Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives

Chemistry - An Asian Journal

Volumn 1, Issue 6, 2006, Pages 845-851

  Matsuzawa, Masayoshi ^a   Kakeya, Hideaki ^b   Yamaguchi, Junichiro ^a   Shoji, Mitsuru ^a   Onose, Rie ^b   Osada, Hiroyuki ^b   Hayashi, Yujiro ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b Japan Science and Technology Agency   (Japan)

Author keywords

Asymmetric synthesis; Chemical biology; Natural products; Panepophenanthrin; Total synthesis

Indexed keywords

ENZYME INHIBITOR; PANEPOPHENANTHRIN; PHENANTHRENE DERIVATIVE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; STEREOISOMERISM; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PHENANTHRENES; STEREOISOMERISM; UBIQUITIN-ACTIVATING ENZYMES;

EID: 33845923179     PISSN: 18614728     EISSN: 1861471X     Source Type: Journal    
DOI: 10.1002/asia.200600199     Document Type: Article

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