Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives

Current Pharmaceutical Biotechnology

Volumn 7, Issue 6, 2006, Pages 457-466

  Das, Undurti N ^a  

^a UND LIFE SCIENCES   (United States)

Author keywords

COX 1; Docosahexaenoic acid (DHA); Eicosapentaenoic acid (EPA); Glioma; Intracellular calcium

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; ESSENTIAL FATTY ACID; GAMMA LINOLENIC ACID; GAMMA LINOLENIC ACID DERIVATIVE; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LITHIUM GAMMA LINOLEIC ACID; LITHIUM GAMMA LINOLEIC ACID IODIZED CONJUGATE; LONG CHAIN FATTY ACID COENZYME A LIGASE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYUNSATURATED FATTY ACID; PSEUDOEPHEDRINE PLUS TRIPROLIDINE; STEARIC ACID; TAMOXIFEN; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER; CANCER INHIBITION; CANCER RESISTANCE; CANCER SURVIVAL; CELL PROLIFERATION; CELL PROTECTION; CLINICAL TRIAL; COLON ADENOCARCINOMA; COMBINATION CHEMOTHERAPY; DNA DAMAGE; DRUG DOSE ESCALATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; EPIMER; FATTY ACID METABOLISM; GIANT CELL TUMOR; GLIOMA; HUMAN; INJECTION SITE PAIN; KIDNEY CARCINOMA; LIPID PEROXIDATION; LIVER CELL CARCINOMA; MELANOMA CELL; MONOTHERAPY; NONHUMAN; OSTEOCLASTOMA; PANCREAS CANCER; PATHOGENESIS; POSTOPERATIVE CARE; REVIEW; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR CELL; UNSPECIFIED SIDE EFFECT;

ANIMALS; APOPTOSIS; CLINICAL TRIALS; GAMMA-LINOLENIC ACID; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 33845904127     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920106779116892     Document Type: Review

References (95)

1. Benedetti, A., Malvaldi, G., Fulceri, R., Comporti, M. (1984) Cancer Res. 44, 5712-5717.
2. Cheeseman, K.H., Burton, G.W., Ingold, K.U., Slater, T.F. (1984) Toxicol. Pathol. 12, 235-239.
3. Nassar, B.A., Das, U.N., Huang, Y.S., Ells, G., Horrobin, D.F. (1992) Proc. Soc. Exp. Biol. Med. 199, 365-368.
4. Galeotti, T., Borrello, S., Masoti, L. Oxyradical sources, scavenger systems and membrane damage in cancer cells. In, Das, O.K., Essman, R., eds., Oxygen radicals, systemic events and disease processes, Basel, S. (1990) Karger 129-148.
5. Das, U.N. (1992) Asia Pacific J. Pharmacol. 7, 305-327.
6. Huang, P., Feng, L., Oldham, E.A., Keating, M.J., Plunkett, W. (2000) Nature 407, 390-395.
7. Kumar, S.G., Das, U.N. (1995) Cancer Lett. 92, 27-38.
8. Das, U.N. (2002) Med. Sci. Monit. 8, RA79-RA92.
9. Marx, J. (2004) Science 306, 966-968
10. Das, U.N., Devi, G.R., Rao, K.P., Rao, M.S. (1985) Prostaglandins 29, 911-920.
11. Das, U.N., Devi, G.R., Rao, K.P., Rao, M.S. (1989) Prostaglandins 38, 689-716.
12. Das, U.N., Devi, G.R., Rao, K.P., Rao, M.S. (1985) Nutrition Res. 5, 101-105.
13. Koratkar, R., Das, U.N., Sangeetha, P.S., Ramesh, G., Padma, M., Sravan Kumar, K. and Madhavi, N. (1993) Essential Fatty Acids 48, 175-184.
14. Das, U.N. (2005) J. Assoc. Physicians India 53, 472-476.
15. Das, U.N. Med. Sci. Monit. in press.
16. Claria, J., Serhan, C.N. (1995) Proc. Natl. Acad. Sci. USA 92, 9475-9479.
17. Chiang, N., Gronert, K., Clish, C.B., O'Brien, J.A., Freeman, M.W., Serhan, C.N. (1999) J. Clin. Invest. 104, 36.
18. Egan, K.M., Lawson, J.A., Fries, S., Koller, B., Rader, E.M., Fitzgerald, G.A. (2004) Science 306, 1954-1957.
19. Chiang, N., Gronert, K., Clish, C.B., O'Brien, J.A., Freeman, M.W., Serhan, C.N. (1999) J. Clin. Invest. 104, 309-316.
20. Xiao, G., Tasi A-L, Palmer, G., Boyar, W.C., Marshall, P.J., Kulmacz, R.J. (1997) Biochemistry 36, 1836-1845.
21. Levy, B.D., Clish, C.B., Schmidt, B., Gronert, K., Serhan, C.N. (2001) Nat. Immunol. 2, 612-619.
22. Bandeira-Melo, C., Serra, M.F., Diaz, B.I., Cordeiro, R.S.B., Silva, P.M.R., Lenzi, H.L., Bakhle, Y.S., Serhan, C.N., Martins, M.A. (2000) J. Immunol. 164, 1029-1036.
23. Serhan, C.N., Maddox, J.F., Petasis, N.A., Akritopoulou-Zanze, I., Papayianni, A., Brady, H.R., Colgan, S.P., Madara, J.L. (1995) Biochemistry 34, 14609-14615.
24. Serhan, C.N., Maddox, J.F., Petasis, N.A., Akritopoulou-Zanze, I., Papayianni, A., Brady, H.R., Colgan, S.P., Madara, J.L. (1995) Biochemistry 34, 14609-14615.
25. Sethi, S., Eastman, A.Y., Eaton, J.W. (1996) J. Lab. Clin. Med. 128, 27-38.
26. Serhan, C.N., Clish, C.B., Brannon, J., Colgan, S.P., Chiang, N., Gronert K. (2000) J. Exp. Med. 192, 1197-1204.
27. Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronet, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G. (2003) J. Biol. Chem. 278, 43807-43817.
28. Das, U.N., Begin, M.E., Ells, G., Huang, Y.S., Horrobin, D.F. (1987) Biochem. Biophys. Res. Commun. 145, 15-24.
29. Das, U.N. (1991) Cancer Lett. 56, 235-243.
30. Das, U.N., Huang, Y.S., Begin, M.E., Ells, G., Horrobin, D.F. (1987) Free Radical Biol. Med. 3, 9-14.
31. Colquhoun, A., Schumacher, R.I. (2001) Biochim. Biophys. Acta 1533, 207-219.
32. Leaver, H.A., Williams, J.R., Ironside, J.W., Miller, E.P., Gregor, A., Su, B.H., Prescott, R.J., Whittle, I.R. (1999) Eur. J. Clin. Invest. 29, 220-231.
33. Begin, M.E., Das, U.N., Ells, G., Horrobin, D.F. (1985) Prostaglandins Leukot. Med. 19, 177-186.
34. Das, U.N. (1999) Nutrition 15, 239-241.
35. Das, U.N. (1990) Nutrition 6, 429-434.
36. Begin, M.E., Ells, G., Das, U.N., Horrobin, D.F. (1986) J. Natl. Cancer Inst. 77, 1053-1062.
37. Begin, M.E., Das, U.N., Ells, G. (1986) Prog. Lipid. Res. 25, 573-576.
38. Mengeaud, V., Nano, J.L., Fournel, S., Rampal, P. (1992) Prostaglandins Leukot. Essen. Fatty Acids 47, 313-319.
39. Vartak, S., McCaw, R., Davis, C.S., Robbins, M.E., Spector, A.A. (1998) Br. J. Cancer 77, 1612-1620.
40. Mainou-Fowler, T., Proctor, S.J., Dickinson, A.M. (2001) Leuk. Lymphoma 40, 393-403.
41. Ells, G., Chisholm, K.A., Simmons, V.A., Horrobin, D.F. (1996) Cancer Lett. 98, 207-211.
42. Chajes, V., Sattler, W., Stranzl, A., Kostner, G.M. (1995) Breast Cancer Res. Treat. 34, 199-212.
43. Takeda, S., Sim, P.G., Horrobin, D.F., Sanford, T., Chisholm, K., Simmons, V. (1993) Anticancer Res. 13, 193-199.
44. Das, U.N. (1999) Prostaglandins Leukot. Essen. Fatty Acids 61, 157-163.
45. Leaver, H.A., Wharton, S.B., Bell, H.S, Leaver-Yap, I.M.M., Whittle, I.R. (2002) Prostaglandins Leukot. Essen. Fatty Acids 67, 283-292.
46. Das, U.N. (2004) Prostaglandins Leukot. Essen. Fatty Acids 70, 539-552.
47. Awad, A.B., Young, A.L., Fink, C.S. (1996) Cancer Lett. 108, 25-33.
48. Colquhoun, A. (2002) Biochim. Biophys. Acta 1583, 74-84.
49. Colquhoun A and Schumacher, R.I. (2001) Mol. Cell Biochem. 218, 13-20.
50. Baron, J.A., Cole, B.F., Sandler, R.S., Haile, R.W., Almen, D., Bresalier, R., McKeown-Eyssen, G., Summers, R.W., Rothstein, R., Burke, C.A., Snover, D.C., Church, T.R., Allen, J.I., Beach, M., Beek, G.J., Bond, J.H., Byers, T., Greenberg, E.R., Mandel, J.S., Marcon, N., Mott, L.A., Pearson, L., Saibil, F., van Stolk, R.U. (2003) N. Engl. J. Med. 348, 891-899.
51. Sandler, R.S., Halabi, S., Baron, J.A., Budinger, S., Paskett, E., Keresztes, R., Petrelli, N., Pipas, J.M., Karp, D.D., Loprinzi, C.L., Steinbach, G., Schilsky, R. (2003) N. Engl. J. Med. 348, 883-890.
52. Boudreau, M.D., Sohn, K.H., Rhee, S.H., Lee, S.W., Hunt, J.D., Hwang, D.H. (2001) Cancer Res. 61, 1386-1391.
53. Arita, K., Kobuchi, H., Utsumi, T., Takehara, Y., Akiyama, J., Horton, A.A., Utsumi, K. (2001) Biochem. Pharmacol. 62, 821-828.
54. Higuchi, Y. (2001) Arch. Biochem. Biophys. 392, 65-70.
55. Albino, A.P., Juan, G., Traganos, F., Reinhart, L., Connolly, J., Rpse, D.P., Darzynkiewicz, Z. (2000) Cancer Res. 60, 4139-4145.
56. Cao, Y., Pearman, A.T., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. (2000) Proc. Natl. Acad. Sci. USA 97, 11280-11285.
57. Chow, S.C. (1990) J. Biol. Chem. 265, 902-907.
58. Scorrano, L., Oakes, S.A., Opferman, J.T., Cheng, E.H., Sorcinelli, M.D., Pozzan, T., Korsmeyer, S.J. (2003) Science 300, 135-139.
59. Joubert, A.M., Panzer, A., Joubert, F., Lottering, M.L., Bianchi, P.C., Seegers, J.C. (1999) Prostaglandins Leukot. Essen. Fatty Acids 61, 171-182.
60. Diggle, C.P., Pitt, E., Roberts, P., Trejdosiewicz, L.K., Southgate, J. (2000) J. Lipid. Res. 41, 1509-1515.
61. Ramesh, G. and Das, U.N. (1992) Nutrition 8, 343-347.
62. Hayashi, Y., Fukushima, S., Hirata, T., Kishimoto, S., Katsuki, T., Nakano, M. (1990) J. Pharmacobiodyn. 13, 705-711.
63. Takeda, S., Horrobin, D.F., Manku, M.S., Sim, P.G., Ells, G., Simmons, V. (1992) Anticancer Res. 12, 329-333.
64. Cantrill, R.C., Ells, G., Chisholm, K., Horrobin, D.F. (1993) Cancer Lett. 72, 99-102.
65. Perkins, D.M., Duncan, J.R. (1991) Prostaglandins Leukot. Essen. Fatty Acids 43, 43-48.
66. Robinson, K.M., Botha, J.H. (1985) Prostaglandins Leukot. Med. 20, 209-221.
67. Kenny, F.S., Gee, J.M., Nicholson, R.I., Ellis, I.O., Morris, T.M., Watson, S.A., Bryce, R.P., Robertson, J.F. (2001) Int. J. Cancer 92, 342-347.
68. Awad, A.B., Young, A.L., Fink, C.S. (1996) Cancer Lett. 108, 25-33.
69. Jiang, W.G., Hiscox, S., Hallett, M.B., Scott, C., Horrobin, D.F., Puntis, M.C. (1995) Br. J. Cancer 71, 744-752.
70. Jiang, W.G., Bryce, R.P., Horrobin, D.F., Mansel, R.E. (1998) Biochem. Biophys. Res. Commun. 244, 414-420.
71. Jiang, W.G., Hiscox, S., Bryce, R.P., Horrobin, D.F., Mansel, R.E. (1998) Br. J. Cancer 77, 731-738.
72. Jiang, W.G., Hiscox, S., Horrobin, D.F., Hallett, M.B., Mansel, R.E., Puntis, M.C. (1995) Anticancer Res. 15, 2569-2573.
73. Jiang, W.G., Hiscox, S., Hallett, M.B., Horrobin, D.F., Mansel, R.E., Puntis, M.C. (1995) Cancer Res. 55, 5043-5048.
74. Jiang, W.G., Singhrao, S.K., Hiscox, S., Hallett, M.B., Bryce, R.P., Horrobin, D.F., Puntis, M.C., Mansel, R.E. (1997) Clin. Exp. Metastasis 15, 593-602.
75. Jiang, W.G., Hiscox, S., Horrobin, D.F., Bryce, R.P., Mansel, R.E. (1997) Biochem. Biophys. Res. Commun. 237, 639-644.
76. Jiang, W.G., Bryce, R.P., Mansel, R.E. (1997) Prostaglandins Leukot. Essen. Fatty Acids 56, 307-316.
77. Cai, J., Jiang, W.G., Mansel, R.E. (1999) Prostaglandins Leukot. Essen. Fatty Acids 60, 21-29.
78. Cai, J., Jiang, W.G., Mansel, R.E. (1999) Biochem. Biophys. Res. Commun. 258, 113-118.
79. Jiang, W.G., Redfern, A., Bryce, R.P., Mansel, R.E. (2000) Prostaglandins Leukot. Essen. Fatty Acids 62, 119-127.
80. Sangeetha, Sagar, P. and Das, U.N. (1993) Med. Sci. Res. 21, 457-459.
81. Kenny, F.S., Pinder, S.E., Ellis, I.O., Gee, J.M., Nicholson, R.I., Bryce, R.P., Robertson, J.F. (2000) Int. J. Cancer 85, 643-648.
82. Lonergan, P.E., Martin, D.S.D., Horrobin, D.F., Lynch, M.A. (2002) J. Biol. Chem. 277, 20804-20811.
83. Ramesh, G. and Das, U.N. (1995) Cancer Lett 95, 237-245.
84. Ramesh, G. and Das, U.N. (1996) Cancer Lett. 100, 199-209.
85. Ramesh, G. and Das, U.N. (1998) Prostaglandins Leukot. Essen. Fatty Acids 59, 155-161.
86. Ramesh, G. and Das, U.N. (1998) Cancer Lett. 123, 207-214.
87. Botha, J.H., Robinson, K.M., Leary, W.P. (1993) S. Afr. Med. J. 64, 11-12.
88. Ravichandran, D., Cooper, A., Johnson, C.D. (2000) Eur. J. Cancer 36, 423-427.
89. Ravichandran, D., Cooper, A., Johnson, C.D. (1998) Br. J. Surg. 85, 1201-1205.
90. Fearon, K.C., Falconer, J.S., Ross, J.A., Carter, D.C., Hunter, J.O., Reynolds, P.D., Tuffnell, Q. (1996) Anticancer Res. 16, 867-874.
91. Naidu, M.R.C., Das, U.N., Kishan, A. (1992) Prostaglandins Leukot. Essen. Fatty Acids 45, 181-184.
92. Das U.N., Prasad, V.V.S., K., Reddy D.R. (1995) Cancer Lett. 94, 147-155.
93. Bakshi, A., Mukherjee, D., Bakshi, A., Banerji, A.K., Das, U.N. (2003) Nutrition 19, 305-309.
94. Das U.N. (2002) Nutrition 18, 662-664.
95. Das, U.N. (2004) Prostaglandins Leukot. Essen. Fatty Acids 70, 23-32.