Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 5, 2001, Pages 527-536

  Maebashi, Kazunori ^a   Niimi, Masakazu ^b   Kudoh, Michinari ^a   Fischer, Frank J ^b   Makimura, Koichi ^a   Niimi, Kyoko ^b   Piper, R Jane ^b   Uchida, Katsuhisa ^a   Arisawa, Mikio ^c   Cannon, Richard D ^b   Yamaguchi, Hideyo ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ABC TRANSPORTER; AMPHOTERICIN B; BREFELDIN A; CERULENIN; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; MESSENGER RNA; MICONAZOLE; PHENANTHROLINE; PYRROLE DERIVATIVE; RHODAMINE; TERBINAFINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA ALBICANS; CELL LEVEL; CELL MEMBRANE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; ENERGY; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC CODE; HUMAN; JAPAN; NUCLEOTIDE SEQUENCE;

EID: 0035022252     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.5.527     Document Type: Article

References (33)

1. Rex, J. H., Rinaldi, M. G. & Pfaller, M. A. (1995). Resistance of Candida species to fluconazole. Antimicrobial Agents and Chemotherapy 39, 1-8.
2. Ghannoum, M. A., Rex, J. H. & Galgiani, J. N. (1996). Susceptibility testing of fungi: current status of correlation of in vitro data with clinical outcome. Journal of Clinical Microbiology 34, 489-95.
3. White, T. C., Marr, K. A. & Bowden, R. A. (1998). Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clinical Microbiology Reviews 11, 382-402.
4. Vanden Bossche, H., Marichal, P. & Odds, F. C. (1994). Molecular mechanisms of drug resistance in fungi. Trends in Microbiology 2, 393-400.
5. Vanden Bossche, H., Marichal, P., Gorrens, J., Bellens, D., Moereels, H. & Janssen, P. A. (1990). Mutation in cytochrome P-450-dependent 14α-demethylase results in decreased affinity for azole antifungals. Biochemical Society Transactions 18, 56-9.
6. Venkateswarlu, K., Denning, D. W., Manning, N. J. & Kelly, S. L. (1996). Comparison of D0870, a new triazole antifungal agent, to fluconazole for inhibition of Candida albicans cytochrome P-450 by using in vitro assays. Antimicrobial Agents and Chemotherapy 40, 1382-6.
7. White, T. C. (1997). Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 41, 1482-7.
8. Franz, R., Kelly, S. L., Lamb, D. C., Kelly, D. E., Ruhnke, M. & Morschhauser, J. (1998). Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrobial Agents and Chemotherapy 42, 3065-72.
9. Hitchcock, C. A., Barrett-Bee, K. J. & Russell, N. J. (1987). Inhibition of 14α-sterol demethylase activity in Candida albicans Darlington dose not correlate with resistance to azole. Journal of Medical and Veterinary Mycology 25, 329-33.
10. Howell, S. A., Mallet, A. I. & Noble, W. C. (1990). A comparison of the sterol content of multiple isolates of the Candida albicans Darlington strain with other clinically azole-sensitive and -resistant strains. Journal of Applied Bacteriology 69, 692-6.
11. Lamb, D. C., Kelly, D. E., Schunck, W. H., Shyadehi, A. Z., Akhtar, M., Lowe, D. J. et al. (1997). The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity. Journal of Biological Chemistry 272, 5682-8.
12. Sanglard, D., Ischer, F., Koymans, L. & Bille, J. (1998). Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrobial Agents and Chemotherapy 42, 241-53.
13. Ryley, J. F., Wilson, R. G. & Barrett-Bee, K. J. (1984). Azole resistance in Candida albicans. Sabouraudia 22, 53-63.
14. Venkateswarlu, K., Denning, D. W., Manning, N. J. & Kelly, S. L. (1995). Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. FEMS Microbiology Letters 131, 337-41.
15. Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M. & Bille, J. (1995). Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrobial Agents and Chemotherapy 39, 2378-86.
16. Albertson, G. D., Niimi, M., Cannon, R. D. & Jenkinson, H. F. (1996). Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance. Antimicrobial Agents and Chemotherapy 40, 2835-41.
17. Sanglard, D., Ischer, F., Monod, M. & Bille, J. (1997). Cloning of Candida albicans genes conferring resistance of azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143, 405-16.
18. Prasad, R., De Wergifosse, P., Goffeau, A. & Balzi, E. (1995). Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Current Genetics 27, 320-9.
19. Fling, M. E., Kopf, J., Tamarkin, A., Gorman, J. A., Smith, H. A. & Koltin, Y. (1991). Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Molecular and General Genetics 227, 318-29.
20. Oka, S. (1994). Fungal infections in AIDS patients. Japanese Journal of Medical Mycology 35, 241-5.
21. National Committee for Clinical Laboratory Standards. (1997). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard M27-A. NCCLS, Villanova, PA.
22. Vanden Bossche, H., Marichal, P., Odds, F. C., Le Jeune, L. & Coene, M. C. (1992). Characterization of an azole-resistant Candida glabrata isolate. Antimicrobial Agents and Chemotherapy 36, 2602-10.
23. Lowry, O. H., Resebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with Folin phenol reagent. Journal of Biological Chemistry 193, 265-75.
24. Brown, A. J. P. (1994). RNA extraction and mRNA quantitation in Candida albicans. In Molecular Biology of Pathogenic Fungi, (Maresca, B. & Kobayashi, G. S., Eds), pp. 127-31. Telos Press, New York.
25. Kan, V. L. (1993). Polymerase chain reaction for the diagnosis of candidemia. Journal of Infectious Diseases 168, 779-83.
26. +-ATPase from Candida albicans. Journal of Bacteriology 173, 6826-36.
27. Rex, J. H., Pfaller, M. A., Galgiani, J. N., Bartlett, M. S., Espinellngroff, A., Ghannoum, M. A. et al. (1997). Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections. Subcommittee on Antifungal Susceptibility Testing of the National Committee for Clinical Laboratory Standards. Clinical Infectious Diseases 24, 235-47.
28. Balan, I., Alarco, A.-M. & Raymond, M. (1997). The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter. Journal of Bacteriology 179, 7210-8.
29. Franz, R., Michel, S. & Morschhauser, J. (1998). A fourth gene from the Candida albicans CDR family of ABC transporters. Gene 220, 91-8.
30. Talibi, D. & Raymond, M. (1999). Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae. Journal of Bacteriology 181, 231-40.
31. Sudo, T., Makimura, K., Kawata, K., Ito, A., Oka, S., Uchida, K. et al. (1997). Evaluation of antifungal susceptibility testing by the broth microdilution method against Candida species: activities of 5 antifungal agents against Candida species isolated from oral candidiasis or other candidal infectious diseases and correlation of vitro data and clinical outcome of fluconazole therapy. Japanese Journal of Chemotherapy 45, 115-22.
32. Clark, F. S., Parkinson, T., Hitchcock, C. A. & Gow, N. A. (1996). Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance. Antimicrobial Agents and Chemotherapy 40, 419-25.
33. Odds, F. C. (1996). Resistance of clinically important yeasts to antifungal agents. International Journal of Antimicrobial Agents 6, 145-7.