Synthesis of the spiroacetal parts of spirofungin A and B

Tetrahedron Letters

Volumn 41, Issue 17, 2000, Pages 3141-3144

  Shimizu, Yuko ^a   Kiyota, Hiromasa ^a   Oritani, Takayuki ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Antibiotics; Lactonization; Polyketides; Spiro compounds

Indexed keywords

ANTIFUNGAL AGENT; EPIDERMAL GROWTH FACTOR; POLYKETIDE; SPIROFUNGIN A; SPIROFUNGIN B; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; COUPLING FACTOR; DRUG SYNTHESIS; EXTRACTION; MITOGENESIS; REACTION ANALYSIS; STEREOCHEMISTRY; THERMODYNAMICS;

EID: 0034701511     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00371-3     Document Type: Article

References (15)

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7. Constructions of spiroacetal compounds by an analogous methodology were reported: (b) Baker, R.; Herbert, R. H.; Parton, A. H. J. Chem. Soc., Chem. Commun. 1982, 601-603.
8. For a review on the construction of spiroacetals, see: (c) Vaillancourt, V.; Pratt, N. E.; Perron, F.; Albizati, K. F. In The Total Synthesis of Natural Products; ApSimon, J., Ed.; John Wiley & Sons: New York, 1992; Vol. 8, pp. 533-691.
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13. 3N; (iii) NaBr, DMF (total 80%)].
14. Preparation of racemic 9 was reported: Molander, G. A.; Harris, C. R. J. Org. Chem. 1997, 62, 7418-7429.
15. 4: 348.2301, found: 348.2298.