메뉴 건너뛰기




Volumn 96, Issue 1, 2007, Pages 16-20

Targeting BRAF in thyroid cancer

Author keywords

Papillary thyroid cancer; RAS; RET PTC oncogene

Indexed keywords

AAL 881; ANTINEOPLASTIC AGENT; B RAF KINASE; ENZYME INHIBITOR; LBT 613; SORAFENIB; UNCLASSIFIED DRUG;

EID: 33846227109     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603520     Document Type: Short Survey
Times cited : (85)

References (43)
  • 1
    • 33645232222 scopus 로고    scopus 로고
    • Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    • Adeniran AJ, Zhu Z, Gandhi M, Steward DL, Fidler JP, Giordano TJ, Biddinger PW, Nikiforov YE (2006) Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. Am J Surg Pathol 30: 216-222
    • (2006) Am J Surg Pathol , vol.30 , pp. 216-222
    • Adeniran, A.J.1    Zhu, Z.2    Gandhi, M.3    Steward, D.L.4    Fidler, J.P.5    Giordano, T.J.6    Biddinger, P.W.7    Nikiforov, Y.E.8
  • 2
    • 0038460022 scopus 로고    scopus 로고
    • Systemic administration of vascular endothelial growth factor monoclonal antibody reduces the growth of papillary thyroid carcinoma in a nude mouse model
    • Bauer AJ, Patel A, Terrell R, Doniparthi NK, Saji M, Ringel MD, Tuttle MR, Francis GL (2003) Systemic administration of vascular endothelial growth factor monoclonal antibody reduces the growth of papillary thyroid carcinoma in a nude mouse model. Ann Clin Lab Sci 33: 192-199
    • (2003) Ann Clin Lab Sci , vol.33 , pp. 192-199
    • Bauer, A.J.1    Patel, A.2    Terrell, R.3    Doniparthi, N.K.4    Saji, M.5    Ringel, M.D.6    Tuttle, M.R.7    Francis, G.L.8
  • 3
    • 8144230516 scopus 로고    scopus 로고
    • BRAF mutations in anaplastic thyroid carcinoma: Implications for tumor origin, diagnosis and treatment
    • Begum S, Rosenbaum E, Henrique R, Cohen Y, Sidransky D, Westra WH (2004) BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment. Mod Pathol 17: 1359-1363
    • (2004) Mod Pathol , vol.17 , pp. 1359-1363
    • Begum, S.1    Rosenbaum, E.2    Henrique, R.3    Cohen, Y.4    Sidransky, D.5    Westra, W.H.6
  • 4
    • 0038707599 scopus 로고    scopus 로고
    • Beyond radioiodine: A review of potential new therapeutic approaches for thyroid cancer
    • Braga-Basaria M, Ringel MD (2003) Beyond radioiodine: a review of potential new therapeutic approaches for thyroid cancer. J Clin Endocrinol Metab 88: 1947-1960
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1947-1960
    • Braga-Basaria, M.1    Ringel, M.D.2
  • 6
    • 33846211146 scopus 로고    scopus 로고
    • Ret/Ptc rearrangements and braf mutations in thyroid tumorigenesis
    • August 31; Epub ahead of print
    • Ciampi R, Nikiforov YE (2006) Ret/Ptc rearrangements and braf mutations in thyroid tumorigenesis. Endocrinology August 31; Epub ahead of print
    • (2006) Endocrinology
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 7
    • 18444374405 scopus 로고    scopus 로고
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA (2002) Mutations of the BRAF gene in human cancer. Nature 417: 949-954
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA (2002) Mutations of the BRAF gene in human cancer. Nature 417: 949-954
  • 8
    • 33646442046 scopus 로고    scopus 로고
    • Increasing incidence of thyroid cancer in the United States, 1973-2002
    • Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295: 2164-2167
    • (2006) JAMA , vol.295 , pp. 2164-2167
    • Davies, L.1    Welch, H.G.2
  • 15
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA (2003) High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63: 1454-1457
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 17
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S, Asa SL (2006) Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 6: 292-306
    • (2006) Nat Rev Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 19
    • 33746166501 scopus 로고    scopus 로고
    • Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
    • Mesa Jr C, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA (2006) Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer Res 66: 6521-6529
    • (2006) Cancer Res , vol.66 , pp. 6521-6529
    • Mesa Jr, C.1    Mirza, M.2    Mitsutake, N.3    Sartor, M.4    Medvedovic, M.5    Tomlinson, C.6    Knauf, J.A.7    Weber, G.F.8    Fagin, J.A.9
  • 20
    • 16844367605 scopus 로고    scopus 로고
    • Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells
    • Mitsutake N, Knauf JA, Mitsutake S, Mesa Jr C, Zhang L, Fagin JA (2005a) Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells. Cancer Res 65: 2465-2473
    • (2005) Cancer Res , vol.65 , pp. 2465-2473
    • Mitsutake, N.1    Knauf, J.A.2    Mitsutake, S.3    Mesa Jr, C.4    Zhang, L.5    Fagin, J.A.6
  • 21
    • 30944445020 scopus 로고    scopus 로고
    • BRAF mediates RET/PTC-induced MAPK activation in thyroid cells: Functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis
    • Mitsutake N, Miyagishi M, Mitsutake S, Akeno N, Mesa Jr C, Knauf JA, Zhang L, Taira K, Fagin JA (2005b) BRAF mediates RET/PTC-induced MAPK activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology 147: 1014-1019
    • (2005) Endocrinology , vol.147 , pp. 1014-1019
    • Mitsutake, N.1    Miyagishi, M.2    Mitsutake, S.3    Akeno, N.4    Mesa Jr, C.5    Knauf, J.A.6    Zhang, L.7    Taira, K.8    Fagin, J.A.9
  • 25
    • 33645698808 scopus 로고    scopus 로고
    • Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo
    • Ouyang B, Knauf JA, Smith EP, Zhang L, Ramsey T, Yusuff N, Batt D, Fagin JA (2006) Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clin Cancer Res 12: 1785-1793
    • (2006) Clin Cancer Res , vol.12 , pp. 1785-1793
    • Ouyang, B.1    Knauf, J.A.2    Smith, E.P.3    Zhang, L.4    Ramsey, T.5    Yusuff, N.6    Batt, D.7    Fagin, J.A.8
  • 27
    • 33846246441 scopus 로고    scopus 로고
    • Ries LAG, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, Hayat M, Hankey BF (eds) EBK (2006) SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2003/based on November 2005 SEER data submission, posted to the SEER web site
    • Ries LAG, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, Hayat M, Hankey BF (eds) EBK (2006) SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2003/based on November 2005 SEER data submission, posted to the SEER web site
  • 28
    • 33645964942 scopus 로고    scopus 로고
    • The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane
    • Riesco-Eizaguirre G, Gutierrez-Martinez P, Garcia-Cabezas MA, Nistal M, Santisteban P (2006) The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. Endocr Relat Cancer 13: 257-269
    • (2006) Endocr Relat Cancer , vol.13 , pp. 257-269
    • Riesco-Eizaguirre, G.1    Gutierrez-Martinez, P.2    Garcia-Cabezas, M.A.3    Nistal, M.4    Santisteban, P.5
  • 35
    • 21644440921 scopus 로고    scopus 로고
    • Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery
    • Thompson N, Lyons J (2005) Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 5: 350-356
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 350-356
    • Thompson, N.1    Lyons, J.2
  • 40
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12: 245-262
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 43
    • 85047687680 scopus 로고    scopus 로고
    • Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
    • Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE (2003) Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol 120: 71-77
    • (2003) Am J Clin Pathol , vol.120 , pp. 71-77
    • Zhu, Z.1    Gandhi, M.2    Nikiforova, M.N.3    Fischer, A.H.4    Nikiforov, Y.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.