Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6958-6963

  Rosowsky, Andre ^a   Forsch, Ronald A ^a   Wright, Joel E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [(2,4 DIAMINOPTERIDIN 6 YL)METHYLAMINO] 2,3 DIHYDRO 1 OXO 2(1H) ISOINDOLYL]GLUTARIC ACID; 2 [5 [N (2,4 DIAMINOPTERIDIN 6 YL)METHYL N METHYLAMINO] 2,3 DIHYDRO 1 OXO 2(1H) ISOINDOLYL]GLUTARIC ACID; AMINOPTERIN DERIVATIVE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; FOLIC ACID ANTAGONIST; METHOTREXATE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FOLATE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINOPTERIN; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 11144242402     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040122s     Document Type: Article

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