Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 951-961

  Siskou, Ioanna C ^a   Rekka, Eleni A ^a   Kourounakis, Angeliki P ^b   Chrysselis, Michael C ^a   Tsiakitzis, Kariofyllis ^a   Kourounakis, Panos N ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Antioxidant activity; Cerebral ischemia reperfusion injury; Ibuprofen derivatives; Inflammation

Indexed keywords

1 [2 (4 ISOBUTYLPHENYL)PROPANOYL] N (2 MERCAPTOETHYL)PYRROLIDINE 2 CARBOXAMIDE; 2 METHOXY 4 METHYLPHENYL 1 (ISOBUTYRYL)PYRROLIDINE 2 CARBOXYLATE; 2 METHOXY 4 METHYLPHENYL 1 [2 (4 ISOBUTYLPHENYL)PROPANOYL]PYRROLIDINE 2 CARBOXYLATE; 3 (PYRIDIN 3 YL)PROPYL 1 (ISOBUTYRYL)PYRROLIDINE 2 CARBOXYLATE; 3 (PYRIDIN 3 YL)PROPYL 1 [2 (4 ISOBUTYLPHENYL)PROPANOYL]PYRROLIDINE 2 CARBOXYLATE; ACETYLCHOLINESTERASE; ANTIOXIDANT; CYCLOOXYGENASE 2; ETHYL 2 [1 [2 (4 ISOBUTYLPHENYL)PROPANOYL]PYRROLIDINE 2 CARBOXAMIDO] 3 MERCAPTOPROPANOATE; GLUTATHIONE; IBUPROFEN; IBUPROFEN DERIVATIVE; LIPOXYGENASE;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG DESIGN; ENZYME SYNTHESIS; GASTROINTESTINAL TOXICITY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PAW EDEMA; RAT; REPERFUSION INJURY;

ANIMALS; ANTIOXIDANTS; ARTHRITIS, EXPERIMENTAL; BLOOD-BRAIN BARRIER; CHOLESTEROL; CHOLINESTERASE INHIBITORS; CYCLOOXYGENASE 2 INHIBITORS; FREUND'S ADJUVANT; GASTROINTESTINAL DISEASES; GLUTATHIONE; HYPERLIPIDEMIAS; HYPOXIA-ISCHEMIA, BRAIN; IBUPROFEN; LIPID PEROXIDATION; LIPOXYGENASE INHIBITORS; MICE; MICROSOMES, LIVER; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; OXIDATIVE STRESS; PICRATES; RATS; SPLEEN; TRIGLYCERIDES;

EID: 33845448622     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.056     Document Type: Article

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