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Volumn 6, Issue 8, 2006, Pages 1107-1116

α-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease

Author keywords

synuclein; Apoptosis; Glutathione; Methylglyoxal; ROS; Saccharomyces cerevisiae

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN; BETA SYNUCLEIN; BIOLOGICAL MARKER; CATALASE; CYTOCHROME C; CYTOCHROME C OXIDASE; DNA FRAGMENT; DOPAMINE; GAMMA SYNUCLEIN; GLUTAREDOXIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 70; HYDROXYACYLGLUTATHIONE HYDROLASE; LACTOYLGLUTATHIONE LYASE; LIPID; MESSENGER RNA; PEROXIDASE; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; UBIQUINOL CYTOCHROME C REDUCTASE;

EID: 33751372793     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00135.x     Document Type: Short Survey
Times cited : (51)

References (63)
  • 1
    • 0036852712 scopus 로고    scopus 로고
    • Pharmacological prevention of Parkinson disease in Drosophila
    • Auluck PK & Bonini NM (2002) Pharmacological prevention of Parkinson disease in Drosophila. Nat Med 8: 1185-1186.
    • (2002) Nat Med , vol.8 , pp. 1185-1186
    • Auluck, P.K.1    Bonini, N.M.2
  • 2
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • Auluck PK, Chan HY, Trojanowski JQ, Lee VM & Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295: 865-868.
    • (2002) Science , vol.295 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.2    Trojanowski, J.Q.3    Lee, V.M.4    Bonini, N.M.5
  • 3
    • 13244267202 scopus 로고    scopus 로고
    • Mechanisms of suppression of alpha-synuclein neurotoxicity by geldanamycin in Drosophila
    • Auluck PK, Meulener MC & Bonini NM (2005) Mechanisms of suppression of alpha-synuclein neurotoxicity by geldanamycin in Drosophila. J Biol Chem 280: 2873-2878.
    • (2005) J Biol Chem , vol.280 , pp. 2873-2878
    • Auluck, P.K.1    Meulener, M.C.2    Bonini, N.M.3
  • 4
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ & Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152: 879-884.
    • (1998) Am J Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Trojanowski, J.Q.7    Iwatsubo, T.8
  • 6
    • 11344262265 scopus 로고    scopus 로고
    • Ubiquitin-proteasome system and Parkinson's diseases
    • Betarbet R, Sherer TB & Greenamyre JT (2005) Ubiquitin-proteasome system and Parkinson's diseases. Exp Neurol 191: S17-S27.
    • (2005) Exp Neurol , vol.191
    • Betarbet, R.1    Sherer, T.B.2    Greenamyre, J.T.3
  • 7
    • 0030761248 scopus 로고    scopus 로고
    • Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins
    • Bito A, Haider M, Hadler I & Breitenbach M (1997) Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. J Biol Chem 272: 21509-21519.
    • (1997) J Biol Chem , vol.272 , pp. 21509-21519
    • Bito, A.1    Haider, M.2    Hadler, I.3    Breitenbach, M.4
  • 8
    • 0037551741 scopus 로고    scopus 로고
    • Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
    • Caughey B & Lansbury PT (2003) Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 26: 267-298.
    • (2003) Annu Rev Neurosci , vol.26 , pp. 267-298
    • Caughey, B.1    Lansbury, P.T.2
  • 9
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway KA, Rochet JC, Bieganski RM & Lansbury PT Jr (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294: 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury Jr., P.T.4
  • 10
    • 0242363670 scopus 로고    scopus 로고
    • Molecular pathways of neurodegeneration in Parkinson's disease
    • Dawson TM & Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822.
    • (2003) Science , vol.302 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 11
    • 17644383748 scopus 로고    scopus 로고
    • Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species
    • Dedmon MM, Christodoulou J, Wilson MR & Dobson CM (2005) Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem 280: 14733-14740.
    • (2005) J Biol Chem , vol.280 , pp. 14733-14740
    • Dedmon, M.M.1    Christodoulou, J.2    Wilson, M.R.3    Dobson, C.M.4
  • 12
    • 0037072284 scopus 로고    scopus 로고
    • Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
    • Ding TT, Lee SJ, Rochet JC & Lansbury PT Jr (2002) Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Biochemistry 41: 10209-10217.
    • (2002) Biochemistry , vol.41 , pp. 10209-10217
    • Ding, T.T.1    Lee, S.J.2    Rochet, J.C.3    Lansbury Jr., P.T.4
  • 13
    • 20444372698 scopus 로고    scopus 로고
    • alpha-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast
    • Dixon C, Mathias N, Zweig RM, Davis DA & Gross DS (2005) alpha-Synuclein targets the plasma membrane via the secretory pathway and induces toxicity in yeast. Genetics 170: 47-59.
    • (2005) Genetics , vol.170 , pp. 47-59
    • Dixon, C.1    Mathias, N.2    Zweig, R.M.3    Davis, D.A.4    Gross, D.S.5
  • 14
    • 0036014117 scopus 로고    scopus 로고
    • Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome c oxidase
    • Elkon H, Don J, Melamed E, Ziv I, Shirvan A & Offen D (2002) Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome c oxidase. J Mol Neurosci 18: 229-238.
    • (2002) J Mol Neurosci , vol.18 , pp. 229-238
    • Elkon, H.1    Don, J.2    Melamed, E.3    Ziv, I.4    Shirvan, A.5    Offen, D.6
  • 16
    • 23644442282 scopus 로고    scopus 로고
    • Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease
    • Flower TR, Chesnokova LS, Froelich CA, Dixon C & Witt SN (2005) Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. J Mol Biol 351: 1081-1100.
    • (2005) J Mol Biol , vol.351 , pp. 1081-1100
    • Flower, T.R.1    Chesnokova, L.S.2    Froelich, C.A.3    Dixon, C.4    Witt, S.N.5
  • 23
    • 0032492689 scopus 로고    scopus 로고
    • Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins
    • Jenco JM, Rawlingson A, Daniels B & Morris AJ (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37: 4901-4909.
    • (1998) Biochemistry , vol.37 , pp. 4901-4909
    • Jenco, J.M.1    Rawlingson, A.2    Daniels, B.3    Morris, A.J.4
  • 25
    • 9444279547 scopus 로고    scopus 로고
    • Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease
    • Kim S, Jeon BS, Heo C et al. (2004) Alpha-synuclein induces apoptosis by altered expression in human peripheral lymphocyte in Parkinson's disease. FASEB J 18: 1615-1617.
    • (2004) FASEB J , vol.18 , pp. 1615-1617
    • Kim, S.1    Jeon, B.S.2    Heo, C.3
  • 27
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW & Irwin I (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 28
    • 0035824537 scopus 로고    scopus 로고
    • Vesicle-associated membrane protein of Arabidopsis suppresses Bax-induced apoptosis in yeast downstream of oxidative burst
    • Levine A, Belenghi B, Damari-Weisler H & Granot D (2001) Vesicle-associated membrane protein of Arabidopsis suppresses Bax-induced apoptosis in yeast downstream of oxidative burst. J Biol Chem 276: 46284-46289.
    • (2001) J Biol Chem , vol.276 , pp. 46284-46289
    • Levine, A.1    Belenghi, B.2    Damari-Weisler, H.3    Granot, D.4
  • 29
    • 0037424245 scopus 로고    scopus 로고
    • Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production
    • Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA & Robinson JP (2003) Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem 278: 8516-8525.
    • (2003) J Biol Chem , vol.278 , pp. 8516-8525
    • Li, N.1    Ragheb, K.2    Lawler, G.3    Sturgis, J.4    Rajwa, B.5    Melendez, J.A.6    Robinson, J.P.7
  • 31
    • 20744442130 scopus 로고    scopus 로고
    • A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: Implications for pathogenesis of Parkinson disease
    • Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN & Thomas PJ (2005) A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 280: 22670-22678.
    • (2005) J Biol Chem , vol.280 , pp. 22670-22678
    • Liu, C.W.1    Giasson, B.I.2    Lewis, K.A.3    Lee, V.M.4    Demartino, G.N.5    Thomas, P.J.6
  • 32
    • 0034489853 scopus 로고    scopus 로고
    • Alpha-synuclein and Parkinson's disease
    • Lucking CB & Brice A (2000) Alpha-synuclein and Parkinson's disease. Cell Mol Life Sci 57: 1894-1908.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1894-1908
    • Lucking, C.B.1    Brice, A.2
  • 33
    • 0036678040 scopus 로고    scopus 로고
    • Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae
    • Ludovico P, Rodrigues F, Almeida A, Silva MT, Barrientos A & Côrte-Real M (2002) Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol Biol Cell 13: 2598-2606.
    • (2002) Mol Biol Cell , vol.13 , pp. 2598-2606
    • Ludovico, P.1    Rodrigues, F.2    Almeida, A.3    Silva, M.T.4    Barrientos, A.5    Côrte-Real, M.6
  • 35
    • 18344374857 scopus 로고    scopus 로고
    • A caspase-related protease regulates apoptosis in yeast
    • Madeo F, Herker E, Maldener C et al. (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9: 911-917.
    • (2002) Mol Cell , vol.9 , pp. 911-917
    • Madeo, F.1    Herker, E.2    Maldener, C.3
  • 37
    • 15744405993 scopus 로고    scopus 로고
    • Synuclein, dopamine and oxidative stress: Co-conspirators in Parkinson's disease?
    • Maguire-Zeiss KA, Short DW & Federoff HJ (2005) Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res Mol Brain Res 134: 18-23.
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 18-23
    • Maguire-Zeiss, K.A.1    Short, D.W.2    Federoff, H.J.3
  • 38
    • 0034468706 scopus 로고    scopus 로고
    • Crosslinking of alpha-synuclein by advanced glycation endproducts - An early pathophysiological step in Lewy body formation?
    • Munch G, Luth HJ, Wong A, Arendt T, Hirsch E, Ravid R & Riederer P (2000) Crosslinking of alpha-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? J Chem Neuroanat 20: 253-257.
    • (2000) J Chem Neuroanat , vol.20 , pp. 253-257
    • Munch, G.1    Luth, H.J.2    Wong, A.3    Arendt, T.4    Hirsch, E.5    Ravid, R.6    Riederer, P.7
  • 39
    • 0035928748 scopus 로고    scopus 로고
    • Membrane binding and self-association of alpha-synucleins
    • Narayanan V & Scarlata S (2001) Membrane binding and self-association of alpha-synucleins. Biochemistry 40: 9927-9934.
    • (2001) Biochemistry , vol.40 , pp. 9927-9934
    • Narayanan, V.1    Scarlata, S.2
  • 40
    • 0345189364 scopus 로고    scopus 로고
    • Yeast cells provide insight into alpha-synuclein biology and pathobiology
    • Outeiro TF & Lindquist S (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302: 1772-1775.
    • (2003) Science , vol.302 , pp. 1772-1775
    • Outeiro, T.F.1    Lindquist, S.2
  • 41
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos MH, Lavedan C, Leroy E et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 46
    • 0037056045 scopus 로고    scopus 로고
    • Respiratory chain supercomplexes of mitochondria and bacteria
    • Schagger H (2002) Respiratory chain supercomplexes of mitochondria and bacteria. Biochim Biophys Acta 1555: 154-159.
    • (2002) Biochim Biophys Acta , vol.1555 , pp. 154-159
    • Schagger, H.1
  • 47
    • 2942699852 scopus 로고    scopus 로고
    • Yeast genetics targets lipids in Parkinson's disease
    • Scherzer CR & Feany MB (2004) Yeast genetics targets lipids in Parkinson's disease. Trends Genet 20: 273-277.
    • (2004) Trends Genet , vol.20 , pp. 273-277
    • Scherzer, C.R.1    Feany, M.B.2
  • 48
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR & Greenamyre JT (2002) An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci 22: 7006-7015.
    • (2002) J Neurosci , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3    Lund, S.4    Baptista, M.5    Panov, A.V.6    Cookson, M.R.7    Greenamyre, J.T.8
  • 50
    • 0036049850 scopus 로고    scopus 로고
    • The unfolding story of the Escherichia coli Hsp70 DnaK: Is DnaK a holdase or an unfoldase?
    • Slepenkov SV & Witt SN (2002) The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase? Mol Microbiol 45: 1197-1206.
    • (2002) Mol Microbiol , vol.45 , pp. 1197-1206
    • Slepenkov, S.V.1    Witt, S.N.2
  • 51
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
    • Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM & Ross CA (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14: 3801-3811.
    • (2005) Hum Mol Genet , vol.14 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3    Tanaka, Y.4    Morita, H.5    Sawa, A.6    Dawson, V.L.7    Dawson, T.M.8    Ross, C.A.9
  • 52
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza JM, Giasson BI, Chen Q, Lee VM & Ischiropoulos H (2000) Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J Biol Chem 275: 18344-18349.
    • (2000) J Biol Chem , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 55
    • 0035873812 scopus 로고    scopus 로고
    • alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro
    • Turnbull S, Tabner BJ, El-Agnaf OM, Moore S, Davies Y &Allsop D (2001) alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro. Free Radical Biol Med 30: 1163-1170.
    • (2001) Free Radical Biol Med , vol.30 , pp. 1163-1170
    • Turnbull, S.1    Tabner, B.J.2    El-Agnaf, O.M.3    Moore, S.4    Davies, Y.5    Allsop, D.6
  • 57
    • 0033966487 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP
    • Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M & Przedborski S (2000) Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem 74: 721-729.
    • (2000) J Neurochem , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 58
    • 16344362746 scopus 로고    scopus 로고
    • The role of alpha-synuclein in the pathogenesis of multiple system atrophy
    • Wenning GK & Jellinger KA (2005) The role of alpha-synuclein in the pathogenesis of multiple system atrophy. Acta Neuropathol (Berlin) 109: 129-140.
    • (2005) Acta Neuropathol (Berlin) , vol.109 , pp. 129-140
    • Wenning, G.K.1    Jellinger, K.A.2
  • 59
    • 1642547105 scopus 로고    scopus 로고
    • Regulation of redox homeostasis in the yeast Saccharomyces cerevisiae
    • Wheeler GL & Grant CM (2004) Regulation of redox homeostasis in the yeast Saccharomyces cerevisiae. Physiol Plant 120: 12-20.
    • (2004) Physiol Plant , vol.120 , pp. 12-20
    • Wheeler, G.L.1    Grant, C.M.2
  • 60
    • 0345189365 scopus 로고    scopus 로고
    • Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein
    • Willingham S, Outeiro TF, DeVit MJ, Lindquist SL & Muchowski PJ (2003) Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302: 1769-1772.
    • (2003) Science , vol.302 , pp. 1769-1772
    • Willingham, S.1    Outeiro, T.F.2    DeVit, M.J.3    Lindquist, S.L.4    Muchowski, P.J.5
  • 61
    • 4644246439 scopus 로고    scopus 로고
    • An AIF orthologue regulates apoptosis in yeast
    • Wissing S, Ludovico P, Herker E et al. (2004) An AIF orthologue regulates apoptosis in yeast. J Cell Biol 166: 969-974.
    • (2004) J Cell Biol , vol.166 , pp. 969-974
    • Wissing, S.1    Ludovico, P.2    Herker, E.3
  • 62
    • 0036278335 scopus 로고    scopus 로고
    • Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
    • Xu J, Kao SY, Lee FJ, Song W, Jin LW & Yankner BA (2002) Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med 8: 600-606.
    • (2002) Nat Med , vol.8 , pp. 600-606
    • Xu, J.1    Kao, S.Y.2    Lee, F.J.3    Song, W.4    Jin, L.W.5    Yankner, B.A.6


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