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Volumn 16, Issue 2, 2000, Pages 123-138

Cholinesterase inhibitors for the treatment of Alzheimer's disease in the elderly

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR;

EID: 0034091808     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200016020-00004     Document Type: Review
Times cited : (29)

References (96)
  • 1
    • 0002014890 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Dipiro J, Talbet RL, Yee GC, et al., editors. New York: Elsiever
    • 1. Eggert A, Crismon ML, Ereshefsky L. Alzheimer's disease. In: Dipiro J, Talbet RL, Yee GC, et al., editors. Pharmacotherapy. 3rd ed. New York: Elsiever, 1997: 1325-44
    • (1997) Pharmacotherapy. 3rd Ed. , pp. 1325-1344
    • Eggert, A.1    Crismon, M.L.2    Ereshefsky, L.3
  • 2
    • 0025089076 scopus 로고
    • Adverse drug reactions: An overview of special considerations in the management of the elderly patient
    • 2. Brawn LA, Castleden CM. Adverse drug reactions: an overview of special considerations in the management of the elderly patient. Drug Saf 1990; 5 (6): 421 -35
    • (1990) Drug Saf , vol.5 , Issue.6 , pp. 421-435
    • Brawn, L.A.1    Castleden, C.M.2
  • 3
    • 0031854072 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic changes in the elderly
    • 3. Hammerlein A, Derendorf H, Lowenthal DT. Pharmacokinetic and pharmacodynamic changes in the elderly. Clin Pharmacokinet 1998; 35 (1): 49-64
    • (1998) Clin Pharmacokinet , vol.35 , Issue.1 , pp. 49-64
    • Hammerlein, A.1    Derendorf, H.2    Lowenthal, D.T.3
  • 4
    • 0030894452 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic considerations in geriatric psychopharmacology
    • 4. Catterson ML, Preskorn SH, Martin RL. Pharmacodynamic and pharmacokinetic considerations in geriatric psychopharmacology. Psychiatr Clin North Am 1997; 20 (1): 205-18
    • (1997) Psychiatr Clin North Am , vol.20 , Issue.1 , pp. 205-218
    • Catterson, M.L.1    Preskorn, S.H.2    Martin, R.L.3
  • 5
    • 0028198828 scopus 로고
    • Tacrine: The first drug approved for Alzheimer's disease
    • 5. Crismon ML. Tacrine: the first drug approved for Alzheimer's disease. Ann Pharmacother 1994; 28: 744-51
    • (1994) Ann Pharmacother , vol.28 , pp. 744-751
    • Crismon, M.L.1
  • 6
    • 0032507788 scopus 로고    scopus 로고
    • Donepezil improves the cognition and global function in Alzheimer's disease: A 15-week, double-blind, placebo-controlled study
    • 6. Rogers SL, Doody RS, Mohs RC, the Donepezil Study Group, et al. Donepezil improves the cognition and global function in Alzheimer's disease: a 15-week, double-blind, placebo-controlled study. Arch Intern Med 1998; 58: 1021-31
    • (1998) Arch Intern Med , vol.58 , pp. 1021-1031
    • Rogers, S.L.1    Doody, R.S.2    Mohs, R.C.3
  • 7
    • 0031043364 scopus 로고    scopus 로고
    • Galanthamine in Alzheimer's disease: A new alternative to tacrine?
    • 7. Rainer M. Galanthamine in Alzheimer's disease: a new alternative 10 tacrine? CNS Drugs 1997; 7 (2): 89-97
    • (1997) CNS Drugs , vol.7 , Issue.2 , pp. 89-97
    • Rainer, M.1
  • 8
    • 0031718551 scopus 로고    scopus 로고
    • Clinical pharmacology of rivastigmine: A new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
    • 8. Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther 1998; 20 (4): 634-47
    • (1998) Clin Ther , vol.20 , Issue.4 , pp. 634-647
    • Polinsky, R.J.1
  • 9
    • 0025788873 scopus 로고
    • Kinetics of cholinesterase inhibition by eptastigmine in man
    • 9. Unni LK, Hutt V, Imbimbo BP, et al. Kinetics of cholinesterase inhibition by eptastigmine in man. Eur J Clin Pharmacol 1991; 41: 83-4
    • (1991) Eur J Clin Pharmacol , vol.41 , pp. 83-84
    • Unni, L.K.1    Hutt, V.2    Imbimbo, B.P.3
  • 10
    • 0031896106 scopus 로고    scopus 로고
    • Preclinical pharmacology of metrifonate
    • 10. Jann MW. Preclinical pharmacology of metrifonate. Pharmacotherapy 1998; 18 (2 Pt 2); 55-67S
    • (1998) Pharmacotherapy , vol.18 , Issue.2 PT 2
    • Jann, M.W.1
  • 12
    • 0026594121 scopus 로고
    • Drug therapy in the elderly
    • 12. Williams L, Lowenthal DT. Drug therapy in the elderly. South Med J 1992; 85 (2): 127-31
    • (1992) South Med J , vol.85 , Issue.2 , pp. 127-131
    • Williams, L.1    Lowenthal, D.T.2
  • 14
    • 0026607590 scopus 로고
    • Predictive performance of equations to estimate creatinine clearance in hospitalized elderly patients
    • 14. O'Connell MB, Dwindell AM, Bannick-Mohrland SD. Predictive performance of equations to estimate creatinine clearance in hospitalized elderly patients. Ann Pharmacother 1992; 26: 627-35
    • (1992) Ann Pharmacother , vol.26 , pp. 627-635
    • O'Connell, M.B.1    Dwindell, A.M.2    Bannick-Mohrland, S.D.3
  • 15
    • 0032439162 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in the treatment of Alzheimer's disease: A comparison of tolerability and pharmacology
    • 15. Nordberg A, Svensson AL. Cholinesterase inhibitors in the treatment of Alzheimer's disease: a comparison of tolerability and pharmacology. Drug Saf 1998; 19 (6): 465-80
    • (1998) Drug Saf , vol.19 , Issue.6 , pp. 465-480
    • Nordberg, A.1    Svensson, A.L.2
  • 16
    • 0027519441 scopus 로고
    • Pharmacodynamics and pharmacokinetics of eptastigmine in elderly subjects
    • 16. Auteri A, Mosca A, Lattuada N, et al. Pharmacodynamics and pharmacokinetics of eptastigmine in elderly subjects. Eur J Clin Pharmacol 1993; 45 (4): 373-6
    • (1993) Eur J Clin Pharmacol , vol.45 , Issue.4 , pp. 373-376
    • Auteri, A.1    Mosca, A.2    Lattuada, N.3
  • 17
    • 0027141935 scopus 로고
    • Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects
    • 17. Ohnishi A, Mihara M, Kamakura H, et al. Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects. J Clin Pharmacol 1993; 33: 1086-91
    • (1993) J Clin Pharmacol , vol.33 , pp. 1086-1091
    • Ohnishi, A.1    Mihara, M.2    Kamakura, H.3
  • 18
    • 0001691708 scopus 로고    scopus 로고
    • The effects of renal and hepatic impairment on the disposition of the acetylcholinesterasc (AChE) inhibitor SDX ENA 713
    • 18. Schran HF, Habucky K, Mancione LC, et al. The effects of renal and hepatic impairment on the disposition of the acetylcholinesterasc (AChE) inhibitor SDX ENA 713 [abstract]. Pharmacol Res 1996; 13: S428
    • (1996) Pharmacol Res , vol.13
    • Schran, H.F.1    Habucky, K.2    Mancione, L.C.3
  • 19
    • 0032420656 scopus 로고    scopus 로고
    • An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function
    • 19. Tiseo PJ, Varga R, Perdomo CA, et al. An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function. Br J Clin Pharmacol 1998; 46 Suppl. 1: 51-5
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 51-55
    • Tiseo, P.J.1    Varga, R.2    Perdomo, C.A.3
  • 20
    • 0032420657 scopus 로고    scopus 로고
    • An evaluation of the pharmacokinetics of donepezil HCl in patients wiih moderately to severely impaired renal function
    • 20. Tiseo PJ, Foley K, Friedhoff LT. An evaluation of the pharmacokinetics of donepezil HCl in patients wiih moderately to severely impaired renal function. Br J Clin Pharmacol 1998; 46 Suppl. 1: 56-60
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 56-60
    • Tiseo, P.J.1    Foley, K.2    Friedhoff, L.T.3
  • 22
    • 85007768150 scopus 로고    scopus 로고
    • Alzheimer's disease
    • 22. Masters CL, Beyreuther K. Alzheimer's disease. BMJ 1998; 316: 446-8
    • (1998) BMJ , vol.316 , pp. 446-448
    • Masters, C.L.1    Beyreuther, K.2
  • 23
    • 0027420369 scopus 로고
    • Tau protein and the neurofibrillary pathology of Alzheimer's disease
    • 23. Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 1993; 16: 460-5
    • (1993) Trends Neurosci , vol.16 , pp. 460-465
    • Goedert, M.1
  • 24
    • 0002795025 scopus 로고    scopus 로고
    • Alzheimer neurofibrillary degeneration: A feasible and key target for therapeutics
    • Becker R, Giacobini E, editors. Boston (MA): Birkhauser
    • 24. Iqbal K, Alonso AC, Gong CX, et al. Alzheimer neurofibrillary degeneration: a feasible and key target for therapeutics. In: Becker R, Giacobini E, editors. Alzheimer disease: from molecular biology to therapy. Boston (MA): Birkhauser, 1996: 31-6
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 31-36
    • Iqbal, K.1    Alonso, A.C.2    Gong, C.X.3
  • 25
    • 0032486423 scopus 로고    scopus 로고
    • Tau protein mutations confirmed as neuron killers
    • 25. Vogel G. Tau protein mutations confirmed as neuron killers. Science 1998; 280: 1524-5
    • (1998) Science , vol.280 , pp. 1524-1525
    • Vogel, G.1
  • 26
    • 0028174973 scopus 로고
    • β-Amyloid formation as a potential therapeutic target for Alzheimer's disease
    • 26. Cordell B. β-Amyloid formation as a potential therapeutic target for Alzheimer's disease. Annu Rev Pharmacol Toxicol 1994; 34: 69-89
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 69-89
    • Cordell, B.1
  • 27
    • 0025991945 scopus 로고
    • Amyloid protein and Alzheimer's disease
    • 27. Selkoe D. Amyloid protein and Alzheimer's disease. Sci Am 1991; 265: 68-78
    • (1991) Sci Am , vol.265 , pp. 68-78
    • Selkoe, D.1
  • 28
    • 0024426526 scopus 로고
    • The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is the protease nexin-II
    • 28. Oltersdorf T, Fritz LC, Schen DB, et al. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is the protease nexin-II. Nature 1989; 341: 144-7
    • (1989) Nature , vol.341 , pp. 144-147
    • Oltersdorf, T.1    Fritz, L.C.2    Schen, D.B.3
  • 29
    • 0025365401 scopus 로고
    • Platelet coagulation factor Xia-inhibitor, a form of Alzheimer amyloid precursor protein
    • 29. Smith RP, Higuchi DA, Broze GJ. Platelet coagulation factor Xia-inhibitor, a form of Alzheimer amyloid precursor protein. Science 1990; 248: 1126-8
    • (1990) Science , vol.248 , pp. 1126-1128
    • Smith, R.P.1    Higuchi, D.A.2    Broze, G.J.3
  • 30
    • 0029257190 scopus 로고
    • Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
    • 30. Qiu WQ, Ferreira A, Miller C, et al. Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 1995; 15: 217-67
    • (1995) J Neurosci , vol.15 , pp. 217-267
    • Qiu, W.Q.1    Ferreira, A.2    Miller, C.3
  • 31
    • 0024395366 scopus 로고
    • Secreted form of amyloid α protein precursor is involved in the growth regulation of fibroblasts
    • 31. Saitoh T, Sundsmo M, Roch JM, et al. Secreted form of amyloid α protein precursor is involved in the growth regulation of fibroblasts. Cell 1989; 58: 615-22
    • (1989) Cell , vol.58 , pp. 615-622
    • Saitoh, T.1    Sundsmo, M.2    Roch, J.M.3
  • 32
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraveuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
    • 32. Mattson MP, Cheng B, Culwell AR, et al. Evidence for excitoprotective and intraveuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 1993; 10: 243-54
    • (1993) Neuron , vol.10 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Culwell, A.R.3
  • 33
    • 0013635867 scopus 로고    scopus 로고
    • A new focus on cytoskeletal therapy in Alzheimer's disease
    • Becker R, Giacobini E, editors. Boston (MA): Birkhauser
    • 33. Geerts H, Nuydens R, de Jong M, et al. A new focus on cytoskeletal therapy in Alzheimer's disease. In: Becker R, Giacobini E, editors. Alzheimer disease: from molecular biology to therapy. Boston (MA): Birkhauser, 1996: 61-5
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 61-65
    • Geerts, H.1    Nuydens, R.2    De Jong, M.3
  • 34
    • 0013635240 scopus 로고    scopus 로고
    • Novel cathepsin D inhibitors prevent the β-secretase-derived intracellular formation of a 12 kDa potentially amyloidogenic product in human cells
    • Becker R, Giacobini E, editors. Boston (MA): Birkhauser
    • 34. Chevallier N, Marambaud P, Vincent JP, et al. Novel cathepsin D inhibitors prevent the β-secretase-derived intracellular formation of a 12 kDa potentially amyloidogenic product in human cells. In: Becker R, Giacobini E, editors. Alzheimer disease: from molecular biology to therapy. Boston (MA): Birkhauser, 1996: 67-73
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 67-73
    • Chevallier, N.1    Marambaud, P.2    Vincent, J.P.3
  • 35
    • 0013635954 scopus 로고
    • Alzheimer's disease: Scientific progress for future trends
    • 35. Cacabelos R, Hofman A, Mullan M, et al. Alzheimer's disease: scientific progress for future trends. DN&P 1993; 6: 242-4
    • (1993) DN&P , vol.6 , pp. 242-244
    • Cacabelos, R.1    Hofman, A.2    Mullan, M.3
  • 36
    • 0001388038 scopus 로고
    • Therapeutic strategies in Alzheimer's disease
    • 36. Cacabelos R, Nordberg A, Caamaño J, et al. Therapeutic strategies in Alzheimer's disease. Ann Psychiatry 1995; 4: 221-79
    • (1995) Ann Psychiatry , vol.4 , pp. 221-279
    • Cacabelos, R.1    Nordberg, A.2    Caamaño, J.3
  • 37
    • 0028103819 scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Implications for therapy
    • 37. Aisen PS, Davis KL. Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 1994; 151: 1105-13
    • (1994) Am J Psychiatry , vol.151 , pp. 1105-1113
    • Aisen, P.S.1    Davis, K.L.2
  • 38
    • 0029838038 scopus 로고    scopus 로고
    • Neuropsychiatric aspects of Alzheimer's disease: The cholinergic hypothesis revisited
    • 38. Cummings JL, Kaufer D. Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited. Neurology 1996; 47: 876-83
    • (1996) Neurology , vol.47 , pp. 876-883
    • Cummings, J.L.1    Kaufer, D.2
  • 39
    • 0001659625 scopus 로고
    • Neurotransmitter receptors in Alzheimer's disease
    • Terry RD, Katzman R, Bick KL, editors. New York (NY): Raven Press
    • 39. Young AB, Penney JB. Neurotransmitter receptors in Alzheimer's disease. In: Terry RD, Katzman R, Bick KL, editors. Alzheimer's disease. New York (NY): Raven Press, 1994: 293-303
    • (1994) Alzheimer's Disease , pp. 293-303
    • Young, A.B.1    Penney, J.B.2
  • 40
    • 0003130520 scopus 로고    scopus 로고
    • Recognition and management of early Alzheimer's disease
    • 40. Steele CD, Steinberg M, Milles G, et al. Recognition and management of early Alzheimer's disease. J Clin Outcomes Manage 1999; 6 (3): 52-68
    • (1999) J Clin Outcomes Manage , vol.6 , Issue.3 , pp. 52-68
    • Steele, C.D.1    Steinberg, M.2    Milles, G.3
  • 41
    • 0030976004 scopus 로고    scopus 로고
    • Cognitive enhancement therapy for Alzheimer's disease
    • 41. Parnetti L, Senin U, Mecocci P. Cognitive enhancement therapy for Alzheimer's disease. Drugs 1997; 53 (3): 752-68
    • (1997) Drugs , vol.53 , Issue.3 , pp. 752-768
    • Parnetti, L.1    Senin, U.2    Mecocci, P.3
  • 42
    • 0026792979 scopus 로고
    • A controlled trial of tacrine in Alzheimer's disease
    • 42. Farlow M, Gracon SI, Hershey LA, et al. A controlled trial of tacrine in Alzheimer's disease. JAMA 1992; 268: 2523-9
    • (1992) JAMA , vol.268 , pp. 2523-2529
    • Farlow, M.1    Gracon, S.I.2    Hershey, L.A.3
  • 43
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
    • 43. Knapp MJ, Knopman DS, Soloman PR, et al. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA 1994; 271: 985-91
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Soloman, P.R.3
  • 44
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled, trial of donepezil in patients with Alzheimer's disease
    • 44. Rogers SL, Farlow MR, Doody RS, et al. A 24-week, double-blind, placebo-controlled, trial of donepezil in patients with Alzheimer's disease. Neurology 1998; 50: 136-45
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3
  • 45
    • 0031902795 scopus 로고    scopus 로고
    • A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease
    • 45. Corey-Bloom J, Anand R, Veach J. A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease. Int J Geriatr Psychopharmacol 1998; 1: 55-65
    • (1998) Int J Geriatr Psychopharmacol , vol.1 , pp. 55-65
    • Corey-Bloom, J.1    Anand, R.2    Veach, J.3
  • 46
    • 0033528436 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomised controlled trial
    • 46. Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomised controlled trial. BMJ 1999; 318: 633-40
    • (1999) BMJ , vol.318 , pp. 633-640
    • Rosler, M.1    Anand, R.2    Cicin-Sain, A.3
  • 47
    • 0031842292 scopus 로고    scopus 로고
    • Metrifonate treatment of the cognitive deficits of Alzheimer's disease: The Metrifonate Study Group
    • 47. Cummings JL, Cyrus PA, Bierber F, et al. Metrifonate treatment of the cognitive deficits of Alzheimer's disease: the Metrifonate Study Group. Neurology 1998; 50: 1214-21
    • (1998) Neurology , vol.50 , pp. 1214-1221
    • Cummings, J.L.1    Cyrus, P.A.2    Bierber, F.3
  • 48
    • 0031842293 scopus 로고    scopus 로고
    • Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease
    • 48. Morris JC, Cyrus PA, Orazem J, et al. Metrifonate benefits cognitive, behavioral, and global function in patients with Alzheimer's disease. Neurology 1998; 50: 1222-30
    • (1998) Neurology , vol.50 , pp. 1222-1230
    • Morris, J.C.1    Cyrus, P.A.2    Orazem, J.3
  • 49
    • 10544220019 scopus 로고    scopus 로고
    • A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease
    • 49. Thal LJ, Schwartz G, Sano M, et al. A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease. Neurology 1996; 47: 1389-95
    • (1996) Neurology , vol.47 , pp. 1389-1395
    • Thal, L.J.1    Schwartz, G.2    Sano, M.3
  • 50
    • 0030801772 scopus 로고    scopus 로고
    • Diagnosis and treatment of Alzheimer disease and related disorders
    • 50. Small GW, Rabins PV, Barry PP, et al. Diagnosis and treatment of Alzheimer disease and related disorders. JAMA 1997; 278 (16): 1363-71
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1363-1371
    • Small, G.W.1    Rabins, P.V.2    Barry, P.P.3
  • 51
    • 0003370509 scopus 로고
    • FDA guidance on Alzheimer's drug clinical utility assessments
    • 51. Food, Drug and Cosmetic Reports. FDA guidance on Alzheimer's drug clinical utility assessments. FDC Rep 1992: 13-5
    • (1992) FDC Rep , pp. 13-15
  • 52
    • 0026756286 scopus 로고
    • A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease
    • 52. Davis KL, Thal LJ, Gamzu ER, et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. N Engl J Med 1992; 327: 1253-9
    • (1992) N Engl J Med , vol.327 , pp. 1253-1259
    • Davis, K.L.1    Thal, L.J.2    Gamzu, E.R.3
  • 53
    • 0025908283 scopus 로고
    • Scales for the assessment of Alzheimer's disease
    • 53. Kluger A, Ferris H. Scales for the assessment of Alzheimer's disease. Psychiatr Clin North Am 1991; 14 (2): 309-26
    • (1991) Psychiatr Clin North Am , vol.14 , Issue.2 , pp. 309-326
    • Kluger, A.1    Ferris, H.2
  • 54
    • 0030889948 scopus 로고    scopus 로고
    • Neuropsychological testing and assessment scales for dementia of the Alzheimer's type
    • 54. Morgan CD, Baade LE. Neuropsychological testing and assessment scales for dementia of the Alzheimer's type. Psychiatr Clin North Am 1997; 20 (1): 25-43
    • (1997) Psychiatr Clin North Am , vol.20 , Issue.1 , pp. 25-43
    • Morgan, C.D.1    Baade, L.E.2
  • 55
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • 55. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1356-64
    • (1984) Am J Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 56
    • 0025917752 scopus 로고
    • Galanthamine treatment in Alzheimer's disease
    • 56. Dal-Bianco P, Maly J, Wober C, et al. Galanthamine treatment in Alzheimer's disease. J Neural Transm 1991; Suppl. 33: 59-63
    • (1991) J Neural Transm , Issue.SUPPL. 33 , pp. 59-63
    • Dal-Bianco, P.1    Maly, J.2    Wober, C.3
  • 57
    • 0001873546 scopus 로고    scopus 로고
    • Galanthamine hydrobromide: Interim results of a group comparative, placebo-controlled study of the efficacy and safety in patients with a diagnosis of senile dementia of the Alzheimer's type
    • 57. Wilcock G, Wilkinson D. Galanthamine hydrobromide: interim results of a group comparative, placebo-controlled study of the efficacy and safety in patients with a diagnosis of senile dementia of the Alzheimer's type. Neurobiol Aging 1996; 17 Suppl. 4: S144
    • (1996) Neurobiol Aging , vol.17 , Issue.SUPPL. 4
    • Wilcock, G.1    Wilkinson, D.2
  • 58
    • 0028114429 scopus 로고
    • The Clinician Interview Based Impression (CIBI): A clinician's global change rating scale in Alzheimer's disease
    • 58. Knopman DS, Knapp MJ, Gracon SI, et al. The clinician interview based impression (CIBI): a clinician's global change rating scale in Alzheimer's disease. Neurology 1994; 44: 2315-21
    • (1994) Neurology , vol.44 , pp. 2315-2321
    • Knopman, D.S.1    Knapp, M.J.2    Gracon, S.I.3
  • 59
    • 0029914548 scopus 로고    scopus 로고
    • Effect of tacrine on behavioral symptoms in Alzheimer's disease: An open-label study
    • 59. Kaufer DI, Cummings JL, Christine D. Effect of tacrine on behavioral symptoms in Alzheimer's disease: an open-label study. J Geriatr Psychiatry Neurol 1996; 9: 1-6
    • (1996) J Geriatr Psychiatry Neurol , vol.9 , pp. 1-6
    • Kaufer, D.I.1    Cummings, J.L.2    Christine, D.3
  • 60
    • 0030958347 scopus 로고    scopus 로고
    • The neuropsychiatric inventory: Assessing psychopathology in dementia patients
    • 60. Cummings JL. The neuropsychiatric inventory: assessing psychopathology in dementia patients. Neurology 1997; 48 Suppl. 6: S10-16
    • (1997) Neurology , vol.48 , Issue.SUPPL. 6
    • Cummings, J.L.1
  • 61
    • 0026566736 scopus 로고
    • Predictors of the placement of cognitively impaired residents on special care units
    • 61. Riter RN, Fries BE. Predictors of the placement of cognitively impaired residents on special care units. Gerontologist 1992; 32: 184-90
    • (1992) Gerontologist , vol.32 , pp. 184-190
    • Riter, R.N.1    Fries, B.E.2
  • 62
    • 0024346285 scopus 로고
    • Measurement of quality of life changes in patients with Alzheimer's disease
    • 62. DeJong R, Osterlund OW, Roy GW. Measurement of quality of life changes in patients with Alzheimer's disease. Clin Ther 1989; 11 (4): 545-54
    • (1989) Clin Ther , vol.11 , Issue.4 , pp. 545-554
    • DeJong, R.1    Osterlund, O.W.2    Roy, G.W.3
  • 63
    • 0002099952 scopus 로고    scopus 로고
    • The bridging study: Optimizing the dose for phase II/III
    • Becker R, Giacobini E, et al. Boston (MA): Birkhauser
    • 63. Cutler NR, Sramek JJ. The bridging study: optimizing the dose for phase II/III. In: Becker R, Giacobini E, et al. Alzheimer disease: from molecular biology to therapy. Boston (MA): Birkhauser, 1996: 387-91
    • (1996) Alzheimer Disease: From Molecular Biology to Therapy , pp. 387-391
    • Cutler, N.R.1    Sramek, J.J.2
  • 64
    • 0032513106 scopus 로고    scopus 로고
    • Safety and tolerability of metrifonate in patients with Alzheimer's disease: Results of a maximum tolerated dose study
    • 64. Cutler NR, Jhee SS, Cyrus P, et al. Safety and tolerability of metrifonate in patients with Alzheimer's disease: results of a maximum tolerated dose study. Life Sci 1998; 62 (16): 1433-41
    • (1998) Life Sci , vol.62 , Issue.16 , pp. 1433-1441
    • Cutler, N.R.1    Jhee, S.S.2    Cyrus, P.3
  • 65
    • 0031879846 scopus 로고    scopus 로고
    • Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers
    • 65. Mant T, Troetel WM, Imbimbo BP. Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers. J Clin Pharmacol 1998; 38: 610-7
    • (1998) J Clin Pharmacol , vol.38 , pp. 610-617
    • Mant, T.1    Troetel, W.M.2    Imbimbo, B.P.3
  • 66
    • 0027310305 scopus 로고
    • Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease
    • 66. Ford JM, Truman CA, Wilcock GK, et al. Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease. Clin Pharmacol Ther 1993; 53: 691-5
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 691-695
    • Ford, J.M.1    Truman, C.A.2    Wilcock, G.K.3
  • 67
    • 0032406418 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses
    • 67. Rogers SL, Cooper NM, Sukavaty R, et al. Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses. Br J Pharmacol 1998; 46 Suppl. 1: 7-12
    • (1998) Br J Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 7-12
    • Rogers, S.L.1    Cooper, N.M.2    Sukavaty, R.3
  • 68
    • 0001184410 scopus 로고    scopus 로고
    • Antiemetic therapy for Alzheimer's patients receiving the cholinesterase inhibitor SDZ ENA 713
    • 68. Cutler NR, Anand R, Hartman RD, et al. Antiemetic therapy for Alzheimer's patients receiving the cholinesterase inhibitor SDZ ENA 713 [abstract]. Clin Pharmacol Ther 1998; 63 (2): 188
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.2 , pp. 188
    • Cutler, N.R.1    Anand, R.2    Hartman, R.D.3
  • 69
    • 0032053154 scopus 로고    scopus 로고
    • Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure
    • 69. Sarin S, Gill KD. Biochemical and behavioral deficits in adult rat following chronic dichlorvos exposure. Pharmacol Biochem Behav 1998; 59 (4): 1081-6
    • (1998) Pharmacol Biochem Behav , vol.59 , Issue.4 , pp. 1081-1086
    • Sarin, S.1    Gill, K.D.2
  • 70
    • 0032032459 scopus 로고    scopus 로고
    • Neuropathy target esterase: Immunolocalization to neuronal cell bodies and axons
    • 70. Glynn P, Holton JL, Nolan CC, et al. Neuropathy target esterase: immunolocalization to neuronal cell bodies and axons. Neuroscience 1998; 83 (1): 295-302
    • (1998) Neuroscience , vol.83 , Issue.1 , pp. 295-302
    • Glynn, P.1    Holton, J.L.2    Nolan, C.C.3
  • 71
    • 26844576446 scopus 로고    scopus 로고
    • Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity
    • 71. Ehrich M, Correll L, Veronesi B. Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Fundam Appl Toxicol 1997; 38 (1): 55-63
    • (1997) Fundam Appl Toxicol , vol.38 , Issue.1 , pp. 55-63
    • Ehrich, M.1    Correll, L.2    Veronesi, B.3
  • 72
    • 0029877604 scopus 로고    scopus 로고
    • Lymphocyte esterases and hydroxylases in neurotoxicology
    • 72. Fournier L, Musard D, Lecorsier A. Lymphocyte esterases and hydroxylases in neurotoxicology. Vet Hum Toxicol 1996; 38 (3): 190-5
    • (1996) Vet Hum Toxicol , vol.38 , Issue.3 , pp. 190-195
    • Fournier, L.1    Musard, D.2    Lecorsier, A.3
  • 73
    • 0019487374 scopus 로고
    • Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse
    • 73. Sterri SH, Lyngaas S, Fonnum F. Toxicity of soman after repetitive injection of sublethal doses in guinea-pig and mouse. Acta Pharmacol Toxicol (Copenh) 1981; 49: 8-13
    • (1981) Acta Pharmacol Toxicol (Copenh) , vol.49 , pp. 8-13
    • Sterri, S.H.1    Lyngaas, S.2    Fonnum, F.3
  • 74
    • 0031048155 scopus 로고    scopus 로고
    • The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse
    • 74. Williams FM, Charlton C, de Blaquiere GE, et al. The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse. Hum Exp Toxicol 1997; 16: 67-71
    • (1997) Hum Exp Toxicol , vol.16 , pp. 67-71
    • Williams, F.M.1    Charlton, C.2    De Blaquiere, G.E.3
  • 75
    • 0028609306 scopus 로고
    • Dichlorvos carcinogenicity: An assessment of the weight of experimental evidence
    • 75. Mennear JH. Dichlorvos carcinogenicity: an assessment of the weight of experimental evidence. Regul Toxicol Pharmacol 1994; 20 (3 Pt 1): 354-61
    • (1994) Regul Toxicol Pharmacol , vol.20 , Issue.3 PT 1 , pp. 354-361
    • Mennear, J.H.1
  • 76
    • 0003168702 scopus 로고    scopus 로고
    • Bayer suspends metrifonate trials
    • Sep 30
    • 76. Anonymous. Bayer suspends metrifonate trials. Scrip 1998 Sep 30; 2374: 19
    • (1998) Scrip , vol.2374 , pp. 19
  • 77
    • 0028316959 scopus 로고
    • Hepatotoxic effects of tacrinc administration in patients with Alzheimer's disease
    • 77. Watkins PB, Zimmerman HJ, Knapp MJ, et al. Hepatotoxic effects of tacrinc administration in patients with Alzheimer's disease. JAMA 1994; 271: 992-8
    • (1994) JAMA , vol.271 , pp. 992-998
    • Watkins, P.B.1    Zimmerman, H.J.2    Knapp, M.J.3
  • 78
    • 0025972223 scopus 로고
    • Carcinogenesis studies of dichlorvos in Fischer rats and B6C3F1 mice
    • 78. Chan PC, Huff J, Haseman JK, et al. Carcinogenesis studies of dichlorvos in Fischer rats and B6C3F1 mice. Jpn J Cancer Res 1991; 82 (2): 157-64
    • (1991) Jpn J Cancer Res , vol.82 , Issue.2 , pp. 157-164
    • Chan, P.C.1    Huff, J.2    Haseman, J.K.3
  • 79
    • 0017128793 scopus 로고
    • Dichlorvos: A two-year inhalation carcinogenesis study in rats
    • 79. Blair D, Dix KM, Hunt PF, et al. Dichlorvos: a two-year inhalation carcinogenesis study in rats. Arch Toxicol 1976: 281-94
    • (1976) Arch Toxicol , pp. 281-294
    • Blair, D.1    Dix, K.M.2    Hunt, P.F.3
  • 80
    • 0030777814 scopus 로고    scopus 로고
    • Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine)
    • 80. Zeiger E, Erexson G, Mortelmans K, et al. Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). Mutat Res 1997; 393 (3): 189-97
    • (1997) Mutat Res , vol.393 , Issue.3 , pp. 189-197
    • Zeiger, E.1    Erexson, G.2    Mortelmans, K.3
  • 81
    • 0031746034 scopus 로고    scopus 로고
    • Important drug-drug interactions in the elderly
    • 81. Seymour RM, Routledge PA. Important drug-drug interactions in the elderly. Drugs Aging 1998; 12 (6): 485-94
    • (1998) Drugs Aging , vol.12 , Issue.6 , pp. 485-494
    • Seymour, R.M.1    Routledge, P.A.2
  • 82
    • 0031896009 scopus 로고    scopus 로고
    • Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer's disease
    • 82. Crismon ML. Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer's disease. Pharmacothcrapy 1998; 18 (2 Pt 2): 47-54S
    • (1998) Pharmacothcrapy , vol.18 , Issue.2 PT 2
    • Crismon, M.L.1
  • 83
    • 0030977293 scopus 로고    scopus 로고
    • Influence of the CYPIA2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans
    • 83. Becquemont L, Ragueneau I, Le Bot MA, et al. Influence of the CYPIA2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans. Clin Pharmacol Ther 1997; 61: 619-27
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 619-627
    • Becquemont, L.1    Ragueneau, I.2    Le Bot, M.A.3
  • 84
    • 0031970304 scopus 로고    scopus 로고
    • Use of heterologously expressed human cytochrome P450 1A2 to predict tacrine-fluvoxamine drug interaction in man
    • 84. Becquemont L, Le Bot MA, Riche C, et al. Use of heterologously expressed human cytochrome P450 1A2 to predict tacrine-fluvoxamine drug interaction in man. Pharmacogenetics 1998; 8: 101-8
    • (1998) Pharmacogenetics , vol.8 , pp. 101-108
    • Becquemont, L.1    Le Bot, M.A.2    Riche, C.3
  • 85
    • 0031975185 scopus 로고    scopus 로고
    • Update: Clinically significant cytochrome P-450 drug interactions
    • 85. Michalets EL. Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy 1998; 18: 84-112
    • (1998) Pharmacotherapy , vol.18 , pp. 84-112
    • Michalets, E.L.1
  • 86
    • 0001417691 scopus 로고
    • The effect of smoking on the pharmacokinetics and metabolism of Cognex® in healthy volunteers
    • 86. Welty D, Pool W, Woolf T, et al. The effect of smoking on the pharmacokinetics and metabolism of Cognex® in healthy volunteers [abstract], Pharmacol Res 1993; 10: S334
    • (1993) Pharmacol Res , vol.10
    • Welty, D.1    Pool, W.2    Woolf, T.3
  • 87
    • 0032420331 scopus 로고    scopus 로고
    • Concurrent administration of donepezil HCl and ketoconazole: Assessment of pharmacokinetic changes following single and multiple doses
    • 87. Tiseo PJ, Perdomo CA, Friedhoff LT. Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses. Br J Clin Pharmacol 1998; 46 Suppl. 1: 30-4
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 30-34
    • Tiseo, P.J.1    Perdomo, C.A.2    Friedhoff, L.T.3
  • 88
    • 0001673330 scopus 로고    scopus 로고
    • The effect of cimetidine and ketoconazole on the pharmacokinetics of donepezil HCl
    • 88. Tiseo PJ, Rogers SL, Perdomo CA, et al. The effect of cimetidine and ketoconazole on the pharmacokinetics of donepezil HCl [abstract]. Clin Pharmacol Ther 1998; 63 (2): 234
    • (1998) Clin Pharmacol Ther , vol.63 , Issue.2 , pp. 234
    • Tiseo, P.J.1    Rogers, S.L.2    Perdomo, C.A.3
  • 89
    • 0032420196 scopus 로고    scopus 로고
    • Concurrent administration of donepezil HCl and cimetidine: Assessment of pharmacokinetic changes following single and multiple doses
    • 89. Tiseo PJ, Perdomo CA, Friedhoff LT. Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses. Br J Clin Pharmacol 1998; 46 Suppl. 1: 25-9
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 25-29
    • Tiseo, P.J.1    Perdomo, C.A.2    Friedhoff, L.T.3
  • 91
    • 0032435194 scopus 로고    scopus 로고
    • Concurrent administration of donepezil HCl and digoxin: Assessment of pharmacokinetic changes
    • 91. Tiseo PJ, Perdomo CA, Friedhoff LT. Concurrent administration of donepezil HCl and digoxin: assessment of pharmacokinetic changes. Br J Clin Pharmacol 1998; 46 Suppl. I: 40-4
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 40-44
    • Tiseo, P.J.1    Perdomo, C.A.2    Friedhoff, L.T.3
  • 92
    • 0032420196 scopus 로고    scopus 로고
    • Concurrent administration of donepezil HCl and theophylline: Assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers
    • 92. Tiseo PJ, Foley K, Friedhoff LT. Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers. Br J Clin Pharmacol 1998; 46 Suppl. 1: 35-9
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 35-39
    • Tiseo, P.J.1    Foley, K.2    Friedhoff, L.T.3
  • 93
    • 0032406257 scopus 로고    scopus 로고
    • The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin
    • 93. Tiseo PJ, Foley K, Friedhoff LT. The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin. Br J Clin Pharmacol 1998; 46 Suppl. I: 45-50
    • (1998) Br J Clin Pharmacol , vol.46 , Issue.SUPPL. 1 , pp. 45-50
    • Tiseo, P.J.1    Foley, K.2    Friedhoff, L.T.3
  • 94
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact on delaying disease onset
    • 94. Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact on delaying disease onset. Am J Public Health 1998; 88: 1337-42
    • (1998) Am J Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 95
    • 0030832997 scopus 로고    scopus 로고
    • Metrifonate
    • 95. Lamb HM, Faulds D. Metrifonate. Drugs Aging 1997; 11 (6): 490-6
    • (1997) Drugs Aging , vol.11 , Issue.6 , pp. 490-496
    • Lamb, H.M.1    Faulds, D.2
  • 96
    • 0031894164 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safely of metrifonate in patients with Alzheimer's disease
    • 96. Pettigrew LC, Bieber F, Lettieri J, et al. Pharmacokinetics, pharmacodynamics, and safely of metrifonate in patients with Alzheimer's disease. J Clin Pharmacol 1998; 38: 236-45
    • (1998) J Clin Pharmacol , vol.38 , pp. 236-245
    • Pettigrew, L.C.1    Bieber, F.2    Lettieri, J.3


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