Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 825-829

  Doulgkeris, Christos M ^a   Galanakis, Dimitrios ^a,b   Kourounakis, Angeliki P ^c   Tsiakitzis, Karyofyllis C ^a   Gavalas, Antonios M ^a   Eleftheriou, Phaedra T ^a   Victoratos, Panagiotis ^a   Rekka, Eleni A ^a   Kourounakis, Panos N ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b PAPAGEORGIOU GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Anti inflammatories; Antioxidants; Gastrointestinal toxicity; Hypocholesterolemics; L Cysteine; Lipoxygenase; Neurodegeneration; NSAIDs; Proline amide conjugates

Indexed keywords

AMIDE; HYDROXYPROLINE; HYPOCHOLESTEROLEMIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; NOOTROPIC AGENT; PIPECOLIC ACID; POLYFUNCTIONAL GROUP; PROLINE;

AMIDATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG SYNTHESIS; FEMALE; GASTROINTESTINAL TOXICITY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; NONHUMAN; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; ARTHRITIS; CHOLESTEROL; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FEMALE; INFLAMMATION; PIPECOLIC ACIDS; PROLINE; RATS; RATS, INBRED F344; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

ANIMALIA;

EID: 30344477361     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.027     Document Type: Article

References (37)

1. Davis, K. L.; Sammels, S. C. Dementia and Delirium. In Pharmacological Management of Neurological and Psychiatric Disorders, Enna, S. J., Coyle, J.T., Eds.; McGraw-Hill: New York, 1998; pp 267-316.
2. A.M. Palmer Trends. Pharmacol. Sci. 23 2002 426
3. H. Akiyamma, S. Barger, S. Barnum, and B. Bradt Neurobiol. Aging 21 2000 383 30 authors
4. Halliwell, B., Gutteridge, J. M. C., Eds.; In Free Radicals in Biology and Medicine, 3rd ed.; Oxford University Press: Oxford, 1999; a: pp 661-662;
5. Halliwell, B., Gutteridge, J. M. C., Eds.; In Free Radicals in Biology and Medicine, 3rd ed.; Oxford University Press: Oxford, 1999; b: pp 744-751;
6. Halliwell, B., Gutteridge, J. M. C., Eds.; In Free Radicals in Biology and Medicine, 3rd ed.; Oxford University Press: Oxford, 1999; c: pp 755-756;
7. Halliwell, B., Gutteridge, J. M. C., Eds.; In Free Radicals in Biology and Medicine, 3rd ed.; Oxford University Press: Oxford, 1999; d: pp 625-638.
8. C.N. Bassett, and T.J. Montine J. Nutr. Health Aging 7 2003 24
9. K.J. Yanagisawa Neurosci. Res. 70 2002 361
10. D. Galanakis, A.P. Kourounakis, K.C. Tsiakitzis, C.M. Doulgkeris, E.A. Rekka, A. Gavalas, K. Kravaritou, C. Charitos, and P.N. Kourounakis Bioorg. Med. Chem. Lett. 14 2004 3639
11. A.P. Kourounakis, D. Galanakis, K. Tsiakitzis, E.A. Rekka, and P.N. Kourounakis Drug Dev. Res. 41 1999 9
12. T.A. Gudasheva, T.A. Voronina, R.U. Ostrovstaya, G.G. Rozantsev, N.I. Vasilevich, S.S. Trofimov, E.V. Kravshenko, A.P. Skoldinov, and S.B. Seredenin Eur. J. Med. Chem. 31 1996 151
13. Rault, S.; Foloppe, M.; Robba, M.; Boulouard, M.; Renard, P.; Devissaquet, M.; Adam, G.; Eur. Pat. Appl. EP 486386, 1992; Chem. Abstr. 1992, 117, 111468n.
14. O. Vajragupta, S. Toasaksiri, C. Boonyarat, Y. Wongkrajana, P. Peungvicha, H. Watanabe, and P. Boonchoong Free Radical Res. 32 2000 145
15. B. Halliwel Free Radical Res. Commun. 9 1990 1
16. O.I. Aruoma Mutat. Res. 523 2003 9
17. L. Hadjipetrou-Kourounakis, E. Rekka, and A. Kourounakis Ann. N.Y. Acad. Sci. 650 1992 19
18. Y. Yao, Ch.M. Clark, J.Q. Trojanowski, V.M.-Y. Lee, and D. Praticò Annals Neurobiol. 2005 published on-line 21 July 2005
19. K. Sugaya, T. Uz, V. Kumar, and H. Manev Jpn. J. Pharmacol. 82 2000 85
20. E. Rekka, M. Chrysselis, I. Siskou, and A. Kourounakis Chem. Pharm. Bull. 50 2002 904
21. J. Tanaka, and Y. Yuda Biol. Pharm. Bull. 19 1996 716
22. S.R. Naik, R. Kalyampur, and U.K. Sheth Biochem. Pharmacol. 21 1972 511
23. F. Ursini, R. Barsacchi, G. Pelosi, and A. Benassi J. Biolumin. Chemilumin. 4 1989 241
24. S. Szabo, J.S. Trier, and P.W. Frankel Science 214 1981 200
25. K. Gyires Acta Physiol. Hung. 80 1992 247
26. P.L. McGeer, M. Shculzer, and E.G. McGeer Neurology 47 1996 425
27. W.F. Stewart, C. Kawas, and M. Corrada Neurology 48 1997 626
28. J. Rogers, L.C. Kirby, and S.R. Hempelman Neurology 43 1993 1609
29. C. Napoli, and W. Palinski Neurobiol. Aging 26 2005 293
30. W.Y. Ong, and B. Halliwell Ann. NY Acad. Sci. 1012 2004 51
31. A.B. Reiss Am. J. Alzheimers Dis. Other Demen. 20 2005 91
32. L. Puglielli, R.E. Tanzi, and D.M. Kovacs Nat. Neurosci. 6 2003 345
33. I. Casserly, and E. Topol Lancet 363 2004 1139
34. A.P. Kourounakis, P. Victoratos, N. Peroulis, N. Stefaniu, M. Yangou, L. Hadjipetrou, and P.N. Kourounakis Exp. Mol. Pathol. 73 2002 135
35. M.C. Chrysselis, E.A. Rekka, and P.N. Kourounakis Expert Opin. Ther. Patents 11 2001 33
36. M.C. Chrysselis, E.A. Rekka, and P.N. Kourounakis J. Med. Chem. 43 2000 609
37. V.R. Shanbhag, A.M. Crider, R. Gokhale, A. Harpalani, and R.M. Dick J. Pharm. Sci. 81 1992 149