Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina

Infection and Immunity

Volumn 65, Issue 7, 1997, Pages 2676-2684

  Bergquist, Charlotta ^a   Johansson, Eva Liz ^a   Lagergård, Teresa ^a   Holmgren, Jan ^a   Rudin, Anna ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN B SUBUNIT;

ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CHOLERA; CLINICAL ARTICLE; HUMAN; INTRANASAL DRUG ADMINISTRATION; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT; VACCINATION; VIBRIO CHOLERAE;

EID: 0030940274     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.7.2676-2684.1997     Document Type: Article

References (44)

1. Aizpurua, H. J., and G. J. Russell-Jones. 1988. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oval feeding. J. Exp. Med. 167:440-451.
2. Bäckström, M., M. Lebens, F. Schödel, and J. Holmgren. 1994. Insertion of a MIV-l-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit. Gene 149:211-217.
3. Bergquist, C., T. Lagergård, M. Lindblad, and J. Holmgren. 1995. Local and systemic responses to dextran-cholera toxin B subunit conjugates. Infect. Immun. 63:2021-2025.
4. Bouvet, J. P., L. Bélec, R. Pirès, and J. Pillot. 1994. Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination. Infect. Immun. 62:3957-3961.
5. Brandtzaeg, P. 1985. Cells producing immunoglobulins and other immune factors in human nasal mucosa. Protides Biol. Fluids 32:363-366.
6. Clements, M. L., R. F. Betts, E. L. Tierney, and B. R. Murphy. 1986. Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine. J. Clin. Microbiol. 23:73-76.
7. Cui, Z.-D., T. D. Tristam, L. J. LaScolea, T. Kwiatkowski, Jr., S. Kopti, and P. Ogra. 1991. Induction of anlihody response to Chlamydia trachomatis in the genital tract by oral immunization. Infect. Immun. 59:1465-1469.
8. Czerkinsky, C., M. W. Russell, N. Lycke, M. Lindblad, and J. Holmgren. 1989. Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues. Infect. Immun. 57:1072-1077.
9. De Fijter, J. W., J. W. Elgenraam, C. A. Braam, J. Holmgren, M. R. Daha, L. A. van Es, and A. W. L. van den Wall Bake. 1996. Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int. 50:952-961.
10. Di Tommaso, A., G. Saletti, M. Pizza, R. Rappuoli, G. Douyan, S. Abrignani, G. Douce, and M. T. de Magistris. 1996. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect. Immun. 64:974-979.
11. Gallichan, W. S., D. C. Johnson, F. L. Graham, and K. L. Rosenthal. 1993. Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein B. J. Infect. Dis. 168:622-629.
12. Gallichan, W. S., and K. L. Rosenthal. 1995. Specific secretory immune responses in the female genital tract following intranasal imnumization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. Vaccine 13:1589-1595.
13. Gorse, G. J., E. E. Otto, D. C. Powers, G. W. Chambers, C. S. Eickhoff, and F. K. Newman. 1996. Induction of mucosal antibodies by live attenuated and inactivated influenza virus vaccines in the chronically ill elderly. J. Infect. Dis. 173:285-290.
14. Haneberg, B., D. Kendall, H. M. Amerongen, F. M. Apter, J.-P. Kraehenbuhl, and M. Neutra. 1994. Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for col- lection of secretions from local mucosal surfaces. Infect. Immun. 62:15-23.
15. Husigucci, K., H. Ogawa, T. Ishidate, R. Yamashita, H. Kamiya, K. Wanatabe, N. Hattori, T. Sato, V. Suzuki, T. Nagemine, C. Alzawa, S. Tamura, T. Kurata, and A. Oya. 1996. Antibody responses in volunteers induced by nasal influenza vaccine combined with Escherichia coli heat labile enterotoxin B suhunit containing a trace amount of the holotoxin. Vaccine 14:113-119.
16. Hirabayashi, V., H. Kurata, H. Fumito, T. Nagamine, C. Aizawa, S. Tamura, K. Shimnda, and T. Kuruta. 1990. Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination. Vaccine 8:243-248.
17. Holmgren, J. 1981. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292:413-417.
18. Holmgren, J., C. Czerkinsky, N. Lycke, and A.-M. Svennerholm. 1994. Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen carrier and adjuvant. Am. J. Trop. Med. Hyg. 50(5)(Suppl.):42-54.
19. Holmgren, J., and A.-M. Svennerholm. 1992. Bacterial enteric infections and vaccine development. Gast. Clin. N. Am. 21:283-302.
20. Hopkins, S., J.-P. Kraehenbuhl, F. Schödel, A. Potts, D. Peterson, P. de Gandi, and D. Nardelli-Haefliger. 1945. A rocombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization. Infect. Immun, 63:3279-3286.
21. Hordness, K., T. Tynning, A. I. Kvam, R. Jonsson, and B. Haneberg. 1996. Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women. Infect. Immun. 64:1643-1652.
22. Jertborn, M., A.-M. Svennerholm, and J. Holmgren. 1986. Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease. J. Clin. Microbiol. 24:203-209.
23. Jertborn, M., A.-M. Svennerholm, and J. Holmgren. 1993. Evaluation of different immunization schedules for oral cholera B subunit-whole cell vaccine in Swedish volunteers. Vaccine 11:1007-1012.
24. Jertborn, M., et al. Unpublished data.
25. Johansson, E.-L.. et al. Unpublished data.
26. Lehner, T., L. A. Bergmeier, C. Panagiotidi, L. Tao, R. Brookes, L. S. Klavinskis, P. Walker, J. Walker, R. G. Ward, L. Hussain, A. J. H. Gearing, and S. E. Adams. 1992. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein. Science 258:1365-1369.
27. Mancini, G., A. O. Carbonara, and J. F. Hereman. 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2:235-254.
28. Mazanek, M. B., M. E. Lamm, D. Lyn, A. Portner, and J. G. Nedrud. 1992. Comparison of IgA versus IgG monoclonal antibodies for passive immunization of the murine respiratory tract. Virus Res. 23:1-12.
29. McDermott, M. R., and J. Bienenstock. 1979. Evidence for a common mucosal immune system. I. Migration of B immunoblasts into intestinal, respiratory and genital tissues. J. Immunol. 122:1892-1898.
30. Menge, A.C., S. M. Michalek, M. W. Russell, and J. Mestecky. 1993. Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to the cholera toxin B subunit. Infect. Immun. 61:2162-2171.
31. Mestecky, J. 1987. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7:265-276.
32. Moldoveanu, Z., M. L. Clements, S. J. Prince, B. R. Murphy, and J. Mestecky. 1995. Human immune responses to influenza virus vaccines administered by systemic or mucosal routes. Vaccine 13:1006-1012.
33. Parr, M. B., and E. L. Parr. 1994. Mucosal immunity in the female and male reproductive tracts, p. 677-689. In P. L. Ogra, M. E. Lamm, J. R. McGhee, J. Mestecky, W. Stroeber, and J. Bienenstock (ed.), Handbook of mucosal immunology. Academic Press, San Diego, Calif.
34. Quiding, M., I. Nordström, A. Kilander, G. Andersson, L.-Å. Hansson, J. Holmgren, and C. Czerkinsky. 1991. Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-γ production and evokes local immunological meory. J. Clin. Invest. 88:143-148.
35. Quiding-Järbrink, M., G. Granström, I. Nordström, J. Holmgren, and C. Czerkinsky. 1995. Induction of compartmentalized B-cell responses in the human tonsils. Infect. Immun. 63:853-857.
36. Roberts, M., A. Bacon, R. Rappouli, M. Pizza, I. Cropley, G. Dorce, G. Dougan, M. Marinaro, J. McGhee, and S. Chatfield. 1995. A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/ 129G, is an effective mucosal adjuvant for intranasally delivered proteins. Infect. Immun. 63:2100-2108.
37. Rosenthal, K. L., and W. S. Gallichan. 1997. Intranasal immunization induces optimal protection in the female genital tract against herpes simplex virus type 2 infection. Immunol. Cell Biol. 75(Suppl.):A11.
38. Russell, M. W., Z. Moldoveanu, P. L. White, G. J. Sibert, J. Mestecky, and S. Michalek. 1996. Salivary, nasal, genital, and systemic antibody responses in monkeys immunized intranasally with a bacterial protein antigen and the cholera toxin B subunit. Infect. Immun. 64:1272-1283.
39. Sanchez, J., and J. Holmgren. 1989. Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development. Proc. Natl. Acad. Sci. USA 86:481-485.
40. Snider, D. P., J. S. Marshall, M. H. Perdue, and H. Liang. 1994. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153:647-657.
41. Svennerholm, A.-M., and J. Holmgren. 1978. Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbent assay (GM1-ELISA) procedure. Curr. Microbiol. 1:19-23.
42. Tamura, S., V. Shoji, K. Hasiguchi, C. Aizawa, and T. Kurata. 1994. Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalhumin. Vaccine 12:1238-1240.
43. Wassén, L., K. Schön, J. Holmgren, M. Jertborn, and N. Lycke. 1996. Local intravaginal vaccination of the female genital tract. Scand. J. Immunol. 44:408-414.
44. Wu, H.-Y., and M. W. Russell. 1993. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 61:314-322.