Effect of 1-γlinolenyl-3-eicosapentaenoyl propane diol on the growth of human pancreatic carcinoma in vitro and in vivo

European Journal of Cancer

Volumn 36, Issue 3, 2000, Pages 423-427

  Ravichandran, D ^a,b   Cooper, A ^a   Johnson, C D ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Eicosapentaenoic acid; Gamma linolenic acid; Pancreatic neoplasms

Indexed keywords

GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; IRON SACCHARATE; LIPID EMULSION; PRIMROSE OIL;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; CARCINOMA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SCREENING ASSAYS, ANTITUMOR; EICOSAPENTAENOIC ACID; FATTY ACIDS; GAMMA-LINOLENIC ACID; HUMANS; IRON; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; STATISTICS, NONPARAMETRIC; TUMOR CELLS, CULTURED;

EID: 0033996081     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(99)00268-3     Document Type: Article

References (21)

1. Ravichandran D, Cooper A, Johnson CD. Growth inhibitory effect of lithium gammalinolenate on pancreatic cancer cell lines: the influence of albumin and iron. Eur J Cancer 1998, 34, 188-192.
2. Falconer JS, Ross JA, Fearon KCH, Hawkins RA, O'Riordain MG, Carter DC. Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines. Br J Cancer 1994, 69, 826-832.
3. Begin ME, Ells G, Horrobin DF. Polyunsaturated fatty acid-induced cytotoxicity against tumour cells and its relationship to lipid peroxidation. J Natl Cancer Inst 1988, 80, 188-194.
4. Mengeaud V, Nano JL, Fournel S, Rampal P. Effects of eicosapentaenoic acid, gammalinolenic acid and prostaglandin E1 on three human colon carcinoma cell lines. Prostaglandins Leukot Essent Fatty Acids 1992, 47, 313-319.
5. Madhavi N, Das UN. Effect of n-6 and n-3 fatty acids on the survival of vincristine sensitive and resistant human cervical carcinoma cells in vitro. Cancer Lett 1994, 84, 31-41.
6. Fearon KCH, Falconer JS, Ross JA, et al. An open label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate. Anticancer Res 1996, 16, 867-874.
7. Wigmore SJ, Ross JA, Falconer JS, et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 1996, 12, S27-S30.
8. Alley MC, Scudiero DA, Monks A, et al. Feasibility of drug screening with panels of human tumour cell lines using a microculture tetrazolium assay. Cancer Res 1988, 48, 589-601.
9. Euhus DM, Hudd C, LaRegina MC, Johnson FE. Tumour measurement in the nude mouse. J Surg Oncol 1986, 31, 229-234.
10. de Antueno RJ, Cantrill RC, Huang YS, Ells GW, Elliot M, Horrobin DF. Metabolism of n-6 fatty acids by NIH-3T3 cells transfected with the ras oncogene. Mol Cell Biochem 1994, 139, 71-81.
11. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957, 226, 497-509.
12. Ravichandran D, Cooper A, Johnson CD. Effect of lithium gammalinolenate on the growth of experimental human pancreatic carcinoma. Br J Surg 1998, 85, 1201-1205.
13. Heiling VJ, Miles JM, Jensen MD. How valid are isotopic measurements of fatty acid oxidation? Am J Physiol (Endocrinol Metab 24) 1991, 261, E572-577.
14. Fujiwara F, Todo S, Imashuku S. Fatty acid modification of cultured neuroblastoma cells by gamma linolenic acid relevant to its antitumour effect. Prostaglandins Leukotrienes Medicine 1987, 30, 37-49.
15. Hayashi Y, Fukushima S, Hirata T, Kishimoto S, Katsuki T, Nakano M. Anticancer activity of free gamma linolenic acid on AH-109A rat hepatoma cells and the effect of serum albumin on anticancer activity of gamma linolenic acid in vitro. J Pharmacobio-Dyn 1990, 13, 705-711.
16. Hostmark AT, Lystad E. Growth inhibition of human hepatoma cells (HepG2) by polyunsaturated fatty acids. Protection by albumin and vitamin E. Acta Physiol Scand 1992, 144, 83-88.
17. Das UN. Tumoricidal action of cis-unsaturated fatty acids and their relationship to free radicals and lipid peroxidation. Cancer Lett 1991, 56, 235-243.
18. Cantrill RC, Ells G, Chisholm K, Horrobin DF. Concentration-dependent effect of iron on gamma-linolenic acid toxicity in ZR-75-1 human breast tumour cells in culture. Cancer Lett 1993, 72, 99-102.
19. Takeda S, Horrobin DF, Manku M, Sim PG, Ells G, Simmons V. Lipid peroxidation in human breast cancer cells in response to gamma linolenic acid and iron. Anticancer Res 1992, 12, 329-334.
20. Gonzalez MJ, Schemmel RA, Gray JI, Dugan L, Sheffield LG, Welsch CW. Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels. Carcinogenesis 1991, 12, 1231-1235.
21. Hardman WE, Cameron IL, Knight C, Barnes CJ, Grant W. Dietary n-3 polyunsaturated fatty acids as an effective adjuvant to ET-18-OCH3 (edelfosine) chemotherapy. Am Assoc Cancer Res 1996, 37, 387 (abstract).