Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 1, 2004, Pages 38-45

  Shukla, Suneet ^a   Ambudkar, Suresh V ^b   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Azoles; C. albicans; Multidrug resistance; Synergy

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE DERIVATIVE; ANISOMYCIN; ASCOMYCIN; AZIDOPINE; CALCINEURIN INHIBITOR; CDR1 PROTEIN; CYCLOHEXIMIDE; FLUCONAZOLE; GREEN FLUORESCENT PROTEIN; KETOCONAZOLE; MICONAZOLE; MULTIDRUG RESISTANCE PROTEIN; NYSTATIN; PRAZOSIN; PYRROLE DERIVATIVE; RHODAMINE 6G; TACROLIMUS; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CELL SURFACE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TRANSPORT; ENZYME LINKED IMMUNOSPOT ASSAY; FUNGUS MUTANT; GENE FUNCTION; GENE OVEREXPRESSION; ISOTOPE LABELING; MINIMUM INHIBITORY CONCENTRATION; MUTATIONAL ANALYSIS; NONHUMAN; PHOTOAFFINITY LABELING; POINT MUTATION; PREDICTION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE;

AFFINITY LABELS; AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; AZOLES; CALCINEURIN; CANDIDA ALBICANS; CELL MEMBRANE; DRUG RESISTANCE, MULTIPLE, FUNGAL; DRUG SYNERGISM; ESCHERICHIA COLI; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; IMMUNOSUPPRESSIVE AGENTS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; MUTAGENESIS, SITE-DIRECTED; SACCHAROMYCES CEREVISIAE; TACROLIMUS; THREONINE; TRANSFORMATION, BACTERIAL;

EID: 3543108437     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh308     Document Type: Article

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