Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells

Journal of Biological Rhythms

Volumn 21, Issue 2, 2006, Pages 93-103

  Houl, Jerry H ^a   Yu, Wangjie ^a   Dudek, Scott M ^a,b   Hardin, Paul E ^a,c  

^a UNIVERSITY OF HOUSTON   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Circadian; CLOCK; Drosophila; Non oscillator cells; Oscillator cells

Indexed keywords

ANTIBODY; CLK ANTIBODY; PER1 PROTEIN; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

ARTICLE; BEHAVIOR; BODY ARMOR; BRAIN; CELL NUCLEUS; CIRCADIAN RHYTHM; GENE EXPRESSION; HEAD; IMMUNOREACTIVITY; LEARNING; MEMORY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; BRAIN; CELL NUCLEUS; CIRCADIAN RHYTHM; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; OSCILLOMETRY; PROTEIN BINDING; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 33644605957     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748730405283697     Document Type: Article

References (44)

1. Allada R, White NE, So WV, Hall JC, and Rosbash M (1998) A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell 93:791-804.
2. Amir S and Stewart J (1996) Resetting of the circadian clock by a conditioned stimulus. Nature 379:542-545.
3. Andretic R, Chaney S, and Hirsh J (1999) Requirement of circadian genes for cocaine sensitization in Drosophila. Science 285:1066-1068.
4. Bell-Pedersen D, Cassone VM, Earnest DJ, Golden SS, Hardin PE, Thomas TL, and Zoran MJ (2005) Circadian rhythms from multiple oscillators: Lessons from diverse species. Nat Rev Genet 6:544-556.
5. Belvin MP, Zhou H, and Yin JC (1999) The Drosophila dCREB2 gene affects the circadian clock. Neuron 22:777-787.
6. Blanchardon E, Grima B, Klarsfeld A, Chelot E, Hardin PE, Preat T, and Rouyer F (2001) Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur J Neurosci 13:871-888.
7. Blau J and Young MW (1999) Cycling vrille expression is required for a functional Drosophila clock. Cell 99:661-671.
8. Callaerts P, Leng S, Clements J, Benassayag C, Cribbs D, Kang YY, Walldorf U, Fischbach KF, and Strauss R (2001) Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. J Neurobiol 46:73-88.
9. Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M, and Kay SA (2002) Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci 22:9305-9319.
10. Cheng Y and Hardin PE (1998) Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling. J Neurosci 18:741-750.
11. Claridge-Chang A, Wijnen H, Naef F, Boothroyd C, Rajewsky N, and Young MW (2001) Circadian regulation of gene expression systems in the Drosophila head. Neuron 32:657-671.
12. Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, Young MW, Storti RV, and Blau J (2003) vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell 112:329-341.
13. Darlington TK, Wager-Smith K, Ceriani MF, Staknis D, Gekakis N, Steeves TD, Weitz CJ, Takahashi JS, and Kay SA (1998) Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280:1599-1603.
14. Edery I, Zwiebel LJ, Dembinska ME, and Rosbash M (1994) Temporal phosphorylation of the Drosophila period protein. Proc Natl Acad Sci USA 91:2260-2264.
15. Fernandez RI, Lyons LC, Levenson J, Khabour O, and Eskin A (2003) Circadian modulation of long-term sensitization in Aplysia. Proc Natl Acad Sci USA 100:14415-14420.
16. Garcia JA, Zhang D, Estill SJ, Michnoff C, Rutter J, Reick M, Scott K, Diaz-Arrastia R, and McKnight SL (2000) Impaired cued and contextual memory in NPAS2-deficient mice. Science 288:2226-2230.
17. Glossop NR and Hardin PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J Cell Sci 115:3369-3377.
18. Glossop NR, Houl JH, Zheng H, Ng FS, Dudek SM, and Hardin PE (2003) VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron 37:249-261.
19. Hao H, Glossop NR, Lyons L, Qiu J, Morrish B, Cheng Y, Helfrich-Forster C, and Hardin P (1999) The 69 bp circadian regulatory sequence (CRS) mediates per-like developmental, spatial, and circadian expression and behavioral rescue in Drosophila. J Neurosci 19:987-994.
20. Hardin PE (2004) Transcription regulation within the circadian clock: The E-box and beyond. J Biol Rhythms 19:348-360.
21. Heisenberg M (2003) Mushroom body memoir: From maps to models. Nat Rev Neurosci 4:266-275.
22. Helfrich-Forster C (1995) The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster. Proc Natl Acad Sci USA 92:612-616.
23. Helfrich-Forster C (2003) The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster. Microsc Res Tech 62:94-102.
24. Helfrich-Forster C, Wulf J, and de Belle JS (2002) Mushroom body influence on locomotor activity and circadian rhythms in Drosophila melanogaster. J Neurogenet 16:73-109.
25. Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, and Sehgal A (2003) Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms 18:12-25.
26. Kaneko M and Hall JC (2000) Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J Comp Neurol 422:66-94.
27. Kim EY, Bae K, Ng FS, Glossop NR, Hardin PE, and Edery I (2002) Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron 34:69-81.
28. Kondratov RV, Chernov MV, Kondratova AA, Gorbacheva VY, Gudkov AV, and Antoch MP (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: Posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev 17:1921-1932.
29. Lee C, Bae K, and Edery I (1998) The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron 21:857-867.
30. Lee C, Bae K, and Edery I (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription. Mol Cell Biol 19:5316-5325.
31. Lee C, Etchegaray JP, Cagampang FR, Loudon AS, and Reppert SM (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107:855-867.
32. Lin Y, Han M, Shimada B, Wang L, Gibler TM, Amarakone A, Awad TA, Stormo GD, Van Gelder RN, and Taghert PH (2002) Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster. Proc Natl Acad Sci USA 99:9562-9567.
33. Mardon G, Solomon NM, and Rubin GM (1994) dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. Development 120:3473-3486.
34. McBride SM, Giuliani G, Choi C, Krause P, Correale D, Watson K, Baker G, and Siwicki KK (1999) Mushroom body ablation impairs short-term memory and long-term memory of courtship conditioning in Drosophila melanogaster. Neuron 24:967-977.
35. McDonald MJ and Rosbash M (2001) Microarray analysis and organization of circadian gene expression in Drosophila. Cell 107:567-578.
36. Park JH, Helfrich-Forster C, Lee G, Liu L, Rosbash M, and Hall JC (2000) Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci USA 97:3608-3613.
37. Reick M, Garcia JA, Dudley C, and McKnight SL (2001) NPAS2: An analog of clock operative in the mammalian forebrain. Science 293:506-509.
38. Rutila JE, Suri V, Le M, So WV, Rosbash M, and Hall JC (1998) CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell 93:805-814.
39. Sakai T, Tamura T, Kitamoto T, and Kidokoro Y (2004) A clock gene, period, plays a key role in long-term memory formation in Drosophila. Proc Natl Acad Sci USA 101:16058-16063.
40. Shaw PJ, Tononi G, Greenspan RJ, and Robinson DF (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417:287-291.
41. Ueda HR, Matsumoto A, Kawamura M, Iino M, Tanimura T, and Hashimoto S (2002) Genome-wide transcriptional orchestration of circadian rhythms in Drosophila. J Biol Chem 277:14048-14052.
42. Yin JC and Tully T (1996) CREB and the formation of long-term memory. Curr Opin Neurobiol 6:264-268.
43. Zars T (2000) Behavioral functions of the insect mushroom bodies. Curr Opin Neurobiol 10:790-795.
44. Zerr DM, Hall JC, Rosbash M, and Siwicki KK (1990) Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila. J Neurosci 10:2749-2762.