Interspecies dose extrapolation for inhaled dimethyl sulfate: A PBPK model-based analysis using nasal cavity N7-methylguanine adducts

Inhalation Toxicology

Volumn 16, Issue 9, 2004, Pages 593-605

  Sarangapani, Ramesh ^a,e   Teeguarden, Justin G ^b   Gentry, P Robinan ^b   Clewell III, Harvey J ^b   Barton, Hugh A ^c   Bogdanffy, Matthew S ^d  

^a ICF Consulting   (United States)

^b ENVIRON INTERNATIONAL CORPORATION   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d DUPONT COMPANY   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLGUANINE; DIMETHYL SULFATE; DNA; SULFUR ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENOTOXICITY; HUMAN; HUMAN TISSUE; MACROMOLECULE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RESPIRATORY SYSTEM; TOXICITY TESTING; TOXICOKINETICS;

ADMINISTRATION, INHALATION; ALGORITHMS; ALKYLATING AGENTS; ANIMALS; ATMOSPHERE EXPOSURE CHAMBERS; DNA ADDUCTS; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANINE; HUMANS; MODELS, BIOLOGICAL; MUTAGENS; NASAL CAVITY; RATS; SPECIES SPECIFICITY; SULFURIC ACID ESTERS;

ANIMALIA;

EID: 3343002172     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370490464562     Document Type: Article

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