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Volumn 85, Issue 1, 2007, Pages 55-59

Immunoepigenetics: The unseen side of cancer immunoediting

Author keywords

DNA methylation; Epigenetic drugs; Immune escape; Immunoediting; Immunoepigenetics; Immunosurveillance

Indexed keywords

ALLELE; ARTICLE; CANCER CELL; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CANCER RESISTANCE; CANCER RISK; CARCINOGENESIS; DNA METHYLATION; DNA POLYMORPHISM; DRUG TREATMENT FAILURE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE FUNCTION; GENE LOCUS; HOST; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENCE; IMMUNOGENETICS; IMMUNOGENICITY; IMMUNOSURVEILLANCE; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; RNA EDITING; TUMOR ESCAPE; TUMOR IMMUNITY; TUMOR RESISTANCE;

EID: 33846089959     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100006     Document Type: Article
Times cited : (26)

References (74)
  • 1
  • 2
    • 4644293572 scopus 로고    scopus 로고
    • Cancer immunotherapy: Breaking the barriers to harvest the crop
    • Pardoll D, Allison J. Cancer immunotherapy: breaking the barriers to harvest the crop. Nat Med 2004; 10: 887-892.
    • (2004) Nat Med , vol.10 , pp. 887-892
    • Pardoll, D.1    Allison, J.2
  • 3
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004; 10: 909-913.
    • (2004) Nat Med , vol.10 , pp. 909-913
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 4
    • 5044220448 scopus 로고    scopus 로고
    • The critical role of type-1 innate and acquired immunity in tumor immunotherapy
    • Ikeda H, Chamoto K, Tsuji T, Suzuki Y, Wakita D, Takeshima T et al. The critical role of type-1 innate and acquired immunity in tumor immunotherapy. Cancer Sci 2004; 95: 697-703.
    • (2004) Cancer Sci , vol.95 , pp. 697-703
    • Ikeda, H.1    Chamoto, K.2    Tsuji, T.3    Suzuki, Y.4    Wakita, D.5    Takeshima, T.6
  • 6
    • 0030272703 scopus 로고    scopus 로고
    • Is cancer dangerous to the immune system?
    • Fuchs EJ, Matzinger P. Is cancer dangerous to the immune system? Semin Immunol 1996; 8: 271-280.
    • (1996) Semin Immunol , vol.8 , pp. 271-280
    • Fuchs, E.J.1    Matzinger, P.2
  • 7
    • 14844345227 scopus 로고    scopus 로고
    • CD4+ Tregs and immune control
    • Fehervari Z, Sakaguchi S. CD4+ Tregs and immune control. J Clin Invest 2004; 114: 1209-1217.
    • (2004) J Clin Invest , vol.114 , pp. 1209-1217
    • Fehervari, Z.1    Sakaguchi, S.2
  • 8
    • 0038730996 scopus 로고    scopus 로고
    • Heterogeneity of CD4+ and CD8+ T cells
    • Woodland DL, Dutton RW. Heterogeneity of CD4+ and CD8+ T cells. Curr Opin Immunol 2003; 15: 336-342.
    • (2003) Curr Opin Immunol , vol.15 , pp. 336-342
    • Woodland, D.L.1    Dutton, R.W.2
  • 9
    • 18844372332 scopus 로고    scopus 로고
    • Understanding the generation and function of memory T cell subsets
    • Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005; 17: 326-332.
    • (2005) Curr Opin Immunol , vol.17 , pp. 326-332
    • Lanzavecchia, A.1    Sallusto, F.2
  • 10
    • 18844447815 scopus 로고    scopus 로고
    • Human tumor-specific T lymphocytes: Does function matter more than number?
    • Coulie PG, Connerotte T. Human tumor-specific T lymphocytes: does function matter more than number? Curr Opin Immunol 2005; 17: 320-325.
    • (2005) Curr Opin Immunol , vol.17 , pp. 320-325
    • Coulie, P.G.1    Connerotte, T.2
  • 11
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • Smyth MJ, Godfrey DI, Trapani JA. A fresh look at tumor immunosurveillance and immunotherapy. Nat Immunol 2001; 2: 293-299.
    • (2001) Nat Immunol , vol.2 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 12
    • 0036903228 scopus 로고    scopus 로고
    • Principles of tumor immunosurveillance and implications for immunotherapy
    • Ochsenbein AF. Principles of tumor immunosurveillance and implications for immunotherapy. Cancer Gene Ther 2002; 9: 1043-1055.
    • (2002) Cancer Gene Ther , vol.9 , pp. 1043-1055
    • Ochsenbein, A.F.1
  • 13
    • 1542357603 scopus 로고    scopus 로고
    • Tumour escape: Antitumour effectors too much of a good thing?
    • Pawelec G. Tumour escape: antitumour effectors too much of a good thing? Cancer Immunol Immunother 2004; 53: 262-274.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 262-274
    • Pawelec, G.1
  • 14
    • 0029787726 scopus 로고    scopus 로고
    • Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice
    • Svane IM, Engel AM, Nielsen MB, Ljunggren HG, Rygaard J, Werdelin O. Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice. Eur J Immunol 1996; 26: 1844-1850.
    • (1996) Eur J Immunol , vol.26 , pp. 1844-1850
    • Svane, I.M.1    Engel, A.M.2    Nielsen, M.B.3    Ljunggren, H.G.4    Rygaard, J.5    Werdelin, O.6
  • 15
    • 0031004968 scopus 로고    scopus 로고
    • MCA sarcomas induced in Scid mice are more immunogenic than MCA sarcomas induced in congenic immunocompetent mice
    • Engel AM, Svane IM, Rygaard J, Werdelin O. MCA sarcomas induced in Scid mice are more immunogenic than MCA sarcomas induced in congenic immunocompetent mice. Scand J Immunol 1997; 45: 463-470.
    • (1997) Scand J Immunol , vol.45 , pp. 463-470
    • Engel, A.M.1    Svane, I.M.2    Rygaard, J.3    Werdelin, O.4
  • 16
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran V, Ikeda H, Bruce AT, White JM, Swanson PE, Old LJ et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-1111.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6
  • 17
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396: 643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 18
    • 0032842878 scopus 로고    scopus 로고
    • Selective MHC expression in tumours modulates adaptive and innate antitumour responses
    • Rees RC, Mian S. Selective MHC expression in tumours modulates adaptive and innate antitumour responses. Cancer Immunol Immunother 1999; 48: 374-381.
    • (1999) Cancer Immunol Immunother , vol.48 , pp. 374-381
    • Rees, R.C.1    Mian, S.2
  • 19
    • 22144444216 scopus 로고    scopus 로고
    • Type I interferon and cancer immunoediting
    • Smyth MJ. Type I interferon and cancer immunoediting. Nat Immunol 2005; 7: 646-648.
    • (2005) Nat Immunol , vol.7 , pp. 646-648
    • Smyth, M.J.1
  • 22
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004; 21: 137-148.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 23
    • 21844459726 scopus 로고    scopus 로고
    • Cancer Vaccines 2004 opening address: The molecular and cellular basis of cancer immunosurveillance and immunoediting
    • Schreiber RD. Cancer Vaccines 2004 opening address: the molecular and cellular basis of cancer immunosurveillance and immunoediting. Cancer Immunity 2005; 5 (Suppl 1): 1-8.
    • (2005) Cancer Immunity , vol.5 , Issue.SUPPL. 1 , pp. 1-8
    • Schreiber, R.D.1
  • 25
    • 2442677370 scopus 로고    scopus 로고
    • Polymorphism in clinical immunology - from HLA typing to immunogenetic profiling
    • Jin P, Wang E. Polymorphism in clinical immunology - from HLA typing to immunogenetic profiling. J Translation Med 2003; 1: 8.
    • (2003) J Translation Med , vol.1 , pp. 8
    • Jin, P.1    Wang, E.2
  • 27
    • 4744348510 scopus 로고    scopus 로고
    • Down-regulation of ζ-chain expression in T-cells: A biomarker of prognosis in cancer?
    • Whiteside TL. Down-regulation of ζ-chain expression in T-cells: a biomarker of prognosis in cancer? Cancer Immunol Immunother 2004; 53: 865-878.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 865-878
    • Whiteside, T.L.1
  • 28
    • 0742286835 scopus 로고    scopus 로고
    • Mutations and regulatory anomalies effecting tumor cell immune functions
    • Blanck G. Mutations and regulatory anomalies effecting tumor cell immune functions. Cancer Immunol Immunother 2004; 53: 1-16.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 1-16
    • Blanck, G.1
  • 29
    • 0142216237 scopus 로고    scopus 로고
    • DNA methylation in the immune system
    • Teitell M, Richardson B. DNA methylation in the immune system. Clin Immunol 2003; 109: 2-5.
    • (2003) Clin Immunol , vol.109 , pp. 2-5
    • Teitell, M.1    Richardson, B.2
  • 30
    • 0142216213 scopus 로고    scopus 로고
    • Methylation and demethylation in the regulation of genes, cells, and responses in the immune system
    • Fitzpatrick DR, Wilson CB. Methylation and demethylation in the regulation of genes, cells, and responses in the immune system. Clin Immunol 2003; 109: 37-45.
    • (2003) Clin Immunol , vol.109 , pp. 37-45
    • Fitzpatrick, D.R.1    Wilson, C.B.2
  • 31
    • 17444382745 scopus 로고    scopus 로고
    • Epigenetic control in the immune response
    • Reiner SL. Epigenetic control in the immune response. Hum Mol Genet 2005; 14: R41-R46.
    • (2005) Hum Mol Genet , vol.14
    • Reiner, S.L.1
  • 32
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004; 4: 143-153.
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 33
    • 17444417521 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Laird PW. Cancer epigenetics. Hum Mol Genet 2005; 14: R65-R76.
    • (2005) Hum Mol Genet , vol.14
    • Laird, P.W.1
  • 34
    • 21844446596 scopus 로고    scopus 로고
    • Overview of cancer epigenetics
    • Jones PA. Overview of cancer epigenetics. Semin Hematol 2005; 42: S3-S8.
    • (2005) Semin Hematol , vol.42
    • Jones, P.A.1
  • 35
    • 24144437770 scopus 로고    scopus 로고
    • Silencing of genes by promoter hypermethylation: Key event in rodent and human lung cancer
    • Belinsky SA. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 2005; 26: 1481-1487.
    • (2005) Carcinogenesis , vol.26 , pp. 1481-1487
    • Belinsky, S.A.1
  • 36
    • 0036216109 scopus 로고    scopus 로고
    • Chromatin structure and gene regulation in the immune system
    • Smale ST, Fisher AG. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol 2002; 20: 427-462.
    • (2002) Annu Rev Immunol , vol.20 , pp. 427-462
    • Smale, S.T.1    Fisher, A.G.2
  • 38
    • 17644414480 scopus 로고    scopus 로고
    • Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer
    • Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF et al. Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 2005; 11: 2466-2470.
    • (2005) Clin Cancer Res , vol.11 , pp. 2466-2470
    • Russo, A.L.1    Thiagalingam, A.2    Pan, H.3    Califano, J.4    Cheng, K.H.5    Ponte, J.F.6
  • 39
    • 0034492545 scopus 로고    scopus 로고
    • Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation
    • Walker PR, Calzascia T, Schnuriger V, Chalmers D, Saas P, Dietrich P-Y. Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation. Cell Immunol 2000; 206: 51-58.
    • (2000) Cell Immunol , vol.206 , pp. 51-58
    • Walker, P.R.1    Calzascia, T.2    Schnuriger, V.3    Chalmers, D.4    Saas, P.5    Dietrich, P.-Y.6
  • 40
    • 0035004527 scopus 로고    scopus 로고
    • Cancer and autoimmunity: Autoimmune and rheumatic features in patients with malignancies
    • Abu-Shakra M, Buskila D, Ehrenfeld M, Conrad K, Shoenfeld Y. Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies. Ann Rheum Dis 2001; 60: 433-440.
    • (2001) Ann Rheum Dis , vol.60 , pp. 433-440
    • Abu-Shakra, M.1    Buskila, D.2    Ehrenfeld, M.3    Conrad, K.4    Shoenfeld, Y.5
  • 41
    • 0242521341 scopus 로고    scopus 로고
    • Relative paradigms between autoantibodies in lupus and autoantibodies in cancer
    • Tan EM, Shi F-D. Relative paradigms between autoantibodies in lupus and autoantibodies in cancer. Clin Exp Immunol 2003; 134: 169-177.
    • (2003) Clin Exp Immunol , vol.134 , pp. 169-177
    • Tan, E.M.1    Shi, F.-D.2
  • 42
    • 0034885644 scopus 로고    scopus 로고
    • Rheumatic diseases and malignancy - is there an association?
    • Leandro MJ, Isenberg DA. Rheumatic diseases and malignancy - is there an association? Scand J Rheumatol 2001; 30: 185-188.
    • (2001) Scand J Rheumatol , vol.30 , pp. 185-188
    • Leandro, M.J.1    Isenberg, D.A.2
  • 43
    • 3342981630 scopus 로고    scopus 로고
    • Systemic autoimmune diseases in elderly patients: Atypical presentation and association with neoplasia
    • Ramos-Casals M, Brito-Zerón P, López-Soto A, Font J. Systemic autoimmune diseases in elderly patients: atypical presentation and association with neoplasia. Autoimmun Rev 2004; 3: 376-382.
    • (2004) Autoimmun Rev , vol.3 , pp. 376-382
    • Ramos-Casals, M.1    Brito-Zerón, P.2    López-Soto, A.3    Font, J.4
  • 44
    • 0142247168 scopus 로고    scopus 로고
    • DNA methylation and autoimmune disease
    • Richardson B. DNA methylation and autoimmune disease. Clin Immunol 2003; 109: 72-79.
    • (2003) Clin Immunol , vol.109 , pp. 72-79
    • Richardson, B.1
  • 45
    • 2942755745 scopus 로고    scopus 로고
    • Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus
    • Januchowski R, Prokop J, Jagodzinski PP. Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus. J Appl Genet 2004; 45: 237-248.
    • (2004) J Appl Genet , vol.45 , pp. 237-248
    • Januchowski, R.1    Prokop, J.2    Jagodzinski, P.P.3
  • 46
    • 0036328026 scopus 로고    scopus 로고
    • Role of DNA methylation in the regulation of cell function: Autoimmunity, aging and cancer
    • Richardson BC. Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J Nutr 2002; 132: 2401S-2405S.
    • (2002) J Nutr , vol.132
    • Richardson, B.C.1
  • 48
    • 0042565930 scopus 로고    scopus 로고
    • The potential contributions of chronic inflammation to lung carcinogenesis
    • Ballaz S, Mulshine JL. The potential contributions of chronic inflammation to lung carcinogenesis. Clin Lung Cancer 2003; 5: 46-62.
    • (2003) Clin Lung Cancer , vol.5 , pp. 46-62
    • Ballaz, S.1    Mulshine, J.L.2
  • 49
    • 4043081982 scopus 로고    scopus 로고
    • Helicobacter pylori and molecular events in precancerous gastric lesions
    • Nardone G, Rocco A, Malfertheiner P. Helicobacter pylori and molecular events in precancerous gastric lesions. Aliment Pharmacol Ther 2004; 20: 261-270.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 261-270
    • Nardone, G.1    Rocco, A.2    Malfertheiner, P.3
  • 50
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res 2001; 61: 3573-3577.
    • (2001) Cancer Res , vol.61 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 51
    • 0242692456 scopus 로고    scopus 로고
    • Molecular pathways to prostate cancer
    • Gonzalgo ML, Issacs WB. Molecular pathways to prostate cancer. J Urol 2003; 170: 2444-2452.
    • (2003) J Urol , vol.170 , pp. 2444-2452
    • Gonzalgo, M.L.1    Issacs, W.B.2
  • 52
    • 20044369539 scopus 로고    scopus 로고
    • Aberrant methylations in cancer cells: Where do they come from?
    • Ushijima T, Okochi-Takada E. Aberrant methylations in cancer cells: where do they come from? Cancer Sci 2005; 96: 206-211.
    • (2005) Cancer Sci , vol.96 , pp. 206-211
    • Ushijima, T.1    Okochi-Takada, E.2
  • 53
    • 0142169940 scopus 로고    scopus 로고
    • Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: Antioxidant therapeutic targets
    • Rahman I. Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. Curr Drug Targets Inflamm Allergy 2002; 1: 291-315.
    • (2002) Curr Drug Targets Inflamm Allergy , vol.1 , pp. 291-315
    • Rahman, I.1
  • 55
    • 0037068351 scopus 로고    scopus 로고
    • Gene silencing in mammalian cells and the spread of DNA methylation
    • Turker MS. Gene silencing in mammalian cells and the spread of DNA methylation. Oncogene 2002; 21: 5388-5393.
    • (2002) Oncogene , vol.21 , pp. 5388-5393
    • Turker, M.S.1
  • 56
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001; 293: 1068-1070.
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 57
    • 0028662430 scopus 로고
    • Uptake of foreign DNA by mammalian cells via the gastrointestinal tract in mice: Methylation of foreign DNA - a cellular defense mechanism
    • Doerfler W. Uptake of foreign DNA by mammalian cells via the gastrointestinal tract in mice: methylation of foreign DNA - a cellular defense mechanism. Curr Top Microbiol Immunol 1995; 197: 209-224.
    • (1995) Curr Top Microbiol Immunol , vol.197 , pp. 209-224
    • Doerfler, W.1
  • 58
    • 0035958048 scopus 로고    scopus 로고
    • Foreign DNA integration. Genome-wide perturbations of methylation and transcription in the recipient genomes
    • Muller K, Heller H, Doerfler W. Foreign DNA integration. Genome-wide perturbations of methylation and transcription in the recipient genomes. J Mol Biol 2001; 276: 14271-14278.
    • (2001) J Mol Biol , vol.276 , pp. 14271-14278
    • Muller, K.1    Heller, H.2    Doerfler, W.3
  • 59
    • 0036868960 scopus 로고    scopus 로고
    • Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma
    • Osawa T, Chong JM, Sudo M, Sakuma K, Uozaki H, Shibahara J et al. Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma. Jpn J Cancer Res 2002; 93: 1195-1200.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1195-1200
    • Osawa, T.1    Chong, J.M.2    Sudo, M.3    Sakuma, K.4    Uozaki, H.5    Shibahara, J.6
  • 60
    • 0036121312 scopus 로고    scopus 로고
    • Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    • Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 2002; 160: 787-794.
    • (2002) Am J Pathol , vol.160 , pp. 787-794
    • Kang, G.H.1    Lee, S.2    Kim, W.H.3    Lee, H.W.4    Kim, J.C.5    Rhyu, M.G.6
  • 61
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - a comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 2000; 32: 970-979.
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 62
    • 0037463277 scopus 로고    scopus 로고
    • CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection
    • Matsukura S, Soejima H, Nakagawachi T, Yakushiji H, Ogawa A, Fukuhara M et al. CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Br J Cancer 2003; 88: 521-529.
    • (2003) Br J Cancer , vol.88 , pp. 521-529
    • Matsukura, S.1    Soejima, H.2    Nakagawachi, T.3    Yakushiji, H.4    Ogawa, A.5    Fukuhara, M.6
  • 63
    • 4344635044 scopus 로고    scopus 로고
    • Identification of aberrantly methylated genes in association with adult T-cell leukemia
    • Yasunaga J, Taniguchi Y, Nosaka K, Yoshida M, Satou Y, Sakai T et al. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res 2004; 64: 6002-6009.
    • (2004) Cancer Res , vol.64 , pp. 6002-6009
    • Yasunaga, J.1    Taniguchi, Y.2    Nosaka, K.3    Yoshida, M.4    Satou, Y.5    Sakai, T.6
  • 65
    • 0141792797 scopus 로고    scopus 로고
    • Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: Two case reports
    • Sugimori C, Kaito K, Nakao S. Persistent remission after immunosuppressive therapy of hairy cell leukemia mimicking aplastic anemia: two case reports. Int J Hematol 2003; 77: 391-394.
    • (2003) Int J Hematol , vol.77 , pp. 391-394
    • Sugimori, C.1    Kaito, K.2    Nakao, S.3
  • 66
    • 1642453610 scopus 로고    scopus 로고
    • New agents in acute myeloid leukemia and other myeloid disorders
    • Ravandi F, Kantarjian H, Giles F, Cortes J. New agents in acute myeloid leukemia and other myeloid disorders. Cancer 2004; 100: 441-454.
    • (2004) Cancer , vol.100 , pp. 441-454
    • Ravandi, F.1    Kantarjian, H.2    Giles, F.3    Cortes, J.4
  • 67
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004; 429: 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 68
    • 0038747956 scopus 로고    scopus 로고
    • Relevance of DNA methylation in the management of cancer
    • Esteller M. Relevance of DNA methylation in the management of cancer. Lancet Oncol 2003; 4: 351-358.
    • (2003) Lancet Oncol , vol.4 , pp. 351-358
    • Esteller, M.1
  • 70
    • 0038677615 scopus 로고    scopus 로고
    • Epigenetic silencing of multiple interferon pathway genes after cellular immortalization
    • Kulaeva OI, Draghici S, Tang L, Kraniak JM, Land SJ, Tainsky MA. Epigenetic silencing of multiple interferon pathway genes after cellular immortalization. Oncogene 2003; 22: 4118-4127.
    • (2003) Oncogene , vol.22 , pp. 4118-4127
    • Kulaeva, O.I.1    Draghici, S.2    Tang, L.3    Kraniak, J.M.4    Land, S.J.5    Tainsky, M.A.6
  • 71
    • 3442883892 scopus 로고    scopus 로고
    • Modern criteria to establish human cancer etiology
    • Carbone M, Klein G, Gruber J, Wong M. Modern criteria to establish human cancer etiology. Cancer Res 2004; 64: 5518-5524.
    • (2004) Cancer Res , vol.64 , pp. 5518-5524
    • Carbone, M.1    Klein, G.2    Gruber, J.3    Wong, M.4
  • 74
    • 2342657444 scopus 로고    scopus 로고
    • Genetics, epigenetics, and the environment: Switching, buffering, releasing
    • Vercelli D. Genetics, epigenetics, and the environment: switching, buffering, releasing. J Allergy Clin Immunol 2004; 113: 381-386.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 381-386
    • Vercelli, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.