Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2

Infection and Immunity

Volumn 75, Issue 1, 2007, Pages 164-174

  Kida, Yutaka ^a   Inoue, Hiroyoshi ^a   Shimizu, Takashi ^a   Kuwano, Koichi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PEPTIDE; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; RECEPTOR BLOCKING AGENT; SERRALYSIN; TRYPSIN; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CANCER CELL CULTURE; CARCINOMA CELL; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; HELA CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SERRATIA MARCESCENS; SQUAMOUS CELL CARCINOMA;

CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HELA CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; METALLOENDOPEPTIDASES; NF-KAPPA B; PROMOTER REGIONS (GENETICS); RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERRATIA MARCESCENS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 33845995107     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01239-06     Document Type: Article

References (63)

1. Adam, E., K. K. Hansen, O. F. Astudillo, L. Coulon, F. Bex, X. Duhant, E. Jaumotte, M. D. Hollenberg, and A. Jacquet. 2006. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J. Biol. Chem. 281:6910-6923.
2. Al-Ani, B., M. Saifeddine, S. J. Wijesuriya, and M. D. Hollenberg. 2002. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J. Pharmacol. Exp. Ther. 300:702-708.
3. Albers, M. J., J. W. Mouton, and D. Tibboel. 2001. Colonization and infection by Serratia species in a paediatric surgical intensive care unit. J. Hosp. Infect. 48:7-12.
4. Asokananthan, N., P. T. Graham, D. J. Stewart, A. J. Bakker, K. A. Eidne, P. J. Thompson, and G. A. Stewart. 2002. House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J. Immunol. 169:4572-4578.
5. Aucken, H. M., and T. L. Pitt. 1998. Antibiotic resistance and putative virulence factors of Serratia marcescens with respect to O and K serotypes. J. Med. Microbiol. 47:1105-1113.
6. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87: 13-20.
7. Belas, R., J. Manos, and R. Suvanasuthi. 2004. Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptides. Infect. Immun. 72:5159-5167.
8. Bohm, S. K., W. Kong, D. Bromme, S. P. Smeekens, D. C. Anderson, A. Connolly, M. Kahn, N. A. Nelken, S. R. Coughlin, D. G. Payan, and N. W. Bunnett. 1996. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314(Pt. 3):1009-1016.
9. Borger, P., G. H. Koeter, J. A. Timmerman, E. Vellenga, J. F. Tomee, and H. F. Kauffman. 1999. Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J. Infect. Dis. 180:1267-1274.
10. Bosi, C., A. Davin-Regli, R. Charrel, B. Rocca, D. Monnet, and C. Bollet. 1996. Serratia marcescens nosocomial outbreak due to contamination of hexetidine solution. J. Hosp. Infect. 33:217-224.
11. Cenac, N., A. M. Coelho, C. Nguyen, S. Compton, P. Andrade-Gordon, W. K. MacNaughton, J. L. Wallace, M. D. Hollenberg, N. W. Bunnett, R. Garcia-Villar, L. Bueno, and N. Vergnolle. 2002. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am. J. Pathol. 161:1903-1915.
12. Chung, W. O., S. R. Hansen, D. Rao, and B. A. Dale. 2004. Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J. Immunol. 173:5165-5170.
13. Compton, S. J., B. Renaux, S. J. Wijesuriya, and M. D. Hollenberg. 2001. Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase. Br. J. Pharmacol. 134:705-718.
14. Compton, S. J., S. Sandhu, S. J. Wijesuriya, and M. D. Hollenberg. 2002. Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling. Biochem. J. 368:495-505.
15. Dery, O., C. U. Corvera, M. Steinhoff, and N. W. Bunnett. 1998. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 274:C1429-C1452.
16. Dulon, S., D. Leduc, G. S. Cottrell, J. D'Alayer, K. K. Hansen, N. W. Bunnett, M. D. Hollenberg, D. Pidard, and M. Chignard. 2005. Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. Am. J. Respir. Cell Mol. Biol. 32:411-419.
17. Ferrell, W. R., J. C. Lockhart, E. B. Kelso, L. Dunning, R. Plevin, S. E. Meek, A. J. Smith, G. D. Hunter, J. S. McLean, F. McGarry, R. Ramage, L. Jiang, T. Kanke, and J. Kawagoe. 2003. Essential role for proteinase-activated receptor-2 in arthritis. J. Clin. Investig. 111:35-41.
18. Goullet, P., and B. Picard. 1997. An epidemiological study of Serratia marcescens isolates from nosocomial infections by enzyme electrophoresis. J. Med. Microbiol. 46:1019-1028.
19. Hamamoto, K., Y. Kida, Y. Zhang, T. Shimizu, and K. Kuwano. 2002. Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D-amino acid substitutions. Microbiol. Immunol. 46:741-749.
20. Hansen, K. K., P. M. Sherman, L. Cellars, P. Andrade-Gordon, Z. Pan, A. Baruch, J. L. Wallace, M. D. Hollenberg, and N. Vergnolle. 2005. A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc. Natl. Acad. Sci. USA 102:8363-8368.
21. Hejazi, A., and F. R. Falkiner. 1997. Serratia marcescens. J. Med. Microbiol. 46:903-912.
22. Hines, D. A., P. N. Saurugger, G. M. Ihler, and M. J. Benedik. 1988. Genetic analysis of extracellular proteins of Serratia marcescens. J. Bacteriol. 170: 4141-4146.
23. Hollenberg, M. D., and S. J. Compton. 2002. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol. Rev. 54:203-217.
24. Hou, L., G. L. Howells, S. Kapas, and M. G. Macey. 1998. The protease-activated receptors and their cellular expression and function in blood-related cells. Br. J. Haematol. 101:1-9.
25. Howells, G. L., M. G. Macey, C. Chinni, L. Hou, M. T. Fox, P. Harriott, and S. R. Stone. 1997. Proteinase-activated receptor-2: expression by human neutrophils. J. Cell Sci. 110(Pt. 7):881-887.
26. Kamata, R., K. Matsumoto, R. Okamura, T. Yamamoto, and H. Maeda. 1985. The serratial 56K protease as a major pathogenic factor in serratial keratitis. Clinical and experimental study. Ophthalmology 92:1452-1459.
27. Kanke, T., S. R. Macfarlane, M. J. Seatter, E. Davenport, A. Paul, R. C. McKenzie, and R. Plevin. 2001. Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory κB kinases in NCTC 2544 keratinocytes. J. Biol. Chem. 276:31657-31666.
28. Kauffman, H. F., J. F. Tomee, M. A. van de Riet, A. J. Timmerman, and P. Borger. 2000. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J. Allergy Clin. Immunol. 105:1185-1193.
29. Kawagoe, J., T. Takizawa, J. Matsumoto, M. Tamiya, S. E. Meek, A. J. Smith, G. D. Hunter, R. Plevin, N. Saito, T. Kanke, M. Fujii, and Y. Wada. 2002. Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn. J. Pharmacol. 88:77-84.
30. Kida, Y., K. Kuwano, Y. Zhang, and S. Arai. 2001. Acholeplasma laidlawii up-regulates granulysin gene expression via transcription factor activator protein-1 in a human monocytic cell line, THP-1. Immunology 104:324-332.
31. Kida, Y., T. Shimizu, and K. Kuwano. 2005. Conditional expression of liver-enriched transcriptional activator protein augments Acholeplasma laidlawii-induced granulysin gene expression in a human monocytic cell line, THP-1. Immunology 114:121-132.
32. Kida, Y., T. Shimizu, and K. Kuwano. 2002. Opposing roles of activator protein-1 and CCAAT/enhancer binding protein beta in the regulation of inducible granulysin gene expression in a human monocytic cell line, THP-1. Immunology 107:507-516.
33. Kida, Y., T. Shimizu, and K. Kuwano. 2006. Sodium butyrate up-regulates cathelicidin gene expression via activator protein-1 and histone acetylation at the promoter region in a human lung epithelial cell line, EBC-1. Mol. Immunol. 43:1972-1981.
34. King, C., S. Brennan, P. J. Thompson, and G. A. Stewart. 1998. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J. Immunol. 161:3645-3651.
35. Lindner, J. R., M. L. Kahn, S. R. Coughlin, G. R. Sambrano, E. Schauble, D. Bernstein, D. Foy, A. Hafezi-Moghadam, and K. Ley. 2000. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J. Immunol. 165:6504-6510.
36. Macfarlane, S. R., M. J. Seatter, T. Kanke, G. D. Hunter, and R. Plevin. 2001. Proteinase-activated receptors. Pharmacol. Rev. 53:245-282.
37. Maeda, H. 1996. Role of microbial proteases in pathogenesis. Microbiol. Immunol. 40:685-699.
38. Maeda, H., and A. Molla. 1989. Pathogenic potentials of bacterial proteases. Clin. Chim. Acta 185:357-367.
39. Maeda, H., and K. Morihara. 1995. Serralysin and related bacterial proteinases. Methods Enzymol. 248:395-413.
40. Matsumoto, K., H. Maeda, K. Takata, R. Kamata, and R. Okamura. 1984. Purification and characterization of four proteases from a clinical isolate of Serratia marcescens kums 3958. J. Bacteriol. 157:225-232.
41. Matsumoto, K., T. Yamamoto, R. Kamata, and H. Maeda. 1984. Pathogenesis of serratial infection: activation of the Hageman factor-prekallikrein cascade by serratial protease. J. Biochem. 96:739-749.
42. Molla, A., K. Matsumoto, I. Oyamada, T. Katsuki, and H. Maeda. 1986. Degradation of protease inhibitors, immunoglobulins, and other serum proteins by Serratia protease and its toxicity to fibroblast in culture. Infect. Immun. 53:522-529.
43. Naka, T., M. Shinozaki, T. Akizawa, Y. Shima, H. Takaesu, and H. Nasu. 2006. The effect of continuous veno-venous hemofiltration or direct hemoperfusion with polymyxin B-immobilized fiber on neutrophil respiratory oxidative burst in patients with sepsis and septic shock. Ther. Apher. Dial. 10:7-11.
44. Nakahama, K., K. Yoshimura, R. Marumoto, M. Kikuchi, I. S. Lee, T. Hase, and H. Matsubara. 1986. Cloning and sequencing of Serratia protease gene. Nucleic Acids Res. 14:5843-5855.
45. Nystedt, S., K. Emilsson, A. K. Larsson, B. Strombeck, and J. Sundelin. 1995. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur. J. Biochem. 232:84-89.
46. Nystedt, S., V. Ramakrishnan, and J. Sundelin. 1996. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells: comparison with the thrombin receptor. J. Biol. Chem. 271:14910-14915.
47. Ossovskaya, V. S., and N. W. Bunnett. 2004. Protease-activated receptors: contribution to physiology and disease. Physiol. Rev. 84:579-621.
48. Page, K., V. S. Hughes, K. K. Odoms, K. E. Dunsmore, and M. B. Hershenson. 2005. German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 32:225-231.
49. Poli, V. 1998. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J. Biol. Chem. 273:29279- 29282.
50. Ramji, D. P., and P. Foka. 2002. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 365:561-575.
51. Reed, C. E., and H. Kita. 2004. The role of protease activation of inflammation in allergic respiratory diseases. J. Allergy Clin. Immunol. 114:997-1008.
52. Riewald, M., V. V. Kravchenko, R. J. Petrovan, P. J. O'Brien, L. F. Brass, R. J. Ulevitch, and W. Ruf. 2001. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood 97:3109-3116.
53. Schmidlin, F., S. Amadesi, K. Dabbagh, D. E. Lewis, P. Knott, N. W. Bunnett, P. R. Gater, P. Geppetti, C. Bertrand, and M. E. Stevens. 2002. Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J. Immunol. 169:5315-5321.
54. Schmidtchen, A., I. M. Frick, E. Andersson, H. Tapper, and L. Bjorck. 2002. Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Mol. Microbiol. 46:157-168.
55. Seeliger, S., C. K. Derian, N. Vergnolle, N. W. Bunnett, R. Nawroth, M. Schmelz, P. Y. Von Der Weid, J. Buddenkotte, C. Sunderkotter, D. Metze, P. Andrade-Gordon, E. Harms, D. Vestweber, T. A. Luger, and M. Steinhoff. 2003. Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J. 17:1871-1885.
56. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
57. Stacey, M. A., G. Sun, G. Vassalli, M. Marini, A. Bellini, and S. Mattoli. 1997. The allergen Der p1 induces NF-κB activation through interference with IκB α function in asthmatic bronchial epithelial cells. Biochem. Biophys. Res. Commun. 236:522-526.
58. Sun, G., M. A. Stacey, M. Schmidt, L. Mori, and S. Mattoli. 2001. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J. Immunol. 167:1014-1021.
59. Thanos, D., and T. Maniatis. 1995. NF-κβ: a lesson in family values. Cell 80:529-532.
60. Tomee, J. F., A. T. Wierenga, P. S. Hiemstra, and H. K. Kauffman. 1997. Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J. Infect. Dis. 176:300-303.
61. . Uehara, A., K. Muramoto, H. Takada, and S. Sugawara. 2003. Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2. J. Immunol. 170:5690-5696.
62. van Ogtrop, M. L., D. van Zoeren-Grobben, E. M. Verbakel-Salomons, and C. P. van Boven. 1997. Serratia marcescens infections in neonatal departments: description of an outbreak and review of the literature. J. Hosp. Infect. 36:95-103.
63. Yu, V. L. 1979. Serratia marcescens: historical perspective and clinical review. N. Engl. J. Med. 300:887-893.