Cognitive dysfunction resulting from hippocampal hyperactivity - A possible cause of anxiety disorder?

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 4, 1997, Pages 603-611

  McNaughton, Neil ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

anxiety; anxiolytics; behavioral inhibition; cognition; hippocampus; memory; risk assessment; theta rhythm

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE; BUSPIRONE;

ANXIETY NEUROSIS; ARTICLE; BEHAVIOR; COGNITION; COGNITIVE DEFECT; EMOTION; HIPPOCAMPUS; HUMAN; HYPERACTIVITY; LIMBIC SYSTEM; MEMORY; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SEPTUM NUCLEUS; THETA RHYTHM;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; COGNITION DISORDERS; EMOTIONS; HIPPOCAMPUS; HUMANS; MEMORY;

EID: 0030935295     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00419-4     Document Type: Article

References (69)

1. Bishop K. I., Curran H. V. Psychopharmacological analysis of implicit and explicit memory. A study with lorazepam and the benzodiazepine antagonist flumazenil Psychopharmacology. 121:1995;267-278.
2. Blanchard D. C., Blanchard R. J. Effects of ethanol, benzodiazepines and serotonin compounds on ethopharmacological models of anxiety. McNaughton N., Andrews G. Anxiety. 1990;University of Otago Press, Dunedin, New Zealand.
3. Blanchard, D. C.; Blanchard, R. J.; Rodgers, R. J.: Risk assessment and animal models of anxiety. In: Olovier, B.; Mos, J.; Slangen, J. L., eds. Animal models in psychopharmacology. 1991:117-134.
4. Blanchard R. J., Blanchard D. C. Anti-predator defense as models of animal fear and anxiety. Brain P. F., Parmigiani S., Blanchard R. J., Mainardi D. Fear and defence. 1990;89-108 Harwood Academic Publishers, Chur, Switzerland.
5. Blanchard R. J., Yudko E. B., Rodgers R. J., Blanchard D. C. Defense system psychopharmacology. An ethological approach to the pharmacology of fear and anxiety Behav. Brain Res. 58:1993;155-165.
6. Brown J., Brown M. W. The effects of repeating a recognition test in lorazepam-induced amnesia. Evidence for impaired contextual memory as a cause of amnesia Q. J. Exp. Psychol. 42A:1990;279-290.
7. Cannon W. B. The James-Lange theory of emotion. Am. J. Psychol. 39:1927;115-124.
8. Cohen N. J., Eichenbaum H. Memory, amnesia and the hippocampal system. 1993;MIT Press, Cambridge, MA.
9. Coover G. D., Goldman L., Levine S. Plasma corticosteone increases produced by extinction of operant behaviour in rats. Physiol. Behav. 6:1971;261-263.
10. Coover G. D., Ursin H., Levine S. Plasma corticosterone levels during active avoidance learning in rats. J. Comp. Physiol. Psychol. 82:1973;170-174.
11. Curran H. V. Benzodiazepines, memory and mood. A review Psychopharmacology. 105:1991;1-8.
12. Cutler N. R., Sramek J. J., Hesselink J. M. K., Krol A., Roeschen J., Rickels K., Schweizer E. A double-blind, placebo-controlled study comparing the efficacy and safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder. A prospective multicenter trial J. Clin. Psychopharmacol. 13:1993;429-437.
13. Danion J. M., Weingartner H., File S. E., Jaffard R., Sunderland T., Tulving E., Warburton D. M. Pharmacology of human memory and cognition. Illustrations from the effects of benzodiazepines and cholinergic drugs J. Psychopharmacol. 7:1993;371-377.
14. Davis M. The role of the amygdala in fear conditioning. Aggleton J. P. The amygdala. 1992;Wiley-Liss, New York.
15. Dickinson A. Contemporary animal learning theory. 1980;Cambridge University Press, Cambridge, UK.
16. Eichenbaum H., Otto T., Cohen N. J. Two functional components of the hippocampal memory system. Behav. Brain Sci. 17:1994;449-518.
17. Eysenck M. W. The nature of anxiety. Gale A., Eysenck M. W. Handbook of individual differences. Biological perspectives:1992;157-178 John Wiley & Sons, New York.
18. Eysenck M. W., Byrne A. Anxiety and suceptibility to distraction. Pers. Individ. Differ. 13:1992;793-798.
19. File S. E., Goodall E. M., Fluck E. J., Sanders F. L., Murray A., Skelly A. M., Joyce E. M. Contrasting effects of midazolam and nitrous oxide on memory and cognitive bias in dentally phobic patients. Hum. Psychopharmacol. 8:1993;195-202.
20. Gray J. A. The neuropsychology of anxiety. An enquiry into the functions of the septo-hippocampal system:1982;Oxford University Press, Oxford, UK.
21. Gray J. A., McNaughton N. Comparison between the behavioural effects of septal and hippocampal lesions. A review Neurosci. Biobehav. Rev. 7:1983;119-188.
22. Gray, J. A.; McNaughton, N.: The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system, 2nd ed. Oxford, UK: Oxford University Press; in prep.
23. Gray J. A., McNaughton N., James D. T. D., Kelly P. Effect of minor tranquillisers on hippocampal theta rhythm mimicked by depletion of forebrain noradrenaline. Nature. 258:1975;424-425.
24. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders. More than 30 years of research Pharmacol. Ther. 65:1995;319-395.
25. Hebb D. O. The organization of behaviour. 1949;John Wiley & Sons, New York.
26. Hogg S., File S. E. Regional differences in rat benzodiazepine binding in response to novelty and cat odor. Neuropharmacology. 33:1994;865-868.
27. James W. What is an emotion? Mind. 9:1884;188-205. Reprinted in Arnold, M., ed.: The nature of emotion. New York: Penguin; 1968.
28. Kirk I. J., McNaughton N. Supramammillary cell firing and hippocampal rhythmical slow activity. NeuroReport. 2:1991;723-725.
29. Kirk I., McNaughton N. Mapping of differential effects of procaine on frequency and amplitude of reticularly-elicited hippocampal rhythmical slow activity. Hippocampus. 3:1993;517-526.
30. Le Doux J. Emotion and the amygdala. Aggleton J. P. The amygdala. 1992;339-352; Wiley-Liss, New York.
31. Lucki I., Rickels K., Giesecke M. A., Geller A. Differential effects of the anxiolytic drugs, diazepam and buspirone, on memory function. Br. J. Clin. Pharmacol. 23:1987;207-211.
32. MacKay D. The organization of perception and action. 1987;Springer-Verlag, Berlin.
33. Mathews A., MacLeod C. Cognitive approaches to emotion and emotional disorders. Annu. Rev. Psychol. 45:1994;25-30.
34. McKay G., Alford C., Bhatti J. Z., Curran S., Hindmarch I. Effects of acute doses of buspirone and clobazam on cognitive function and psychomotor performance. Med. Sci. Res. 17:1989;301-302.
35. McKay G., Alford C., Bhatti J. Z., Curran S., Hindmarch I. Repeated dose effects of buspirone and clobazam on cognitive and psychomotor performance. Med. Sci. Res. 17:1989;325-326.
36. McNaughton B. L., Morris R. G. M. Hippocampal synaptic enhancement and information storage within a distributed memory system. Trends Neurosci. 10:1987;408-415.
37. McNaughton N. Chlordiazepoxide and successive discrimination. Different effects on acquisition and performance Pharmacol. Biochem. Behav. 23:1985;487-494.
38. McNaughton N. Biology and emotion. 1989;Cambridge University Press, Cambridge, UK.
39. McNaughton N. The hippocampus. Relational processor or antiprocessor? Behav. Brain Sci. 17:1994;487-488.
40. McNaughton N., Coop C. F. Neurochemically dissimilar anxiolytic drugs have common effects on hippocampal rhythmic slow activity. Neuropharmacology. 30:1991;855-863.
41. McNaughton N., James D. T. D., Stewart J., Gray J. A., Valero I., Drewnowski A. Septal driving of hippocampal theta rhythm as a function of frequency in the male rat. Drug effects Neuroscience. 2:1977;1019-1027.
42. McNaughton N., Logan B., Panickar K. S., Kirk I., Pan W.-X., Brown N. T., Heenan A. The contribution of synapses in the medial supramammillary nucleus to the frequency of hippocampal theta rhythm in freely-moving rats. Hippocampus. 5:1995;534-545.
43. McNaughton N., Morris R. G. M. Chlordiazepoxide, an anxiolytic benzodiazepine, impairs place navigation in rats. Behav. Brain Res. 24:1987;39-46.
44. McNaughton N., Morris R. G. M. Buspirone produces a dose-related impairment in spatial navigation. Pharmacol. Biochem. Behav. 43:1992;167-171.
45. McNaughton N., Panickar K. S., Logan B. The pituitary-adrenal axis and the different behavioural effects of buspirone and chlordiazepoxide. Pharmacol. Biochem. Behav. 54:1996;51-56.
46. McNaughton N., Richardson J., Gore C. Hippocampal slow waves generated by reticular stimulation. Common effects of anxiolytic drugs Neuroscience. 19:1986;899-903.
47. McNaughton N., Sedgwick E. M. Reticular stimulation and hippocampal theta rhythm in rats. Effects of drugs Neuroscience. 3:1978;629-632.
48. Miller R. Cortico-hippocampal interplay and the representation of contexts in the brain. 1991;Springer-Verlag, Berlin.
49. Morris R. G. M., Garrud P., Rawlins J. N. P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
50. O'Keefe J., Burgess N. Geometric determinants of the place fields of hippocampal neurons. Nature. 381:1996;425-428.
51. O'Keefe J., Nadel L. The hippocampus as a cognitive map. 1978;Oxford University Press, Oxford.
52. Panickar K. M., McNaughton N. Dose-response analysis of the effects of buspirone on rearing in rats. J. Psychopharmacol. 5:1991;72-76.
53. Panickar K. M., McNaughton N. Effects of buspirone on fixed interval responding in rats. Psychopharmacology. 5:1991;410-417.
54. Panickar K. M., McNaughton N. Comparison of the effects of buspirone and chlordiazepoxide on differential reinforcement of low rates of response. Eur. J. Pharmacol. 210:1991;307-313.
55. Panickar K. M., McNaughton N. Comparison of the effects of buspirone and chlordiazepoxide on successive discrimination in rats. Pharmacol. Biochem. Behav. 39:1991;275-278.
56. Papez J. W. A proposed mechanism of emotion. Arch. Neurol. Psychiatry. 38:1937;725-743.
57. Risold P. Y., Swanson L. W. Structural evidence for functional domains in the rat hippocampus. Science. 272:1996;1484-1486.
58. Stoerig P. Varieties of vision. From blind responses to conscious recognition Trends Neurosci. 19:1996;401-406.
59. Wees H. G., Steinberg R., Pritzel M. Mnestic disorders in long-term high-dose diazepam abuse. A pilot study Eur. J. Psychiatry. 9:1994;254-259.
60. Weinstein A. M., Nutt D. J. A cognitive dysfunction in anxiety and its amelioration by effective treatment with SSRIs. J. Psychopharmacol. 9:1995;83-89.
61. Zangrossi H., File S. E. Behavioral consequences in animal tests of anxiety and exploration of exposure to cat odor. Brain Res. Bull. 29:1992;381-388.
62. Zangrossi H., File S. E. Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor. Pharmacol. Biochem. Behav. 43:1992;1195-1200.
63. Zangrossi H., File S. E. Habituation and generalization of phobic responses to cat odor. Brain Res. Bull. 33:1994;189-194.
64. Zhu X.-O., McNaughton N. Effects of long-term administration of anxiolytics on reticular-elicited hippocampal rhythmical slow activity. Neuropharmacology. 30:1991;1095-1099.
65. Zhu X.-O., McNaughton N. Effects of long-term administration of imipramine on hippocampal rhythmical slow activity. Psychopharmacology. 105:1991;433-438.
66. Zhu X.-O., McNaughton N. A comparison of the acute effects of a tricyclic and a MAOI antidepressants on septal driving of hippocampal rhythmical slow activity. Psychopharmacology. 114:1994;337-344.
67. Zhu X.-O., McNaughton N. Effects of long-term administration of phenelzine on reticular-elicited hippocampal rhythmical slow activity. Neurosci. Res. 21:1995;311-316.
68. Zhu X.-O., McNaughton N. Similar effects of buspirone and chlordiazepoxide on a fixed interval schedule with long-term, low-dose administration. J. Psychopharmacol. 9:1995;326-330.
69. Zhu X.-O., McNaughton N. Minimal changes with long-term administration of anxiolytics on septal driving of hippocampal rhythmical slow activity. Psychopharmacology. 118:1995;93-100.