Total synthesis of the novel angiogenesis inhibitors epoxyquinols A and B

Tetrahedron Letters

Volumn 44, Issue 17, 2003, Pages 3569-3572

  Mehta, Goverdhan ^a   Islam, Kabirul ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOQUINONE; ANGIOGENESIS INHIBITOR; CYCLOPENTADIENE DERIVATIVE; DIMER; EPOXYQUINOL A; EPOXYQUINOL B; POLYKETIDE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BIODIVERSITY; CRYSTAL STRUCTURE; DIELS ALDER REACTION; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BETULACEAE;

EID: 0037459852     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00621-X     Document Type: Article

References (19)

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17. 2=0.1129, GOF=1.042. Restrained GOF=1.042 for all data. Crystallographic data (without structure factors) have been deposited with the Cambridge Crystallographic Data Center and the depository number is CCDC 199400. ORTEP diagrams of 13 and 16 are shown above.
18. We have elaborated the Z-isomer 17 to a new Z-epoxyquinol corresponding to 5 and its chemistry is being investigated.
19. 4 have found that transformation of 4 to furnish 1 and 2 via 3a,b is quite sensitive to time, temperature and solvent regimes and efforts are underway to optimize the conditions for this process.