boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 2, 2007, Pages 316-326

  Clark, Robert S B ^a,b,c   Nathaniel, Paula D ^a   Zhang, Xiaopeng ^a   Dixon, C Edward ^a   Alber, Sean M ^b   Watkins, Simon C ^b   Melick, John A ^a   Kochanek, Patrick M ^a,b,c   Graham, Steven H ^b,d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspase; Cysteine protease; Head injury; Nerve growth factor; Programmed cell death

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE INHIBITOR; CYTOCHROME C; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CONTUSION; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CELL DEATH; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME RELEASE; HIPPOCAMPUS; MALE; MAZE TEST; MOTOR PERFORMANCE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OSMOTIC PUMP; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; TASK PERFORMANCE; TISSUE INJURY; TRAUMATIC BRAIN INJURY;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN INJURIES; CASPASE 2; CASPASE 3; CASPASE 8; CELL SURVIVAL; CYTOCHROMES C; IN SITU NICK-END LABELING; MALE; MAZE LEARNING; MITOCHONDRIA; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33846459404     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600338     Document Type: Article

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