Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 23, 2005, Pages 6485-6492

  Ziakas, George N ^a   Rekka, Eleni A ^a   Gavalas, Antonios M ^a   Eleftheriou, Phaedra T ^a   Tsiakitzis, Karyofillis C ^a   Kourounakis, Panos N ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatory agents; cyclooxygenase inhibition; Lipoxygenase; Nitric oxide donors; Tolfenamic acid esters

Indexed keywords

ALCOHOL DERIVATIVE; ANTIINFLAMMATORY AGENT; CARBON; CARRAGEENAN; ESTER DERIVATIVE; LIPOXYGENASE INHIBITOR; NITRIC OXIDE DONOR; PROSTAGLANDIN SYNTHASE INHIBITOR; TOLFENAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GASTROINTESTINAL TOXICITY; GASTROINTESTINAL TRACT FUNCTION; IN VITRO STUDY; MALE; NONHUMAN; PAW EDEMA; RAT; TOXICITY;

ANIMALS; ANTHRANILIC ACIDS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENZYME INHIBITORS; FEMALE; HINDLIMB; INTESTINES; ISOENZYMES; LIPOXYGENASE; MALE; MOLECULAR STRUCTURE; NITRIC OXIDE; RATS; STOMACH;

ANIMALIA;

EID: 27544444640     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.07.049     Document Type: Article

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