Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to β-secretase

Acta Pharmacologica Sinica

Volumn 27, Issue 12, 2006, Pages 1586-1593

  Hu, Bin ^a   Xiong, Bing ^a   Qiu, Bei Ying ^a   Li, Xin ^a   Yu, Hai Ping ^a   Xiao, Kun ^a   Wang, Xin ^a   Li, Jia ^a   Shen, Jing Kang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

secretase; Alzheimer's disease; Hydroxyethylene; OM99 2; Structure activity relationship

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR; OM 99 2; PEPTIDE LIBRARY; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; COMPUTER SIMULATION; CRYSTAL STRUCTURE; DRUG TARGETING; ENERGY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; POLYACRYLAMIDE GEL ELECTROPHORESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; COMPUTER SIMULATION; ETHYLENES; HYDROGEN BONDING; INSECTS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 33751377755     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00432.x     Document Type: Article

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