Blockade of neuronal sodium channels by the antiepileptic drugs phenytoin, carbamazepine and sodium valproate

Proceedings of the Western Pharmacology Society

Volumn 42, Issue , 1999, Pages 105-108

  Pugsley, Michael K ^a   Esther, J Y U ^a,b   Mclean, Thomas H ^c   Goldin, Alan L ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b XOMA Corporation   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHENYTOIN; SODIUM ION; VALPROIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; BRAIN ELECTROPHYSIOLOGY; CHANNEL GATING; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; EPILEPSY; NONHUMAN; SODIUM TRANSPORT; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTICONVULSANTS; BRAIN CHEMISTRY; CARBAMAZEPINE; MEMBRANE POTENTIALS; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENYTOIN; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; VALPROIC ACID; XENOPUS LAEVIS;

EID: 0032718286     PISSN: 00838969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Feely M. Br Med J 318.106 (1999).
2. Goldin AL. Voltage-gated sodium channels, In. Ligand- and Voltage-Gated Ion Channels, (ed) RA North, CRC Press, Boca Raton, FL. 73-112 (1995).
3. Ragsdale DS & Avoli M. Brain Res Rev 26.16 (1998).
4. Hodgkin AL & Huxley AF. J Physiol 116.497 (1952).
5. Courtney KR & Etter EF. Eur J Pharmacol 88.1 (1983).
6. Urenjak J & Obrenovitch TP. Pharmacol Rev 48.21 (1996).
7. Auld VJ, Goldin AL, Kräfte DS, Catterall WA, Lester HA, Davidson N & Dünn RJ. Proc Natl Acad Sei USA 87.323 (1990).
8. Goldin AL & Sumikawa K. Methods Enzymol 207.279 (1992).
9. Isom LL, DeJongh KS, Patton DE, Reber BFX, Offord J, Charbonneau H, Walsh K, Goldin AL & Catterall WA. Science 256.839 (1992).
10. Patton DE & Goldin AL. Neuron 7.637 (1991).
11. Bennett PB, Valenzuela C, Chen L-Q & Kallen RG. Circ Res 77.584 (1995).
12. Hille B. J Gen Physiol 69.497 (1977).