-
2
-
-
0033605559
-
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
-
Brown JD, DiChiara MR, Anderson KR, Gimbrone MA Jr, and Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J Biol Chem 274: 8797-8805, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 8797-8805
-
-
Brown, J.D.1
DiChiara, M.R.2
Anderson, K.R.3
Gimbrone Jr., M.A.4
Topper, J.N.5
-
3
-
-
2342471301
-
Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis
-
Conery AR, Cao Y, Thompson EA, Townsend CM Jr, Ko TC, and Luo K. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β induced apoptosis. Nat Cell Biol 6: 366-372, 2004.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 366-372
-
-
Conery, A.R.1
Cao, Y.2
Thompson, E.A.3
Townsend Jr., C.M.4
Ko, T.C.5
Luo, K.6
-
4
-
-
0032101178
-
Direct binding of Smad3 and Smad4 to critical TGF-β inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, and Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF-β inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Ten Dijke, P.4
Huet, S.5
Gauthier, J.M.6
-
5
-
-
0034682848
-
Transforming growth factor-β1 inhibits cytokine-mediated induction of human metalloelastase in macrophages
-
Feinberg MW, Jain MK, Werner F, Sibinga NE, Wiesel P, Wang H, Topper JN, Perrella MA, and Lee ME. Transforming growth factor-β1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J Biol Chem 275: 25766-25773, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 25766-25773
-
-
Feinberg, M.W.1
Jain, M.K.2
Werner, F.3
Sibinga, N.E.4
Wiesel, P.5
Wang, H.6
Topper, J.N.7
Perrella, M.A.8
Lee, M.E.9
-
6
-
-
19544386091
-
Fibulin-5 interacts with fibrillin-1 molecules and microfibrils
-
Freeman LJ, Lomas A, Hodson N, Sherratt MJ, Mellody KT, Weiss AS, Shuttleworth A, and Kielty CM. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils. Biochem J 388: 1-5, 2005.
-
(2005)
Biochem J
, vol.388
, pp. 1-5
-
-
Freeman, L.J.1
Lomas, A.2
Hodson, N.3
Sherratt, M.J.4
Mellody, K.T.5
Weiss, A.S.6
Shuttleworth, A.7
Kielty, C.M.8
-
7
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
-
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, and Falb D. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89: 1165-1173, 1997.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone Jr., M.A.9
Wrana, J.L.10
Falb, D.11
-
8
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, and Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74, 2002.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
Nicolas, F.J.2
Callahan, J.F.3
Harling, J.D.4
Gaster, L.M.5
Reith, A.D.6
Laping, N.J.7
Hill, C.S.8
-
9
-
-
0030765945
-
Smad6 inhibits signalling by the TGF-β superfamily
-
Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, and Miyazono K. Smad6 inhibits signalling by the TGF-β superfamily. Nature 389: 622-626, 1997.
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
11
-
-
0033612354
-
EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature
-
Kowal RC, Richardson JA, Miano JM, and Olson EN. EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature. Circ Res 84: 1166-1176, 1999.
-
(1999)
Circ Res
, vol.84
, pp. 1166-1176
-
-
Kowal, R.C.1
Richardson, J.A.2
Miano, J.M.3
Olson, E.N.4
-
12
-
-
0033106484
-
A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras
-
Kretzschmar M, Doody J, Timokhina I, and Massagué J. A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras. Genes Dev 13: 804-816, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
13
-
-
0030922981
-
Regulation of type I collagen mRNA by amino acid deprivation in human lung fibroblasts
-
Krupsky M, Kuang PP, and Goldstein RH. Regulation of type I collagen mRNA by amino acid deprivation in human lung fibroblasts. J Biol Chem 272: 13864-13868, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 13864-13868
-
-
Krupsky, M.1
Kuang, P.P.2
Goldstein, R.H.3
-
14
-
-
0036089019
-
NF-κB induced by IL-1β inhibits elastin transcription and myofibroblast phenotype
-
Kuang PP, Berk JL, Rishikof DC, Foster JA, Humphries DE, Ricupero DA, and Goldstein RH. NF-κB induced by IL-1β inhibits elastin transcription and myofibroblast phenotype. Am J Physiol Cell Physiol 283: C58-C65, 2002.
-
(2002)
Am J Physiol Cell Physiol
, vol.283
-
-
Kuang, P.P.1
Berk, J.L.2
Rishikof, D.C.3
Foster, J.A.4
Humphries, D.E.5
Ricupero, D.A.6
Goldstein, R.H.7
-
15
-
-
0142150945
-
Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair
-
Kuang PP, Goldstein RH, Liu Y, Rishikof DC, Jean JC, and Joyce-Brady M. Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair. Am J Physiol Lung Cell Mol Physiol 285: L1147-L1152, 2003.
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.285
-
-
Kuang, P.P.1
Goldstein, R.H.2
Liu, Y.3
Rishikof, D.C.4
Jean, J.C.5
Joyce-Brady, M.6
-
16
-
-
23944479697
-
Regulation of elastin gene transcription by proteasome dysfunction
-
Kuang PP and Goldstein RH. Regulation of elastin gene transcription by proteasome dysfunction. Am J Physiol Cell Physiol 289: C766-C773, 2005.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
-
-
Kuang, P.P.1
Goldstein, R.H.2
-
17
-
-
0842310831
-
Elastic fiber homeostasis requires lysyl oxidase-like 1 protein
-
Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, and Li T. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet 36: 178-182, 2004.
-
(2004)
Nat Genet
, vol.36
, pp. 178-182
-
-
Liu, X.1
Zhao, Y.2
Gao, J.3
Pawlyk, B.4
Starcher, B.5
Spencer, J.A.6
Yanagisawa, H.7
Zuo, J.8
Li, T.9
-
18
-
-
0036713921
-
Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa
-
Loeys B, Van Maldergem L, Mortier G, Coucke P, Gerniers S, Naeyaert JM, and De Paepe A. Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. Hum Mol Genet 11: 2113-2118, 2002.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2113-2118
-
-
Loeys, B.1
Van Maldergem, L.2
Mortier, G.3
Coucke, P.4
Gerniers, S.5
Naeyaert, J.M.6
De Paepe, A.7
-
20
-
-
0025500761
-
Transforming growth factor-β increases elastin production by neonatal rat lung fibroblasts
-
McGowan SE and McNamer R. Transforming growth factor-β increases elastin production by neonatal rat lung fibroblasts. Am J Respir Cell Mol Biol 3: 369-376, 1990.
-
(1990)
Am J Respir Cell Mol Biol
, vol.3
, pp. 369-376
-
-
McGowan, S.E.1
McNamer, R.2
-
21
-
-
25444527720
-
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension
-
Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, and Rabinovitch M. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res 97: 596-604, 2005.
-
(2005)
Circ Res
, vol.97
, pp. 596-604
-
-
Merklinger, S.L.1
Wagner, R.A.2
Spiekerkoetter, E.3
Hinek, A.4
Knutsen, R.H.5
Kabir, M.G.6
Desai, K.7
Hacker, S.8
Wang, L.9
Cann, G.M.10
Ambartsumian, N.S.11
Lukanidin, E.12
Bernstein, D.13
Husain, M.14
Mecham, R.P.15
Starcher, B.16
Yanagisawa, H.17
Rabinovitch, M.18
-
22
-
-
0037117796
-
Elastic fibers: Building bridges between cells and their matrix
-
Midwood KS and Schwarzbauer JE. Elastic fibers: building bridges between cells and their matrix. Curr Biol 12: R279-R281, 2002.
-
(2002)
Curr Biol
, vol.12
-
-
Midwood, K.S.1
Schwarzbauer, J.E.2
-
23
-
-
0037435009
-
6-mediated TGF-β activation causes Mmp12-dependent emphysema
-
6-mediated TGF-β activation causes Mmp12-dependent emphysema. Nature 422: 169-173, 2003.
-
(2003)
Nature
, vol.422
, pp. 169-173
-
-
Morris, D.G.1
Huang, X.2
Kaminski, N.3
Wang, Y.4
Shapiro, S.D.5
Dolganov, G.6
Glick, A.7
Sheppard, D.8
-
24
-
-
0037050030
-
Fibulin-5/DANCE is essential for elastogenesis in vivo
-
Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, Minamisawa S, Cheng CF, Kobuke K, Dalton N, Takada Y, Tashiro K, Ross J Jr, Honjo T, and Chien KR. Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature 415: 171-175, 2002.
-
(2002)
Nature
, vol.415
, pp. 171-175
-
-
Nakamura, T.1
Lozano, P.R.2
Ikeda, Y.3
Iwanaga, Y.4
Hinek, A.5
Minamisawa, S.6
Cheng, C.F.7
Kobuke, K.8
Dalton, N.9
Takada, Y.10
Tashiro, K.11
Ross Jr., J.12
Honjo, T.13
Chien, K.R.14
-
25
-
-
0033529668
-
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries
-
Nakamura T, Ruiz-Lozano P, Lindner V, Yabe D, Taniwaki M, Furukawa Y, Kobuke K, Tashiro K, Lu Z, Andon NL, Schaub R, Matsumori A, Sasayama S, Chien KR, and Honjo T. DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries. J Biol Chem 274: 22476-22483, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 22476-22483
-
-
Nakamura, T.1
Ruiz-Lozano, P.2
Lindner, V.3
Yabe, D.4
Taniwaki, M.5
Furukawa, Y.6
Kobuke, K.7
Tashiro, K.8
Lu, Z.9
Andon, N.L.10
Schaub, R.11
Matsumori, A.12
Sasayama, S.13
Chien, K.R.14
Honjo, T.15
-
26
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
-
Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, and ten Dijke P. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389: 631-635, 1997.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Moren, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
Ten Dijke, P.11
-
27
-
-
0037373277
-
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
-
Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, and Dietz HC. Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33: 407-411, 2003.
-
(2003)
Nat Genet
, vol.33
, pp. 407-411
-
-
Neptune, E.R.1
Frischmeyer, P.A.2
Arking, D.E.3
Myers, L.4
Bunton, T.E.5
Gayraud, B.6
Ramirez, F.7
Sakai, L.Y.8
Dietz, H.C.9
-
28
-
-
9344252227
-
Fibulin-5 is a novel binding protein for extracellular superoxide dismutase
-
Nguyen A, Itoh S, Jeney V, Yanagisawa H, Fujimoto M, Ushio-Fukai M, and Fukai T. Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ Res 95: 1067-1074, 2004.
-
(2004)
Circ Res
, vol.95
, pp. 1067-1074
-
-
Nguyen, A.1
Itoh, S.2
Jeney, V.3
Yanagisawa, H.4
Fujimoto, M.5
Ushio-Fukai, M.6
Fukai, T.7
-
29
-
-
0036933489
-
The myofibroblast in pulmonary fibrosis
-
Phan SH. The myofibroblast in pulmonary fibrosis. Chest 122: 286S-289S, 2002.
-
(2002)
Chest
, vol.122
-
-
Phan, S.H.1
-
30
-
-
2342647439
-
PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3
-
Remy I, Montmarquette A, and Michnick SW. PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3. Nat Cell Biol 6: 358-365, 2004.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 358-365
-
-
Remy, I.1
Montmarquette, A.2
Michnick, S.W.3
-
32
-
-
0036006811
-
The ever-increasing complexity of TGF-β signaling
-
Roberts AB. The ever-increasing complexity of TGF-β signaling. Cytokine Growth Factor Rev 13: 3-5, 2002.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 3-5
-
-
Roberts, A.B.1
-
33
-
-
0029449572
-
Structure of the elastin gene
-
Rosenbloom J, Abrams WR, Indik Z, Yeh H, Ornstein-Goldstein N, and Bashir MM. Structure of the elastin gene. Ciba Found Symp 192: 59-74, 1995.
-
(1995)
Ciba Found Symp
, vol.192
, pp. 59-74
-
-
Rosenbloom, J.1
Abrams, W.R.2
Indik, Z.3
Yeh, H.4
Ornstein-Goldstein, N.5
Bashir, M.M.6
-
34
-
-
1642535424
-
The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1
-
Runyan CE, Schnaper HW, and Poncelet AC. The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1. J Biol Chem 279: 2632-2639, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 2632-2639
-
-
Runyan, C.E.1
Schnaper, H.W.2
Poncelet, A.C.3
-
35
-
-
0037178816
-
Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-β and affects protein kinase cascades
-
Schiemann WP, Blobe GC, Kalume DE, Pandey A, and Lodish HF. Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-β and affects protein kinase cascades. J Biol Chem 277: 27367-27377, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 27367-27377
-
-
Schiemann, W.P.1
Blobe, G.C.2
Kalume, D.E.3
Pandey, A.4
Lodish, H.F.5
-
36
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi Y and Massague J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
37
-
-
20044379927
-
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration
-
Spencer JA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson JA, Olson EN, and Yanagisawa H. Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc Natl Acad Sci USA 102: 2946-2951, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2946-2951
-
-
Spencer, J.A.1
Hacker, S.L.2
Davis, E.C.3
Mecham, R.P.4
Knutsen, R.H.5
Li, D.Y.6
Gerard, R.D.7
Richardson, J.A.8
Olson, E.N.9
Yanagisawa, H.10
-
38
-
-
3242719404
-
Missense variations in the fibulin 5 gene and age-related macular degeneration
-
Stone EM, Braun TA, Russell SR, Kuehn MH, Lotery AJ, Moore PA, Eastman CG, Casavant TL, and Sheffield VC. Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med 351: 346-353, 2004.
-
(2004)
N Engl J Med
, vol.351
, pp. 346-353
-
-
Stone, E.M.1
Braun, T.A.2
Russell, S.R.3
Kuehn, M.H.4
Lotery, A.J.5
Moore, P.A.6
Eastman, C.G.7
Casavant, T.L.8
Sheffield, V.C.9
-
39
-
-
0037686257
-
Fibulins: A versatile family of extracellular matrix proteins
-
Timpl R, Sasaki T, Kostka G, and Chu ML. Fibulins: a versatile family of extracellular matrix proteins. Nat Rev Mol Cell Biol 4: 479-489, 2003.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 479-489
-
-
Timpl, R.1
Sasaki, T.2
Kostka, G.3
Chu, M.L.4
-
40
-
-
0034713224
-
Transforming growth factor-β1 promotes the morphological and functional differentiation of the myofibroblast
-
Vaughan MB, Howard EW, and Tomasek JJ. Transforming growth factor-β1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res 257: 180-189, 2000.
-
(2000)
Exp Cell Res
, vol.257
, pp. 180-189
-
-
Vaughan, M.B.1
Howard, E.W.2
Tomasek, J.J.3
-
41
-
-
0037049996
-
Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo
-
Yanagisawa H, Davis EC, Starcher BC, Ouchi T, Yanagisawa M, Richardson JA, and Olson EN. Fibulin-5 is an elastin-binding protein essential for elastic fiber development in vivo. Nature 415: 168-171, 2002.
-
(2002)
Nature
, vol.415
, pp. 168-171
-
-
Yanagisawa, H.1
Davis, E.C.2
Starcher, B.C.3
Ouchi, T.4
Yanagisawa, M.5
Richardson, J.A.6
Olson, E.N.7
|