Gamma linolenic acid with tamoxifen as primary therapy in breast cancer

International Journal of Cancer

Volumn 85, Issue 5, 2000, Pages 643-648

  Kenny, Frances S ^a   Pinder, Sarah E ^a   Ellis, Ian O ^a   Gee, Julia M W ^b   Nicholson, Robert I ^b   Bryce, Richard P ^c   Robertson, John F R ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c Scotia Pharmaceuticals   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; GAMMA LINOLENIC ACID; PROTEIN BCL 2; TAMOXIFEN;

AGED; ARTICLE; BREAST BIOPSY; BREAST CANCER; CANCER THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGED; ANTINEOPLASTIC AGENTS, HORMONAL; BIOPSY; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; GAMMA-LINOLENIC ACID; HUMANS; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ESTROGEN; TAMOXIFEN;

EID: 0033950395     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000301)85:5<643::AID-IJC8>3.0.CO;2-Z     Document Type: Article

References (28)

1. BORRAS, M. and LECLERCQ, G., Modulatory effect of nonesterified fatty acids on structure and binding characteristics of oestrogen receptor from MCF-7 human breast cancer cells. J. Receptor Res., 12, 463-484 (1992).
2. CLERC-HOFFMAN, F., VALLETTE, G., SECCO-MILLET, C, CHRISTEFF, N., BENASSAYAG, C. and NUNEZ, E., Inhibition of the uterine binding of oestrogens by unsaturated fatty acids in the immature rat. C. R. Acad. Sci. (Paris), 296, 53-58 (1983).
3. COLLETTA, A.A., BENSON, J.R. and BAUM, M., Alternative mechanisms of action of anti-oestrogens. Breast Cancer Res. Treat., 31, 5-9 (1994).
4. DAUVOIS, S., DANIELIAN, P.S., WHITE, R. and PARKER, M.G., Antiestrogen ICI 164384 reduces cellular estrogen receptor content by increasing its turnover. Proc. nat. Acad. Sci. (Wash.), 89, 4037-4041 (1992).
5. DE KOCK, M., LOTTERING, M-L., GROBLER, C.J.S., VILJOEN, T.C., LE ROUX, M. and SEEGERS, J.C., The induction of apoptosis in human cervical carcinoma (HeLa) cells by gamma-linolenic acid. Prostaglandins Leukotrienes Essential Fatty Acids, 55, 403-411 (1996).
6. GEE, J.M.W., ROBERTSON, J.F.R., ELLIS, I.O., WILLSHER, P.C., MCCLELLAND, R.A., HOYLE, H.B., KYME, S.R., FINLAY, P., BLAMEY, R.W. and NICHOLSON, R.I., Immunocytochemical localization of bcl-2 protein in human breast cancers and its relationship to a series of prognostic markers and response to endocrine therapy. Int. J. Cancer, 59, 619-628 (1994).
7. GIBSON, M.K., NEMMERS, L.A., BECKMAN, L.A., BECKMAN, W.C., DAVIES, V.L., CURTIS, S.W. and KORACH, K.S., The mechanism of ICI 164384 antioestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology, 129, 2000-2010 (1991).
8. GOULDIMG, H., PINDER, S., CANNON, P., PEARSON, D., NICHOLSON, R.I., ROBERTSON, J.F., BLAMEY, R.W. and ELLIS, I.O., A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples. Human Pathol., 26, 291-294 (1995).
9. HAWKINS, R.A., SANGSTER, K. and ARENDS, M.J., Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. J. Pathol., 185, 61-70 (1998).
10. HAWKINS, R.A., SANGSTER, K. and ARENDS, M.J., The apoptosis-inducing effects of polyunsaturated fatty acids (PUFAs) on benign and malignant breast cells in vitro. Breast, 8, 16-20 (1999).
11. HORROBIN, D.F., Unsaturated lipids and cancer. In: D.F. Horrobin (ed.), New approaches to cancer treatment, pp. 1-29. Churchill, Edinburgh (1994).
12. HORROBIN, D.F. and MANKU, M.S., Premenstrual syndrome and premenstrual breast pain (cyclical mastalgia): disorders of essential fatty acid (EFA) metabolism. Prostaglandins Leukotrienes Essential Fatty Acids, 37, 255-261 (1989).
13. HOWELL, A., DEFRIEND, D.J., ROBERTSON, J.F.R., BLAMEY, R.W., ANDERSON, L., ANDERSON, E., SUTCLIFFE, F.A. and WALTON, P., Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer. Brit. J. Cancer, 74, 300-308 (1996).
14. HWANG, P., Interaction of unsaturaled fatty acids with anti-oestrogen-binding sites. J. Biochem., 243, 359-364 (1987).
15. JIANG, W.G., BRYCE, R.P. and HORROBIN, D.F., Essential fatty acids: molecular and cellular basis of their anti-cancer action and clinical implications. Crit. Rev. Oncol. Hematol., 27, 179-209 (1998).
16. JOHNSTON, S.R.D., MACCLENNON, K.A., SACKS, N.P.M., SALTER, J., SMITH. I.E. and DOWSETT, M., Modulation of bcl-2 and Ki-67 expression in oestrogen receptor-positive human breast cancer by tamoxifen. Europ. J. Cancer, 30, 1663-1669 (1994).
17. JORDAN, V.C., Molecular mechanisms of anti-oestrogen action in breast cancer. Brit. Cancer Res. Treat., 31, 41-52 (1994).
18. KATO, J., Arachidonic acid as a possible modulator of estrogen, progestin, androgen and glucocorticoid receptors in the central and peripheral tissues. J. Steroid Biochem., 34, 219-227 (1989).
19. KENNY, F.S., WILLSHER, P.C., GEE, J.M.W., NICHOLSON, R.I., ELLIS, I.O., BLAMEY, R.W. and ROBERTSON. J.F.R., Change in expression of ER and bcl-2 predict for quality and duration of response in endocrine-sensitive breast cancer. Europ. J. Cancer, 34, S18 (1998).
20. MITSUHASHI, N., MIZUNO, M., MIYAGAWA, A. and KATO, J., Inhibitory effect of fatty acids on the binding of androgen receptor and R1881. Endocrinol. Japon, 35, 93-96 (1988).
21. MITSUHASHI, N., TAKANO, A. and KATO, J., Inhibition of the binding of R-5020 and rat uterine progesterone receptors by long-chain fatty acids. Endocrinol. Japon, 33, 251-256 (1986).
22. NOGUCHI, S., MIYAUCHI, K., NISHIZAWA, Y. and KOYAMA, H., Induction of progesterone receptor with tamoxifen in human breast cancer with special reference to its behaviour over time. Cancer, 61, 1345-1349 (1988).
23. REED, J.C., Bcl-2 and the regulation of programmed cell death (Review). J. Cell. Biol, 124, 1-6 (1994).
24. ROBERTSON, J.F.R., Oestrogen receptor: a stable phenotype in breast cancer (Review). Brit. J. Cancer, 73, 5-12 (1996).
25. SPECTOR, A.A. and YOREK, M.A., Membrane lipid composition and cellular function. J. Lipid Res., 26, 1015-1035 (1985).
26. VALLETTE, G., CHRISTEFF, N., BOGARD, C., BENASSAYAG, C. and NUNEZ, E. Dynamic pattern of estradiol binding to uterine receptors of the rat. J. biol. Chem., 263, 3639-3645 (1988).
27. VALLETTE, G., VANET, A., SUMIDA, C. and NUNEZ, E., Modulatory effects of unsaturated fatty acids on the binding of glucocorticoids to rat liver glucocorticoid receptors. Endocrinology, 129, 1293-1363 (1991).
28. WILLSHER, P.C., GEE, J.M.W., BLAMEY, R.W., NICHOLSON, R.I. and ROBERTSON, J.F.R., Changes in ER, PgR and pS2 protein during tamoxifen therapy for primary breast cancer. Brit. J. Cancer (1999). In press.