003) 11708-11717
40. Haimovici F., Mayer K.H., and Anderson D.J. Quantitation of HIV-1-specific IgG, IgA, and IgM antibodies in human genital tract secretions. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15 (1997) 185-191
41. He B., et al. HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving B cell-activating factor of the TNF family and C-type lectin receptors. J. Immunol. 176 (2006) 3931-3941
42. Hel Z., et al. HIV infection: first battle decides the war. Trends Immunol. 27 (2006) 274-281
43. Hocini H., et al. High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160. AIDS Res. Hum. Retroviruses 13 (1997) 1179-1185
44. Honjo T., et al. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20 (2002) 165-196
45. Huang Y.T., et al. Intraepithelial cell neutralization of HIV-1 replication by IgA. J. Immunol. 174 (2005) 4828-4835
46. Israel Z.R., and Marx P.A. Nonclassical mucosal antibodies predominate in genital secretions of HIV-1 infected chimpanzees. J. Med. Primatol. 24 (1995) 53-60
47. Jackson S., et al. Decreased IgA-producing cells in the gut of SIV-infected rhesus monkeys. Adv. Exp. Med. Biol. 371B (1995) 1035-1038
48. Jackson S., et al. False positivity of enzyme-linked immunosorbent assay for measurement of secretory IgA antibodies directed at HIV type 1 antigens. AIDS Res. Hum. Retroviruses 16 (2000) 595-602
49. Jackson S., et al. Appendix I: collection and processing of human mucosal secretions. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 1829-1839
50. Jaiswal Y.K., et al. Identification of human seminal plasma components that bind IgG2 variant. Arch. Androl. 33 (1994) 23-29
51. Jalanti R., and Isliker H. Immunoglobulins in human cervico-vaginal secretions. Int. Arch. Allergy Appl. Immunol. 53 (1977) 402-408
52. Janoff E.N., et al. Class-specific antibody response to pneumococcal capsular polysaccharides in men infected with human immunodeficiency virus type 1. J. Infect. Dis. 158 (1988) 983-990
53. Joag S.V., et al. Oral immunization of macaques with attenuated vaccine virus induces protection against vaginally transmitted AIDS. J. Virol. 72 (1998) 9069-9078
54. Kaetzel C.S., and Mostov K. Immunoglobulin transport and the polymeric immunoglobulin receptor. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 211-250
55. Kamada M., et al. Identification of IgG and Fc-binding proteins in human seminal plasma and sperm. Arch. Androl. 27 (1991) 1-7
56. Kantele A., et al. Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: evidence for compartmentalization within the common mucosal immune system in humans. Infect. Immun. 66 (1998) 5630-5635
57. Kaul R., et al. HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers. AIDS 13 (1999) 23-29
58. Kozlowski P.A., and Neutra M.R. The role of mucosal immunity in prevention of HIV transmission. Curr. Mol. Med. 3 (2003) 217-228
59. Kutteh W.H., et al. Secretory immune system of the female reproductive tract: I. Immunoglobulin and secretory component-containing cells. Obstet. Gynecol. 71 (1988) 56-60
60. Kutteh W.H., et al. Production of immunoglobulin A by the cervix of the human female genital tract. In: Dondero F., and Johnson P.M. (Eds). Reproductive Immunology (1993), Raven Press, New York 151-158
61. Kutteh W.H., et al. Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin. Exp. Immunol. 104 (1996) 538-542
62. Kutteh W.H., et al. Induction of specific immune responses in the genital tract of women after oral or rectal immunization and rectal boosting with Salmonella typhi Ty 21a vaccine. J. Reprod. Immunol. 52 (2001) 61-75
63. Lambert J.S., et al. A Phase I safety and immunogenicity trial of UBI microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects. Vaccine 19 (2001) 3033-3042
64. Lehner T. Innate and adaptive mucosal immunity in protection against HIV infection. Vaccine 21 (2003) S68-S76
65. Lehner T., and Bergmeier L.A. Mucosal infection and immune responses to simian immunodeficiency virus. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 1179-1197
66. Lehner T., et al. European Union and EDCTP strategy in the global context: recommendations for preventive HIV/AIDS vaccines research. Vaccine 23 (2005) 5551-5556
67. Lewis D.J., et al. Immune response following oral administration of cholera toxin B subunit to HIV-1-infected UK and Kenyan subjects. AIDS 8 (1994) 779-785
68. Li Q., et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434 (2005) 1148-1152
69. Lo Caputo S., et al. Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men. AIDS 17 (2003) 531-539
70. Lü F.X. Predominate HIV-1-specific IgG activity in various mucosal compartments of HIV-1-infected individuals. Clin. Immunol. 97 (2000) 59-68
71. Macpherson A.J., et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288 (2000) 2222-2226
72. Mascola J.R., et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat. Med. 6 (2000) 207-210
73. Mazzoli S., et al. HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals. Nat. Med. 3 (1997) 1250-1257
74. Mazzoli S., et al. Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons. J. Infect. Dis. 180 (1999) 871-875
75. McGhee J.R., et al. Regulation of IgA synthesis and immune response by T cells and interleukins. J. Clin. Immunol. 9 (1989) 175-199
76. Mehandru S., et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 200 (2004) 761-770
77. Meng G., et al. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nat. Med. 8 (2002) 150-156
78. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7 (1987) 265-276
79. Mestecky J., and Russell M.W. Induction of mucosal immune responses in the human genital tract. FEMS Immunol. Med. Microbiol. 27 (2000) 351-355
80. Mestecky J., and Russell M.W. Intestinal immunoglobulin A: role in host defense. In: Hecht G. (Ed). Microbial Pathogens and the Intestinal Epithelial Cell (2003), ASM Press, Washington, DC 95-112
81. Mestecky J., et al. The mucosal immune system. In: Paul W.E. (Ed). Fundamental Immunology. fifth ed. (2003), Lippincott-Raven, Philadelphia 965-1020
82. Mestecky J., et al. Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals. AIDS Res. Hum. Retroviruses 20 (2004) 972-988
83. Mestecky J., et al. Immunologic uniqueness of the genital tract: challenge for vaccine development. Am. J. Reprod. Immunol. 53 (2005) 208-214
84. Mestecky J., et al. Mucosal immunoglobulins. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 153-181
85. Moldoveanu Z., et al. Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity. J. Immunol. 175 (2005) 4127-4136
86. Nag P., et al. Women with cervicovaginal antibody-dependent cell-mediated cytotoxicity have lower genital HIV-1 RNA loads. J. Infect. Dis. 190 (2004) 1970-1978
87. Northrop J.K., and Shen H. CD8+ T-cell memory: only the good ones last. Curr. Opin. Immunol. 16 (2004) 451-455
88. Pabst R., and Rosenberg Y.J. Interpreting data on lymphocyte subsets in the blood of HIV patients-organ distribution, proliferation and migration kinetics are critical factors. Pathobiology 66 (1998) 117-122
89. Pinching A.J. Antibody responses in HIV infection. Clin. Exp. Immunol. 84 (1991) 181-184
90. Pudney J., and Anderson D.J. Immunobiology of the human penile urethra. Am. J. Pathol. 147 (1995) 155-165
91. Qiao X., et al. Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells. Nat. Immunol. 7 (2006) 302-310
92. Quesnel A., et al. Comparative analysis of methods for collection and measurement of immunoglobulins in cervical and vaginal secretions of women. J. Immunol. Methods 202 (1997) 153-161
93. Raux M., et al. Comparison of the distribution of IgG and IgA antibodies in serum and various mucosal fluids of HIV type 1-infected subjects. AIDS Res. Hum. Retroviruses 15 (1999) 1365-1376
94. Rudin A., et al. Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66 (1998) 3390-3396
95. Russell M.W., and Mestecky J. Humoral immune responses to microbial infections in the genital tract. Microbes Infect. 4 (2002) 667-677
96. Russell M.W., and Kilian M. Biological activities of IgA. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 267-289
97. Russell M.W., et al. Mucosal immunology of sexually transmitted diseases. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 1693-1720
98. Sankaran S., et al. Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 9860-9865
99. Scamurra R.W., et al. Mucosal plasma cell repertoire during HIV-1 infection. J. Immunol. 169 (2002) 4008-4016
100. Schafer F., et al. Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaques. Gut 50 (2002) 608-614
101. Schneider T., et al., Berlin Diarrhea/Wasting Syndrome Study Group. Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Gut 37 (1995) 524-529
102. Schneider T., et al. Secretory immunity in HIV infection. Pathobiology 66 (1998) 131-138
103. Schnittman S.M., et al. Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus. Science 233 (1986) 1084-1086
104. Sedor J., et al. Soluble FcγRIII (CD16) and immunoglobulin G levels in seminal plasma of men with immunological infertility. J. Androl. 14 (1993) 187-193
105. Shattock R.J., and Moore J.P. Inhibiting sexual transmission of HIV-1 infection. Nat. Rev. Microbiol. 1 (2003) 25-34
106. Shirai A., et al. Human immunodeficiency virus infection induces both polyclonal and virus-specific B cell activation. J. Clin. Invest. 89 (1992) 561-566
107. Skurnick J.H., et al. Correlates of nontransmission in US women at high risk of human immunodeficiency virus type 1 infection through sexual exposure. J. Infect. Dis. 185 (2002) 428-438
108. Smit-McBride Z., et al. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J. Virol. 72 (1998) 6646-6656
109. Smith P.D., and Wahl S.W. Immunobiology of mucosal HIV-1 infection. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 1199-1211
110. Strober W., et al. IgA B cell development. In: Mestecky J., et al. (Ed). Mucosal Immunology. third ed. (2005), Elsevier/Academic Press, Amsterdam 583-616
111. Svanborg Eden C., et al. Urinary immunoglobulins in healthy individuals and children with acute pyelonephritis. Scand. J. Immunol. 21 (1985) 305-313
112. Tan X., et al. Productive infection of a cervical epithelial cell line with human immunodeficiency virus: implications for sexual transmission. J. Virol. 67 (1993) 6447-6452
113. Thaler C.J., et al. Soluble antigens of IgG receptor FcγRIII in human seminal plasma. J. Immunol. 143 (1989) 1937-1942
114. Vajdy M., et al. Differential effects of simian immunodeficiency virus infection on immune inductive and effector sites in the rectal mucosa of rhesus macaques. Am. J. Pathol. 157 (2000) 485-495
115. Veazey R.S., et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280 (1998) 427-431
116. Veazey R.S., and Lackner A.A. Getting to the guts of HIV pathogenesis. J. Exp. Med. 200 (2004) 697-700
117. + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection. J. Infect. Dis. 187 (2003) 769-776
118. Veazey R.S., et al. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat. Med. 9 (2003) 343-346
119. Vermund S.H. Transmission of HIV. In: DeVita F., et al. (Ed). AIDS. fourth ed. (1997), Lippincott-Raven, Philadelphia 147-165
120. Wolff H., et al. A comparison of HIV-1 antibody classes, titers, and specificities in paired semen and blood samples from HIV-1 seropositive men. J. Acquir. Immune Defic. Syndr. 5 (1992) 65-69
121. Wright P.F., et al. Detection of mucosal antibodies in HIV type 1-infected individuals. AIDS Res. Hum. Retroviruses 18 (2002) 1291-1300
122. Wright P.F., et al. Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. J. Infect. Dis. 189 (2004) 1221-1231