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Volumn 140, Issue 5, 2006, Pages 609-617

Regulating a circadian clock's period, phase and amplitude by phosphorylation: Insights from Drosophila

Author keywords

Circadian clock; Drosophila; Feedback loops; Period; Phosphorylation

Indexed keywords

PER1 PROTEIN; PER2 PROTEIN; RNA; TRANSCRIPTION FACTOR CLOCK;

EID: 33846102215     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj198     Document Type: Review
Times cited : (58)

References (67)
  • 1
    • 0034625822 scopus 로고    scopus 로고
    • Circadian rhythms in a nutshell
    • Edery, I. (2000) Circadian rhythms in a nutshell. Physiol. Genomics 3, 59-74
    • (2000) Physiol. Genomics , vol.3 , pp. 59-74
    • Edery, I.1
  • 2
    • 33846034859 scopus 로고    scopus 로고
    • Hastings, J.W., Rusak, B., and Boulos, Z. (1991) Circadian rhythms: the physiology of biological timing in Neural and Integrative Animal Physiology (Presser, C.L., ed.) pp. 435-546, Wiley-Liss Inc., New York
    • Hastings, J.W., Rusak, B., and Boulos, Z. (1991) Circadian rhythms: the physiology of biological timing in Neural and Integrative Animal Physiology (Presser, C.L., ed.) pp. 435-546, Wiley-Liss Inc., New York
  • 3
    • 0033970107 scopus 로고    scopus 로고
    • Molecular clock genes in man and lower animals: Possible implications for circadian abnormalities in depression
    • Bunney, W.E. and Bunney, B.G. (2000) Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression. Neuropsychopharmacology 22, 335-345
    • (2000) Neuropsychopharmacology , vol.22 , pp. 335-345
    • Bunney, W.E.1    Bunney, B.G.2
  • 4
    • 0037020198 scopus 로고    scopus 로고
    • The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
    • Fu, L., Pelicano, H., Liu, J., Huang, P., and Lee, C. (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111, 41-50
    • (2002) Cell , vol.111 , pp. 41-50
    • Fu, L.1    Pelicano, H.2    Liu, J.3    Huang, P.4    Lee, C.5
  • 6
    • 30044448307 scopus 로고    scopus 로고
    • When the clock stops ticking, metabolic syndrome explodes
    • Staels, B. (2006) When the clock stops ticking, metabolic syndrome explodes. Nat. Med. 12, 54-55
    • (2006) Nat. Med , vol.12 , pp. 54-55
    • Staels, B.1
  • 7
    • 0037217052 scopus 로고    scopus 로고
    • Cancer chronotherapy: Principles, applications, and perspectives
    • Mormont, M.C. and Levi, F. (2003) Cancer chronotherapy: principles, applications, and perspectives. Cancer 97, 155-169
    • (2003) Cancer , vol.97 , pp. 155-169
    • Mormont, M.C.1    Levi, F.2
  • 8
    • 24044444531 scopus 로고    scopus 로고
    • The circadian timekeeping system of Drosophila
    • Hardin, P.E. (2005) The circadian timekeeping system of Drosophila. Curr. Biol. 15, R714-722
    • (2005) Curr. Biol , vol.15
    • Hardin, P.E.1
  • 9
    • 0015119210 scopus 로고
    • Clock mutants of Drosophila melanogaster
    • Konopka, R.J. and Benzer, S. (1971) Clock mutants of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 68, 2112-2116
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 2112-2116
    • Konopka, R.J.1    Benzer, S.2
  • 10
    • 0025044560 scopus 로고
    • Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
    • Hardin, P.E., Hall, J.C., and Rosbash, M. (1990) Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343, 536-540
    • (1990) Nature , vol.343 , pp. 536-540
    • Hardin, P.E.1    Hall, J.C.2    Rosbash, M.3
  • 11
    • 0033595790 scopus 로고    scopus 로고
    • Interlocked feedback loops within the Drosophila circadian oscillator
    • Glossop, N.R., Lyons, L.C., and Hardin, P.E. (1999) Interlocked feedback loops within the Drosophila circadian oscillator. Science 286, 766-768.
    • (1999) Science , vol.286 , pp. 766-768
    • Glossop, N.R.1    Lyons, L.C.2    Hardin, P.E.3
  • 13
    • 0031006674 scopus 로고    scopus 로고
    • Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY
    • Garceau, N.Y., Liu, Y., Loros, J.J., and Dunlap, J.C. (1997) Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell 89, 469-476
    • (1997) Cell , vol.89 , pp. 469-476
    • Garceau, N.Y.1    Liu, Y.2    Loros, J.J.3    Dunlap, J.C.4
  • 14
    • 0035966317 scopus 로고    scopus 로고
    • Posttranslational mechanisms regulate the mammalian circadian clock
    • Lee, C., Etchegaray, J.P., Cagampang, F.R., Loudon, A.S., and Reppert, S.M. (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107, 855-867
    • (2001) Cell , vol.107 , pp. 855-867
    • Lee, C.1    Etchegaray, J.P.2    Cagampang, F.R.3    Loudon, A.S.4    Reppert, S.M.5
  • 15
    • 0032504041 scopus 로고    scopus 로고
    • The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon
    • Kloss, B., Price, J.L., Saez, L., Blau, J., Rothenfluh, A., Wesley, C.S., and Young, M.W. (1998) The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell 94, 97-107
    • (1998) Cell , vol.94 , pp. 97-107
    • Kloss, B.1    Price, J.L.2    Saez, L.3    Blau, J.4    Rothenfluh, A.5    Wesley, C.S.6    Young, M.W.7
  • 16
    • 0032503969 scopus 로고    scopus 로고
    • double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    • Price, J.L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., and Young, M.W. (1998) double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 94, 83-95
    • (1998) Cell , vol.94 , pp. 83-95
    • Price, J.L.1    Blau, J.2    Rothenfluh, A.3    Abodeely, M.4    Kloss, B.5    Young, M.W.6
  • 18
    • 4544255715 scopus 로고    scopus 로고
    • Posttranscriptional and posttranslational regulation of clock genes
    • Harms, E., Kivimae, S., Young, M.W., and Saez, L. (2004) Posttranscriptional and posttranslational regulation of clock genes. J. Biol. Rhythms 19, 361-373
    • (2004) J. Biol. Rhythms , vol.19 , pp. 361-373
    • Harms, E.1    Kivimae, S.2    Young, M.W.3    Saez, L.4
  • 19
    • 0035136677 scopus 로고    scopus 로고
    • An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
    • Toh, K.L., Jones, C.R., He, Y., Eide, E.J., Hinz, W.A., Virshup, D.M., Ptacek, L.J., and Fu, Y.H. (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291, 1040-1043
    • (2001) Science , vol.291 , pp. 1040-1043
    • Toh, K.L.1    Jones, C.R.2    He, Y.3    Eide, E.J.4    Hinz, W.A.5    Virshup, D.M.6    Ptacek, L.J.7    Fu, Y.H.8
  • 21
    • 0034602768 scopus 로고    scopus 로고
    • Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock
    • Liu, Y., Loros, J., and Dunlap, J.C. (2000) Phosphorylation of the Neurospora clock protein FREQUENCY determines its degradation rate and strongly influences the period length of the circadian clock. Proc. Natl. Acad. Sci. USA 97, 234-239
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 234-239
    • Liu, Y.1    Loros, J.2    Dunlap, J.C.3
  • 22
    • 33646591926 scopus 로고    scopus 로고
    • Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    • Kim, E.Y. and Edery, I. (2006) Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc. Natl. Acad. Sci. USA 103, 6178-6183
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 6178-6183
    • Kim, E.Y.1    Edery, I.2
  • 23
    • 33645010948 scopus 로고    scopus 로고
    • PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription
    • Yu, W., Zheng, H., Houl, J.H., Dauwalder, B., and Hardin, P.E. (2006) PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription. Genes Dev. 20, 723-733
    • (2006) Genes Dev , vol.20 , pp. 723-733
    • Yu, W.1    Zheng, H.2    Houl, J.H.3    Dauwalder, B.4    Hardin, P.E.5
  • 24
    • 0034161394 scopus 로고    scopus 로고
    • dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
    • Bae, K., Lee, C., Hardin, P.E., and Edery, I. (2000) dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. J. Neurosci. 20, 1746-1753
    • (2000) J. Neurosci , vol.20 , pp. 1746-1753
    • Bae, K.1    Lee, C.2    Hardin, P.E.3    Edery, I.4
  • 25
    • 0037587790 scopus 로고    scopus 로고
    • A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude
    • Allada, R., Kadener, S., Nandakumar, N., and Rosbash, M. (2003) A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. EMBO J. 22, 3367-3375
    • (2003) EMBO J , vol.22 , pp. 3367-3375
    • Allada, R.1    Kadener, S.2    Nandakumar, N.3    Rosbash, M.4
  • 26
    • 0037187636 scopus 로고    scopus 로고
    • Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity
    • Kim, E.Y., Bae, K., Ng, F.S., Glossop, N.R., Hardin, P.E., and Edery, I. (2002) Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron 34, 69-81
    • (2002) Neuron , vol.34 , pp. 69-81
    • Kim, E.Y.1    Bae, K.2    Ng, F.S.3    Glossop, N.R.4    Hardin, P.E.5    Edery, I.6
  • 27
    • 0141843617 scopus 로고    scopus 로고
    • A fly's eye view of circadian entrainment
    • Ashmore, L.J. and Sehgal, A. (2003) A fly's eye view of circadian entrainment. J. Biol. Rhythms 18, 206-216
    • (2003) J. Biol. Rhythms , vol.18 , pp. 206-216
    • Ashmore, L.J.1    Sehgal, A.2
  • 28
    • 0033543596 scopus 로고    scopus 로고
    • A role for the proteasome in the light response of the timeless clock protein
    • Naidoo, N., Song, W., Hunter-Ensor, M., and Sehgal, A. (1999) A role for the proteasome in the light response of the timeless clock protein. Science 285, 1737-1741
    • (1999) Science , vol.285 , pp. 1737-1741
    • Naidoo, N.1    Song, W.2    Hunter-Ensor, M.3    Sehgal, A.4
  • 29
    • 0029161853 scopus 로고
    • Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless
    • Price, J.L., Dembinska, M.E., Young, M.W., and Rosbash, M. (1995) Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless. Embo J. 14, 4044-4049
    • (1995) Embo J , vol.14 , pp. 4044-4049
    • Price, J.L.1    Dembinska, M.E.2    Young, M.W.3    Rosbash, M.4
  • 30
    • 0033199242 scopus 로고    scopus 로고
    • How a circadian clock adapts to seasonal decreases in temperature and day length
    • Majercak, J., Sidote, D., Hardin, P.E., and Edery, I. (1999) How a circadian clock adapts to seasonal decreases in temperature and day length. Neuron 24, 219-230
    • (1999) Neuron , vol.24 , pp. 219-230
    • Majercak, J.1    Sidote, D.2    Hardin, P.E.3    Edery, I.4
  • 32
    • 0037461716 scopus 로고    scopus 로고
    • VRILLE feeds back to control circadian transcription of clock in the Drosophila circadian oscillator
    • Glossop, N.R., Houl, J.H., Zheng, H., Ng, F.S., Dudek, S.M., and Hardin, P.E. (2003) VRILLE feeds back to control circadian transcription of clock in the Drosophila circadian oscillator. Neuron 37, 249-261
    • (2003) Neuron , vol.37 , pp. 249-261
    • Glossop, N.R.1    Houl, J.H.2    Zheng, H.3    Ng, F.S.4    Dudek, S.M.5    Hardin, P.E.6
  • 33
    • 1942480148 scopus 로고    scopus 로고
    • The mammalian circadian clock: A network of gene expression
    • Albrecht, U. (2004) The mammalian circadian clock: a network of gene expression. Front. Biosci. 9, 48-55
    • (2004) Front. Biosci , vol.9 , pp. 48-55
    • Albrecht, U.1
  • 34
    • 0023152057 scopus 로고
    • Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster
    • Yu, Q., Jacquier, A.C., Citri, Y., Kambien, M., Hall, J.C., and Rosbash, M. (1987) Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 84, 784-788
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 784-788
    • Yu, Q.1    Jacquier, A.C.2    Citri, Y.3    Kambien, M.4    Hall, J.C.5    Rosbash, M.6
  • 35
    • 0037069671 scopus 로고    scopus 로고
    • Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
    • Ko, H.W., Jiang, J., and Edery, I. (2002) Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420, 673-678
    • (2002) Nature , vol.420 , pp. 673-678
    • Ko, H.W.1    Jiang, J.2    Edery, I.3
  • 36
    • 0028838141 scopus 로고
    • Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock
    • Curtin, K.D., Huang, Z.J., and Rosbash, M. (1995) Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock. Neuron 14, 365-372
    • (1995) Neuron , vol.14 , pp. 365-372
    • Curtin, K.D.1    Huang, Z.J.2    Rosbash, M.3
  • 37
    • 0037079034 scopus 로고    scopus 로고
    • The F-box protein slimb controls the levels of clock proteins period and timeless
    • Grima, B., Lamouroux, A., Chelot, E., Papin, C., Limbourg-Bouchon, B., and Rouyer, F. (2002) The F-box protein slimb controls the levels of clock proteins period and timeless. Nature 420, 178-182
    • (2002) Nature , vol.420 , pp. 178-182
    • Grima, B.1    Lamouroux, A.2    Chelot, E.3    Papin, C.4    Limbourg-Bouchon, B.5    Rouyer, F.6
  • 38
    • 0034964474 scopus 로고    scopus 로고
    • Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock
    • Kloss, B., Rothenfluh, A., Young, M.W., and Saez, L. (2001) Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron 30, 699-706.
    • (2001) Neuron , vol.30 , pp. 699-706
    • Kloss, B.1    Rothenfluh, A.2    Young, M.W.3    Saez, L.4
  • 39
    • 0033711617 scopus 로고    scopus 로고
    • A TIMELESS-independent function for PERIOD proteins in the Drosophila clock
    • Rothenfluh, A., Young, M.W., and Saez, L. (2000) A TIMELESS-independent function for PERIOD proteins in the Drosophila clock. Neuron 26, 505-514
    • (2000) Neuron , vol.26 , pp. 505-514
    • Rothenfluh, A.1    Young, M.W.2    Saez, L.3
  • 40
    • 0030012253 scopus 로고    scopus 로고
    • Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex
    • Lee, C., Parikh, V., Itsukaichi, T., Bae, K., and Edery, I. (1996) Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex. Science 271, 1740-1744
    • (1996) Science , vol.271 , pp. 1740-1744
    • Lee, C.1    Parikh, V.2    Itsukaichi, T.3    Bae, K.4    Edery, I.5
  • 41
    • 0032805313 scopus 로고    scopus 로고
    • Role of posttranscriptional regulation in circadian clocks: Lessons from Drosophila
    • Edery, I. (1999) Role of posttranscriptional regulation in circadian clocks: lessons from Drosophila. Chronobiol. Int. 16, 377-414
    • (1999) Chronobiol. Int , vol.16 , pp. 377-414
    • Edery, I.1
  • 43
    • 0035883159 scopus 로고    scopus 로고
    • The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA
    • Bao, S., Rihel, J., Bjes, E., Fan, J.Y., and Price, J.L. (2001) The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA. J. Neurosci. 21, 7117-7126
    • (2001) J. Neurosci , vol.21 , pp. 7117-7126
    • Bao, S.1    Rihel, J.2    Bjes, E.3    Fan, J.Y.4    Price, J.L.5
  • 44
    • 20044390202 scopus 로고    scopus 로고
    • The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    • Cyran, S.A., Yiannoulos, G., Buchsbaum, A.M., Saez, L., Young, M.W., and Blau, J. (2005) The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period. J. Neurosci. 25, 5430-5437
    • (2005) J. Neurosci , vol.25 , pp. 5430-5437
    • Cyran, S.A.1    Yiannoulos, G.2    Buchsbaum, A.M.3    Saez, L.4    Young, M.W.5    Blau, J.6
  • 46
    • 30644471172 scopus 로고    scopus 로고
    • In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD
    • Lin, J.M., Schroeder, A., and Allada, R. (2005) In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD. J. Neurosci. 25, 11175-11183
    • (2005) J. Neurosci , vol.25 , pp. 11175-11183
    • Lin, J.M.1    Schroeder, A.2    Allada, R.3
  • 47
    • 0442319504 scopus 로고    scopus 로고
    • The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
    • Nawathean, P. and Rosbash, M. (2004) The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol. Cell. 13, 213-223
    • (2004) Mol. Cell , vol.13 , pp. 213-223
    • Nawathean, P.1    Rosbash, M.2
  • 48
    • 0027564206 scopus 로고
    • Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both
    • Wheeler, D.A., Hamblen-Coyle, M.J., Dushay, M.S., and Hall, J.C. (1993) Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J. Biol. Rhythms 8, 67-94
    • (1993) J. Biol. Rhythms , vol.8 , pp. 67-94
    • Wheeler, D.A.1    Hamblen-Coyle, M.J.2    Dushay, M.S.3    Hall, J.C.4
  • 49
    • 1342285689 scopus 로고    scopus 로고
    • Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    • Sathyanarayanan, S., Zheng, X., Xiao, R., and Sehgal, A. (2004) Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116, 603-615
    • (2004) Cell , vol.116 , pp. 603-615
    • Sathyanarayanan, S.1    Zheng, X.2    Xiao, R.3    Sehgal, A.4
  • 51
    • 17044451254 scopus 로고    scopus 로고
    • A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
    • Allada, R., White, N.B., So, W.V., Hall, J.C., and Rosbash, M. (1998) A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93, 791-804
    • (1998) Cell , vol.93 , pp. 791-804
    • Allada, R.1    White, N.B.2    So, W.V.3    Hall, J.C.4    Rosbash, M.5
  • 52
    • 0031681288 scopus 로고    scopus 로고
    • Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators
    • Bae, K., Lee, C., Sidote, D., Chuang, K.Y., and Edery, I. (1998) Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol. Cell. Biol. 18, 6142-6151
    • (1998) Mol. Cell. Biol , vol.18 , pp. 6142-6151
    • Bae, K.1    Lee, C.2    Sidote, D.3    Chuang, K.Y.4    Edery, I.5
  • 54
    • 0032191902 scopus 로고    scopus 로고
    • The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex
    • Lee, C., Bae, K., and Edery, I. (1998) The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron 21, 857-867
    • (1998) Neuron , vol.21 , pp. 857-867
    • Lee, C.1    Bae, K.2    Edery, I.3
  • 55
    • 33644605957 scopus 로고    scopus 로고
    • Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells
    • Houl, J.H., Yu, W., Dudek, S.M., and Hardin, P.E. (2006) Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J. Biol. Rhythms 21, 93-103
    • (2006) J. Biol. Rhythms , vol.21 , pp. 93-103
    • Houl, J.H.1    Yu, W.2    Dudek, S.M.3    Hardin, P.E.4
  • 56
    • 0042626226 scopus 로고    scopus 로고
    • BMAL1-dependent circadian oscillation of nuclear CLOCK: Posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
    • Kondratov, R.V., Chernov, M.V., Kondratova, A.A., Gorbacheva, V.Y., Gudkov, A.V., and Antoch, M.P. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 17, 1921-1932
    • (2003) Genes Dev , vol.17 , pp. 1921-1932
    • Kondratov, R.V.1    Chernov, M.V.2    Kondratova, A.A.3    Gorbacheva, V.Y.4    Gudkov, A.V.5    Antoch, M.P.6
  • 58
    • 33745101711 scopus 로고    scopus 로고
    • Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription
    • Weber, F., Hung, H.C., Maurer, C., and Kay, S.A. (2006) Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J. Neurochem. 98, 248-257
    • (2006) J. Neurochem , vol.98 , pp. 248-257
    • Weber, F.1    Hung, H.C.2    Maurer, C.3    Kay, S.A.4
  • 59
    • 0029965130 scopus 로고    scopus 로고
    • Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
    • Hunter-Ensor, M., Ousley, A., and Sehgal, A. (1996) -Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light. Cell 84, 677-685
    • (1996) Cell , vol.84 , pp. 677-685
    • Hunter-Ensor, M.1    Ousley, A.2    Sehgal, A.3
  • 60
    • 0029989521 scopus 로고    scopus 로고
    • Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
    • Myers, M.P., Wager-Smith, K., Rothenfluh-Hilfiker, A., and Young, M. W. (1996) Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 271, 1736-1740
    • (1996) Science , vol.271 , pp. 1736-1740
    • Myers, M.P.1    Wager-Smith, K.2    Rothenfluh-Hilfiker, A.3    Young, M.W.4
  • 61
    • 0029979174 scopus 로고    scopus 로고
    • A light-entrainment mechanism for the Drosophila circadian clock
    • Zeng, H., Qian, Z., Myers, M.P., and Rosbash, M. (1996) A light-entrainment mechanism for the Drosophila circadian clock. Nature 380, 129-135
    • (1996) Nature , vol.380 , pp. 129-135
    • Zeng, H.1    Qian, Z.2    Myers, M.P.3    Rosbash, M.4
  • 62
    • 0035875069 scopus 로고    scopus 로고
    • A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
    • Martinek, S., Inonog, S., Manoukian, A.S., and Young, M.W. (2001) A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell 105, 769-779
    • (2001) Cell , vol.105 , pp. 769-779
    • Martinek, S.1    Inonog, S.2    Manoukian, A.S.3    Young, M.W.4
  • 63
    • 33745503975 scopus 로고    scopus 로고
    • JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS
    • Koh, K., Zheng, X., and Sehgal, A. (2006) JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 312, 1809-1812
    • (2006) Science , vol.312 , pp. 1809-1812
    • Koh, K.1    Zheng, X.2    Sehgal, A.3
  • 65
    • 21544433803 scopus 로고    scopus 로고
    • Serotonin modulates circadian entrainment in Drosophila
    • Yuan, Q., Lin, F., Zheng, X., and Sehgal, A. (2005) Serotonin modulates circadian entrainment in Drosophila. Neuron 47, 115-127
    • (2005) Neuron , vol.47 , pp. 115-127
    • Yuan, Q.1    Lin, F.2    Zheng, X.3    Sehgal, A.4
  • 66
    • 0032752042 scopus 로고    scopus 로고
    • Forty years of PRCs-what have we learned?
    • Johnson, C.H. (1999) Forty years of PRCs-what have we learned? Chronobiol. Int. 16, 711-743
    • (1999) Chronobiol. Int , vol.16 , pp. 711-743
    • Johnson, C.H.1
  • 67
    • 17244373578 scopus 로고    scopus 로고
    • Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro
    • Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., and Kondo, T. (2005) Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro. Science 308, 414-415
    • (2005) Science , vol.308 , pp. 414-415
    • Nakajima, M.1    Imai, K.2    Ito, H.3    Nishiwaki, T.4    Murayama, Y.5    Iwasaki, H.6    Oyama, T.7    Kondo, T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.