Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex

Archives of Biochemistry and Biophysics

Volumn 457, Issue 1, 2007, Pages 57-72

  García Castellanos, Raquel ^a   CynthiaTallant, ^a   Marrero, Aniebrys ^a   Solà, Maria ^a,b   Baumann, Ulrich ^a,c   Gomis Rüth, F Xavier ^a  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Astacin; Batimastat; Cancer; Enzyme inhibitor complex; IGF; IGFBP protease; Metalloprotease; Metzincin; Pappalysin; Serralysin; Ulilysin; X ray crystal structure

Indexed keywords

ADAM PROTEIN; ARGININE; BATIMASTAT; HYDROXAMIC ACID; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; METZINCIN; PAPPALYSIN; PROTEIN DERIVATIVE; PROTEINASE INHIBITOR; ULILYSIN; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME MECHANISM; ENZYME SPECIFICITY; HUMAN; IC 50; PRIORITY JOURNAL; PROTEIN BINDING; SPECTRUM; THREE DIMENSIONAL IMAGING;

ARCHAEA; VERTEBRATA;

EID: 33845769485     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.10.004     Document Type: Article

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