Interpreting data on lymphocyte subsets in the blood of HIV patients - Organ distribution, proliferation and migration kinetics are critical factors

Pathobiology

Volumn 66, Issue 3-4, 1998, Pages 117-122

  Pabst, R ^a   Rosenberg, Y J ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Ther Immune Inc   (United States)

Author keywords

Apoptosis; HIV; Lymphocyte migration; Lymphocyte subsets; Lymphocytopoiesis; Organ distribution

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGE; APOPTOSIS; CELL MIGRATION; CELL SURVIVAL; CONFERENCE PAPER; DISEASE COURSE; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTESTINE EPITHELIUM; INTESTINE LYMPHATIC TISSUE; LAMINA PROPRIA; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; CD4-CD8 RATIO; HIV INFECTIONS; HUMANS; INTESTINAL MUCOSA; LYMPH NODES; LYMPHOCYTE COUNT; T-LYMPHOCYTE SUBSETS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0031844176     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028006     Document Type: Conference Paper

References (39)

1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M: Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:125-126.
2. Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH, Saag MS, Shaw GM: Viral dynamics m human immunodeficiency virus type 1 infection. Nature 1995;373:117-122.
3. Frost SDW, Michie CA: Lymphocyte dynamics, apoptosis and HIV infection. Trends Microbiol 1996;4:77-82.
4. Pabst R, Binns RM: Heterogeneity of lymphocyte homing physiology. Several mechanisms operate in the control of migration to lymphoid and non-lymphoid organs in vivo. Immunol Rev 1989;108:83-109.
5. Pabst R, Westermann J: Lymphocyte traffic to lymphoid and non-lymphoid organs in different species is regulated by several mechanisms: in Hamann A (ed): Adhesion Molecules and Chemokines in Lymphocyte Trafficking. Amsterdam, Harwood Academic, 1997.
6. Westermann J, Pabst R: Lymphocyte subsets in the blood: A diagnostic window on the lymphoid system? Immunol Today 1990;11:406-410.
7. Westermann J, Pabst R: Distribution of lymphocyte subsets and natural killer cells in the human body. Clin Invest 1992;70:539-544.
8. Butcher EC, Picker LJ: Lymphocyte homing and homeostasis. Science 1996;272:60-66.
9. Springer TA: Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995;57:827-872.
10. Dunon D, Piali L, Imhof BA: To stick or not to stick: The new leukocyte homing paradigm. Curr Opin Cell Biol 1996;8:714-723.
11. Darby SC, Ewart DW, Giangrande PLF, Spooner RJD, Rizza CR: Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. Lancet 1996;347:1573-1579.
12. Amadori A, Zamarchi R, de Silvestro G, Forza G, Cavatton G, Daniell GA, Clementi M, Chieco-Bianchi L: Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med 1995;1:1279-1283.
13. Brett S, Baxter G, Cooper H, Johnston JM, Tite J, Rapson N: Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody. CAMPATH-1H. Immunology 1996;88:13-19.
14. Mackall CL, Hakim FT, Gress RE: T-cell regeneration: All repertoires are not created equal. Immunol Today 1997;18:245-251.
15. Heeney JL: AIDS: A disease of impaired Thcell renewal? Immunol Today 1995;16:515-520.
16. Debatin KM, Fahrig-Faissner A, Enenkel-Stoodt S, Kreuz W, Benner A, Krammer PH: High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 1994;83:3101-3102.
17. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, Miedema F: Programmed death of T cells in HTV-1 infection. Science 1992;257:217-219.
18. Cotton ME, Cassella C, Rapaport EL, Tseng PO, Marschner S, Finkel TH: Apoptosis in HIV-I infection. Behring Inst Mitt 1996;97:220-231.
19. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995;181:2029-2036.
20. Gougeon ML, Lecoeur H, Dulioust A, Enouf MG, Crouvoisier M, Goujard C, Debord T, Montagnier L: Programmed cell death in peripheral lymphocytes from HIV-infected persons. Increased susceptibility to apoptosis of CD4 and CDS T cells correlates with lymphocyte activation and with disease progression. J Immunol 1996;156:3509-3520.
21. Muro-Cacho CA, Pantaleo G, Fauci AS: Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 1995;154:5555-5566.
22. Wolthers KC, Wisman GBA, Otto SA, Husman AMR, Schaft N, de Wolf F, Goudsmit J, Coutinho RA, van der Zee AGJ, Meyaard L, Miedema F: T cell telomere length in HIV-1 infection: No evidence for increased CD4+ T cell turnover. Science 1996;274:1543-1547.
23. Palmer LD, Weng NP, Levine BL, June CH, Lane HC, Hodes RJ: Telomere length, telomerase activity, and replicative potential in HIV infection: Analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins. J Exp Med 1997;185:1381-1386.
24. Westermann J, Pabst R: How organ-specific is the migration of 'naive' and "memory" T cells? Immunol Today 1996;17:278-282.
25. Rabin RL, Roederer M, Maldonado Y, Petru A, Herzenberg LA, Herzenberg LA: Altered representation of naive and memory CDS T cell subsets in HIV-infected children. J Clin Invest 1995;95:2054-2060.
26. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA: CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995;95:2061-2066.
27. Kelleher AD, Carr A, Zaunders J, Cooper DA: Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis 1996;173:321-329
28. Rosenberg YJ, Andersen AO, Pabst R: Decline in blood CD4/CD8 ratios during HIV infections: Viral killing or altered lymphocyte trafficking? Immunol Today 1998;19:10-17.
29. + T cells: A new T-lymphocyte subset expanded during human immunodeficiency virus infection. Blood 1992;79:1746-1753.
30. Schneider T, Jahn HU, Schmidt W, Riecken EO, Zeitz M, Ullrich R: Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood. Gut 1995;37:524-529.
31. Zeitz M, Kewenig S, Lampe-Dreyer K, Stahl-Hennig C, Kaup FJ, Schneider T: Phenotypic alterations of mucosa-associated and circulating T-cells during SIV infection of nonhuman primates. Immunol Cell Biol 1997;75(suppl 1):A94.
32. Clayton F, Snow G, Reka S, Kotler DP: Selective depletion of rectal lamina propria rather than lymphoid aggregate CD4 lymphocytes in HIV infection. Clin Exp Immunol 1997;107:288-292.
33. + lymphocyte population in the blood of SIV-infected macaques is not reflected in lymph nodes. AIDS Res Hum Retrovir 1993;9:639-646.
34. Janossy G, Pinching AJ, Bofill M, Weber J, McLaughlin JE, Ornstein M, Ivory K, Harris JR, Favrot M, Macdonald-Burns DC: An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS. Clin Exp Immunol 1985;59:257-266.
35. Rácz P, Tenner-Rácz K, Kahl C, Feller AC, Kern P, Dietrich M: Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complexes. Progr Allergy 1986;37:81-181.
36. Tedla N, Palladinetti P, Kelly M, Kumar RK, DiGirolamo N, Chattophadhay U, Cooke B, Truskett P, Dwyer J, Wakefield D, Lloyd A: Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection Am J Pathol 1996;148:1367-1373.
37. Rosok BI, Bostad L, Voltersvik P, Bjerknes R, Olofsson J, Asjo B, Brinchmann JE: Reduced CD4 cell counts in blood do not reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection. AIDS 1996;10:F35-F38.
38. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, Fauci AS: Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 1991;88:9838-9842.
39. Agostini C, Zambello R, Trentin L, Semenzato G: HIV and pulmonary immune responses. Immunol Today 1996;17:359-364.