Novel microdeletion in the transforming growth factor β type II receptor gene is associated with giant and large cell variants of nonsmall cell lung carcinoma

Genes Chromosomes and Cancer

Volumn 46, Issue 2, 2007, Pages 192-201

  Wang, Jiu Cun ^a   Su, Cheng Chang ^a   Xu, Ji Bin ^b   Chen, Le Zhen ^c   Hu, Xiao A ^a   Wang, Gui Ying ^a   Bao, Yang ^b   Huang, Qiang ^a   Fu, Song Bin ^d   Li, Pu ^d   Lu, Chen Qi ^a   Zhang, Rong Mei ^a   Luo, Z W ^a,e,f  

^a FUDAN UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d HARBIN MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GENETICS; CELL ACTIVITY; CELL LINE; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; FEMALE; FETUS; GENE DELETION; GENE MICRODELETION; GENE MUTATION; GERM LINE; GIANT CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LARGE CELL CARCINOMA; LUNG CANCER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STOP CODON; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR GENE; TUMOR SUPPRESSOR GENE; WILD TYPE;

ADULT; AGED; BASE SEQUENCE; CARCINOMA, GIANT CELL; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

EID: 33845502024     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20400     Document Type: Article

References (44)

1. Akhurst RJ, Derynck R. 2001. TGF-β signaling in cancer-A double-edged sword. Trends Cell Biol 11:S44-S51.
2. Anumanthan G, Halder SK, Osada H, Takahashi T, Massion PP, Carbone DR Datta PK. 2005. Rescoracion of TGF-β signalling reduces tumorigenicity in human lung cancer cells. Br J Cancer 93:1157-1167.
3. Chang J, Park K, Bang YJ, Kim WS, Kim D, Kim SJ. 1997. Expression of transforming growch factor β type II receptor reduces tumorigenicity in human gastric cancer cells. Cancer Res 57: 2856-2859.
4. Chen LZ, Huang JX, You LB, Li WH. 1983. Establishment of human pulmonary giant cell carcinoma cell line and observations of its biologic properties. Chin J Oncol 5:409-412.
5. Chung YJ, Song JM, Lee JY, Jung YT, Seo EJ, Choi SW Rhyu MG. 1996. Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. Cancer Res 56:4662-4665.
6. de Planque MR, Killian JA. 2003. Protein-lipid interactions studied with designed transmembrane peptides: Role of hydrophobic matching and interfacial anchoring. Mol Membr Biol 20:271-284.
7. Department of Epidemiology of Shanghai Cancer Institute (DESCI). 1998. Annual report of cancer incidences (1995). Tumor 18:1,2.
8. Derynck R, Akhurst RJ, Balmain A. 2001. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 29:117-129.
9. Derynck R, Zhang YE. 2003. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425:577-584.
10. + conduction and selectivity. Science 280:69-77.
11. Garrigue-Antar L, Munoz-Antonia T, Antonia SJ, Gesmonde J, Vellucci VF, Reiss M. 1995. Missense mutations of the transforming growth factor β type II receptor in human head and neck squamous carcinoma cells. Cancer Res 55:3982-3987.
12. Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ, Kinzler KW, Vogelstein B, Wilson JK, Markowitz S. 1999. Mutational inactivation of transforming growth factor β receptor type U in microsatellite stable colon cancers. Cancer Res 59:320-324.
13. Herskowitz I. 1987. Functional inactivation of genes by dominant negative mutations. Nature 329:219-222.
14. Hougaard S, Norgaard P, Abrahamsen N, Moses HL, Spang-Thomsen M, Skovgaard Poulsen H. 1999. Inactivation of the transforming growth factor β type II receptor in human small cell lung cancer cell lines. Br J Cancer 79:1005-1011.
15. Ignotz RA, Massague J. 1986. Transforming growth factor-β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 261:4337-4345.
16. Izumoto S, Arita N, Ohnishi T, Hiraga S, Taki T, Tomita N, Ohue M, Hayakawa T. 1997. Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas. Cancer Lett 112:251-256.
17. Killian JA, von Heijne G. 2000. How proteins adapt to a membrane-water interface. Trends Biochem Sci 25:429-434.
18. Kim WS, Park C, Hong SK, Park BK, Kim HS, Park K. 2000. Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is highly associated with transforming growth factor-β type II receptor (TGF-β RII) frameshift mutation. Anticancer Res 20:1499-1502.
19. Kuzniar TJ, Masters GA. Ray DW. 2004. Screening for lung cancer-A review. Med Sci Monit 10:RA21-RA30.
20. Lin HY, Moustakas A, Knaus P, Wells RG, Henis YI, Lodish HF. 1995. The soluble exoplasmic domain of the type II transforming growth factor (TGF)-β receptor. A heterogeneously glycosylated piotein with high affinity and selectivity for TGF-β ligands. J Biol Chem 270:2747-2754.
21. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF. 1992. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775-785.
22. Lu SL, Zhang WC, Akiyama Y, Nomizu T, Yuasa Y 1996. Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res 56:4595-4598.
23. Lu YL, Huang JX, Li XH, Li HF, Chen LZ, Li WH. 1989. Spontaneous metastasis of clonal cell subpopulations of human lung giant cell carcinoma after subcutaneous inoculation in nude mice. Chin J Oncol 11:3-7.
24. Lucke CD, Philpott A, Metcalfe JC, Thompson AM, Hughes-Davies L, Kemp PR, Hesketh R. 2001. Inhibiting mutations in the transforming growth factor β type 2 receptor in recurrent human breast cancer. Cancer Res 61:482-485.
25. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV. 1995. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268:1336-1338.
26. Massague J, Blain SW, Lo RS. 2000. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103:295-309.
27. Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J, Park K. 1995. A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res 55:5545-5547.
28. Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, Takahashi T. 2001. Heterogeneous transforming growth factor (TGF)-β unresponsiveness and loss of TGF-β receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res 61:8331-8339.
29. Park K, Kim SJ, Bang YJ, Park JG, Kim NK, Roberts AB, Sporn MB. 1994. Genetic changes in the transforming growth factor (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β. Proc Natl Acad Sci USA 91:8772-8776.
30. Pasche B. 2001. Role of transforming growth factor β in cancer. J Cell Physiol 186:153-168.
31. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
32. Siegel PM, Massague J. 2003. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat Rev Cancer 3:807-821.
33. Sun L, Wu G, Willson JK. Zborowska E, Yang J, Rajkarunanayake I, Wang J, Gentry LE, Wang XF, Brattain MG. 1994. Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J Biol Chem 269:26449-26455.
34. Toyoshima C, Nakasako M, Nomura H, Ogawa H. 2000. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution. Nature 405:647-655.
35. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E, In collaboration with Sobin LH and pathologists from 14 countries. 1999. WHO International Classification of Tumors. Histologic Typing of Lung and Pleural Tumors, 3rd ed. New York: Springer-Verlag.
36. Ulmschneider MB, Sansom MS, Di Nola A. 2005. Properties of integral membrane protein structures: Derivation of an implicit membrane potential. Proteins 59:252-265.
37. Wang J, Sun L, Myeroff L, Wang X. Gentiy LE, Yang J, Liang J, Zboiowska E, Markowitz S, Willson JK, Brattain MG. 1995. Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J Biol Chem 270:22044-22049.
38. White SH, von Heijne G. 2005. Transmembrane helices before, during, and after insertion. Curr Opin Struct Biol 15:378-386.
39. Wieser R, Attisano L, Wrana JL, Massague J. 1993. Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region. Mol Cell Biol 13:7239-7247.
40. World Health Organization. 1982. The World Health Organization typing of lung tumours, 2nd ed. Am J Clin Pathol 77:12321-12327.
41. Wrana JL, Attisano L, Carcamo J, Zemella A, Doody J, Laiho M, Wang XF, Massague J. 1992. TGFβ signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014.
42. Wu BQ, Sun YK, Zheng J, Wang JL, Fang WG, Tang Y, Gong EC, Zhao XS, Xing GZ, You JF. 1985. Establishment of highly metastatic human tumor cell line in nude mice. Chin J Oncol 7:324-328.
43. Zhang HT, Chen XF, Wang MH, Wang JC, Qi QY, Zhang RM, Xu WQ, Fei QY, Wang F, Cheng QQ, Chen F, Zhu CS, Tao SH, Luo Z. 2004. Defective expression of transforming growth factor β receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res 10:2359-2367.
44. Zhao H, Shiina H, Greene KL, Li LC, Tanaka Y, Kishi H, Igawa M, Kane CJ, Carroll P. Dahiya R. 2005. CpG methylation at promoter site -140 inactivates TGFβ2 receptor gene in prostate cancer. Cancer 104:44-52.