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Volumn 47, Issue 4, 2006, Pages 275-281

Amino acid residues affecting drug pump function in Candida albicans - C. albicans drug pump function

Author keywords

Allelic variation; Antifungal efflux; Candida albicans; Single nucleotide polymorphisms (SNPs)

Indexed keywords

ABC TRANSPORTER; AMINO ACID; ANTIFUNGAL AGENT; FLUCONAZOLE; PROTEIN CDR1P; PROTEIN CDR2P;

EID: 33751578892     PISSN: 09164804     EISSN: 09164804     Source Type: Journal    
DOI: 10.3314/jjmm.47.275     Document Type: Review
Times cited : (3)

References (49)
  • 1
    • 0026316853 scopus 로고
    • Thrush can be prevented in patients with acquired immunodeficiency syndrome and the acquired immunodeficiency syndrome-related complex. Randomized, double-blind, placebo-controlled study of 100-mg oral fluconazole daily
    • Stevens DA, Greene SI, Lang OS: Thrush can be prevented in patients with acquired immunodeficiency syndrome and the acquired immunodeficiency syndrome-related complex. Randomized, double-blind, placebo-controlled study of 100-mg oral fluconazole daily. Arch Intern Med 151: 2458-2464, 1991.
    • (1991) Arch Intern Med , vol.151 , pp. 2458-2464
    • Stevens, D.A.1    Greene, S.I.2    Lang, O.S.3
  • 2
    • 0028001183 scopus 로고
    • Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection
    • Ruhnke M, Eigler A, Tennagen I, Geiseler B, Engelmann E, Trautmann M: Emergence of fluconazole-resistant strains of Candida albicans in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection. J Clin Microbiol 32: 2092-2098, 1994.
    • (1994) J Clin Microbiol , vol.32 , pp. 2092-2098
    • Ruhnke, M.1    Eigler, A.2    Tennagen, I.3    Geiseler, B.4    Engelmann, E.5    Trautmann, M.6
  • 4
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA: Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev 11: 382-402, 1998.
    • (1998) Clin Microbiol Rev , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 6
    • 0033803407 scopus 로고    scopus 로고
    • Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy
    • Kaplan JE, Hanson D, Dworkin MS, Frederick T, Bertolli J, Lindegren ML, Holmberg S, Jones JL: Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis 30 Suppl 1: S5-14, 2000.
    • (2000) Clin Infect Dis , vol.30 , Issue.SUPPL. 1
    • Kaplan, J.E.1    Hanson, D.2    Dworkin, M.S.3    Frederick, T.4    Bertolli, J.5    Lindegren, M.L.6    Holmberg, S.7    Jones, J.L.8
  • 8
    • 0035912249 scopus 로고    scopus 로고
    • HIV chemotherapy
    • Richman DD: HIV chemotherapy. Nature 410: 995-1001, 2001.
    • (2001) Nature , vol.410 , pp. 995-1001
    • Richman, D.D.1
  • 10
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhauser J: The genetic basis of fluconazole resistance development in Candida albicans. Biochim Biophys Acta 1587: 240-248, 2002.
    • (2002) Biochim Biophys Acta , vol.1587 , pp. 240-248
    • Morschhauser, J.1
  • 11
    • 22744455661 scopus 로고    scopus 로고
    • An update on antifungal targets and mechanisms of resistance in Candida albicans
    • Akins RA: An update on antifungal targets and mechanisms of resistance in Candida albicans. Med Mycol 43: 285-318, 2005.
    • (2005) Med Mycol , vol.43 , pp. 285-318
    • Akins, R.A.1
  • 12
    • 10444285332 scopus 로고    scopus 로고
    • Multidrug resistance in yeast Candida
    • Prasad R, Kapoor K: Multidrug resistance in yeast Candida. Int Rev Cytol 242: 215-248, 2005.
    • (2005) Int Rev Cytol , vol.242 , pp. 215-248
    • Prasad, R.1    Kapoor, K.2
  • 13
    • 0002896893 scopus 로고    scopus 로고
    • Current understanding of the modes of action of and resistance mechanisms to conventional and emerging antifungal agents for treatment of Candida infections
    • (R. Calderone, Ed), ASM Press, Washington
    • Sanglard D, Bille J: Current understanding of the modes of action of and resistance mechanisms to conventional and emerging antifungal agents for treatment of Candida infections. In Candida and Candidiasis (R. Calderone, Ed), p.349-383, ASM Press, Washington, 2002.
    • (2002) Candida and Candidiasis , pp. 349-383
    • Sanglard, D.1    Bille, J.2
  • 16
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • Perea S, Lopez-Ribot JL, Kirkpatrick WR, McAtee RK, Santillan RA, Martinez M, Calabrese D, Sanglard D, Patterson TF: Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 45: 2676-2684, 2001.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2676-2684
    • Perea, S.1    Lopez-Ribot, J.L.2    Kirkpatrick, W.R.3    McAtee, R.K.4    Santillan, R.A.5    Martinez, M.6    Calabrese, D.7    Sanglard, D.8    Patterson, T.F.9
  • 17
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J: Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob Agents Chemother 39: 2378-2386, 1995.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 18
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White TC: Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob Agents Chemother 41: 1482-1487, 1997.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1482-1487
    • White, T.C.1
  • 19
    • 0037378017 scopus 로고    scopus 로고
    • Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates
    • Rogers PD, Barker KS: Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates. Antimicrob Agents Chemother 47: 1220-1227, 2003.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1220-1227
    • Rogers, P.D.1    Barker, K.S.2
  • 20
    • 2542494102 scopus 로고    scopus 로고
    • Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles
    • Chau AS, Mendrick CA, Sabatelli FJ, Loebenberg D, McNicholas PM: Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles. Antimicrob Agents Chemother 48: 2124-2131, 2004.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2124-2131
    • Chau, A.S.1    Mendrick, C.A.2    Sabatelli, F.J.3    Loebenberg, D.4    McNicholas, P.M.5
  • 21
    • 27544514993 scopus 로고    scopus 로고
    • Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans
    • Gaur M, Choudhury D, Prasad R: Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans. J Mol Microbiol Biotechnol 9: 3-15, 2005.
    • (2005) J Mol Microbiol Biotechnol , vol.9 , pp. 3-15
    • Gaur, M.1    Choudhury, D.2    Prasad, R.3
  • 22
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard D, Ischer F, Monod M, Bille J: Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother 40: 2300-2305, 1996.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 24
    • 30144440366 scopus 로고    scopus 로고
    • Yeast ATP-binding cassette transporters: Cellular cleaning pumps
    • Ernst R, Klemm R, Schmitt L, Kuchler K: Yeast ATP-binding cassette transporters: cellular cleaning pumps. Methods Enzymol 400: 460-484, 2005.
    • (2005) Methods Enzymol , vol.400 , pp. 460-484
    • Ernst, R.1    Klemm, R.2    Schmitt, L.3    Kuchler, K.4
  • 25
    • 30144435485 scopus 로고    scopus 로고
    • The genetics of ATP-binding cassette transporters
    • Dean M: The genetics of ATP-binding cassette transporters. Methods Enzymol 400: 409-429, 2005.
    • (2005) Methods Enzymol , vol.400 , pp. 409-429
    • Dean, M.1
  • 26
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M, Rzhetsky A, Allikmets R: The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11: 1156-1166, 2001.
    • (2001) Genome Res , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 28
    • 23844521998 scopus 로고    scopus 로고
    • P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy
    • Breier A, Barancik M, Sulova Z, Uhrik B: P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy. Curr Cancer Drug Targets 5: 457-468, 2005.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 457-468
    • Breier, A.1    Barancik, M.2    Sulova, Z.3    Uhrik, B.4
  • 29
    • 1842610700 scopus 로고    scopus 로고
    • The ABC transporter structure and mechanism: Perspectives on recent research
    • Jones PM, George AM: The ABC transporter structure and mechanism: perspectives on recent research. Cell Mol Life Sci 61: 682-699, 2004.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 682-699
    • Jones, P.M.1    George, A.M.2
  • 30
    • 0346887115 scopus 로고    scopus 로고
    • Structure and function of efflux pumps that confer resistance to drugs
    • Borges-Walmsley MI, McKeegan KS, Walmsley AR: Structure and function of efflux pumps that confer resistance to drugs. Biochem J 376: 313-338, 2003.
    • (2003) Biochem J , vol.376 , pp. 313-338
    • Borges-Walmsley, M.I.1    McKeegan, K.S.2    Walmsley, A.R.3
  • 31
    • 0036727680 scopus 로고    scopus 로고
    • Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae
    • De Hertogh B, Carvajal E, Talla E, Dujon B, Baret P, Goffeau A: Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2: 154-170, 2002.
    • (2002) Funct Integr Genomics , vol.2 , pp. 154-170
    • De Hertogh, B.1    Carvajal, E.2    Talla, E.3    Dujon, B.4    Baret, P.5    Goffeau, A.6
  • 32
    • 0028352302 scopus 로고
    • Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast
    • Decottignies A, Kolaczkowski M, Balzi E, Goffeau A: Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast. J Biol Chem 269: 12797-12803, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 12797-12803
    • Decottignies, A.1    Kolaczkowski, M.2    Balzi, E.3    Goffeau, A.4
  • 34
    • 24044514014 scopus 로고    scopus 로고
    • Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: Identification of amino acid residues critical for drug efflux
    • Saini P, Prasad T, Gaur NA, Shukla S, Jha S, Komath SS, Khan LA, Haq QM, Prasad R: Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux. J Antimicrob Chemother 56: 77-86, 2005.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 77-86
    • Saini, P.1    Prasad, T.2    Gaur, N.A.3    Shukla, S.4    Jha, S.5    Komath, S.S.6    Khan, L.A.7    Haq, Q.M.8    Prasad, R.9
  • 35
    • 3543108437 scopus 로고    scopus 로고
    • Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520
    • Shukla S, Ambudkar SV, Prasad R: Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520. J Antimicrob Chemother 54: 38-45, 2004.
    • (2004) J Antimicrob Chemother , vol.54 , pp. 38-45
    • Shukla, S.1    Ambudkar, S.V.2    Prasad, R.3
  • 36
    • 0037195962 scopus 로고    scopus 로고
    • Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties
    • Wada S, Niimi M, Niimi K, Holmes AR, Monk BC, Cannon RD, Uehara Y: Candida glabrata ATP-binding cassette transporters Cdr1p and Pdh1p expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties. J Biol Chem 277: 46809-46821, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 46809-46821
    • Wada, S.1    Niimi, M.2    Niimi, K.3    Holmes, A.R.4    Monk, B.C.5    Cannon, R.D.6    Uehara, Y.7
  • 41
    • 31844452412 scopus 로고    scopus 로고
    • Insight in eukaryotic ABC transporter function by mutation analysis
    • Frelet A, Klein M: Insight in eukaryotic ABC transporter function by mutation analysis. FEBS Lett, 2006.
    • (2006) FEBS Lett
    • Frelet, A.1    Klein, M.2
  • 42
    • 16644381719 scopus 로고    scopus 로고
    • Pharmacogenomics of drug transporters: A new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1)
    • Ishikawa T, Onishi Y, Hirano H, Oosumi K, Nagakura M, Tarui S: Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1). Biol Pharm Bull 27: 939-948, 2004.
    • (2004) Biol Pharm Bull , vol.27 , pp. 939-948
    • Ishikawa, T.1    Onishi, Y.2    Hirano, H.3    Oosumi, K.4    Nagakura, M.5    Tarui, S.6
  • 43
    • 0042318833 scopus 로고    scopus 로고
    • Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: Uncommon cysteine 193 of Walker a is critical for ATP hydrolysis
    • Jha S, Karnani N, Dhar SK, Mukhopadhayay K, Shukla S, Saini P, Mukhopadhayay G, Prasad R: Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis. Biochemistry 42: 10822-10832, 2003.
    • (2003) Biochemistry , vol.42 , pp. 10822-10832
    • Jha, S.1    Karnani, N.2    Dhar, S.K.3    Mukhopadhayay, K.4    Shukla, S.5    Saini, P.6    Mukhopadhayay, G.7    Prasad, R.8
  • 44
    • 0141868865 scopus 로고    scopus 로고
    • Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump
    • Jha S, Karnani N, Lynn AM, Prasad R: Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump. Biochem Biophys Res Commun 310: 869-875, 2003.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 869-875
    • Jha, S.1    Karnani, N.2    Lynn, A.M.3    Prasad, R.4
  • 45
    • 4744371579 scopus 로고    scopus 로고
    • ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry
    • Jha S, Dabas N, Karnani N, Saini P, Prasad R: ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry. FEMS Yeast Res 5: 63-72, 2004.
    • (2004) FEMS Yeast Res , vol.5 , pp. 63-72
    • Jha, S.1    Dabas, N.2    Karnani, N.3    Saini, P.4    Prasad, R.5
  • 46
    • 0347694571 scopus 로고    scopus 로고
    • Functional characterization of Candida albicans ABC transporter Cdr1p
    • Shukla S, Saini P, Smriti, Jha S, Ambudkar SV, Prasad R: Functional characterization of Candida albicans ABC transporter Cdr1p. Eukaryot Cell 2: 1361-1375, 2003.
    • (2003) Eukaryot Cell , vol.2 , pp. 1361-1375
    • Shukla, S.1    Saini, P.2    Smriti3    Jha, S.4    Ambudkar, S.V.5    Prasad, R.6
  • 47
    • 0034063860 scopus 로고    scopus 로고
    • The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility
    • Egner R, Bauer BE, Kuchler K: The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility. Mol Microbiol 35: 1255-1263, 2000.
    • (2000) Mol Microbiol , vol.35 , pp. 1255-1263
    • Egner, R.1    Bauer, B.E.2    Kuchler, K.3
  • 48
    • 0037113961 scopus 로고    scopus 로고
    • Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein
    • Loo TW, Clarke DM: Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein. J Biol Chem 277: 44332-44338, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 44332-44338
    • Loo, T.W.1    Clarke, D.M.2
  • 49
    • 12844283318 scopus 로고    scopus 로고
    • Phosphorylation of Candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability
    • Wada S, Tanabe K, Yamazaki A, Niimi M, Uehara Y, Niimi K, Lamping E, Cannon RD, Monk BC: Phosphorylation of Candida glabrata ATP-binding cassette transporter Cdr1p regulates drug efflux activity and ATPase stability. J Biol Chem 280: 94-103, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 94-103
    • Wada, S.1    Tanabe, K.2    Yamazaki, A.3    Niimi, M.4    Uehara, Y.5    Niimi, K.6    Lamping, E.7    Cannon, R.D.8    Monk, B.C.9


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