Pioglitazone reverses down-regulation of cardiac PPARγ expression in Zucker diabetic fatty rats

Biochemical and Biophysical Research Communications

Volumn 329, Issue 2, 2005, Pages 726-732

  Pelzer, Theo ^a   Jazbutyte, Virginija ^a   Arias Loza, Paula Anahi ^a   Segerer, Stephan ^a   Lichtenwald, Margit ^a   Law, Marilyn P ^b   Schäfers, Michael ^b   Ertl, Georg ^a   Neyses, Ludwig ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Peroxisome proliferator activated receptor ; PET; Pioglitazone; ZDF rats

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; MYOSIN HEAVY CHAIN ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLACEBO; RECOMBINANT HUMAN INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTRIGLYCERIDEMIA; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SPECIES COMPARISON;

EID: 14644398608     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.02.029     Document Type: Article

References (23)

1. D. Aronson, E.J. Rayfield, and J.H. Chesebro Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction Ann. Intern. Med. 126 1997 296 306
2. D. Muller-Wieland, J. Kotzka, B. Knebel, and W. Krone Metabolic syndrome and hypertension: pathophysiology and molecular basis of insulin resistance Basic Res. Cardiol. 93 Suppl 2 1998 131 134
3. F.S. Fein, and E.H. Sonnenblick Diabetic cardiomyopathy Cardiovasc. Drugs Ther. 8 1994 65 73
4. E. Picano Diabetic cardiomyopathy. The importance of being earliest J. Am. Coll. Cardiol. 42 2003 454 457
5. M.M. El-Omar, Z.K. Yang, A.O. Phillips, and A.M. Shah Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus Basic Res. Cardiol. 99 2004 133 141
6. P.M. Barger, A.C. Browning, A.N. Garner, and D.P. Kelly p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response J. Biol. Chem. 276 2001 44495 44501
7. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 1994 1147 1156
8. K. Schoonjans, G. Martin, B. Staels, and J. Auwerx Peroxisome proliferator-activated receptors, orphans with ligands and functions Curr. Opin. Lipidol. 8 1997 159 166
9. T. Shiomi, H. Tsutsui, S. Hayashidani, N. Suematsu, M. Ikeuchi, J. Wen, M. Ishibashi, T. Kubota, K. Egashira, and A. Takeshita Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction Circulation 106 2002 3126 3132
10. M. Asakawa, H. Takano, T. Nagai, H. Uozumi, H. Hasegawa, N. Kubota, T. Saito, Y. Masuda, T. Kadowaki, and I. Komuro Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo Circulation 105 2002 1240 1246
11. M. Scheuermann-Freestone, P.L. Madsen, D. Manners, A.M. Blamire, R.E. Buckingham, P. Styles, G.K. Radda, S. Neubauer, and K. Clarke Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes Circulation 107 2003 3040 3046
12. M.A. Schafers, T. Wichter, K.P. Schafers, S. Rahman, C.G. Rhodes, A.A. Lammertsma, H. Lerch, M. Knickmeier, F. Hermansen, O. Schober, P.G. Camici, and G. Breithardt Pulmonary beta adrenoceptor density in arrhythmogenic right ventricular cardiomyopathy and idiopathic tachycardia Basic Res. Cardiol. 96 2001 91 97
13. A.J. Reader, and J. Zweit Developments in whole-body molecular imaging of live subjects Trends Pharmacol. Sci. 22 2001 604 607
14. J.R. Zierath, J.W. Ryder, T. Doebber, J. Woods, M. Wu, J. Ventre, Z. Li, C. McCrary, J. Berger, B. Zhang, and D.E. Moller Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action Endocrinology 139 1998 5034 5041
15. K. Yamamoto, R. Ohki, R.T. Lee, U. Ikeda, and K. Shimada Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes Circulation 104 2001 1670 1675
16. M. Iglarz, R.M. Touyz, E.C. Viel, P. Paradis, F. Amiri, Q.N. Diep, and E.L. Schiffrin Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid- dependent hypertension Hypertension 42 2003 737 743
17. P.D. Berk, S.L. Zhou, C.L. Kiang, D. Stump, M. Bradbury, and L.M. Isola Uptake of long chain free fatty acids is selectively up-regulated in adipocytes of Zucker rats with genetic obesity and non-insulin-dependent diabetes mellitus J. Biol. Chem. 272 1997 8830 8835
18. V.H. Maier, D.R. Melvin, C.A. Lister, H. Chapman, G.W. Gould, and G.J. Murphy v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats Diabetes 49 2000 618 625
19. P. Razeghi, M.E. Young, T.C. Cockrill, O.H. Frazier, and H. Taegtmeyer Down-regulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure Circulation 106 2002 407 411
20. A. Hammarstedt, P.A. Jansson, C. Wesslau, X. Yang, and U. Smith Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance Biochem. Biophys. Res. Commun. 301 2003 578 582
21. A. Zorzano, L. Sevilla, M. Camps, C. Becker, J. Meyer, H. Kammermeier, P. Munoz, A. Guma, X. Testar, M. Palacin, J. Blasi, and Y. Fischer Regulation of glucose transport, and glucose transporters expression and trafficking in the heart: studies in cardiac myocytes Am. J. Cardiol. 80 1997 A65 A76
22. E.B. Katz, A.E. Stenbit, K. Hatton, R. DePinho, and M.J. Charron Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 Nature 377 1995 151 155
23. L.M. Semeniuk, A.J. Kryski, and D.L. Severson Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice Am. J. Physiol. Heart Circ. Physiol. 283 2002 H976 H982