Avian Models with Spontaneous Autoimmune Diseases

Advances in Immunology

Volumn 92, Issue , 2006, Pages 71-117

  Wick, Georg ^a   Andersson, Leif ^b   Hala, Karel ^a,c   Gershwin, M Eric ^d   Selmi, Carlo ^d   Erf, Gisela F ^e   Lamont, Susan J ^f   Sgonc, Roswitha ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UPPSALA UNIVERSITY   (Sweden)

^c UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^d Division of Rheumatology Allergy and Clinical Immunology   (United States)

^e UNIVERSITY OF ARKANSAS   (United States)

^f IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCOCORTICOID; IODINE; LIOTHYRONINE; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE; THYROTROPIN; THYROXINE;

ANTIGEN PRESENTING CELL; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; AVIAN LEUKOSIS ONCOVIRUS; B LYMPHOCYTE; BURSA FABRICII; BURSECTOMY; CHICKEN; CHROMOSOME 16; CHROMOSOME SIZE; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; CPG ISLAND; DATA BASE; DNA SEQUENCE; EMBRYOLOGY; FOWL; GENE MUTATION; GENE ORDER; GENE SEQUENCE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME; GENOMICS; GRAFT VERSUS HOST REACTION; HAPLOTYPE; HASHIMOTO DISEASE; HOMOZYGOSITY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNOHISTOLOGY; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LINKAGE ANALYSIS; MYCOPLASMA GALLISEPTICUM; MYCOPLASMA SYNOVIAE; NONHUMAN; ONTOGENY; PARABIOSIS; PHENOTYPE; PHYLOGENY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTAKE; QUANTITATIVE TRAIT LOCUS; REVIEW; ROUS SARCOMA ONCOVIRUS; SCLERODERMA; SEQUENCE ANALYSIS; SEX CHROMOSOME; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; THYMECTOMY; THYROID GLAND; THYROIDITIS; VIRUS VECTOR; VITILIGO;

ANIMALS; AUTOIMMUNE DISEASES; CHICKENS; DISEASE MODELS, ANIMAL; HASHIMOTO DISEASE; HUMANS; SCLERODERMA, SYSTEMIC; VITILIGO;

EID: 33751501713     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(06)92002-1     Document Type: Review

References (169)

1. Abdrakhmanov I., Lodygin D., Geroth P., Arakawa H., Law A., Plachy J., Korn B., and Buerstedde J.M. A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function. Genome Res. 10 (2000) 2062-2069
2. Abplanalp H., Gershwin M.E., Johnston E., and Reid J. Genetic control of avian scleroderma. Immunogenetics 31 (1990) 291-295
3. Aichinger G., Kofler H., Diaz-Merida O., and Wick G. Non-thyroid autoantibodies in obese strain (OS) chickens. Clin. Immunol. Immunopathol. 32 (1984) 57-69
4. Andersson L., and Georges M. Domestic animal genomics: Deciphering the genetics of complex traits. Nat. Rev. Genet. 5 (2004) 202-212
5. Agrawal D., Shajil E.M., Marfatia Y.S., and Begum R. Study on antioxidant status of vitiligo patients of different age-groups in Baroda. Pigment Cell Res. 17 (2004) 289-294
6. Ausserlechner M.J., Sgonc R., Dietrich H., and Wick G. Altered procollagen mRNA expression during the progression of avian scleroderma. Mol. Med. 3 (1997) 654-662
7. Austin L.M., and Boissy R.E. Mammalian tyrosinase-related protein-1 is recognized by autoantibodies from vitiliginous Smyth chickens. An avian model for human vitiligo. Am. J. Pathol. 146 (1995) 1529-1541
8. Bacon L.D., and Witter R.L. Serotype specificity of B-haplotype influence on the relative efficasy of Marek's disease vaccines. Avian Dis. 38 (1994) 65-71
9. Bacon L.D., Kite J.H., and Rose N.R. Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens. Science 186 (1974) 274-275
10. Besedovsky H.O., and Del Rey A. Immune-neuro-endocrine interactions: Facts and hypotheses. Endocr. Rev. 17 (1996) 64-102
11. Billingham R.E., Brent L., and Medawar P.B. Actively acquired tolerance of foreign cells. Nature 172 (1953) 603-606
12. Block J.A., and Sequeira W. Raynaud's phenomenon. Lancet 357 (2001) 2042-2048
13. Boardman P.E., Sanz-Ezquerro J., Overton I.M., Burt D.W., Bosch E., Fong W.T., Tickle C., Brown W.R., Wilson S.A., and Hubbard S.J. A comprehensive collection of chicken cDNAs. Curr. Biol. 12 (2002) 1965-1969
14. Boissy R.E., and Lamoreux M.L. Animal models of an acquired pigmentary disorder-vitiligo. Prog. Clin. Biol. Res. 256 (1988) 207-218
15. Boissy R.E., Smyth Jr. J.R., and Fite K.V. Progressive cytologic changes during the development of delayed feather amelanosis and associated choroidal defects in the DAM chicken line. Am. J. Pathol. 111 (1983) 197-212
16. Boissy R.E., Lamont S.J., and Smyth Jr. J.R. Persistence of abnormal melanocytes in immunosuppressed chickens of the autoimmune "DAM" line. Cell Tissue Res. 235 (1984) 663-668
17. Boissy R.E., Moellmann G., and Smyth Jr. J.R. Melanogenesis and autophagocytosis of melanin within feather melanocytes of delayed amelanotic (DAM) chickens. Pigment Cell 1 (1985) 731-739
18. Boissy R.E., Moellmann G., Trainer A.T., and Smyth Jr. J.R. Delayed-amelanotic (DAM or Smyth) chicken: Melanocyte dysfunction in vivo and in vitro. J. Invest. Dermatol. 86 (1986) 149-156
19. Bottazzo G.F., Pujol-Borrell R., Hanafusa T., and Feldman M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet ii (1983) 1115-1118
20. Bowers R.R. The melanocyte of the chicken: A review. Prog. Clin. Biol. Res. 256 (1988) 49-63
21. Boyd R.L., Oberhuber G., Hala K., and Wick G. Obese strain (OS) chickens with spontaneous autoimmune thyroiditis have a deficiency in thymic nurse cells. J. Immunol. 132 (1984) 718-724
22. Boyd R.L., Hala K., and Wick G. Interactions and quantitative analysis of immunoregulatory cells in the chicken thymus. J. Immunol. 135 (1985) 3039-3049
23. Boyd R.L., Wilson T.J., Van De Water J., Haapanen L.A., and Gershwin M.E. Selective abnormalities in the thymic microenvironment associated with avian scleroderma, an inherited fibrotic disease of L200 chickens. J. Autoimmun. 4 (1991) 369-380
24. Briles W.E., Bumstead N., Ewert D.L., Gilmour D.G., Gogusev J., Hala K., Koch C., Longenecker B.M., Nordskog A.W., Pink J.R., Schierman L.W., Simonsen M., et al. Nomenclature for chicken major histocompatibility (B) complex. Immunogenetics 5 (1982) 441-447
25. Brown T.R., Zhao G., Palmer K.C., and Sundick R.S. Thyroid injury, autoantigen availability, and initiation of autoimmune thyroiditis. Autoimmunity 27 (1998) 1-12
26. Carlborg O., and Haley C. Epistasis: Too often neglected in complex trait studies?. Nat. Rev. Genet. 5 (2004) 618-625
27. Cepeda E.J., and Reveille J.D. Autoantibodies in systemic sclerosis and fibrosing syndromes: Clinical indications and relevance. Curr. Opin. Rheumatol. 16 (2004) 723-732
28. Cihak J., Hoffman-Fezer G., Koller A., Kaspers B., Merkle H., Hala K., Wick G., and Lösch U. Preferential TCR Vβ1 gene usage by autoreactive T cells in spontaneous autoimmune thyroiditis of the obese strain of chickens. J. Autoimmun 8 (1995) 507-520
29. Co H.T., Block J.A., and Sequeira W. Scleroderma lung: Pathogenesis, evaluation, and current therapy. Am. J. Ther. 7 (2000) 321-324
30. Cole R.K. Hereditary hypothyroidism in the domestic fowl. Genetics 53 (1966) 1021-1033
31. Cole R.K., Kite J.H., and Witebsky E. Hereditary autoimmune thyroiditis in the fowl. Science 160 (1968) 1357-1358
32. Cotton S.A., Herrick A.L., Jayson M.I., and Freemont A.J. TGF beta-a role in systemic sclerosis?. J. Pathol. 184 (1998) 4-6
33. Crittenden L.B. Exogenous and endogenous leukosis virus genes-a review. Avian Pathol. 10 (1981) 101-112
34. de Carvalho L., Wick G., and Roitt I.M. Requirement of T cells for the development of spontaneous autoimmune thyroiditis in obese strain (OS) chickens. J. Immunol. 126 (1981) 750-753
35. de Carvalho L.C.P., Templeman J., Wick G., and Roitt I.M. The role of self-antigen in the development of autoimmunity in obese strain (OS) chickens with spontaneous autoallergic thyroiditis. J. Exp. Med. 155 (1982) 1255-1266
36. Deswal A., and Follansbee W.P. Cardiac involvement in scleroderma. Rheum. Dis. Clin. North Am. 22 (1996) 841-860
37. Dietrich H.M. Housing, breeding and selecting chickens of the obese strain (OS) with spontaneous autoimmune thyroiditis. Lab. Anim. 23 (1989) 345-352
38. Dietrich H.M., Oliveira-dos-Santos A.J., Hala K., and Wick G. Skin allograft survival in chicken strains with spontaneous autoimmune diseases. Poult. Sci. 75 (1996) 285-293
39. Dietrich H.M., Oliveira-dos-Santos A.J., and Wick G. Development of spontaneous autoimmune thyroiditis in obese strain (OS) chickens. Vet. Immunol. Immunopathol. 57 (1997) 141-146
40. Dietrich H.M., Cole R.K., and Wick G. The natural history of the obese strain of chickens-an animal model for spontaneous autoimmune thyroiditis. Poult. Sci. 78 (1999) 1359-1371
41. Duncan M.R., Wilson T.J., Van De Water J., Berman B., Boyd R., Wick G., and Gershwin M.E. Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype. J. Autoimmun. 5 (1992) 603-615
42. Duncan M.R., Berman B., Van de Water J., Boyd R.L., Wick G., and Gershwin M.E. Mononuclear cells isolated from fibrotic skin lesions in avian scleroderma constitutively produce fibroblast-activating cytokines and immunoglobulin M. Int. Arch. Allergy Immunol. 107 (1995) 519-526
43. Eischen C.M., Schilling J.D., Lynch D.H., Krammer P.H., and Leibson P.J. Fc receptor-induced expression of Fas ligand on activated NK cells facilitates cell-mediated cytotoxicity and subsequent autocrine NK cell apoptosis. J. Immunol. 156 (1996) 2693-2699
44. Erf G.F. Herpesvirus connection in Smyth line vitiligo. Part II. Vitiligo Newsletter 8 2 (2002) 8
45. Erf G.F., and Smyth Jr. J.R. Alterations in blood leukocyte populations in Smyth line chickens with autoimmune vitiligo. Poult. Sci. 75 (1996) 351-356
46. Erf G.F., Trejo-Skalli A.V., and Smyth Jr. J.R. T cells in regenerating feathers of Smyth line chickens with vitiligo. Clin. Immunol. Immunopathol. 76 (1995) 120-126
47. Erf G.F., Trejo-Skalli A.V., Poulin M., and Smyth Jr. J.R. Dermal lymphoid aggregates in autoimmune Smyth line chickens. Vet. Immunol. Immunopathol. 58 (1997) 335-343
48. Erf G.F., Bersi T.K., Wang X., Sreekumar G.P., and Smyth Jr. J.R. Herpesvirus connection in the expression of autoimmune vitiligo in Smyth line chickens. Pigment Cell Res. 14 (2001) 40-46
49. Erf G.F., Johnson J.C., Parcells M.S., Wang X., and Bersi T.K. A role of turkey herpesvirus in autoimmune Smyth line vitiligo. In: Schat K.A. (Ed). "Current Progress on Avian Immunology Research" (2001), American Association of Avian Pathologists, Inc., Pennsylvania 226-231
50. Erf G.F., Wijesekera H.D., Lockhart B.R., and Golden A.L. Antioxidant capacity and oxidative tress in the local environment of feather-melanocytes in vitiliginous Smyth line chickens. Pigment Cell Res. 18 Suppl. 1 (2005) 69
51. Fabricant C.G., Fabricant J., Minick C.R., and Litrenta M.M. Herpesvirus-induced atherosclerosis in chickens. Fed. Proc. 42 (1983) 2476-2479
52. Falanga V., Tiegs S.L., Alstadt S.P., Roberts A.B., and Sporn M.B. Transforming growth factor-beta: Selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis. J. Invest. Dermatol. 89 (1987) 100-104
53. Feghali-Bostwick C., Medsger Jr. T.A., and Wright T.M. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum. 48 (2003) 1956-1963
54. Fite K.V., Pardue S., Bengston L., Hayden D., and Smyth Jr. J.R. Effects of cyclosporine in spontaneous, posterior uveitis. Curr. Eye Res. 5 (1986) 787-796
55. Fleischmajer R., Perlish J.S., and Reeves J.R. Cellular infiltrates in scleroderma skin. Arthritis Rheum. 20 (1977) 975-984
56. Fritzler M.J., and Kinsella T.D. The CREST syndrome: A distinct serologic entity with anticentromere antibodies. Am. J. Med. 69 (1980) 520-526
57. Fulton J.E., and Delany M.E. Genetics. Poultry genetic resources-operation rescue needed. Science 300 (2003) 1667-1668
58. Gershwin M.E., Abplanalp H., Castles J.J., Ikeda R.M., van der Water J., Eklund J., and Haynes D. Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma). J. Exp. Med. 153 (1981) 1640-1659
59. Gordon M.B., Klein I., Dekker A., Rodnan G.P., and Medsger Jr. T.A. Thyroid disease in progressive systemic sclerosis increased frequency of glandular fibrosis and hypothyroidism. Ann. Intern. Med. 95 (1981) 431
60. Grimes P.E., Sevall J.S., and Vojdani A. Cytomegalovirus DNA identified in skin biopsy specimen of patients with vitiligo. J. Am. Acad. Dermatol. 35 (1996) 21-26
61. Gruschwitz M.S., Moormann S., Kroemer G., Sgonc R., Dietrich H., Boeck G., Gershwin M.E., Boyd R., and Wick G. Phenotypic analysis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma. J. Autoimmun. 4 (1991) 577-593
62. Gruschwitz M.S., Shoenfeld Y., Krupp M., Gershwin M.E., Penner E., Brezinschek H.-P., and Wick G. Antinuclear antibody profile in UCD line 200 chickens: A model for progressive systemic sclerosis. Int. Arch. Allergy Immunol. 100 (1993) 307-313
63. Hala K. Hypothesis: Immunogenetic analysis of spontaneous autoimmune thyroiditis in obese strain (OS) chickens: A two-gene family model. Immunobiology 177 (1988) 354-373
64. Hala K., and Plachy J. Inbred lines of chickens. In: Lefkovits I. (Ed). "Immunology Methods Manual" (1997), Academic Press, New York 2285-2293
65. Hala K., Malin G., Dietrich H., Loesch U., Boeck G., Wolf H., Kaspers B., Geryk J., Falk M., and Boyd R.L. Analysis of the initiation period of spontaneous autoimmune thyroiditis (SAT) in obese strain (OS) of chickens. J. Autoimmun. 9 (1996) 129-138
66. Hala K., Kubek A., Plachy J., and Vasicek D. Expression of nonspecific esterase by thyroid follicular epithelium as a marker for the target organ susceptibility to immune system attack. Immunobiology 201 (2000) 598-610
67. Harning R., Cui J., and Bystryn J.C. Relation between the incidence and the level of pigment cell antibodies and disease activity in vitiligo. J. Invest. Dermatol. 97 (1991) 1078-1080
68. Hasek M. Vegetative hybridization of animals by joint blood circulation during embryonal development [in Czech]. Czechosl. Biol. 2 (1953) 265-277
69. Havenstein G.B., Ferket P.R., Scheideler S.E., and Larson B.T. Growth, livability, and feed conversion of 1957 vs 1991 broilers when fed "typical" 1957 and 1991 broiler diets. Poult. Sci. 73 (1994) 1785-1794
70. Haynes D.C., and Gershwin M.E. Diversity of autoantibodies in avian scleroderma. An inherited fibrotic disease of White Leghorn chickens. J. Clin. Invest. 73 (1984) 1557-1568
71. Herrick A.L. Vascular function in systemic sclerosis. Curr. Opin. Rheumatol. 12 (2000) 527-533
72. Holland M.S., Mackenzie C.D., Bull R.W., and Silva R.F. Latent turkey herpesvirus infection in lymphoid, nervous, and feather tissues of chickens. Avian Dis. 42 (1998) 292-299
73. Ihn H. Scleroderma, fibroblasts, signalling, and excessive extracellular matrix. Curr. Rheumatol. Rep. 7 (2005) 156-162
74. International Chicken Genome Sequencing Consortium. Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432 (2004) 695-716
75. International Chicken Polymorphism Map Consortium. A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature 432 (2004) 717-722
76. Jimenez S.A., and Christner P.J. Murine animal models of systemic sclerosis. Curr. Opin. Rheumatol. 14 (2002) 671-680
77. Jimenez S.A., and Derk C.T. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann. Intern. Med. 140 (2004) 37-50
78. Kaiser P., Rothwell L., Vasicek D., and Hala K. A role for IL-15 in driving the onset of spontaneous autoimmune thyroiditis. J. Immunol. 168 (2002) 4216-4220
79. Kerje S., Carlborg O., Jacobsson L., Schütz K., Hartmann C., Jensen P., and Andersson L. The two-fold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs. Anim. Genet. 34 (2003) 264-274
80. Khoury E.L., Bottazzo G.F., de Carvalho L.C., Wick G., and Roitt I.M. Predisposition to organ-specific autoimmunity in obese strain (OS) chickens: Reactivity to thyroid, gastric, adrenal and pancreatic cytoplasmic antigens. Clin. Exp. Immunol. 49 (1982) 273-282
81. Kikuchi K., Yamakage A., Smith E.A., LeRoy E.C., and Trojanowska M. Differential modulation of bFGF receptors by TGF-beta in adult skin, scleroderma skin, and newborn foreskin fibroblasts. J. Invest. Dermatol. 99 (1992) 201-205
82. Kissin E.Y., and Korn J.H. Fibrosis in scleroderma. Rheum. Dis. Clin. North Am. 29 (2003) 351-369
83. Kofler H., Kofler R., Wolf H., and Wick G. Immunofluorescence studies on the codistribution of immune deposits and complement in the thyroid glands of obese strain (OS) chickens. Immunobiology 164 (1983) 390-401
84. Kroemer G., and Wick G. The role of interleukin-2 in autoimmunity. Immunol. Today 10 (1989) 246-251
85. Kroemer G., Sundick R.S., Schauenstein K., Hala K., and Wick G. Analysis of lymphocytes infiltrating the thyroid gland of obese strain chickens. J. Immunol. 135 (1985) 2452-2457
86. Kroemer G., Neu N., Kuehr T., Dietrich H., Faessler R., Hala K., and Wick G. Immunogenetic analysis of spontaneous autoimmune thyroiditis in obese strain chickens. Clin. Immunol. Immunopathol. 52 (1989) 202-213
87. Kuehr T., Hala K., Dietrich H., Herold H., and Wick G. Genetically determined target organ susceptibility in the pathogenesis of spontaneous autoimmune thyroiditis: Aberrant expression of MHC-class II antigen and possible role of virus. J. Autoimmun. 7 (1994) 13-25
88. Lally E.V., and Jimenez S.A. Impotence in progressively systemic sclerosis. Ann. Intern. Med. 95 (1981) 150-153
89. Lamont S.J., and Smyth Jr. J.R. Effect of bursectomy on development of a spontaneous postnatal amelanosis. Clin. Immunol. Immunopathol. 21 (1981) 407-411
90. Le Douarin N.M., Dieterlen-Lievre F., Teillet M.A., and Ziller C. Interspecific chimeras in avian embryos. Methods Mol. Biol. 135 (2000) 373-386
91. LeRoy E.C., Black C., Fleischmajer R., Jablonska S., Krieg T., Medsger Jr. T.A., Rowell N., and Wollheim F. Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis. J. Rheumatol. 15 (1988) 202-205
92. Lockhart B.R. Antioxidant state and extent of oxidative stress in melanocytes from autoimmune vitiliginous Smyth line and control chickens (2004), University of Arkansas, Fayetteville MS Thesis
93. Longenecker B.M., Pazderka F., Gavora J.S., Spencer J.L., and Ruth R.F. Lymphoma induced by herpesvirus: Resistance associated with a major histocompatibility gene. Immunogenetics 3 (1976) 401-407
94. Malin G., Loesch U., Dietrich H., Geryk J., Falk M., Wick G., and Hala K. Are virus and microbes involved in the induction of autoimmune thyroiditis in chickens?. In: Davison T.F., Bumstead N., and Kaiser P. (Eds). "Advances in Avian Immunology Research" (1994), Carfax, Abingdon, UK 213-219
95. Mason P.J. Vitiligo: The psychosocial effects. Medsburg. Nurs. 6 (1997) 216-218
96. Miller M.M., Bacon L.D., Hala K., Hunt H.D., Ewald S.J., Kaufman J., Zoorob R., and Briles W.E. Nomenclature for the chicken histocompatibility (B and Y) complex. Immunogenetics 56 (2004) 261-279
97. Muir W.M., and Aggrey S.E. "Poultry Genetics, Breeding and Biotechnology." (2003), CABI Publishing, Wallingford, Oxon, UK
98. Nakagawa K., and Harrison L.C. The potential role of endogenous retroviruses in autoimmunity. Immunol. Rev. 152 (1996) 193-236
99. Neu N., Hala K., Dietrich H., and Wick G. Spontaneous autoimmune thyroiditis in obese strain chickens: Genetic analysis of target organ abnormalities. Clin. Immunol. Immunopathol. 37 (1985) 397-405
100. Neu N., Hala K., Dietrich H., and Wick G. Genetic background of spontaneous autoimmune thyroiditis in the obese strain of chickens studied in hybrids with an inbred line. Int. Arch. Allergy Appl. Immunol. 80 (1986) 168-173
101. Nguyen V.A., Sgonc R., Dietrich H., and Wick G. Endothelial injury in internal organs of UCD 200 chickens, an animal model for systemic sclerosis. J. Autoimmun. 14 (2000) 143-149
102. Nordlund J.J., and Lerner A.B. Vitiligo-It is important. Arch. Dermatol. 118 (1982) 5-8
103. Ortonne J.P., and Bose S.K. Vitiligo: Where do we stand?. Pigment Cell Res. 6 (1993) 61-72
104. Pardue S.L., Fite K.V., Bengston L., Lamont S.J., Boyle III M.L., and Smyth Jr. J.R. Enhanced integumental and ocular amelanosis following termination of cyclosporine administration. J. Invest. Dermatol. 88 (1987) 758-761
105. Park Y.K., Kim N.S., Hann S.K., and Im S. Identification of autoantibody to melanocytes and characterization of vitiligo antigen in vitiligo patients. J. Dermatol. Sci. 11 (1996) 111-129
106. Passeron T., and Ortonne J.-P. Physiopathology and genetics of vitiligo. J. Autoimmun. 25 (2005) 63-68
107. Penhale W.J., and Ahmed S.A. Animal model of human disease. Lymphocytic thyroiditis. Autoimmune thyroiditis in rats induced by thymectomy and irradiation. Am. J. Pathol. 106 (1982) 300-302
108. Plachy J., and Hala K. Comparative aspects of the chicken immunogenetics (review). Folia Biol. (Praha) 43 (1997) 133-151
109. Plumlee B.L.X., Wang X., and Erf G.F. Interferon-gamma expression in feathers from vitiliginous Smyth line chickens. J. Immunol. 176 (2006) S283
110. Pope J.E. Musculoskeletal involvement in scleroderma. Rheum. Dis. Clin. North Am. 29 (2003) 391-408
111. Prelog M., Scheidegger P., Peter S., Gershwin M.E., Wick G., and Sgonc R. Diminished TGF-β2 production leads to increased expression of a profibrotic procollagen alpha 2 type I mRNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis. Arthritis Rheum. 52 (2005) 1804-1811
112. Reynaud C.A., Bertocci B., Dahan A., and Weill J.C. Formation of the chicken B-cell repertoire: Ontogenesis, regulation of Ig gene rearrangement, and diversification by gene conversion. Adv. Immunol. 57 (1994) 353-378
113. Rose N.R., Bacon L.D., and Sundick R.S. Genetic determinants of thyroiditis in the OS chickens. Transplant. Rev. 31 (1976) 264-285
114. Rose N.R., Bonito R., and Burek C.L. Iodine: An environmental trigger of thyroiditis. Autoimmun. Rev. 1 (2002) 97-103
115. Rose S., Young M.A., and Reynolds J.C. Gastrointestinal manifestations of scleroderma. Gastroenterol. Clin. North Am. 27 (1998) 563-594
116. Sakaguchi S., and Sakaguchi N. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. J. Immunol. 142 (1989) 471-480
117. Sakaguchi S., and Sakaguchi N. Regulatory T cells in immunologic self-tolerance and autoimmune disease. Int. Rev. Immunol. 24 (2005) 211-226
118. Sakkas L.I., and Platsoucas C.D. Is systemic sclerosis an antigen-driven T cell disease?. Arthritis Rheum. 50 (2004) 1721-1733
119. Savolainen P., Fitzsimmons C., Arvestad L., Andersson L., and Lundeberg J. ESTs from brain and testis of White Leghorn and red junglefowl: Annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Cytogenet. Genome Res. 111 (2005) 79-87
120. Schauenstein K., Kroemer G., Boeck G., Ross K., Hala K., and Wick G. T cell hyperreactivity in obese strain (OS) chickens. Different mechanism operative in spleen and peripheral blood lymphocyte activation. Immunobiology 175 (1987) 226-235
121. Schuurs A.H.W.M., Dietrich H., Gruber J., and Wick G. Effects of sex steroid analogs on spontaneous autoimmune thyroiditis in obese strain chickens. Int. Arch. Allergy Immunol. 97 (1992) 337-344
122. Searle E.A., Austin L.M., Boissy Y.L., Zhoa H., Nordlund J.J., and Boissy R.E. Smyth chicken melanocyte autoantibodies: Cross-species recognition, in vivo binding, and plasma membrane reactivity of the antiserum. Pigment Cell Res. 6 (1993) 145-157
123. Sgonc R. The vascular perspective of systemic sclerosis: Of chickens, mice and men. Int. Arch. Allergy Immunol. 120 (1999) 169-176
124. Sgonc R., and Wick G. What can we learn from an avian model for scleroderma?. In: Shoenfeld Y. (Ed). "The Decade of Autoimmunity" (1999), Elsevier, Amsterdam 209-217
125. Sgonc R., Dietrich H., Gershwin M.E., Colombatti A., and Wick G. Genomic analysis of collagen and endogenous virus loci in the UCD-200 and 206 lines of chickens, animal models for scleroderma. J. Autoimmun. 8 (1995) 763-770
126. Sgonc R., Gruschwitz M.S., Dietrich H., Recheis H., Gershwin M.E., and Wick G. Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. J. Clin. Invest. 98 (1996) 785
127. Sgonc R., Dietrich H., Sieberer C., Wick G., Christner P.J., and Jimenez S.A. Lack of endothelial cell apoptosis in the dermis of tight skin 1 and tight skin 2 mice. Arthritis Rheum. 42 (1999) 581-584
128. Sgonc R., Gruschwitz M., Boeck G., Sepp N., Gruber J., and Wick G. Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95. Arthritis Rheum. 43 (2000) 2550-2562
129. Shresta S., Smyth Jr. J.R., and Erf G.F. Profiles of pulp infiltrating lymphocytes at various times throughout feather regeneration in Smyth line chickens with vitiligo. Autoimmunity 25 (1997) 193-201
130. Simonsen M. Graft-versus-host reactions. Their natural history and applicability as tools of research. Progr. Allergy 6 (1962) 349-467
131. Smyth Jr. J.R. The Smyth chicken: A model for autoimmune amelanosis. Poult. Biol. 2 (1989) 1-19
132. Smyth Jr. J.R., and McNeil M. Alopecia areata and universalis in the Smyth chicken model for spontaneous autoimmune vitiligo. J. Investig. Dermatol. Symp. Proc. 4 (1999) 211-215
133. Smyth Jr. J.R., Boissy R.E., and Fite K.V. The DAM chicken: A model for spontaneous postnatal cutaneous and ocular amelanosis. J. Hered. 72 (1981) 150-156
134. Somes R.G. International registry of poultry genetics stocks. "Storrs Agricultural Experiment Station," (1988), The University of Connecticut Storrs 98 Bulletin 476
135. Spritz R.A. The genetics of generalized vitiligo and associated autoimmune diseases. J. Dermatol. Sci. 41 (2006) 3-10
136. Sreekumar G.P., Erf G.F., and Smyth Jr. J.R. 5-Azacytidine treatment induces autoimmune vitiligo in the parental control strains of the Smyth line chicken model for autoimmune vitiligo. Clin. Immun. Immunopathol. 81 (1996) 136-144
137. Sreekumar G.P., Smyth Jr. J.R., Ambady S., and Ponce de Leon F.A. Analysis of the effect of endogenous viral genes in the Smyth line chicken model for autoimmune vitiligo. Am. J. Pathol. 156 (2000) 1099-1107
138. Sreekumar G.P., Smyth Jr. J.R., and Ponce de Leon F.A. Molecular characterization of the Smyth chicken sublines and their parental controls by RFLP and DNA fingerprint analysis. Poult. Sci. 80 (2001) 1-5
139. Steen V.D. Scleroderma renal crisis. Rheum. Dis. Clin. North Am. 29 (2003) 315-333
140. Sundick R.S., Herdegen D., Brown T.R., Dhar A., and Bagchi N. Thyroidial iodine metabolism in obese strain chickens prior to immune-mediated damage. J. Endocrinol. 128 (1991) 239-244
141. Svoboda J. Rous sarcoma virus. Intervirology 26 (1986) 1-60
142. Tirunagaru V.G., Sofer L., Cui J., and Burnside J. An expressed sequence tag database of T-cell enriched activated chicken splenocytes: Sequence analysis of 5251 clones. Genomics 66 (2000) 144-151
143. Van de Water J., Haapanen L., Boyd R., Abplanalp H., and Gershwin M.E. Identification of T cells in early dermal lymphocytic infiltrates in avian scleroderma. Arthritis Rheum. 32 (1989) 1031-1040
144. Van de Water J., Boyd R., Wick G., and Gershwin M.E. The immunologic and genetic basis of avian scleroderma, an inherited fibrotic disease of line 200 chickens. Int. Rev. Immunol. 11 (1994) 273-282
145. Van de Water J., Jimenez S.A., and Gershwin M.E. Animal models of scleroderma: Contrasts and comparisons. Int. Rev. Immunol. 12 (1995) 201-216
146. Van Laere A.S., Nguyen M., Braunschweig M., Nezer C., Collette C., Moreau L., Archibald A.L., Haley C.S., Buys N., Andersson G., Georges M., and Andersson L. Positional identification of a regulatory mutation in IGF2 causing a major QTL effect on muscle growth in the pig. Nature 425 (2003) 832-836
147. Vasicek D., Vasickova K., Kaiser P., Drozenova R., Citek J., and Hala K. Analysis of genetic regulation of chicken spontaneous autoimmune thyroiditis, an animal model of human Hashimoto's thyroiditis. Immunogenetics 53 (2001) 776-785
148. Wang X., and Erf G.F. Melanocyte-specific cell mediated immune response in vitiliginous Smyth line chickens. J. Autoimmun. 21 (2003) 149-160
149. Wang X., and Erf G.F. Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo. J. Autoimmun. 22 (2004) 21-30
150. Wang X., Smyth Jr. J.R., Bersi T.K., and Erf G.F. MHC class II expression by T cells present in growing feathers from Smyth line chickens with vitiligo. Poult. Sci. 77 Suppl. 1 (1998) 26
151. Wang X., Parcells M.S., and Erf G.F. Marek's disease virus infection of cultured chicken melanocytes. Pigment Cell Res. 13 (2000) 217
152. Whitacre C.C. Sex differences in autoimmune disease. Nat. Immunol. 2 (2001) 777-780
153. White B. Immunopathogenesis of systemic sclerosis. Rheum. Dis. Clin. North Am. 22 (1996) 695-708
154. Wick G., and Graf J. Electron microscopic studies in chickens of the obese strain with spontaneous hereditary autoimmune thyroiditis. Lab. Invest. 27 (1972) 400-411
155. Wick G., and Steiner R. Bursectomy and thymectomy of obese strain (OS) chickens with spontaneous autoimmune thyroiditis and simultaneous experimental and allergic encephalomyelitis. J. Immunol. 109 (1972) 1031-1035
156. Wick G., Kite J.H., Cole R.K., and Witebsky E. Spontaneous thyroiditis in the obese strain of chickens. III. The effect of bursectomy on the development of the disease. J. Immunol. 104 (1970) 45-54
157. Wick G., Kite J.H., and Witebsky E. Spontaneous thyroiditis in the obese strain of chickens. IV. The effect of thymectomy and thymo-bursectomy on the development of the disease. J. Immunol. 104 (1970) 54-62
158. Wick G., Gundolf R., and Hala K. Genetic factors in spontaneous autoimmune thyroiditis in OS chickens. J. Immunogenet. 6 (1979) 177-183
159. Wick G., Boyd R., Hala K., de Carvalho L., Kofler R., Mueller P.U., and Cole R.K. The obese strain (OS) of chickens with spontaneous autoimmune thyroiditis: Review of recent data. Curr. Top. Microbiol. Immunol. 91 (1981) 109-128
160. Wick G., Hala K., Wolf H., Boyd R.L., and Schauenstein K. Distribution and functional analysis of B-L/Ia positive cells in the chicken: Expression of B-L/Ia antigens on thyroid epithelial cells in spontaneous autoimmune thyroiditis. Mol. Immunol. 21 (1984) 1259-1265
161. Wick G., Kroemer G., Neu N., Faessler R., Ziemiecki A., Mueller R.G., Ginzel M., Beladi I., Kuehr T., and Hala K. The multi-factorial pathogenesis of autoimmune disease. Immunol. Lett. 16 (1987) 249-257
162. Wick G., Brezinschek H.-P., Hala K., Dietrich H., Wolf H., and Kroemer G. The obese strain (OS) of chickens. An animal model with spontaneous autoimmune thyroiditis. Adv. Immunol. 47 (1989) 433-500
163. Wick G., Hu Y., Schwarz S., and Kroemer G. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocr. Rev. 14 (1993) 539-563
164. Wick G., Cole R.L., Dietrich H., Maczek C., Müller P.-U., and Hala K. The Obese strain of chickens with spontaneous autoimmune thyroiditis as a model for Hashimoto disease. In: Cohen I.R., and Miller A. (Eds). "Autoimmune Disease Models-A Guidebook" (1994), Academic Press, London 107-122
165. Wick G., Knoflach M., and Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu. Rev. Immunol. 22 (2004) 361-403
166. Wijesekera D.H. Antioxidant state and extent of oxidative stress in autoimmune vitiliginous Smyth line and control chickens (2004), University of Arkansas, Fayetteville MS Thesis
167. Wilson T.J., Van de Water J., Mohr F.C., Boyd R.L., Ansari A., Wick G., and Gershwin M.E. Avian scleroderma: Evidence for qualitative and quantitative T cell defects. J. Autoimmun. 5 (1992) 261-276
168. Worda M., Sgonc R., Dietrich H., Niederegger H., Sundick R.S., Gershwin M.E., and Wick G. In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay. Arthritis Rheum. 48 (2003) 2605-2614
169. Ziemiecki A., Kroemer G., Mueller R.G., Hala K., and Wick G. Ev22, a new endogenous avian leukosis virus locus found in chickens with spontaneous autoimmune thyroiditis. Arch. Virol. 100 (1988) 267-271