Role of endothelial [Ca2+]i in activation of eNOS in pressurized arterioles by agonists and wall shear stress

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 2 50-2, 2001, Pages

  Ungvari, Zoltan ^a,b   Sun, Dong ^b   Huang, An ^b   Kaley, Gabor ^a,b   Koller, Akos ^b  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Calcium independent pathways; Endothelial calcium fluorescence ratio; Endothelium derived hyperpolarizing factor; Fura 2; Tyrosine kinase

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; DAIDZEIN; GENISTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PROTEIN TYROSINE KINASE; CALCIMYCIN; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; IONOPHORE; NOS3 PROTEIN, RAT;

ANIMAL CELL; ARTERIOLE; ARTICLE; CALCIUM CELL LEVEL; ENDOTHELIUM CELL; ENZYME ACTIVATION; GRACILIS MUSCLE; NONHUMAN; PRIORITY JOURNAL; RAT; SHEAR STRESS; ANIMAL; MUSCLE CONTRACTION; PHYSIOLOGY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; ARTERIOLES; CALCIMYCIN; CALCIUM; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; IONOPHORES; MUSCLE CONTRACTION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 0034880758     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.2.h606     Document Type: Article

References (38)

1. Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells
2. Components of acetylcholineinduced dilation in isolated rat arterioles
3. 2+ during acetylcholine-induced dilation of microvessels
4. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc
5. ACh-induced calcium transients in primary cultures of rabbit aortic endothelial cells
6. Elevation of intracellular calcium in smooth muscle causes endothelial cell generation of NO in arterioles
7. 2+) coupling in vascular endothelial cells
8. Endothelial cell calcium increases during flow-induced dilation in isolated arterioles
9. Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress
10. Calcium-dependent and calcium-independent activation of the endothelial NO synthase
11. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells
12. Calcium responses induced by acetylcholine in submucosal arterioles of the guinea-pig small intestine
13. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1
14. Flowinduced calcium transients in single endothelial cells: Spatial and temporal analysis
15. Rapid displacement of vimentin intermediate filaments in living endothelial cells exposed to flow
16. Both nitric oxide and prostaglandinmediated responses are impaired in skeletal muscle arterioles of hypertensive rats
17. In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF
18. Invited review: Effects of flow on vascular endothelial intracellular calcium signaling of rat aortas ex vivo
19. 2+ and ecNOS activity
20. Endothelial regulation of wall shear stress and blood flow in skeletal muscle microcirculation
21. Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles
22. Role of shear stress and endothelial prostaglandins in flow- and viscosity-induced dilation of arterioles in vitro
23. Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells
24. Phenotypic changes in rat and guinea pig coronary microvascular endothelium after culture: Loss of nitric oxide synthase activity
25. The distribution of blood rheological parameters in the microvasculature of cat mesentery
26. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
27. i and membrane potential of vascular endothelium of intact rat blood vessels
28. Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation
29. 2+ signaling of vascular endothelial cells: Effect of shear stress and ATP
30. Coronary arteriolar flow-induced vasodilation signals through tyrosine kinase
31. 2+ concentration during shear stress- and agonist-induced vasodilation
32. Shear stress increases inositol trisphosphate levels in human endothelial cells
33. 2+
34. Prostaglandin H synthase: Protein synthesis-independent regulation in bovine aortic endothelial cells
35. Shear stress-induced calcium transients in endothelial cells from human umbilical cord veins
36. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase
37. 2+ sensitivity of arteriolar smooth muscle
38. Flow-dependent cytosolic acidification of vascular endothelial cells