3D-QSAR design of novel antiepileptic sulfamides

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 3, 2007, Pages 1556-1567

  Gavernet, Luciana ^a   Dominguez Cabrera, M Josefina ^a   Bruno Blanch, Luis E ^a   Estiú, Guillermina L ^b  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Anticonvulsant drugs; CoMFA; Drug design; Sulfamides

Indexed keywords

2,3 O ISOPROPYLIDENE 4,5 O SULFONYL B FRUCTOPYRANOSE SULFAMATE; 4 (VALPROYLAMIDE)BENZOIC ACID; 5 AMINO 1,3,4 THIADIAZOLE 2 SULFONAMIDE; 5 TERT BUTOXYCARBONYLAMINO 1,3,4 THIADIAZOLE 2 SULFONAMIDE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; FELBAMATE; MESUXIMIDE; N (SULFONAMIDEPHENYL)VALPROMIDE; N BUTYLVALPROMIDE; N CYCLOPROPYL 2,3 O ISOPROPYLIDENE 4,5 O SULFONYL B FRUCTOPYRANOSE SULFAMATE; N METHYL 2,3 O ISOPROPYLIDENE 4,5 O SULFONYL B FRUCTOPYRANOSE SULFAMATE; N,N' DIBENZYLSULFAMIDE; N,N' DIBUTYLSULFAMIDE; N,N' DICYCLOHEXYLSULFAMIDE; N,N' DICYCLOPROPYLSULFAMIDE; N,N' SULFONILBISTETRAHYDRO 1,4 OXAZINE; PHENOBARBITAL; PHENYTOIN; PROPYLVALPROATE; PYRIMIDINONE DERIVATIVE; REMACEMIDE; RETIGABINE; SULFAMIDE DERIVATIVE; TOPIRAMATE; UNCLASSIFIED DRUG; VALPROCEMIDE; VALPROIC ACID; VALPROMIDE; VIPOCENTINE; ZONISAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONVULSION; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; ELECTRICITY; FEMALE; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; DRUG DESIGN; EPILEPSY; FEMALE; LIGANDS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33845943300     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.010     Document Type: Article

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